Clinical trials: Overdose Prevention
Medication Abuse, Harm Reduction
Evaluation of Clinical Decision Support in Opioid Tapering
The 2022 Center for Disease Control and Prevention (CDC) clinical practice guideline for prescribing opioids for pain recommends that when tapering a patient's opioid dose, doses should be decreased at a slow rate to reduce the…
- Conditions
- Medication Abuse, Harm Reduction, Opioid Use Disorder, Opioid Prescribing
- Trial name
- NCT06527079
- Testing
- Observational study without a prospective intervention
- Volunteers
- 200,000 people
- Sponsor
- University of Colorado, Denver
Opioid Overdose
Project OOPEN: Opioid Overdose Prevention, Education and Intervention
This prospective, randomized emergency department trial will study the effectiveness of an intervention that combines opioid overdose prevention, education and intervention that includes take home naloxone with brief behavioral…
- Trial name
- OOPEN (NCT01788306)
- Testing
- OOPEN+BBCC
- Where
- 3 sites in United States
- Volunteers
- 256 people
- Sponsor
- University of Washington
Opioid-use Disorder, Addiction
Competitive Revision for CLARO: Collaboration Leading to Addiction Treatment and Recovery From Other Stresses
The purpose of this study is to develop and then test an enhanced version of the parent study's collaborative care intervention for co-occurring disorders (CC-COD) to reduce the risk of suicide and overdose among individuals with…
- Conditions
- Opioid-use Disorder, Addiction, Depression, Post Traumatic Stress Disorder
- Trial name
- NCT04634279
- Testing
- Collaborative care Plus
- Where
- 12 sites in United States
- Volunteers
- 68 people
- Sponsor
- RAND
Drug Overdose, Opioid-Related Disorders
A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses
This project will further develop and test the Tailored Telephone Intervention delivered by Peers to Prevent Recurring Opioid Overdoses (TTIP-PRO), a promising, low-cost, intervention to facilitate entry into medication assisted…
- Conditions
- Drug Overdose, Opioid-Related Disorders, Drug Addiction, Drug Abuse
- Trial name
- TTIP-PRO (NCT02922959)
- Testing
- Peer Intervention, naloxone nasal spray kit, Personally-tailored opioid overdose prevention education (information packet)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Cincinnati
Opioid-Related Disorders
The OPT-IN Project
Prescription opioid overdose represents a public health crisis. A number of efforts have been implemented to address opioid prescribing and opioid risk mitigation strategies for prescribers, but relatively few efforts have sought…
- Trial name
- NCT03526380
- Testing
- Behavioral: the OPT-IN Intervention
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Michigan
Opioid Use Disorder, Opioid Use Disorder, Severe
Buprenorphine Implementation at Syringe Service Programs to Reduce Overdoses
This study is testing whether offering buprenorphine treatment directly at syringe service programs (SSPs) helps more people start and stay in treatment for opioid use disorder (OUD) than referring them to community buprenorphine…
- Conditions
- Opioid Use Disorder, Opioid Use Disorder, Severe, Opioid Use Disorder, Moderate
- Trial name
- BISTRO (NCT07631598)
- Testing
- Standard of Care Referral, Low Threshold Buprenorphine
- Where
- 8 sites in United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Peptic Ulcer Hemorrhage, Peptic Ulcer, Acute With Hemorrhage
Efficacy of Low Dose Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding
We prepare this study to compare the efficacy of intermittent intravenous PPI infusion (relatively low dose PPI therapy) than continous PPI infusion method.
- Conditions
- Peptic Ulcer Hemorrhage, Peptic Ulcer, Acute With Hemorrhage, Peptic Ulcer, Proton Pump Inhibitor Overdose
- Trial name
- NCT03814421
- Testing
- intermittent (40mg as a bolus injection daily for 72hours)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Changwon Hospital
Drug Use
Geographical Information System (GIS) Mapping to Assess the Need for IEP Provision in Tayside
The aim of this study is to review the current provision of IEP services provided across Tayside and consider to what extent they are contributing to keeping this vulnerable population safe.
- Trial name
- NCT04099719
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- NHS Tayside
Overdose
Overdose Prevention Centers and Behavioral Health
The aims of this study are: (Aim 1) Identify sources of heterogeneous impacts of opioid prevention center (OPC) use on non-fatal and fatal overdose risk among individuals with histories of polysubstance use (PSU); (Aim 2)…
- Trial name
- NCT06236087
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- NYU Langone Health
Opioid Overdose Prevention, People Who Use Opioids/People With Opioid Use Disorder (OUD)
Reducing Overdose and Substance Use-related Stigma by Training Non-substance-using Friends and Family Members of People Who Use Opioids to Be Harm Reduction Champions
Fatal opioid overdoses are more frequent among populations with low access to harm reduction (HR) services and with high substance use-related stigma (which is a major barrier to accessing HR services).
