Clinical trials: Out of Hospital Cardiac Arrest
Out of Hospital Cardiac Arrest
Pre-hospital ECMO or Conventional Resuscitation for Refractory Cardiac Arrest
This pilot study aims to determine feasibility of randomising patients to receive pre-hospital Extracorporeal Cardiopulmonary Resuscitation (ECPR) compared to conventional cardiac arrest care for refractory out of hospital…
- Trial name
- PACER (NCT06177730)
- Testing
- Pre-Hospital ECPR
- Volunteers
- 10 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Out-Of-Hospital Cardiac Arrest
Enhanced Community First Responder System Evaluation in Singapore
The rise in out-of-hospital cardiac arrest (OHCA) cases in Singapore highlights the need for effective bystander cardiopulmonary resuscitation (BCPR).
- Trial name
- TCPR-Link (NCT06530433)
- Testing
- CPRCard + TCPR Link App and Web, CPRCard Only
- Where
- Singapore
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Cardiopulmonary Arrest
Compare Outcomes of CPR Between the Video-laryngoscopy (VL) Users and the Direct-laryngoscopy (DL) Users
This is a clinical study based on the analysis of video-clip data of cardiopulmonary resuscitation (CPR) and clinical data for out of hospital cardiac arrest patients between 2011 and 2015.
- Trial name
- NCT03256019
- Testing
- Endotracheal Intubation
- Volunteers
- 600 people
- Sponsor
- Konkuk University Medical Center
Cardiac Arrest (CA)
Strategies for Defibrillation During Out-of-Hospital Cardiac Arrest
The "Strategies for Defibrillation during Out-of-Hospital Cardiac Arrest" (STRAT-DEFI) trial is an investigator-initiated, individually randomized, 3-group clinical trial comparing standard anterior-lateral pad positioning with…
- Trial name
- STRAT-DEFI (NCT06781892)
- Testing
- Anterior-lateral pad positioning, Anterior-posterior pad positioning, Double-sequential defibrillation
- Where
- 6 sites in Denmark
- Volunteers
- 909 people
- Sponsor
- Lars Wiuff Andersen
Out-Of-Hospital Cardiac Arrest, Mobile Phone Use
Impact of Mobile Phone Application Use on Adult BLS
The aim of the study is to investigate whether a serious smartphone game (called MOBI-CPR game) used in the home environment has an impact on the retention of adult basic life support knowledge and skills.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Mobile Phone Use, Stress, Knowledge, Attitudes, Practice
- Trial name
- MOBI-CPR (NCT05784675)
- Testing
- MOBI-CPR game
- Where
- Slovenia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nino Fijačko
Cardiac Arrest With Successful Resuscitation, Cardiac Arrest, Cause Unspecified
Optimization of Transport and Use of a Mobile ECMO Team in Patients With Sudden Cardiac Arrest in the Moravian-Silesian Region
This study evaluates the feasibility of implementing a mobile extracorporeal membrane oxygenation (ECMO) team and optimizing patient transport logistics.
- Trial name
- NCT07009652
- Testing
- Extracorporeal cardiopulmonary resuscitation (ECPR)
- Where
- 2 sites in Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Ostrava
Cardiac Arrest, Out of Hospital Cardiac Arrest
Compression Only-CPR Versus Standard-CPR
Out-of-hospital cardiac arrest (OHCA) is one of the leading causes of mortality in the industrialized world. Bystander CPR before arrival of the Emergency Medical Service (EMS) is a positive predictor of survival.
- Trial name
- TANGO2 (NCT02401633)
- Testing
- CO-CPR, S-CPR
- Where
- Sweden
- Volunteers
- 1,250 people
- Sponsor
- Karolinska Institutet
Out-Of-Hospital Cardiac Arrest
Ventilation Monitoring in OHCA
This is a before-and-after study examining the impact of real-time ventilation monitoring during out-of-hospital cardiac arrest.
- Trial name
- NCT04988906
- Testing
- Zoll Accuvent Ventilation Monitor
- Where
- Canada
- Volunteers
- 412 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA)
The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.
The goal of this clinical trial is to learn whether using Positive End-Expiratory Pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves outcomes for adults who experience out-of-hospital cardiac arrest, a condition…
- Conditions
- Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA), Positive End-expiratory Pressure (PEEP), Ventilation During Resuscitation
- Trial name
- Lazarus-PEEP (NCT06939335)
- Testing
- Disposable PEEP Valve set at 5 cm H20., Controle
- Where
- 7 sites in Belgium, France
- Volunteers
- 132 people
- Sponsor
- University Hospital, Ghent
Out-Of-Hospital Cardiac Arrest
Automatic Ventilation in Prehospital Resuscitation on OHCA
The goal of this randomized controlled trial is to compare prehospital ventilation strategies in out-of-hospital cardiac arrest. The intervention group is automatic ventilation and the control group is manual ventilation.
- Trial name
- NCT06067204
- Testing
- Automatic ventilation, Manual ventilation
- Where
- Taiwan
- Volunteers
- 522 people
- Sponsor
- National Taiwan University Hospital
Cardiac Arrest, Out-Of-Hospital, Ventricular Fibrillation
Ventricular Fibrillation Following Out-of-hospital Cardiac Arrest
The majority of survivors suffering an out-of-hospital cardiac arrest (OHCA) are those who initially present with a shockable rhythm, which is usually ventricular fibrillation (VF).
