Clinical trials: Ovary Disease
Polycystic Ovary Syndrome
Letrozole or Combined Clomiphene Citrate Metformin as a First Line Treatment in Women With Polycystic Ovarian Syndrome
The purpose of this study is to compare and determine the efficacy of letrozole administration to that of combined metformin and Clomiphene in infertile women with polycystic ovary syndrome (PCOS) not treated before with any…
- Trial name
- PCO (NCT01679574)
- Testing
- Letrozole, Clomiphene, Metformin
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Assiut University
Renal Cell Carcinoma (RCC), Clear-cell Renal Cell Carcinoma
A Dose Escalation, Safety and Activity Study of CDX-014 in Patients With Renal Cell Carcinoma and Ovarian Clear Cell Carcinoma
This is a study to determine the safety of CDX-014 and effectiveness (how well the drug works).
- Conditions
- Renal Cell Carcinoma (RCC), Clear-cell Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Kidney Neoplasms
- Trial name
- NCT02837991
- Testing
- CDX-014
- Where
- 5 sites in United States
- Volunteers
- 16 people
- Sponsor
- Celldex Therapeutics
Sleep Disorder, Polycystic Ovarian Syndrome (PCOS)
Association Between Polycystic Ovary Syndrome and Sleep Quality: A Questionnaire-Based Study
This cross-sectional study enrolled 310 women with PCOS (Rotterdam criteria) at a tertiary referral center between September 2025 and January 2026.
- Trial name
- PMOS (NCT07898423)
- Where
- Turkey (Türkiye)
- Volunteers
- 290 people
- Sponsor
- Tepecik Training and Research Hospital
Melanoma, Ovarian Cancer
Follow-up Protocol for Patients With Cancer/AIDS/Skin Disease
This protocol is to provide follow-up medical/surgical visits for DCS patients who are long term survivors and may not currently be a participant entered on an active research protocol.
- Conditions
- Melanoma, Ovarian Cancer, Prostate Cancer, Breast Cancer
- Trial name
- NCT00001503
- Where
- United States
- Volunteers
- 1,031 people
- Sponsor
- National Cancer Institute (NCI)
Epithelial Ovarian Cancer
Phase III Trial of Stage I Ovarian Cancer After Surgery
To compare the Overall survival of adjuvant chemotherapy versus observation in stage I epithelial ovarian cancer after comprehensive staging surgery
- Trial name
- NCT04063527
- Testing
- adjuvant chemotherapy
- Where
- 103 sites in Japan, South Korea
- Volunteers
- 360 people
- Sponsor
- Japanese Gynecologic Oncology Group
Ovarian Cancer
Gene Therapy in Treating Patients With Ovarian Cancer
Phase I trial to study the effectiveness of gene therapy in treating patients with ovarian cancer that has not responded to previous treatment.
- Trial name
- NCT00003588
- Testing
- Ad5CMV-p53 gene, laparoscopic surgery
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Ovarian Cysts
Ovarian Clear Cell Adenocarcinoma Review
Clear cell carcinoma comprises 5-10% of surface epithelial ovarian cancers, and about 30-40% of the patients with clear cell carcinoma are diagnosed in the advanced stage.
- Trial name
- OCCA (NCT02129036)
- Volunteers
- 5 people
- Sponsor
- Cathay General Hospital
Peritoneal Neoplasms, Retroperitoneal Neoplasms
Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Cisplatin for Children With Peritoneal Cancer
There has been no successful treatment of diffuse peritoneal metastasis or carcinomatosis, in childhood tumors. Once this advanced stage of disease is evident, survival is measured in weeks.
- Conditions
- Peritoneal Neoplasms, Retroperitoneal Neoplasms, Gastrointestinal Neoplasms, Adenocarcinoma
- Trial name
- NCT00436657
- Testing
- CHPP of Cisplatin, Abdominal Surgery
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- M.D. Anderson Cancer Center
Ovarian Cancer
Phase 1, Safety and Tolerability Study of XmAb541 and XmAb808 in Advanced Solid Tumors
The primary purpose of this study is to determine whether the combination of the investigational drug XmAb541 in combination with the investigational drug XmAb808 is safe and well tolerated, and to determine an optimal and safe…
- Trial name
- NCT07593092
- Testing
- XmAb541, XmAb808
- Where
- 4 sites in United States
- Volunteers
- 90 people
- Sponsor
- Xencor, Inc.
Breast Cancer, Ovarian Cancer
Genetic Testing for Breast, Ovarian, Pancreatic, and Prostate Cancers
This study is evaluating the effect of two pre-test education methods on participants interested in genetic testing for hereditary cancer risk.
- Conditions
- Breast Cancer, Ovarian Cancer, Pancreatic Cancer, Metastatic Prostate Cancer
- Trial name
- GeneBOPP (NCT04330716)
- Testing
- Standard Genetic Counseling, Educational Video
- Where
- 6 sites in United States
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
In Vitro Fertilization, Infertility
Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology in Polycystic Ovary Syndrome Patients During IVF/ICSI
Selection of developmentally competent oocytes enhances IVF efficiency. Usually, oocyte quality is determined based on its nuclear maturation and the presence of specific cytoplasmic and extracytoplasmic morphologic features.