- Conditions
- Opioid Overdose Prevention, People Who Use Opioids/People With Opioid Use Disorder (OUD), Reduction of Substance Use-related Stigma, Non-substance-using People With a Friend or Family Member Who Uses Opioids
- Trial name
- NCT06823453
- Testing
- Peer Harm Reduction Support Champion Intervention
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
HIV Infections, HCV
The Ganchero Intervention for Migrant People Who Inject Drugs From Puerto Rico in New York City
The goal of this pilot clinical trial is to learn if an intervention that trains Gancheros (people who provide injection services in exchange for drugs or money) to conduct risk-reduction outreach could help lower risk for human…
- Conditions
- HIV Infections, HCV, Overdose
- Trial name
- NCT06316739
- Testing
- Ganchero intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- North Jersey AIDS Alliance dba North Jersey Community Research Initiative (NJCRI)
Burnout, Compassion Satisfaction
PATH to Reducing Burnout Among Peers Who Deliver Overdose Prevention Services (R61 Phase Pilot)
The investigators propose to develop and test the effectiveness of PATH (Peer Advanced Training for total Health) as an educational workforce intervention for improving peer recovery support specialists' (PRSS) overdose…
- Conditions
- Burnout, Compassion Satisfaction, Secondary Trauma
- Trial name
- NCT07218562
- Testing
- PATH (Peer Advanced Training for total Health)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Chestnut Health Systems
Opioid Dependence
Naltrexone vs Buprenorphine-Naloxone for Opioid Dependence in Norway
Persons dependent on opioids like heroin, morphine, or codeine have a high risk of relapse, overdose and overdose death. This risk is elevated even further following discharge from treatment or correctional institutions where…
- Trial name
- NTX-SBX (NCT01717963)
- Testing
- Naltrexone intramuscular suspension, Buprenorphine-naloxone
- Where
- 5 sites in Norway
- Volunteers
- 166 people
- Sponsor
- University of Oslo
Homelessness, Opioid Education and Naloxone Distribution (OEND)
Homeless Overdose Prevention- Expansion
Homeless Overdose Prevention - Expansion (HOPE), tests implementation of overdose education and naloxone distribution (OEND), a program that targets homeless experienced Veterans at risk for overdose, including Veterans in…
- Conditions
- Homelessness, Opioid Education and Naloxone Distribution (OEND), Substance Use Disorder
- Trial name
- HOPE (NCT07716202)
- Testing
- Homeless Overdose Prevention- Expansion (HOPE) - Low Intensity, Homeless Overdose Prevention- Expansion (HOPE) - High Intensity
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- VA Office of Research and Development
Overdose
A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk
Adolescent (ages 10-19) overdose deaths are the third leading cause of pediatric death and continue to rise in the United States.
- Trial name
- NCT07022717
- Testing
- Brief youth overdose prevention education, Information about Naloxone, Usual standard of care
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Boston Medical Center
Opioid Use Disorder
Building Retention and Initiation Through Delivery of Peer-Guided Evidence-Based Practices
This study will provide longitudinal data for 6-months on a target sample of patients with Opioid Use Disorder (OUD) recruited from Prisma Health Mobile Health Clinics in South Carolina.
- Trial name
- BRIDGE-SC (NCT07541417)
- Testing
- Certified Peer Support Specialist Intervention
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Prisma Health-Upstate
Opioid Overdose
European Cohort Study of the Effectiveness of Take Home Naloxone
This study aims to assess the effectiveness of take-home naloxone (THN) to reverse opioid overdose when administered by lay persons in a real world setting.
- Trial name
- NalPORS (NCT05072249)
- Testing
- Naloxone
- Where
- 6 sites in Denmark, Sweden and 1 more
- Volunteers
- 6,000 people
- Sponsor
- King's College London
Accidental Overdose of Opiate
Rapid Self-Testing to Prevent Fentanyl Overdose Among Young People Who Use Drugs
The research team will enroll 100 young adults who use cocaine, heroin, inject drugs, or purchase prescription medications on the illicit market in a pilot study to be known as the Rhode Island Young Adult Prescription and…
- Trial name
- RAPiDS2 (NCT03373825)
- Testing
- Take home rapid drug test
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Brown University
Substance Abuse, Decision Making, Shared
Data2Action Oregon Project: Supporting Data-driven Decision-Making for Substance Use Services, Policy, and Overdose Prevention
Oregon's decision makers (e.g., community service providers, public health, justice, advocacy groups, payers) are calling for comprehensive, current, and trusted data to inform how they allocate resources to improve substance use…
- Conditions
- Substance Abuse, Decision Making, Shared, Implementation Science, Decision Making
- Trial name
- D2A Oregon (NCT06852170)
- Testing
- Co-Design Sessions (CDS), Data products
- Where
- United States
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems
Opioid Overdose
UnityPhilly Response App for Overdose Reversal
The goal of this clinical trial is to discover if an overdose prevention app (UnityPhilly) can encourage citizen responders to respond and prevent opioid overdoses using the UnityPhilly app.
- Trial name
- NCT06466005
- Testing
- UnityPhilly app
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Drexel University