- Trial name
- NCT05325385
- Testing
- There are no interventions - this is a database study only
- Where
- United Kingdom
- Volunteers
- 15,000 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Out-Of-Hospital Cardiac Arrest, Foreign Body Aspiration
Foreign Body Airway Obstruction, Incidence, Survival EMS-treatment and First Aid Treatment by Laypersons
Background: Foreign body airway obstruction (FBAO) is often described as an uncommon cause of Out of Hospital Cardiac Arrest (OHCA) accounting for approximately 1.4% of all OHCA.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Foreign Body Aspiration, Cardiopulmonary Arrest
- Trial name
- NCT04279860
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Out-of-hospital Cardiac Arrest
Evaluation of Out-of-Hospital Cardiac Arrest Recognition by Non-physicians Dispatchers in a French Emergency Dispatch Call Center
The purpose of this study is to measure an improvement in the detection rate of cardiac arrest (CA) in the Dispatch Center as a result of debriefings and repeated trainings for non-medical operators who receive emergency calls.
- Trial name
- OCAR (NCT01992419)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Fire Brigade Of Paris Emergency Medicine Dept
Out-of-hospital Cardiac Arrest (OHCA), ECMO Treatment
Hypothermia Versus Normothermia After Extracorporeal Cardiopulmonary Resuscitation for Out-of-hospital Cardiac Arrest
The SAVE-J NEUROTHERM trial is a cluster randomized trial that evaluated and compared the mortality risk, neurological outcomes, and adverse events between patients who underwent hypothermia and those who underwent normothermia…
- Conditions
- Out-of-hospital Cardiac Arrest (OHCA), ECMO Treatment, Temperature, Post Cardiac Arrest Syndrome
- Trial name
- J-NEURO (NCT06776549)
- Testing
- Temperature control
- Where
- 29 sites in Japan
- Volunteers
- 468 people
- Sponsor
- Kagawa University
Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation
Real Time Amplitude Spectrum Area to Guide Defibrillation
AMSA trial is a multicenter, randomized, controlled study in out-of-hospital cardiac arrest patients. The purpose of the study is to test the hypothesis that a real time AMSA analysis during CPR may predict the success of…
- Trial name
- AMSA (NCT03237910)
- Testing
- AMSA, Defibrillation, CPR
- Where
- 2 sites in Italy
- Volunteers
- 31 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Cardiac Arrest
Cardiac Arrest Survival Score (CRASS)
Survival following cardiopulmonary resuscitation (CPR) from out-of-hospital cardiac arrest (OHCA) depends on numerous prehospital and in-hospital variables and interventions.
- Trial name
- CRASS (NCT03571113)
- Testing
- Survival / not survival
- Volunteers
- 8,603 people
- Sponsor
- German Resuscitation Registry
Cardiac Arrest, Out-Of-Hospital
Brain Oxygenation During Cardiopulmonary Resuscitation
The study is aimed to assess (a) the incidence of hyperoxia at the point of return of spontaneous circulation (ROSC) and (b) the role of arterial blood oxygen partial pressure to brain oxygenation during out-of-hospital cardiac…
- Trial name
- NCT03464123
- Testing
- Standard cardiopulmonary resuscitation
- Where
- Finland
- Volunteers
- 80 people
- Sponsor
- Helsinki University Central Hospital
Out-of-hospital Cardiac Arrest
Immediate Unselected Coronary Angiography Versus Delayed Triage in Survivors of Out-of-hospital Cardiac Arrest Without ST-segment Elevation
The aim of the trial is to compare immediate angiography in survivors of out of hospital cardiac arrest (OHCA) without ST-segment elevation versus delayed/selective catheterization with respect to 30 day mortality.
- Trial name
- TOMAHAWK (NCT02750462)
- Testing
- Immediate coronary angiography, Delayed/selective coronary angiography
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- University Hospital Schleswig-Holstein
Out-Of-Hospital Cardiac Arrest
Medical Dispatchers' Perception of Visual Information in Real Out-of-hospital Cardiac Arrest
Dispatcher-assisted cardiopulmonary resuscitation is a complex, nonvisual procedure that is challenging for the dispatcher. The aim was to explore the medical dispatchers' perception of bystanders' responses and dispatchers'…
- Trial name
- NCT03721666
- Testing
- CCTV footage to the medical dispatcher in OHCA
- Volunteers
- 10 people
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Out of Hospital Cardiac Arrest Without ST-segment Elevation
Performance of Coronary CT Angiography to Rule Out Coronary Artery Disease After Out-of-hospital Cardiac Arrest
Out-of-hospital cardiac arrest (OHCA) has multiple etiologies. In the absence of ST-elevation myocardial infarction, percutaneous coronary intervention (PCI) is delayed.
- Trial name
- PERFECCT (NCT05961488)
- Testing
- Coronary Calcium Score and Coronary CT angiogram
- Where
- France
- Volunteers
- 200 people
- Sponsor
- CHU de Reims