Clinical trials: Overactive Bladder Syndrome
Overactive Bladder Syndrome
Xeomin vs Botox for Treatment of Overactive Bladder Syndrome
Purpose: Multiple formulations and brands of botulinum toxin exist on the market today. Only OnabotulinumtoxinA (BOTOX®) is currently FDA approved for treatment of overactive bladder.
- Trial name
- NCT06034288
- Testing
- Xeomin 100 UNT Injection, Botox 100 UNT Injection
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Overactive Bladder, Painful Bladder Syndrome
Changes in Inflammatory and Contractile Protein Expression in Patients With Painful Bladder Syndrome/IC.
Interstitial cystitis (IC)/chronic pelvic pain syndrome (CPPS) is a clinical syndrome of pelvic pain and/or urinary urgency/frequency in absence of a specific cause such as bacterial infection or damage to the bladder.
- Conditions
- Overactive Bladder, Painful Bladder Syndrome, Chronic Pelvic Pain Syndrome, Cystitis, Interstitial
- Trial name
- NCT00775281
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Healthy, Overactive Bladder Syndrome
Basic Sensations Coming From the Bladder
A major complication in studies to identify the nature of bladder sensations is language. It is difficult, if not near impossible, for the lay person, with no knowledge of physiology, anatomy or pathology, to put into simple…
- Trial name
- NCT01114412
- Where
- Netherlands
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Lower Urinary Tract Dysfunction, Overactive Bladder Syndrome
Correlations of 3D Urethral and Paraurethral Sonographic Findings With Urodynamic Studies, Lower Urinary Tract Symptoms & Sexual Dysfunction in Female Patients With Lower Urinary Tract Symptoms.
The main purpose of this study is to get the urethra and pelvic sonographic imaging by 4D ultrasound examinations, and to correlate the sonographic findings with urodynamic variables, pad weights and LUTS.
- Trial name
- NCT01884753
- Where
- Taiwan
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Overactive Bladder Syndrome
Mobile Application and Bladder Training
The International Continence Society described overactive bladder as urine urgency, frequently accompanied by frequency and nocturia, with or without urgency incontinence, when there is no evident pathology, such as a urinary…
- Trial name
- NCT05792956
- Testing
- Using mobile app
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Marmara University
Urinary Incontinence
Transcutaneous Mechanical Nerve Stimulation (TMNS) by Vibration in the Treatment of Incontinence
During transcutaneous mechanical nerve stimulation in spinal cord injured men an increase in pressure was observed in the external urethral sphincter along with an increase in bladder capacity.
- Trial name
- TMNS (NCT00695058)
- Testing
- Transcutaneous mechanical nerve stimulation by A medical vibrator (FERTI CARE personel, Multicept A/S, Albertslund, Danmark)
- Where
- 3 sites in United States, Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital at Herlev
Overactive Bladder Syndrome
The Effect of Position on Urge Sensation in Volunteers and in Patients With Overactive Bladder Syndrome
Importance of the problem OAB is a common health problem. Milsom et al. [1] randomly selected a population from six European countries.
- Trial name
- NCT00821314
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Microbiota, Urinary Bladder, Overactive
Targeting Microbiota in Female Overactive Bladder Syndrome
The aim of this study is to compare the urinary viral microbiome and bacterial microbiome between overactive bladder syndrome (OAB) patients and healthy controls in order to determine a possible alteration in the urinary…
- Trial name
- NCT05328011
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Prostatitis, Cystitis, Interstitial
Linkage Analysis in Interstitial Cystitis
Urologic pelvic pain syndrome (UCPPS), variably termed painful bladder syndrome/interstitial cystitis (PBS/IC) in females and chronic prostatitis/chronic pelvic pain syndrome in men (CP/CPPS), is a chronic, debilitating clinical…
- Conditions
- Prostatitis, Cystitis, Interstitial, Urinary Bladder, Overactive, Chronic Pelvic Pain Syndrome
- Trial name
- IC (NCT00675298)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Overactive Bladder, Urgency-frequency Syndrome
OAB and the Microbiome
To determine differences in the urinary microbiomes, identified by polymerase change reaction (PCR) (UTIP™), of female patients with urgency and frequency syndrome with or without pelvic pain (Group A) compared to female controls…
- Trial name
- NCT04831801
- Where
- 2 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Miami
Overactive Bladder, Overactive Bladder Syndrome
Experience Sampling Method in OAB Patients
Rationale: The overactive bladder syndrome is diagnosed clinically by using the ICS criteria of ≥8 micturitions and at least 1 urgency episode per 24 hours.
