Clinical trials: Ovarian Failure
Primary Ovarian Insufficiency, Premature Ovarian Failure
The Impact of Granulocyte Colony Stimulating Factor on Premature Ovarian Insufficiency
The goal of this pilot study is to improve ovarian reserve markers in patients with premature ovarian insufficiency. The main question it aims to answer is: Will treatment with G-CSF allow improvement in markers of ovarian…
- Trial name
- NCT06117982
- Testing
- Neupogen
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Trio Fertility
Advanced Solid Tumors or Non-Hodgkin's Lymphoma (NHL)
A Phase 1/2 Trial of SRA737 in Subjects With Advanced Cancer
The purpose of this clinical study is to establish the safety profile, determine the maximum tolerated dose (MTD) and recommend a Phase 2 dose and schedule of SRA737; and to evaluate the efficacy of SRA737 in…
- Trial name
- NCT02797964
- Testing
- SRA737
- Where
- 15 sites in United Kingdom
- Volunteers
- 107 people
- Sponsor
- Sierra Oncology LLC - a GSK company
Breast Cancer, Ovarian Insufficiency
Predictors of Ovarian Insufficiency in Young Breast Cancer Patients
More than two million American women are breast cancer survivors. Approximately one-third of these women are premenopausal at diagnosis and face issues related to reproduction as they undergo cancer treatment.
- Conditions
- Breast Cancer, Ovarian Insufficiency, Ovarian Failure
- Trial name
- POISE (NCT01197456)
- Where
- 2 sites in United States
- Volunteers
- 232 people
- Sponsor
- University of California, San Diego
Turner Syndrome, Hypogonadism
Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism
Estrogen is necessary for feminization during puberty and to decrease bone resorption, the latter critical for the achievement of peak bone mass and normal bone health in the female.
- Conditions
- Turner Syndrome, Hypogonadism, Premature Ovarian Failure
- Trial name
- NCT00837616
- Testing
- 17 B estradiol orally, 17 B estradiol
- Where
- 3 sites in United States, Chile
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Amenorrhea, Premature Ovarian Failure
GnRH Analogue for Ovarian Function Preservation in Hematopoietic Stem Cell Transplantation Patients
Primary Objectives: To determine the effectiveness of the 3-month depot leuprolide in inducing and maintaining secondary amenorrhea in patients undergo hematopoietic stem cell transplantation.
- Conditions
- Amenorrhea, Premature Ovarian Failure, Ovarian Function Insufficiency
- Trial name
- NCT00429494
- Testing
- Leuprolide Acetate, Questionnaire, Hematopoietic Stem Cell Transplantation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Anovulation
Sildenafil Vaginal Gel Co-treatment With Clomiphene Citrate in Infertile Women With Thin Endometrium
This is a prospective self controlled clinical trial. Women with clomiphene Citrate failure, and thin endometrium were recruited (N = 42).
- Trial name
- NCT02710981
- Testing
- clomiphene citrate, Sildenafil vaginal gel
- Volunteers
- 42 people
- Sponsor
- Assiut University
Colorectal and Ovarian Cancer Patients With Liver Metastases
EMD 525797 in Colorectal and Ovarian Cancer Patients With Liver Metastases
This study is intended to test an experimental drug called EMD 525797 (Abituzumab). This drug is not yet approved for sale and has only been tested in a small number of people to date (prior to this study starting another…
- Trial name
- NCT00848510
- Testing
- EMD 525797
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Breast Cancer
Goserelin Acetate Study for Ovarian Function in Patients With Primary Breast Cancer
Primary Objective: To determine the effectiveness of goserelin acetate (Zoladex) in preserving ovarian function in premenopausal women undergoing neoadjuvant and/or adjuvant chemotherapy for primary invasive breast cancer by…
- Trial name
- NCT00429403
- Testing
- Goserelin
- Where
- 2 sites in United States, Japan
- Volunteers
- 1 people
- Sponsor
- M.D. Anderson Cancer Center
Cognitive Impairment, RRSO
IMProving Executive Function Study
This is a double-blind, placebo-controlled, crossover study testing whether Vyvanse (lisdexamfetamine; LDX) improves executive functioning (EF) in 100 postmenopausal women who report onset of EF difficulties after oophorectomy.
