Clinical trials: Overfed, open to volunteers
Healthy Volunteers Only
A Study of Body Fat Distribution and Airway Mechanics in Healthy Adults
This study investigates how body fat distribution affects airway closure and lung mechanics in healthy adults. Using Electrical Impedance Tomography (EIT), esophageal manometry, and computed tomography (CT), we aim to…
- Trial name
- NCT07019831
- Testing
- Body positioning
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maurizio F. Cereda, MD
Gout, Obesity
Orlistat and Weight Management for Uric Acid Control in Obese Gout: A RCT
A total of 120 obese gout patients were included in a 24-week double-blind randomized controlled design. The intervention group received orlistat 120 mg tid + UTL + individualized diet-exercise-behavioral reinforcement weight…
- Trial name
- OWMUAC (NCT07326839)
- Testing
- Orlistat 120 mg, Allopurinol 100 up to 600mg/day, Febuxostat 40mg Tab
- Where
- China
- Volunteers
- 120 people
- Sponsor
- XueMei Guo
Prediabetes, Insulin Resistance
MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity
This Phase 2a study evaluates whether 12 weeks of treatment with investigational MOTS-c improves insulin sensitivity compared with placebo in adults with prediabetes and overweight/obesity.
- Conditions
- Prediabetes, Insulin Resistance, Overweight/Obesity
- Trial name
- MOTS-MET (NCT07505745)
- Testing
- MOTS-c (MDP), Route Subcutaneous injection, Regimen
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Hudson Biotech
Bypass Complication, Obesity
Evaluation of Long-term Adverse Effects of Gastric Bypass in Omega
The omega gastric bypass (OAGB) is developing worldwide as an alternative to the Y gastric bypass (RYGB). Cases of nutrition deficiency after OAGB, in particular protein deficency, are regularly reported in the literature…
- Trial name
- OMEGA10 (NCT04930029)
- Testing
- Ten year evaluation
- Where
- France
- Volunteers
- 320 people
- Sponsor
- University Hospital, Lille
Metabolic and Bariatric Surgery
Tailored One Anastomosis Gastric Bypass
One Anastomosis Gastric Bypass (OAGB) is the most common metabolic and bariatric surgery (MBS) in Israel, recognized for its effectiveness in achieving sustainable weight loss and mitigating obesity-related diseases.
- Trial name
- OAGB-TL (NCT06829381)
- Testing
- Tailored BPL length, Control - BPL 180 cm
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Overweight/Obesity, Metabolic Syndrome
Effects of Cranberry on Gut and Metabolic Health
The consumption of plant-based foods, particularly berries, has been associated with improved health due to their high content of bioactive compounds.
- Conditions
- Overweight/Obesity, Metabolic Syndrome, Insulin Resistance, Microbiota
- Trial name
- CRANOS (NCT07460856)
- Testing
- Cranberry beverage
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Laval University
Overweight and Obesity
Evaluate the Safety and Efficacy of HDM1002 Tablets in Chinese Overweight and Obese Adults
A Phase 3 Trial to Evaluate the Safety and Efficacy of HDM1002 Tablets in Overweight and Obese Adults
- Trial name
- NCT06885021
- Testing
- HDM1002 200mg, oral, once daily, 52 weeks, HDM1002 400mg, oral, once daily, 52 weeks
- Volunteers
- 780 people
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Gastro Esophageal Reflux, Obesity (Disorder)
Association Between Obesity and Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is a chronic disorder marked by heartburn and regurgitation, resulting from the reflux of gastric acid or bile into the esophagus.
- Trial name
- NCT07199582
- Volunteers
- 200 people
- Sponsor
- Assiut University
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Fluoxetine
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03476525
- Testing
- Fluoxetine
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Obesity, Healthy Lifestyle
Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects
All participants will undergo baseline biopsies of subcutaneous abdominal adipose tissue for cellular/molecular profiling via snRNA-seq and metabolic/physiological assessments (insulin sensitivity, glucose tolerance, and β-cell…
- Trial name
- NCT05653258
- Testing
- Lifestyle Intervention, Dasatinib 100 MG, Quercetin 1000mg
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Obesity & Overweight, Type 2 Diabetes
Effects of HIIT Following PTR Programme
Caloric restriction programmes are highly effective and safe interventions for inducing rapid weight loss and improvements in glycaemic control.
