Clinical trials: Out-of Hospital Cardiac Arrest
Out-of-Hospital Cardiac Arrest, Post Cardiac Arrest Syndrome
The Complement Lectin Pathway After Cardiac Arrest
This study includes comatose survivors of out-of-hospital cardiac arrest treated with 24 hours or 48 hours of targeted temperature management.
- Trial name
- NCT02826057
- Testing
- Targeted temperature management (33 degree Celsius)
- Where
- 3 sites in Denmark
- Volunteers
- 82 people
- Sponsor
- University of Aarhus
Cardiac Arrest, Out-Of-Hospital
AED 3 Post-Approval Study
Demonstrate appropriate CPR sensor placement on pediatric and adult patients and demonstrate delivery of appropriate energy level of shocks to pediatric and adult patients.
- Trial name
- NCT05013333
- Testing
- AED 3 with Uni-padz
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Zoll Medical Corporation
Out-of-hospital Cardiac Arrest
Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest
ILCOR guidelines recommend Target Temperature Management (TTM) to between 32°C and 36°C after out-of-hospital cardiac arrest, based on low quality evidence.
- Trial name
- TTM-2 (NCT02908308)
- Testing
- Targeted temperature management to 33°C, Standard care with early treatment of fever
- Where
- 60 sites in United States, Australia and 12 more
- Volunteers
- 1,900 people
- Sponsor
- Helsingborgs Hospital
Out-Of-Hospital Cardiac Arrest
Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest
The TAME Cardiac Arrest trial will study the ability of higher arterial carbon dioxide (PaCO2) levels to reduce brain damage, comparing giving patients 'normal' to 'slightly higher than normal' blood PaCO2 levels and assessing…
- Trial name
- TAME (NCT03114033)
- Testing
- Targeted therapeutic mild hypercapnia, Targeted normocapnia (Standard care)
- Where
- 52 sites in Australia, Belgium and 12 more
- Volunteers
- 1,700 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Cardiac Arrest, Hypoxic Ischemic Brain Injury
TIBOHCA: Safety, Tolerability and Pharmacokinetics of 2-Iminobiotin (2-IB) After OHCA
Following successful cardiopulmonary resuscitation (CPR) after out of hospital cardiac arrest (OHCA), 50% of patients admitted to the Intensive Care Unit (ICU) die.
- Trial name
- TIBOHCA (NCT02836340)
- Testing
- 2-Iminobiotin
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cardiac Arrest
Vasopressin and Epinephrine Versus Epinephrine Alone in Cardiac Arrest
Recent studies have suggested that arginine-vasopressin could be more effective in the treatment of cardiac arrests. The last published study did not outline obvious improvements in the prognosis of all cardiac arrests but…
- Trial name
- NCT00127907
- Testing
- epinephrine (1 mg/1 mL), arginine-vasopressin (40 UI/2 mL)
- Where
- France
- Volunteers
- 2,416 people
- Sponsor
- Hospices Civils de Lyon
Cardiac Arrest, Out-Of-Hospital
Pulse Checks Using Femoral Artery B-Mode Ultrasound With Compressibility Assessment
The goal of this prospective observational study is to investigate B-mode point-of care ultrasound with arterial compressibility assessment on the femoral artery as a method to determine the presence of a pulse and to compare it…
- Trial name
- NCT06491186
- Testing
- Point of Care Ultrasound
- Where
- Austria
- Volunteers
- 69 people
- Sponsor
- Medical University of Vienna
Cardiac Arrest (CA), Hypoxic-Ischemic Brain Injury
Multiomics Profiling of CSF in Cardiac Arrest Survivors
The goal of this observational study is to identify further pathophysiologic mechanism of secondary brain injury following cardiac arrest by using serial multiomics profiling of serum and cerebrospinal fluid (CSF) samples.
- Conditions
- Cardiac Arrest (CA), Hypoxic-Ischemic Brain Injury, Post-Resuscitation Syndrome
- Trial name
- MOPCAS (NCT07090577)
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Chungnam National University Hospital
Out of Hospital Cardiac Arrest
Initiation of Cooling by EMS to Promote Adoption of In-hospital Hypothermia in Cardiac Arrest Survivors
This is a large pragmatic, randomized controlled trial comparing pre-hospital initiation of therapeutic hypothermia by Emergency Medical Services (EMS) providers to conventional post-resuscitation care.
- Trial name
- NCT01528475
- Testing
- Pre-hospital cooling
- Where
- 3 sites in Canada
- Volunteers
- 585 people
- Sponsor
- Sunnybrook Health Sciences Centre
Out-of-Hospital Cardiac Arrest
Resuscitative Balloon Occlusion of the Aorta in Non-traumatic Out of Hospital Cardiac Arrest
The primary aim of this study is to investigate the feasibility and complications of inserting a REBOA-catheter to patients suffering from non-traumatic out-of-hospital cardiac arrest, by anesthesiologist working in the…
- Trial name
- REBOA (NCT03534011)
- Testing
- Resuscitative Balloon Occlusion of the Aorta, REBOA catheter
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Norwegian University of Science and Technology
Cardiac Arrest, Neurologic Dysfunction
Identification of Neuroprognostic Factors for Out-of-hospital Cardiopulmonary Arrest (MIRA29)
From the informatized prehospital care registry, data will be collected anonymously for all patients' requiring cardiopulmonary resuscitation for an out-of-hospital cardiac arrest within the Norther Finistere sanitary region.
