Clinical trials: Overfeeding
Energy Density
Palatability (Energy I Pilot)
A pilot study was conducted to develop the study menus that were similar in appearance, aroma, and taste.
- Trial name
- NCT01653886
- Testing
- Breakfast (1-2 hours, in the morning), Lunch (1-2 Hours, at midday), Dinner (1-2 hours, in the afternoon)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Inflammation, Obesity
Impact of a High Saturated Fat Diet on Fasted Systemic and White Adipose Tissue Inflammatory Responses
This study will investigate the effect of a 7-day westernised high-fat (65% of kilocalories), high-calorie (150% of requirements) diet on markers of inflammation in the blood and white adipose tissue.
- Conditions
- Inflammation, Obesity, Inflammatory Response, Cardiovascular Diseases
- Trial name
- NCT03569189
- Testing
- High Fat Diet
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Obesity
Multi-site Trial Using SMS to Improve Infant Weight
The goals of this multi-site clinical trial are to pilot test weekly SMS sent to parents/caregivers of infants to improve feeding practices and decrease excessive weight gain in infants who are participants of the Women, Infants…
- Trial name
- SMS (NCT02903186)
- Testing
- SMS
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University of Puerto Rico
Obesity, Overfeeding
Overeating Different Fats and Influence on Muscle Mass and Body Fat Accumulation
To investigate metabolic and molecular response to fatty acid-specific overfeeding in overweight subjects, in relation to changes in ectopic fat, lean tissue mass and insulin sensitivity
- Conditions
- Obesity, Overfeeding, Muscle Mass, Body Composition
- Trial name
- LIPOGAIN-2 (NCT02211612)
- Testing
- PUFA-group, SFA-group
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Insulin Sensitivity/Resistance
Protective Effect of Exercise on Acute High-fat Overfeeding
Metabolic flexibility is the ability to switch rapidly from one substrate (i.e. fuel source) to another (e.g. fats to carbohydrates) in response to ingested foods.
- Trial name
- HFDEXC (NCT07633704)
- Testing
- High Fat Overfeeding, High Fat Overfeeding + Exercise
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- George Washington University
Obesity, Normal Physiology
The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure
Background: Diet-induced thermogenesis (DIT) is the amount of energy one's body uses to eat food, absorb the nutrients from the food, and process those nutrients.
- Conditions
- Obesity, Normal Physiology, Healthy Volunteers
- Trial name
- NCT05545306
- Testing
- +200% of dietary requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat, fasting, -50% of energy balance requirements. 50% of calories from carbohydrates, 20% from protein, and 30% from fat
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Thinness
The Effects of Overfeeding on Obesity-Prone (OP) and Obesity-Resistant (OR) Women
This is a longitudinal cohort study of how the responses to a 3 day period of controlled overfeeding relate to subsequent weight gain.
- Conditions
- Obesity, Thinness, Weight Gain
- Trial name
- NCT00072917
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity
PROOF: PROtein OverFeeding Effect on Body Weight
This study is designed to determine the effects of dietary protein content on overfeeding.
- Trial name
- PROOF (NCT00565149)
- Testing
- PROOF
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Insulin Resistance, Type 2 Diabetes
The Influence of Overfeeding Different Macronutrients on Whole-body Insulin Sensitivity
This study will investigate the effect of high-carbohydrate vs. high-fat overfeeding (130% of energy requirements) on whole body insulin sensitivity.
- Conditions
- Insulin Resistance, Type 2 Diabetes, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- NCT03863431
- Testing
- High-fat diet, High-carbohydrate diet
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Obesity
Effects of Milk Proteins on Protein Synthesis in Healthy Male Subjects Fed a Hypercaloric, High Sucrose Diet
This study aims at assessing the hypothesis that dietary protein content is a major factor regulating lean body mass gain and energy expenditure during overfeeding, and thus long term body weight gain To test this hypothesis…
- Trial name
- FruMilk (NCT02168218)
- Testing
- 7-day overfeeding
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Glucocorticoid Effect
Acute Consequences Of Food-induced Glucocorticoid Secretion In Healthy Individuals
In a randomized, cross-over study, 20 healthy volunteers will receive a block and replace therapy that mimics physiological GC rhythm (metyrapone plus hydrocortisone) or placebo.
- Trial name
- Gluco-Feed (NCT05167084)
- Testing
- Metyrapone 250 mg Oral Tablets, Hydrocortisone 19,9mg s.c., pulsatile with a flow rate of 10μl/s
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
Insulin Resistance
The Effect of Tea on Vascular Function and Insulin Sensitivity
The aim of this research is to explore changes in peripheral/cerebrovascular function and insulin sensitivity after a 7-day combination of physical activity reduction (-50% steps per day) and overfeeding (+50% kcal per day…
- Trial name
- NCT02777853
- Testing
- Green tea
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Sleep
Effect of Sleep Restriction on Metabolic Disturbances Caused by Overfeeding
The purpose of this study is to determine if sleep restriction provokes an increase in risk factors for metabolic diseases, such as elevation of ectopic fat and decreased sensitivity to insulin.
- Trial name
- NCT02075723
- Testing
- Overfeeding (130 % of energy requirements ), Sleep restriction (4 hours per night)
- Where
- Switzerland
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Overfeeding
Polyphenols and Overfeeding
Obesity is a complex and multifactorial disease representing a major public health challenge. Indeed, overweight and obese people carry a major risk of developing insulin resistance and type 2 diabetes mellitus.
- Trial name
- Poly-Nut (NCT02145780)
- Testing
- 2g of grape polyphenol extract
- Where
- France
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Obesity
Thermogenenic Responses to Fasting and Overfeeding in Women
This study plans to learn more about why menopause increases the risk of weight gain. During and after menopause, women are prone to increased weight gain.
- Trial name
- NCT06610162
- Testing
- Eucalaloric feeding, Acute Fasting, Acute Overfeeding
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Childhood Obesity, Infant Development
Unintentional Overfeeding of Formula Fed Infants
Although breast milk is recommended exclusively until 6 months of age, two-thirds of infants in the U.S. are fed infant formula.
- Trial name
- Whoa Baby (NCT02701868)
- Where
- United States
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Insulin Resistance, Type2 Diabetes Mellitus
High-fat Overfeeding, Hepatokines and Appetite Regulation
The present study will investigate the effect of high-fat overfeeding on a group of liver-secreted proteins linked to worsened blood sugar control, as well as proteins involved in appetite control.
- Conditions
- Insulin Resistance, Type2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, Obesity
- Trial name
- OVEREAT (NCT03369145)
- Testing
- High-fat diet
- Where
- 2 sites in United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Obesity
Growth Hormone as a Determinant of Weight Regulation
With the alarming increase in the prevalence of obesity, identifying factors that predispose individuals to weight-gain is of critical importance.
- Trial name
- NCT00355784
- Testing
- overfeeding, growth hormone treatment
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Liver Fat, Cardiac Function
Short-term Fat Overfeeding on the Effects of Liver Metabolism
Despite work showing the overconsumption of saturated fatty acids (SFA) to be metabolically deleterious, debate continues about whether there is a link between SFA and cardiovascular disease risk.
- Conditions
- Liver Fat, Cardiac Function, Lipid Disorder, Adiposity
- Trial name
- FOS (NCT05962190)
- Testing
- Diet
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Overfed, Obesity
Experimental Overfeeding in Humans
The objective of this study is to determine the homeostatic mechanisms that counteract weight gain in response to experimental overfeeding.
- Trial name
- ExpO (NCT04065243)
- Testing
- Overfeeding diet, Isocaloric diet
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen