Clinical trials: Ovarian Mass
Endometrial Cancer, Cervical Cancer
Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer
The overarching objective of this project is to develop a pan-gynecologic cancer detection test using gynecologic (unique endometrial, cervical, and ovarian cancer) cancer-specific methylated DNA markers and high-risk human…
- Conditions
- Endometrial Cancer, Cervical Cancer, Atypical Endometrial Hyperplasia, Cervical Dysplasia
- Trial name
- ECHO (NCT05051722)
- Testing
- Vaginal Fluid Collection, Blood Collection
- Where
- 25 sites in United States
- Volunteers
- 3,110 people
- Sponsor
- Mayo Clinic
Body Mass Index 25 or Greater, BRCA1 Gene Mutation
Energy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family Members
This pilot clinical trial studies different types of energy balance interventions to see how well they work in increasing the physical activity levels of breast cancer gene-positive patients, Lynch syndrome-positive patients…
- Conditions
- Body Mass Index 25 or Greater, BRCA1 Gene Mutation, BRCA2 Gene Mutation, Breast Carcinoma
- Trial name
- NCT02194387
- Testing
- Dietary Intervention, Internet-Based Intervention, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 337 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Ovarian Mass, Adnexal Mass
An AI-Assisted Agentic System for Ultrasound Scanning and Diagnosis of Ovarian Lesions
Investigators developed an interactive agentic system designed to guide newly qualified sonographers in ovarian lesion scanning and improve their scanning quality and diagnostic performance toward expert-level standards.
- Trial name
- NCT07801209
- Testing
- non-AI assisted and then AI assisted, AI assisted and then non-AI assisted
- Where
- 2 sites in China
- Volunteers
- 250 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Endometriosis, Fibroids
Impact of Educational Videos on Pre-operative Anxiety
The goal of this clinical trial is to learn if educational videos can reduce pre-operative anxiety in patients undergoing minimally invasive gynecologic surgery.
- Conditions
- Endometriosis, Fibroids, Adenomyosis, Pelvic Pain
- Trial name
- NCT07740759
- Testing
- educational video
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- UConn Health
Ovarian Mass
Concordance Between Radiologic Laparoscopic and Laparotomic Evaluation for Complete Cytoreduction of Ovarian Masses
Ovarian mass occur in women of all ages, and their etiology and frequency range age accordingly. The ovarian mass may come from functional or physiological changes, inflammatory processes, endometriosis, benign and malignant…
- Trial name
- NCT07416435
- Volunteers
- 28 people
- Sponsor
- Assiut University
Ovarian Cancer, Adnexal Mass
ICG-Enabled Mapping of Ovarian Sentinel Lymph Nodes: A Feasibility Study
The purpose of this study is to find out how well ovarian sentinel lymph nodes (SLNs) can be identified with indocyanine green (ICG) dye during risk-reducing ovarian surgery.
- Trial name
- NCT04051502
- Testing
- Method 1: Indocyanine green dye, Method 2: Indocyanine green dye, Method 3: Indocyanine green dye
- Where
- 7 sites in United States
- Volunteers
- 48 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Sonography, Ovarian Mass
Sonographic Evaluation of Ovarian Masses by ORADS System
This observational study will evaluate how well an ultrasound scoring system called O-RADS can distinguish between benign (non-cancerous) and malignant (cancerous) ovarian masses in women aged 18 to 70 years.
- Trial name
- NCT07289126
- Volunteers
- 80 people
- Sponsor
- Assiut University
Adenopathy, Uterine Fibroids
A Clinical Study on the Feasibility and Safety of Abdominal Endoscopic Single-port Surgery System to Assist Gynecological Day Surgery
In this study, a prospective study is used to select patients who will undergo intra-abdominal endoscopic single-port surgery system for benign gynecological diseases from February 2025 to December 2026 in the Second Affiliated…
- Conditions
- Adenopathy, Uterine Fibroids, Ovarian Cysts, Adnexal Mass
- Trial name
- NCT06828419
- Testing
- Domestic single-port laparoscopic surgery system
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Ovarian Cancer, Ovarian Mass
MIRRORS-FROZEN - Comparing Open Vs Robotic Surgery in the Management of Women with Complex Pelvic Adnexal Masses ≤ 8cm.
Adnexal masses are growths that can form in the ovaries or fallopian tubes for different reasons, such as hormonal changes, infection, or cancer.
- Conditions
- Ovarian Cancer, Ovarian Mass, Ovarian Cysts, Fallopian Tube Neoplasms
- Trial name
- MIRRORS-FROZEN (NCT06638593)
- Testing
- MIRRORS-FROZEN Protocol., Standard open surgery
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Ovarian Neoplasms, Adnexal Mass
Research and Application of Ultrasonic Intelligent Diagnosis System for Ovarian Mass
Research on automatic detection of ovarian mass and intelligent auxiliary diagnosis system based on multimodal ultrasound images.
- Trial name
- NCT06528236
- Testing
- Artificial intelligence model
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Zhejiang Provincial People's Hospital
Undetermined Ovarian Mass
Characterization of Ovarian Masses Unable to Classify With Gynecological Ultrasonography: Value of Pelvic MRI With Perfusion- and Diffusion-weighted Imaging
The aim of the study is to prospectively evaluate the value of pelvic MRI including diffusion- and perfusion-weighted sequences in the selected group of patients that have an undetermined ovarian mass at ultrasound.
