Clinical trials: Ovarian
Adnexal Mass, Adnexal Tumor
Masses in Young Patients - International Ovarian Tumour Analysis (MY-IOTA)
This multicenter observational study aims to validate the IOTA Simple Rules, Benign Descriptors, and ADNEX model in a cohort of patients equal or under the age of 20.
- Conditions
- Adnexal Mass, Adnexal Tumor, Adnexal Cyst, Adnexal Masses in Young Girls and Adolescents
- Trial name
- MY-IOTA (NCT06693596)
- Testing
- Group 2: Conservative management (follow-up), Group 1: Surgical management
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lung Cancer, Breast Cancer
Plasma Metabolic Biomarkers for Multi-Cancer Diagnosis
The aim of this observational study is to comprehensively analyze the metabolites in plasma samples from multi-cancer patients using advanced mass spectrometry detection technology, in conjunction with metabolomics approaches.
- Conditions
- Lung Cancer, Breast Cancer, Colorectal Cancer, Thyroid Cancer
- Trial name
- NCT06363123
- Where
- 4 sites in China
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Familial Premature Ovarian Failure
Genetic Analysis of Familial Cases of Premature Ovarian Failure
The Premature ovarian failure (POF) is a rare syndrome observed in women under 40 who induced estrogen deficiency and often leads to infertility final. The etiologies of POF remain unknown in more than 85% of cases.
- Trial name
- FAMIOP (NCT01177891)
- Where
- 2 sites in France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Subfertility
Preimplantation Genetic Testing for Aneuploidy of Polar Bodies
This study intends to randomly group the patients with advanced maternal age and poor ovarian response, and the study group will undergo polar body biopsy, and the next-generation sequencing(NGS) technology will be used to…
- Trial name
- NCT04538560
- Testing
- polar body biopsy
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Polycystic Ovary Syndrome
A Multi-omic Approach to Evaluate and Characterize the Polycystic Ovary Syndrome (PCOS) Phenotype
The purpose of this research study is to explore the relationship between the gut microbiome and hormone levels in women diagnosed with PCOS and determine whether there are differences in the gut microbiome between women with…
- Trial name
- NCT04981275
- Testing
- No intervention study
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Onegevity Health
Polycystic Ovary Syndrome
Clinical and Biochemical Presentation of Polycystic Ovary Syndrome in Different Age Group
To study the clinical and biochemical characteristics women with polycystic ovary syndrome (PCOS) in different aged groups.
- Trial name
- NCT01350895
- Where
- Taiwan
- Volunteers
- 781 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Ovarian Cancer, Caregiver Burden
Multidimensional Burden of Platinum Resistant Ovarian Cancer (PROC) on Patients and Caregivers in Canada
Filling the gap in Canadian evidence on the burden of PROC on QoL is essential. It will help better understand the impact of PROC on multiple aspects of the lives of patients and their caregivers and the real-life hurdles faced…
- Conditions
- Ovarian Cancer, Caregiver Burden, Patient Burden
- Trial name
- NCT07035067
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- PeriPharm
Premature Ovarian Insufficiency
Effect and Mechanism of Jiajian Guishen Optimized Formula on Premature Ovarian Insufficiency: Insights Into m6A Modification and Oxidative Stress
The goal of this clinical study is to evaluate the effectiveness of JiaJian GuiShen Optimized Formula (JJGS) and explore its mechanisms involving m6A modification and oxidative stress in women with premature ovarian insufficiency…
- Trial name
- JJGS ; POI (NCT07843030)
- Testing
- JJGS
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Shi Yun
Turner Syndrome, Ovarian Failure, Premature
Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure
Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition.
- Conditions
- Turner Syndrome, Ovarian Failure, Premature, Sex Chromosome Aberrations, Menopause
- Trial name
- NCT00471731
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Polycystic Ovarian Disease
The Influence of Polycystic Ovairan Syndrome on Embryonic Developmental Timing
Polycystic ovary syndrome is one of the most common causes of female infertility. The cause of infertility in PCOS is unknown. Factors other than anovulation, including inherited or induced changes in the embryo quality have been…
- Trial name
- PCOS (NCT01953146)
- Where
- Denmark
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Oxidative Stress, Ovarian Insufficiency, Primary
Ovarian Reserve and Matrix Metalloproteinases
Primary Ovarian Insufficiency (POI) is dysfunction of ovaries before 40 years of age. It has been reported that genetic factors, endocrine disorders, previous pelvic surgeries, chemotherapy and radiotherapy, and autoimmune…
- Conditions
- Oxidative Stress, Ovarian Insufficiency, Primary, Ovarian Failure, Premature
- Trial name
- NCT05443282
- Testing
- Prolidase Level, Follicle Stimulating Hormone Level, Estradiol Level
- Where
- Turkey (Türkiye)
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Polycystic Ovary Syndrome
Effect of Increased Circulating Androgens on Granulosa Cell Responses to FSH.
