Clinical trials: Ovarian Cancers
Polycystic Ovary Syndrome, Insulin Resistance
The Role of Insulin Resistance in PCOS
Polycystic ovary syndrome (PCOS) phenotype can be structured into three components: anovulation, hyperandrogenism and the metabolic syndrome (of which hyperinsulinemia, secondary to insulin resistance, is the central…
- Conditions
- Polycystic Ovary Syndrome, Insulin Resistance, Obesity
- Trial name
- NCT00173043
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Bladder Cancer, Breast Cancer
A Study Comparing Oral Picoplatin With Intravenous Picoplatin in Subjects With Solid Tumors
Picoplatin is a new platinum-based chemotherapy drug that has been studied in a variety of cancers. Phase 1 and 2 studies have demonstrated that picoplatin may be effective in patients whose cancer returns or does not improve…
- Conditions
- Bladder Cancer, Breast Cancer, Colorectal Cancer, Gastrointestinal Neoplasm
- Trial name
- NCT00465725
- Testing
- Picoplatin
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- Poniard Pharmaceuticals
Hyperandrogenism, Polycystic Ovary Syndrome
Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?
The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism (HA), androgen-receptor blockade (spironolactone) alone normalizes sleep-wake luteinizing hormone (LH) pulse frequency (primary…
- Conditions
- Hyperandrogenism, Polycystic Ovary Syndrome, Puberty
- Trial name
- CBS010 (NCT04723862)
- Testing
- Spironolactone
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Solid Tumors
Phase I Study of MT110 in Lung Cancer (Adenocarcinoma and Small Cell), Gastric Cancer or Adenocarcinoma of the Gastro-Esophageal Junction, Colorectal Cancer, Breast Cancer, Hormone-Refractory Prostate Cancer, and Ovarian Cancer
This phase I dose escalation study is intended to define the safety, tolerability and maximal tolerable dose (MTD) of MT110 in patients with advanced solid tumors.
- Trial name
- MT110-101 (NCT00635596)
- Testing
- MT110
- Where
- 4 sites in Germany
- Volunteers
- 65 people
- Sponsor
- Amgen Research (Munich) GmbH
Ovarian Cancer
Study of the Isotopic Distribution of Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis of Ovarian Origin
The treatment of advanced ovarian cancer is based on the combination of chemotherapy based on platinum salt and surgery whose quality is the major prognostic factor.
- Trial name
- ISOTOVE (NCT02667925)
- Testing
- Intraperitoneal cisplatin with nanocis
- Where
- France
- Sponsor
- Centre Jean Perrin
Borderline Ovarian Tumors
Study Describing the Coverage, Cares and the Fertility of Patients of Less Than 45 Years With a Borderline Ovarian Tumor
Retrospective and prospective multi-center study Indication: Fertility-sparing surgery for patients with borderline ovarian tumor and fertility Objectives: Description of the characteristics of the patients of less than 45 years…
- Trial name
- OPTIBOT (NCT03690440)
- Where
- 11 sites in France
- Volunteers
- 176 people
- Sponsor
- Institut Curie
Myoma;Uterus, Vitamin D Deficiency
Vitamin D Levels And Myoma Uteri
Women with at least one uterine leiomyoma and polycystic ovary syndrome over 10 mm and women with normal ultrasonographic findings were included in the study.
- Conditions
- Myoma;Uterus, Vitamin D Deficiency, Polycystic Ovary
- Trial name
- NCT03871868
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Melanoma, Non-small Cell Lung Cancer
A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies
This is a study to determine the maximum tolerated dose (MTD) for CDX-1140 (CD40 antibody), either alone or in combination with CDX-301 (FLT3L), pembrolizumab, or chemotherapy and to further evaluate its tolerability and efficacy…
- Conditions
- Melanoma, Non-small Cell Lung Cancer, Breast Cancer, Gastric Cancer
- Trial name
- NCT03329950
- Testing
- CDX-1140, CDX-301, pembrolizumab
- Where
- 11 sites in United States
- Volunteers
- 132 people
- Sponsor
- Celldex Therapeutics
Small Cell Lung Cancer, Gastric Adenocarcinoma
PDR001 Plus LAG525 for Patients With Advanced Solid and Hematologic Malignancies
The purpose of this signal seeking study is to determine whether treatment with PDR001 and LAG525 demonstrates sufficient efficacy in advanced malignancies to warrant further study.
- Conditions
- Small Cell Lung Cancer, Gastric Adenocarcinoma, Esophageal Adenocarcinoma, Castration Resistant Prostate Adenocarcinoma
- Trial name
- NCT03365791
- Testing
- PDR001, LAG525
- Where
- 20 sites in United States
- Volunteers
- 76 people
- Sponsor
- Novartis Pharmaceuticals
Ovarian Neoplasms, Peritoneal Neoplasms
Tolerance, Safety, Efficacy, and Pharmacokinetics of Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) Using Paclitaxel for Platinum-resistant Recurrent Ovarian Cancer
The purpose of this study is to evaluate the tolerance, safety, efficacy, and pharmacokinetics of pressurized intraperitoneal aerosol chemotherapy (PIPAC) with paclitaxel in patients with platinum-resistant recurrent ovarian…
- Trial name
- NCT07273396
- Testing
- Pressurized intraperitoneal aerosol chemotherapy (PIPAC) using paclitaxel
- Volunteers
- 53 people
- Sponsor
- Seoul National University Hospital
Ovarian Cancer
The Role of Regulatory T Cell in Ovarian Cancer: Focus on Relationship Between Clinical Prognosis and Regulatory T Cell Expression
Cancer is the leading cause of mortality in our country, and ovarian cancer becomes a more and more important disease gradually in the field of gynecologic malignancies.