- Trial name
- IOTAMRI (NCT02425540)
- Testing
- Pelvic MRI
- Where
- Belgium
- Volunteers
- 74 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ovarian Neoplasms, Ovarian Cancer
Improved Diagnosis of Ovarian Cancer
After implementation of systematic image description of adnexal masses, we aim to improve and evaluate our use of available imaging methods and biomarkers for classifying adnexal masses and distinguishing between benign and…
- Conditions
- Ovarian Neoplasms, Ovarian Cancer, Ovarian Cysts, Adnexal Mass
- Trial name
- NCT05842629
- Where
- Denmark
- Volunteers
- 1,700 people
- Sponsor
- University of Aarhus
Adnexal Mass, Ovarian Cancer
Clinical Validation of the InterVenn Ovarian CAncer Liquid Biopsy
Venn Biosciences Corporation ("InterVenn") has developed a liquid biopsy that is capable of distinguishing benign from malignant masses in women presenting with adnexal (pelvic) masses, through a simple blood test.
- Conditions
- Adnexal Mass, Ovarian Cancer, Pelvic Mass
- Trial name
- VOCAL (NCT03837327)
- Where
- 26 sites in United States, Australia and 2 more
- Volunteers
- 1,025 people
- Sponsor
- Venn Biosciences Corporation
Epithelial Ovarian Cancer, Adnexal Mass
Diagnosis of Epithelial Ovarian Cancer Using Ovarian Cancer Score (OCS) Test
The study is designed to confirm the performance of the 3D Medicines Corporation OCS test in diagnosis of epithelial ovarian cancer in patients with adnexal mass.
- Trial name
- NCT06366997
- Where
- China
- Volunteers
- 1,352 people, healthy volunteers welcome
- Sponsor
- Chongqing University Cancer Hospital
Adnexal Mass, Germline BRCA1 Gene Mutation
Multifactorial Risk Assessment for Breast & Ovarian Cancer Risk Detection
The objective of this project is to validate a next-generation assay that utilizes both the protein biomarkers of our already established ovarian cancer risk assessment combined with a molecular profile in both germline and early…
- Conditions
- Adnexal Mass, Germline BRCA1 Gene Mutation, Germline BRCA2 Gene Mutation, Hereditary Breast and Ovarian Cancer
- Trial name
- OVA360 (NCT04668521)
- Testing
- OVA360
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Aspira Women's Health
Adnexal Mass
Retrospective Review on PAEDIATRIC and ADOLESCENT ADNEXAL MASSES
To review the characteristic, presentation and outcome of girls presented with adnexal masses to hopefully develop a management algorithm for girls with adnexal masses.
- Trial name
- NCT05461872
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Fallopian Tube Serous Adenocarcinoma, High Grade Ovarian Serous Adenocarcinoma
Talazoparib in Determining Genetic Effects on Disease Response in Patients With Advanced Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
This pilot early phase I trial studies talazoparib to determine if certain characteristics of the deoxyribonucleic acid (DNA) affect how the disease responds to therapy in patients with ovarian, fallopian tube, or primary…
- Conditions
- Fallopian Tube Serous Adenocarcinoma, High Grade Ovarian Serous Adenocarcinoma, Ovarian Mass, Primary Peritoneal Serous Adenocarcinoma
- Trial name
- POSITION (NCT02316834)
- Testing
- Laboratory Biomarker Analysis, BMN 673
- Where
- 6 sites in United States
- Volunteers
- 4 people
- Sponsor
- M.D. Anderson Cancer Center
Pelvic Mass
The Use of HE4 With Simple Ultrasound Rules to Predict Malignancy in a Pelvic Mass
Our objective is to determine if the combination of simple ultrasound features (IOTA simple rules) and a new biomarker (HE4) together with a common tumour marker (CA 125) can accurately predict ovarian cancer in women found to…
- Trial name
- NCT03982914
- Where
- 3 sites in Hong Kong
- Volunteers
- 814 people
- Sponsor
- The University of Hong Kong
Fallopian Tube Cancer, Ovarian Cancer
Compare Fallopian Tube Cells Collected by Cytuity With Removed Ovarian/Tubal Tissue to Determine Presence of Malignancy
Prospective, multi-center, non-randomized study to assess the ability of the Cytuity device to collect cell samples from the fallopian tube that can be evaluated for the presence or absence of malignancy.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Ovarian Neoplasms, Ovary Cancer
- Trial name
- nCYT (NCT03593681)
- Testing
- Hysteroscopic cell sampling of the fallopian tube
- Where
- 10 sites in United States
- Volunteers
- 150 people
- Sponsor
- Boston Scientific Corporation
Patients With a Sonographically Unclassifiable Adnexal Mass Using the IOTA Simple Rules
Value of MRI in the Characterization of Ovarian Masses Unable to Classify With Ultrasound Using the International Ovarian Tumor Analysis (IOTA) Simple Rules
Gynecological ultrasound is well known as the preferred exam to assess patients with ovarian tumors. The International Ovarian Tumor Analysis (IOTA) group developed the 'Simple Rules' to classify an ovarian tumor as benign or…
- Trial name
- IOTA-MRI (NCT02836275)
- Testing
- Diffusion/Perfusion-weighted Magnetic Resonance Imaging
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- KU Leuven