Clinical trials: Over Cancer
Head and Neck Squamous Cell Carcinoma (HNSCC)
Hypofractionated Radiotherapy in Elderly Patients With Head & Neck Squamous Cell Carcinoma
The purpose of this research study is to investigate a shorter radiation treatment schedule for head and neck cancers in patients 70 years of age and older.
- Trial name
- NCT04284540
- Testing
- Adjuvant hypofractionation, Definitive Hypofractionation
- Where
- 4 sites in United States
- Volunteers
- 37 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Low Anterior Resection Syndrome, Sacral Neuromodulation - Interstim Therapy
Effectiveness of Sacral Neuromodulation in Low Anterior Resection Syndrome
Low anterior resection syndrome (LARS) is a complex disorder suffered by patients who undergo rectal resection mainly due to rectal cancer.
- Conditions
- Low Anterior Resection Syndrome, Sacral Neuromodulation - Interstim Therapy, Rectal Cancer
- Trial name
- SANLARS (NCT03598231)
- Testing
- Sacral neuromodulation
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Neoplasms
BI 811283 in Various Solid Tumours
The main objective of this trial is to provide safety data in terms of drug-related adverse events (AE) for the recommendation of the dose for further trials in the development of BI 811283.
- Trial name
- NCT00701324
- Testing
- BI 811283
- Where
- 2 sites in Germany
- Volunteers
- 124 people
- Sponsor
- Boehringer Ingelheim
Breast Cancer
Survey Study: Financial Impact of Breast Cancer Treatment
A survey study to evaluate the financial impact of breast cancer as self-reported by breast cancer patients over a period of 1 year.
- Trial name
- NCT03615573
- Testing
- Quality of Life Surveys
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- The Guthrie Clinic
Myasthenia Gravis, Myasthenia Gravis, MuSK
Safety and Efficacy of 3 Dose Levels of NMD670 in Adult Patients With Myasthenia Gravis
This Phase 2 proof-of-concept, dose range finding study aims to evaluate the safety and efficacy of 3 dose levels of NMD670 vs placebo in adult patients with MG with antibodies against AChR or MuSK, administered twice a day (BID)…
- Trial name
- SYNAPSE-MG (NCT06414954)
- Testing
- NMD670
- Where
- 40 sites in United States, Belgium and 8 more
- Volunteers
- 84 people
- Sponsor
- NMD Pharma A/S
Mycosis Fungoides
Effectiveness of Concurrent Ultra-Low-Dose Total-Skin Electron Beam Therapy and Brentuximab Vedotin Given Quarterly Over 12 Months for Patients With Mycosis Fungoides
To learn if a form of radiation therapy (called ultra-low-dose - total skin electron beam therapy [ULD-TSEBT]) in combination with brentuximab vedotin can help to control mycosis fungoides
- Trial name
- NCT05357794
- Testing
- Brentuximab vedotin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Small Cell Lung Cancer (SCLC)
Pembrolizumab in Untreated Extensive SCLC
This is a multicenter, open-label, two armed, controlled, and randomized phase II trial investigating the activity of pembrolizumab in combination with standard chemotherapy in Extensive Disease (ED)-SCLC.
- Trial name
- REACTION (NCT02580994)
- Testing
- Pembrolizumab, cis/carboplatin and etoposide
- Where
- 18 sites in France, Italy and 1 more
- Volunteers
- 125 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Lymphoma, B-cell, Diffuse
Phase I/II Study of SyB L-0501RI in Combination With Rituximab to Treat Lymphoma
For SyB L-0501RI administered by an intravenous rapid infusion in combination with rituximab, the safety will be investigated in previously untreated patients with low-grade B-cell non-Hodgkin's lymphoma (Lg-B-NHL) or mantle cell…
- Trial name
- NCT03900377
- Testing
- SyB L-0501RI
- Where
- 14 sites in Japan
- Volunteers
- 37 people
- Sponsor
- SymBio Pharmaceuticals
Cancer, Diabetes
Monitoring Your Exercise-related Metrics Over Time Via Wearable Electronic Devices
To test the use of a continuous activity and heart rate tracker (Fitbit) and continuous glucose monitor (CGM) in monitoring daily exercise-related activities.
- Trial name
- NCT05124405
- Testing
- Fitbit, Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- M.D. Anderson Cancer Center
ALK Positive Malignancies
Roll-over Study to Allow Access to Certinib (LDK378) for Patients Who Are on Ceritinib Treatment in a Novartis-sponsored Study
The rollover study will provide ceritinib to patients who are currently receiving treatment with ceritinib within a Novartis-sponsored study and in the opinion of the investigator, would benefit from continued treatment with…
- Trial name
- NCT02584933
- Testing
- ceritinib
- Where
- 71 sites in United States, Australia and 19 more
- Volunteers
- 233 people
- Sponsor
- Novartis Pharmaceuticals
Cardiopulmonary Arrest, Pediatric ALL
Impact of 2 Resuscitation Sequences on Management of Simulated Pediatric Cardiac Arrest
The International Liaison Committee on Resuscitation regularly publishes a Consensus on Science with Treatment Recommendations but guidelines can nevertheless differ when knowledge gaps persist.