- Trial name
- NCT03435991
- Testing
- Validation Experience Sampling Method 'Uromate'
- Where
- Netherlands
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Urge Incontinence, Urgency-frequency Syndrome
Percutaneous Nerve Evaluation Trial Time
Sacral neuromodulation (SNM) was approved by the Food and Drug Administration (FDA) for the treatment of urgency incontinence (UUI) in 1998.
- Conditions
- Urge Incontinence, Urgency-frequency Syndrome, Overactive Bladder
- Trial name
- NCT06226220
- Testing
- Sacral neuromodulation
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Overactive Bladder Syndrome
Efficacy of Transcutaneous Versus Percutaneous Posterior Tibial Nerve Stimulation in the Overactive Bladder.
The main aim of this study, is compare the effectiveness of transcutaneous posterior tibial nerve stimulation versus percutaneous posterior nerve stimulation in patients with overactive bladder.
- Trial name
- NCT04483817
- Testing
- Transcutaneous tibial nerve stimulation, Percutaneous tibial nerve stimulation
- Where
- Spain
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Fisiocore LC,SL
Overactive Bladder, Urinary Urge Incontinence
Intradetrusor Botulinum Toxin A for OAB Via 1 Versus 10 Injections: A Randomized Clinical Trial
Patients with either overactive bladder (OAB) or urgency urinary incontinence (UUI) with be randomized (like a flip of a coin) to receive 100 units of bladder Botox® at either one injection site or ten injection sites.
- Conditions
- Overactive Bladder, Urinary Urge Incontinence, Overactive Bladder Syndrome, Urinary Incontinence, Urge
- Trial name
- NCT05308979
- Testing
- OnabotulinumtoxinA 100 UNT [Botox]
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Overactive Bladder, Overactive Bladder Syndrome
Defining the Safety and Efficacy of POSterIor Tibial NeRve StimulatiON in Children
The purpose of this study is to find out if overactive bladder (OAB) can be safely treated by stimulating a nerve near the ankle. This procedure is called percutaneous tibial nerve stimulation (PTNS).
- Trial name
- POSITRON-C (NCT06769854)
- Testing
- Urgent PC
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chi Dang Hornik
Overactive Bladder
Association Between Metabolic Syndrome and Serum Nerve Growth Factor Levels in Women With Overactive Bladder
Nerve growth factor (NGF-R) receptors are between the detrusor muscle fibers and can cause afferent signals. Metabolic syndrome and obesity have been advocated to be risk factors for the development of overactive bladder.
- Trial name
- NGF (NCT02335853)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Overactive Bladder Syndrome, Urinary Incontinence
Improving Overactive Bladder Treatment Access and Adherence
Overactive bladder (OAB) and urinary incontinence (UI) are chronic debilitating and embarrassing conditions that affect 33 million Americans.
- Trial name
- NCT06094543
- Testing
- Patient Engagement Tool
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Stanford University
Lower Urinary Tract Symptoms, Overactive Bladder Syndrome
Non-Micturation Bladder Activity in Relation to Self-Consciousness During Filling Phase and Sensation Measurement During the Filling Phase
Rationale: The sensation of the need for urination (urge) is a complex and only partially understood mechanism. It is our hypothesis that this mechanism is disrupted in patients suffering from overactive bladder syndrome.
- Trial name
- NCT00628615
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Overactive Bladder (OAB)
Vaginal CO2 Laser in Postmenopausal Women With Overactive Bladder Syndrome (OAB)
This study evaluates the clinical efficacy and symptom relief of vaginal fractional CO2 laser treatment in post-menopausal women with Overactive Bladder syndrome(OAB).
- Trial name
- NCT03846895
- Testing
- Microablative Fractional CO2 laser
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Overactive Bladder Syndrome
Efficacy of Different Electrical Stimulation Placement in Patients With Overactive Bladder Syndrome
This experiment is expected to understand the benefits of different settings of electrical stimulation in the treatment of overactive bladder.
- Trial name
- NCT03516435
- Testing
- Parasacral transcutaneous electrical stimulation, Intravaginal electrical stimulation
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University