- Trial name
- IMPRES (NCT03187353)
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Primary Ovarian Insufficiency
Primary Ovarian Insufficiency: Phenotype and Optimal Treatment
This pilot study will observe the progression of newly diagnosed POI patients physical and psychology outcomes after initiating standard of care HRT treatment in comparison to healthy female control participants' physical and…
- Trial name
- NCT03568708
- Testing
- Transdermal Estrogen
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Epithelial Ovarian Cancer
A Study to Compare CAELYX With Topotecan HCL in Patients With Recurrent Epithelial Ovarian Carcinoma Following Failure of First-Line, Platinum-Based Chemotherapy
The purpose of this study is to compare the effectiveness between CAELYX and topotecan hydrochloride (HCl) in Chinese participants with recurrent epithelial ovarian carcinoma following failure of first-line, platinum-based…
- Trial name
- NCT01840943
- Testing
- CAELYX, Topotecan HCl
- Where
- 7 sites in China
- Volunteers
- 32 people
- Sponsor
- Xian-Janssen Pharmaceutical Ltd.
Cancer
Antithymocyte Globulin, Clofarabine, and Rituximab in Treating Patients After an Unsuccessful Stem Cell Transplant
RATIONALE: Antithymocyte globulin, clofarabine, and rituximab may stop the patient's immune system from rejecting the donor's stem cells when they do not exactly match the patient's blood.
- Trial name
- NCT00617929
- Testing
- anti-thymocyte globulin, rituximab, clofarabine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Breast Cancer, Infertility
S0230 Goserelin in Preventing Ovarian Failure in Women Receiving Chemotherapy for Breast Cancer
RATIONALE: Goserelin blocks hormone production in the ovaries. It is not yet known whether ovarian suppression using goserelin will prevent ovarian failure (early menopause) in women receiving chemotherapy for breast cancer.
- Conditions
- Breast Cancer, Infertility, Menopausal Symptoms
- Trial name
- NCT00068601
- Testing
- cyclophosphamide, goserelin acetate
- Where
- 34 sites in Australia, Belgium and 4 more
- Volunteers
- 257 people
- Sponsor
- SWOG Cancer Research Network
Premature Ovarian Failure
Dehydroepiandrosterone (DHEA) Treatment and Premature Ovarian Failure (POF)
The experimental focus of this project is on the interaction of DHEA treatment on pregnancy in women with open tubes, fertile male partners and evidence of premature ovarian failure.
- Trial name
- DHEAFert2 (NCT00948857)
- Testing
- Dehydroepiandrosterone
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- David H. Barad
Ovarian Failure, Premature
Comparison of Transdermal and Oral Estrogens in Adolescent Girls With Ovarian Failure
To directly compare the safety (by laboratory evaluation) and efficacy (feminization and growth) of three commonly used estrogen preparations in adolescent patients with ovarian failure, either due to congenital causes (Turner…
- Trial name
- NCT01023178
- Testing
- 17beta Estradiol, Conjugated estrogens, 17Beta Estradiol - transdermal
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Healthy, Premature Ovarian Failure
Feasibility Study for Development of an Early Test for Ovarian Failure
This purpose of this study is to gain information about normal ovarian function that will be useful in developing a test for early detection of ovarian failure.
- Trial name
- NCT00006156
- Testing
- Control, Drug: FSH
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Breast Cancer
Aromatase Inhibitors in Premenopausal Breast Cancer Patients With Chemotherapy-Induced Ovarian Failure
Women with hormone-receptor positive breast cancer are typically treated with hormone therapy as part of their treatment after surgery.
- Trial name
- NCT00555477
- Testing
- anastrozole
- Where
- 3 sites in United States
- Volunteers
- 69 people
- Sponsor
- University of Michigan Rogel Cancer Center