- Trial name
- HIITpostLCD (NCT07565935)
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Nottingham
Obesity
Optimizing an Online Behavioral Weight Loss Intervention and Novel Culturally Tailored Components for Sexual Minority Women
Obesity disproportionately impacts sexual minority women. Behavioral weight loss programs are the gold standard treatment for mild to moderate obesity.
- Trial name
- NCT05775497
- Testing
- Behavioral weight loss intervention (Online; Rx Weight Loss), Minority stress intervention, Social support intervention
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- The Miriam Hospital
Physical Inactivity, Overweight
Individual Variability in Energy Compensation After a 12-Week Supervised Exercise Intervention
This prospective, single-arm interventional study will investigate why adults receiving the same prescribed dose and relative intensity of exercise show divergent changes in energy balance, body weight, and body composition.
- Conditions
- Physical Inactivity, Overweight, Obesity
- Trial name
- NCT07893249
- Testing
- Supervised Aerobic Exercise Programme
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Obesity & Overweight, Emotional Eating
Online Group Programme on Mindful Eating During Medication-Supported Weight Loss
The goal of this clinical trial is to evaluate the feasibility and acceptability of a digitally delivered, mindfulness-based nutrition group program for adults with obesity who are taking GLP-1 receptor agonist medication and…
- Conditions
- Obesity & Overweight, Emotional Eating, Emotional Eating Behaviour, Online Intervention
- Trial name
- NCT07701291
- Testing
- Online Group Intervention on Mindful Eating
- Volunteers
- 28 people
- Sponsor
- Bern University of Applied Sciences
Obese
Dynamo: a Tailored Lifestyle Promotion Intervention Among Pediatric Patients With Cardiometabolic Risk Factors
The Dyn@mo lifestyle intervention (CHU Sainte-Justine, Quebec, Canada) targets children and adolescents aged 6 to 17 years old with cardiometabolic risk factors, such as obesity, hypertension, disorders in glucose regulation or…
- Trial name
- CIRCUIT (NCT01736748)
- Testing
- Sensor based PA intervention, Traditional PA counseling
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- St. Justine's Hospital
Sarcopenic Obesity
Validation of an Algorithm for the Diagnosis of Sarcopenic Obesity
The proposed research project aims to investigate sarcopenic obesity (SO), a condition characterized by the combination of high body fat and low skeletal muscle mass, with a focus on muscle function.
- Trial name
- NCT06815978
- Testing
- DXA, ultrasonography, indirect calorimetry
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Elisa Giannetta
Weight Loss, Obesity and Overweight
BrainWeighve App Feasibility Study
Childhood obesity within the United States has been a growing concern over the past number of years, and if not addressed, leads to detrimental health outcomes for youth as they move into adulthood.
- Trial name
- NCT05530538
- Testing
- BrainWeighve App
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Obesity (Disorder), Bariatric Surgery
Impact of a Pro-diversity Gut Microbiota Diet After a Bariatric Surgery on Gut Microbiota, Eating Behaviour and Sensory Function
Bariatric surgery is the most effective treatment for long-term weight loss and reducing obesity-related health risks. It alters the gastrointestinal tract as well as metabolic and hormonal functions, influencing eating…
- Trial name
- BariaGut Taste (NCT07268508)
- Testing
- Nutritional counseling
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Obesity, Obesity, Infant
Maternal Characteristics Associated With Child Growth and Adiposity
The goal of this observational study is to investigate the concentrations of leptin, insulin, liver expressed antimicrobial peptide 2 (LEAP2), and cortisol in plasma and breast milk and their relationship with eating behavior…
- Trial name
- NCT05798676
- Testing
- overweight/obesity
- Where
- Argentina
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri
Overweight , Obesity
Asiaticoside for Treating Overweight/Obesity
Centella asiatica is a traditional herbal medicine widely used in China and Southeast Asia for treating various conditions. Preclinical studies have shown that madecassic acid glycosides, including asiaticoside and madecassoside…
- Trial name
- NCT07241533
- Testing
- Asiaticoside tablets
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
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