- Conditions
- Cardiopulmonary Arrest, Pediatric ALL, Resuscitation
- Trial name
- NCT05474170
- Testing
- AHA resuscitation sequence, ERC resuscitation sequence
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Geneve TEAM Ambulances
Colorectal Cancer
Lactobacillus Rhamnosus in Prevention of Chemotherapy-related Diarrhoea
Chemotherapy may cause diarrhoea, which may be associated with treatment delay and infections. The purpose of the study is to investigate whether oral supplementation with lactobacilli will alleviate chemotherapy related…
- Trial name
- NCT00197873
- Testing
- Lactobacillus Rhamnosus supplementation
- Where
- Finland
- Volunteers
- 84 people
- Sponsor
- University of Helsinki
Breast Cancer
Six vs 12 Months of Trastuzumab With Docetaxel Following FEC as Adjuvant Treatment in N+ Breast Cancer
This trial will compare 6 versus 12 months of trastuzumab in combination with dose dense docetaxel following FE75C as adjuvant chemotherapy in women with axillary lymph node positive breast cancer overexpressing HER2
- Trial name
- NCT00615602
- Testing
- Docetaxel, Trastuzumab, Epirubicin
- Where
- 10 sites in Greece
- Volunteers
- 489 people
- Sponsor
- Hellenic Oncology Research Group
Breast Neoplasms
Participant Preference of Subcutaneous (SC) Versus Intravenous (IV) Herceptin (Trastuzumab) in Human Epidermal Growth Factor Receptor (HER) 2-Positive Early Breast Cancer
This randomized, open-label, crossover study will evaluate participants' preference and healthcare professional (HCP) satisfaction with SC versus IV Herceptin administration in HER2-positive early breast cancer.
- Trial name
- PrefHER (NCT01401166)
- Testing
- Herceptin, Single-Use Injection Device
- Where
- 75 sites in Canada, Denmark and 10 more
- Volunteers
- 488 people
- Sponsor
- Hoffmann-La Roche
Leukemia, Nonlymphocytic, Acute
Therapy of Acute Myeloid Leukemia in Patients Over the Age of 60 : DA Versus Mitoxantrone With Intermittent AraC
Single Arm-Studies suggest improved remission and survival rates for a Protocol with Mitoxantron 10mg/m2 for 3 days combined with AraC 1g/m2 bid on days 1+3+5+7 compared to a conventional DA 7+3 protocol (45mg/m2 Daunorubicin).
- Trial name
- NCT00180167
- Testing
- randomization between two established Chemotherapies
- Where
- Germany
- Volunteers
- 492 people
- Sponsor
- Technische Universität Dresden
Osteosarcoma, Spindle Cell Sarcoma of Bone
Will Glucarpidase After Methotrexate Treatment for Bone Sarcoma Lead to Fewer Side Effects and Reduce Chemotherapy Delays?
Methotrexate is one of the most effective chemotherapy drugs in the treatment of osteosarcoma and some other types of bone sarcoma which are treated the same way as osteosarcoma.
- Trial name
- NCT02022358
- Testing
- Glucarpidase, Methotrexate, Folinic Acid
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University College, London
Squamous Cell Carcinoma, Pilonidal; Cyst, Malignant
Surgery Plus Intraoperative Radiotherapy as Treatment for Squamous Cell Carcinoma Over Pilonidal Disease.
Background: Pilonidal sinus is a very common disease. Malignant transformation occurs in 0,1% of patients. The investigators present a case of squamous cell carcinoma arised from recurrent pilonidal disease, managed by multimodal…
- Conditions
- Squamous Cell Carcinoma, Pilonidal; Cyst, Malignant, Surgery
- Trial name
- NCT04201002
- Testing
- Resection plus intraoperative radiotherapy
- Where
- 2 sites in Spain
- Volunteers
- 1 people
- Sponsor
- Hospital Provincial de Castellon
Polycystic Ovary Syndrome
Evaluation of Serum Scube-1 Scube-2 and Scube-3 Levels in Patients With Polikistik Over Syndrome ,
The aim of this study is to investigate serum SCUBE-1 and SCUBE-3 levels in PCOS and non-PCOS cases compared with non-PCOS healthy controls with similar age and body mass index
- Trial name
- NCT03765905
- Testing
- study
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Prostate Cancer
Prostate Volume Changes Following Prostate Brachytherapy With Iodine-125 Seeds
The size of the prostate changes due to insertion of the radioactive seeds. We will measure the prostate size, before and after the procedure.
- Trial name
- NCT00348465
- Testing
- Brachytherapy with Iodine-125 seeds
- Volunteers
- 29 people
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
Neoplasms
Everolimus Roll-over Protocol for Patients Who Have Completed a Previous Novartis-sponsored Everolimus Study.
Study to allow access to everolimus for patients who are on everolimus treatment in a Novartis-sponsored study and are benefiting from the treatment as judged by the investigator
- Trial name
- NCT01789281
- Testing
- Everolimus, Sandostatin LAR Depot
- Where
- 24 sites in United States, Czechia and 7 more
- Volunteers
- 34 people
- Sponsor
- Novartis Pharmaceuticals