The purpose of this study is to evaluate the effect of increased circulating androgens on estradiol production by the granulosa cells in response to FSH stimulus.
- Trial name
- NCT02389088
- Testing
- Letrozole
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Infertility,Female
Recombinant LH Supplementation Timing Strategies (From Day 1 or Day 6) to a Standard GnRH Agonist Long Protocol in Subsequent COS Cycle of Older Patients With Unexpected Poor or Suboptimal Ovarian Response
A randomized, controlled, pilot study, for Patients ≥ 35 years and < 40 years old with sufficient ovarian reserve parameters (AFC≥ 5), but showed an unexpected poor or suboptimal ovarian response(defined as ≤ 9 retrieved oocytes…
- Trial name
- NCT04178135
- Testing
- rLH
- Where
- 2 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Polycystic Ovary Syndrome
The Role of Autoimmunity and Obesity in Polycystic Ovary Syndrome
The goal of the study is to detect autoantibodies in the serum of the women with PCOS and evaluate the obesity markers to investigate the the role of autoimmunity and obesity in PCOS
- Trial name
- NCT05929950
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sohag University
Polycystic Ovary Syndrome
Effects of Metformin vs Oral Contraceptives on CV Risk Markers in PCOS
Cardiovascular risk factors cluster in hyperandrogenic women - including those presenting with the polycystic ovary syndrome - in association with insulin resistance, obesity, and other metabolic disorders.
- Trial name
- NCT00428311
- Testing
- Metformin, Ethynyl-estradiol plus cyproterone acetate
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Ramon y Cajal
PCOS
A Metabolomic Study of Polycystic Ovary Syndrome With Insulin Resistance and Its Relationship With TCM Syndrome Types
The type-2 diabetes mellitus（T2DM）, metabolic syndrome, cardiovascular disease complications induced by polycystic ovary syndrome(PCOS) with insulin resistance(IR）, which become serious threat to public health.
- Trial name
- NCT02992093
- Testing
- all the indicators
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fujian Maternity and Child Health Hospital
Malignancies, Stomach Cancer
The Use of 18F-ALF-NOTA-PRGD2 PET/CT Scan to Predict the Efficacy and Adverse Events of Apatinib in Malignancies.
This is an open-label, single arm study to explore whether 18F-ALF-NOTA-PRGD2 PET/CT scan can predict the efficacy and adverse events of apatinib in patients with malignancies.
- Conditions
- Malignancies, Stomach Cancer, Non-small Cell Lung Cancer, Esophageal Cancer
- Trial name
- NCT03384511
- Testing
- Apatinib
- Where
- China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Shandong Cancer Hospital and Institute
Other Complications Associated With Artificial Fertilization
Efficacy of Luteinizing Hormone (LH) Activity in Low Responder Patients With Transdermal Testosterone
The investigators have previously demonstrated the utility of transdermal testosterone in in vitro fertilization (IVF) low responder patients.
- Trial name
- NCT01291212
- Testing
- Testosterone and FSHr-LHr, testosterone and FSHr alone
- Where
- Spain
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Polycystic Ovary Syndrome, Obesity
Insulin and the Polycystic Ovary Syndrome--Weight Reduction Study
The polycystic ovary syndrome is the leading cause of female infertility in the United States. The disorder affects approximately 6-10% of women of reproductive age.
- Trial name
- NCT00436865
- Testing
- Weight loss
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Ovarian Cancer
Ovarian Screening Study
The objectives of this study are: To identify women at increased risk for developing ovarian cancer To detect ovarian cancers at an early stage To investigate the role of tumor membrane fragments as tumor markers for early…
- Trial name
- NCT00267072
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Louisville