- Conditions
- In Vitro Fertilization, Infertility, Intracytoplasmic Sperm Injection, Polycystic Ovary Syndrome
- Trial name
- NCT04727684
- Testing
- Triptorelin acetate, Cetrorelix, recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin
- Where
- Syria
- Volunteers
- 50 people
- Sponsor
- Damascus University
Polycystic Ovary Syndrome (PCOS)
Optimizing Metformin Use in Polycystic Ovary Syndrome
The goal of this clinical trial is to learn if a metformin dose of 1500 mg or 2250 mg per day is better to treat polycystic ovary syndrome (PCOS) in adults. It will also learn about the adverse effects of metformin.
- Trial name
- MET-PCOS (NCT07120815)
- Testing
- Metformin 1500 mg daily, Metformin 2250 mg daily
- Where
- Finland
- Volunteers
- 184 people
- Sponsor
- Helsinki University Central Hospital
Ovarian Neoplasms
Efficacy Study of Additional Intraperitoneal Chemotherapy to Treat Ovarian Cancer
Most patients with advanced ovarian cancer suffered recurrences. Therefore, adjuvant therapy is recommended for all patients with advanced ovarian cancer.
- Trial name
- NCT00919984
- Testing
- IP chemotherapy
- Where
- South Korea
- Volunteers
- 22 people
- Sponsor
- Korea Cancer Center Hospital
Ovarian Cancer
The Role of CircDENND4C in Epithelial Ovarian Cancer
circular RNAs (circRNAs), a newly discovered type of endogenous noncoding RNAs [8], are involved in the regulation of various biological functions.
- Trial name
- NCT06617585
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Breast Cancer, Chronic Myeloproliferative Disorders
Campath-1H + FK506 and Methylprednisolone for GVHD
RATIONALE: Alemtuzumab, tacrolimus, and methylprednisolone may be an effective treatment for graft-versus-host disease caused by a donor stem cell transplant.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Graft Versus Host Disease
- Trial name
- NCT00109993
- Testing
- alemtuzumab, methylprednisolone, tacrolimus
- Where
- 6 sites in United States
- Volunteers
- 34 people
- Sponsor
- Case Comprehensive Cancer Center
Cardiac Disease
Women With Polycystic Ovary Syndrome Are at High Risk for Cardiac Insults
Objectives: Evaluation of the cardiovascular (CV) risk in a sample of CV asymptomatic infertile women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT05344547
- Testing
- Cardiac risk ratio (CRR)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Tanta University
Ovarian Cancer
Comprehensive Yoga Therapy Based Lifestyle Prehabilitation Program for Women With Ovarian Cancer
To provide a comprehensive yoga therapy (CYT) program to patients with ovarian, fallopian tube, or primary peritoneal cancer who are scheduled to receive chemotherapy and then undergo surgery.
- Trial name
- NCT06545604
- Testing
- Yoga Therapy for Nutritional, Physical, and Psychosocial Prehabilitation, Usual care supportive services including nutrition counseling per usual care
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- M.D. Anderson Cancer Center
Polycystic Ovary Syndrome (PCOS) Women
Metformin Effects on Metabolic, Vitamin B12, Iron, Erythropoietin, and Hematological Parameters in Women With PCOS
This double-blind, placebo-controlled, parallel-group randomized controlled trial evaluated changes in metabolic, vitamin B12, iron-status, erythropoietic, and hematological parameters among women with polycystic ovary syndrome…
- Trial name
- MET-PCOS (NCT07793838)
- Testing
- Metformin
- Where
- Jordan
- Volunteers
- 400 people
- Sponsor
- Jerash Private University
Ovarian Cancer
Safety and Efficacy Study of Panzem® Nanocrystal Colloidal Dispersion in Patients With Ovarian Cancer
The purpose of this study is to evaluate the efficacy, limited pharmacokinetics (PK), and safety of 1,000 mg of Panzem® NCD administered orally four times a day to patients with recurrent or resistant epithelial ovarian cancer.
- Trial name
- NCT00400348
- Testing
- Panzem Nanocrystal Colloidal Dispersion (NCD)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- CASI pharmaceuticals, Inc.
Ovarian Neoplasms, Fallopian Tube Neoplasms
Phase II Study of Clinical Activity of Pegaspargase in Women With Relapsed or Refractory Epithelial Ovarian Cancer, Fallopian Tube Cancer, and/or Primary Peritoneal Cancer
Background: The best treatment for ovarian and related female reproductive tract cancers is not yet known for patients whose disease has not responded to or has recurred after standard treatment.
- Conditions
- Ovarian Neoplasms, Fallopian Tube Neoplasms, Primary Peritoneal Neoplasms
- Trial name
- NCT01313078
- Testing
- Pegylated L-Asparaginase
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- National Cancer Institute (NCI)
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