- Trial name
- Tregs (NCT00854282)
- Testing
- Staging surgery or debulking surgery
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Polycystic Ovary Syndrome
Effects of Gum Arabic Ingestion on Hormonal and Metabolic Changes in Patients With Polycystic Ovary Syndrome
To assess the effects on hormonal and metabolic changes in the PCOs patients after ingestion of Arabic gum
- Trial name
- GA&PCO (NCT04215380)
- Testing
- Acacia Senegal extract, Pectin
- Where
- Sudan
- Volunteers
- 60 people
- Sponsor
- Lamis Kaddam
Ovarian Cancer
Paclitaxel and Carboplatin Combination as 1st Line Treatment in Ovarian Carcinomas
This trial will determine the feasibility and toxicity of dose intense (every 2 weeks) of paclitaxel+carboplatin combination following cytoreductive surgery in patients with stage Ic-IV ovarian cancer.
- Trial name
- NCT00750386
- Testing
- Paclitaxel, Carboplatin
- Where
- 12 sites in Greece
- Volunteers
- 50 people
- Sponsor
- Hellenic Oncology Research Group
Ovarian Cancer, Antibody-drug Conjugates
Efficacy and Safety of Sacituzumab in Patients With OCCC After Immunotherapy Progression
Ovarian clear cell carcinoma (OCCC) is a relatively rare but highly malignant epithelial ovarian cancer, accounting for 5%-10% of all ovarian cancers.
- Conditions
- Ovarian Cancer, Antibody-drug Conjugates, Clear Cell Adenocarcinoma of Ovary
- Trial name
- NCT07168083
- Volunteers
- 22 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Neoplasm, Ovarian, Fallopian Tube Cancer
A Study of Intraperitoneally Administered AVB-001 in Patients With Serous Adenocarcinoma of the Ovary
This is an open-label, First-in-Human, Phase 1/2, multicenter study to evaluate the safety and efficacy of a single dose of AVB-001.
- Conditions
- Neoplasm, Ovarian, Fallopian Tube Cancer, Primary Peritoneal Cavity Cancer, Adenocarcinoma Ovary
- Trial name
- NCT05538624
- Testing
- AVB-001 (Dose Escalation Phase), AVB-001 (Dose Expansion Phase)
- Where
- 5 sites in United States
- Volunteers
- 14 people
- Sponsor
- Avenge Bio, Inc
Endometriosis, Endometriosis-Associated Ovarian Carcinoma
A Study Evaluating the Diagnostic Performance of OCS in the Differential Diagnosis of Endometriosis vs. Endometriosis-Associated Ovarian Cancer
Prospectively enroll patients with endometriosis and EAOC who complete the routine diagnostic and treatment process and consent to surgical intervention for OCS testing.
- Trial name
- NCT07029659
- Testing
- Ovarian Cancer Score
- Where
- China
- Volunteers
- 336 people
- Sponsor
- Peking Union Medical College Hospital
Preventing Postoperative Venous Thromboembolism in Patients Undergoing Ovarian Cancer Surgery
A Study to Evaluate the Efficacy and Safety of SHR-2004 Injection in Preventing Postoperative Venous Thromboembolism in Patients Undergoing Ovarian Cancer Surgery
This study is designed to evaluate the efficacy and safety of SHR-2004 injection in preventing postoperative venous thromboembolism in patients undergoing ovarian cancer surgery.
- Trial name
- NCT06220123
- Testing
- SHR-2004, Enoxaparin Sodium Injection; Rivaroxaban Tablets
- Where
- China
- Volunteers
- 225 people
- Sponsor
- Beijing Suncadia Pharmaceuticals Co., Ltd
Ovarian Cancer
Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Persistent or Platinum Refractory Stage III or IV Ovarian Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Trial name
- NCT00003080
- Testing
- endocrine-modulating drug therapy, melphalan, mitoxantrone hydrochloride
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Effects of Chemotherapy
The Longitudinal Ovarian Reserve Study
Postmenarchal female cancer patients scheduled to undergo cancer therapy may enroll in this study to assess changes in existing and novel surrogate measures of fertility potential before, during and after chemotherapy.
- Trial name
- NCT02395341
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Ovarian Cancer
A Study of Niraparib in Combination With Abemaciclib for Late Line Treatment of Ovarian Cancer (NICHOL TRIAL)
This is an interventional trial. The goal of this clinical trial is dose finding. There are two phases: phase Ib to determine the MTD and recommended phase II dose of niraparib in combination with abemaciclib in patients with…
- Trial name
- NICHOL (NCT06594679)
- Testing
- Niraparib Tosylate Monohydrate
- Where
- Italy
- Volunteers
- 73 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
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