- Conditions
- Cardiac Arrest, Neurologic Dysfunction, Cognitive Impairment
- Trial name
- MIRA29 (NCT06569134)
- Where
- 2 sites in France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Brest
Out of Hospital Cardiac Arrest, Stent Thrombosis
Definite Stent Thrombosis in Comatose Out of Hospital Cardiac Arrest Survivors
Reliable data on stent thrombosis (ST) in comatose out of hospital cardiac arrest (OHCA) survivors is lacking. In comatose OHCA survivors suspicion of ST can be made with precise clinical monitoring of the patient with definite…
- Conditions
- Out of Hospital Cardiac Arrest, Stent Thrombosis, Drug Eluting Stent, Therapeutic Hypothermia
- Trial name
- ST OHCA (NCT03312296)
- Where
- Slovenia
- Volunteers
- 151 people
- Sponsor
- University Medical Centre Ljubljana
Cardiac Arrest, Sudden, Heart Arrest
Influence of the Education in Layperson in Out of Hospital Resuscitation
Cardiac arrest occurs frequently and the outcome after out-of-hospital resuscitation is often fatal. Disturbing is that more than half of the surviving patients suffer from permanent impairment of cognitive functions, such…
- Trial name
- NCT02473679
- Where
- Switzerland
- Volunteers
- 1,662 people
- Sponsor
- University of Zurich
Out-Of-Hospital Cardiac Arrest
Silesian Registry of Out-of-Hospital Cardiac Arrests
Silesian Registry of Out-of-Hospital Cardiac Arrests (SIL-OHCA) which is an initiative of the Voivodeship Rescue Service in Katowice in cooperation with the Silesian Center for Heart Diseases in Zabrze is a prospective…
- Trial name
- SIL-OHCA (NCT03654859)
- Testing
- cardiopulmonary resuscitation
- Where
- Poland
- Volunteers
- 1,560 people
- Sponsor
- Silesian Centre for Heart Diseases
Out-Of-Hospital Cardiac Arrest
Post-resuscitation Care Registry for Survival From Out-of-hospital Cardiac Arrest
The aim of this study is to construct multi-center post-cardiac arrest care registry that can be used for data warehousing and clinical research.
- Trial name
- NCT03695718
- Where
- 3 sites in South Korea
- Volunteers
- 1,057 people
- Sponsor
- Seoul National University Hospital
Out-Of-Hospital Cardiac Arrest
The HeartRunner Trial
The study will assess 30-day survival for cases where volunteer citizen responders ('heart runners') were activated through a smartphone app to retrieve an AED in case of suspected out-of-hospital cardiac arrest (OHCA) versus…
- Trial name
- NCT03835403
- Testing
- Activation of HeartRunners
- Where
- Denmark
- Volunteers
- 2,114 people
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Sudden Cardiac Arrest
LUCAS Chest Compressor Versus Manual Chest Compression in Out-of-hospital Sudden Cardiac Arrest. LUCAT Trial
The goal of this study is to show the superiority in survival at hospital admittance and in neurological outcome on hospital discharge of continuous mechanical chest compression using LUCAS device versus manual chest compressions…
- Trial name
- LUCAT (NCT01521208)
- Testing
- LUCAS (Lund University Cardiac Assist Sysrem), Manual chest compressions
- Where
- 2 sites in Spain
- Volunteers
- 400 people
- Sponsor
- Sistema d'Emergències Mèdiques
Death, Sudden, Cardiac, Out-Of-Hospital Cardiac Arrest
Pre-hospital ECMO in Advanced Resuscitation in Patients With Refractory Cardiac Arrest. ( SUB30 )
To establish whether a pre-hospital advanced physician/ paramedic cardiac arrest team that is ECMO capable can establish ECMO flow within 30 minutes of collapse.
- Conditions
- Death, Sudden, Cardiac, Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation, Cardiopulmonary Arrest With Successful Resuscitation
- Trial name
- SUB30 (NCT03700125)
- Testing
- ECMO resuscitation
- Where
- 2 sites in United Kingdom
- Volunteers
- 5 people
- Sponsor
- Barts & The London NHS Trust
Cardiac Arrest
Refractory IHCA and OHCA Treated With ECMO
Extracorporeal membrane oxygenation (ECMO) support has been suggested to improve the survival rate in patients with refractory cardiac arrest (CA).
- Trial name
- SEAC (NCT01298050)
- Testing
- ECMO
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Milano Bicocca
Heart Arrest, Out-Of-Hospital, Brain Swelling
The Effect of Lumbar CSF Drainage on the Neurologic Outcome Improvement in OHCA Underwent TTM
Aim: The investigators aim to evaluate the effect of lumbar cerebrospinal fluid (CSF) drainage on neurologic outcome in post-cardiac arrest (CA) patients treated with target temperature management (TTM).
- Trial name
- NCT04328974
- Testing
- lumbar CSF drainage
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Chungnam National University Hospital