Clinical trials: Overfeeding
NAFLD
Effects of Overfeeding Followed by Weight Loss on Liver Fat Content and Adipose Tissue Inflammation
A. BACKGROUND Accumulation of fat in the liver due to non-alcoholic causes (NAFLD) is associated with hepatic insulin resistance, which impairs the ability of insulin to inhibit the production of glucose and VLDL .
- Trial name
- NCT02133144
- Testing
- overeating fat, overeating carbohydrate
- Where
- Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Obesity
PROOF: PROtein OverFeeding Effect on Body Weight
This study is designed to determine the effects of dietary protein content on overfeeding.
- Trial name
- PROOF (NCT00565149)
- Testing
- PROOF
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity
Effects of Milk Proteins on Protein Synthesis in Healthy Male Subjects Fed a Hypercaloric, High Sucrose Diet
This study aims at assessing the hypothesis that dietary protein content is a major factor regulating lean body mass gain and energy expenditure during overfeeding, and thus long term body weight gain To test this hypothesis…
- Trial name
- FruMilk (NCT02168218)
- Testing
- 7-day overfeeding
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Insulin Sensitivity/Resistance
Protective Effect of Exercise on Acute High-fat Overfeeding
Metabolic flexibility is the ability to switch rapidly from one substrate (i.e. fuel source) to another (e.g. fats to carbohydrates) in response to ingested foods.
- Trial name
- HFDEXC (NCT07633704)
- Testing
- High Fat Overfeeding, High Fat Overfeeding + Exercise
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- George Washington University
Obesity
Thermogenenic Responses to Fasting and Overfeeding in Women
This study plans to learn more about why menopause increases the risk of weight gain. During and after menopause, women are prone to increased weight gain.
- Trial name
- NCT06610162
- Testing
- Eucalaloric feeding, Acute Fasting, Acute Overfeeding
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Aging, Obesity
Expandability of Aging Adipose Tissue
The purpose of this pilot study is to determine whether adipose tissue loses some of its ability to expand in response to overfeeding in older compared to younger men.
- Trial name
- EAT (NCT02456870)
- Testing
- Overfeeding
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Weight Gain, Resistance Training
Body Composition Changes During Overfeeding Plus Resistance Training
This study will examine the relationship between the rate and composition of mass gain during overfeeding plus resistance training, investigate the validity of multiple assessment methods for quantifying body composition changes…
- Conditions
- Weight Gain, Resistance Training, Overeating
- Trial name
- NCT04069351
- Testing
- High-calorie mass gainer supplement, Resistance Training
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Overweight and Obesity, Metabolic Syndrome
Testing the Adipose Expandability Hypothesis In Vivo During Overfeeding
Adipose, or fat, tissue is a plastic organ that retains the ability to expand and store excess calories during positive energy balance in humans.
- Trial name
- EAT 2 (NCT04583514)
- Testing
- Control, Overfeeding
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Liver Fat, Cardiac Function
Short-term Fat Overfeeding on the Effects of Liver Metabolism
Despite work showing the overconsumption of saturated fatty acids (SFA) to be metabolically deleterious, debate continues about whether there is a link between SFA and cardiovascular disease risk.
- Conditions
- Liver Fat, Cardiac Function, Lipid Disorder, Adiposity
- Trial name
- FOS (NCT05962190)
- Testing
- Diet
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Lipid-induced Insulin Resistance
Overfeeding Induced Fat-tissue Stimulation
Type 2 diabetes is the most common metabolic disease worldwide, characterized by hyperglycemia, decreased whole body insulin sensitivity, and white adipose tissue (WAT) dysfunction.
- Trial name
- OVID_FASTI (NCT06193668)
- Testing
- High-fat overnutrition, Normocaloric macronutrient-balanced nutrition
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Healthy
White Adipose Tissue Clocks and High Calorie Feeding
Peripheral tissues (e.g. liver, adipose, muscle) express self-sustained circadian clocks that coordinate daily metabolic rhythms.
- Trial name
- NCT02809482
- Testing
- Eucaloric feeding, Overfeeding
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity, Normal Physiology
The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure
Background: Diet-induced thermogenesis (DIT) is the amount of energy one's body uses to eat food, absorb the nutrients from the food, and process those nutrients.
- Conditions
- Obesity, Normal Physiology, Healthy Volunteers
- Trial name
- NCT05545306
- Testing
- +200% of dietary requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat, fasting, -50% of energy balance requirements. 50% of calories from carbohydrates, 20% from protein, and 30% from fat
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Overweight and Obesity
Study of the Effects of Overfeeding on Glucocorticoids in Lean and Obese Subjects
Investigators suggest that in lean subjects cortisol increases in response to overfeeding and that this increase is blunted in obese subjects.
- Trial name
- Gluco-Food (NCT04482738)
- Testing
- High-calorie meal
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
Glucocorticoid Effect
Acute Consequences Of Food-induced Glucocorticoid Secretion In Healthy Individuals
In a randomized, cross-over study, 20 healthy volunteers will receive a block and replace therapy that mimics physiological GC rhythm (metyrapone plus hydrocortisone) or placebo.
- Trial name
- Gluco-Feed (NCT05167084)
- Testing
- Metyrapone 250 mg Oral Tablets, Hydrocortisone 19,9mg s.c., pulsatile with a flow rate of 10μl/s
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
Obesity, Overfeeding
Overeating Different Fats and Influence on Muscle Mass and Body Fat Accumulation
To investigate metabolic and molecular response to fatty acid-specific overfeeding in overweight subjects, in relation to changes in ectopic fat, lean tissue mass and insulin sensitivity
- Conditions
- Obesity, Overfeeding, Muscle Mass, Body Composition
- Trial name
- LIPOGAIN-2 (NCT02211612)
- Testing
- PUFA-group, SFA-group
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Obesity
Positive Energy I Through Overfeeding
The purpose of this trial is to examine the metabolic and behavioral effects of a positive energy balance induced by adding food to the usual level of activity.
- Trial name
- NCT01653145
- Testing
- Diet A, Diet B, Diet C
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity
Adaptive Responses to Overfeeding and Weight
To more effectively address the problem of weight regain following weight loss for obese individuals, this study will evaluate the underlying biology of the reduced obese state.
- Trial name
- ARrOW (NCT03857048)
- Testing
- Weight Loss, Exercise training, Overfeeding
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Childhood Obesity, Infant Development
Unintentional Overfeeding of Formula Fed Infants
Although breast milk is recommended exclusively until 6 months of age, two-thirds of infants in the U.S. are fed infant formula.
- Trial name
- Whoa Baby (NCT02701868)
- Where
- United States
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity
Multi-site Trial Using SMS to Improve Infant Weight
The goals of this multi-site clinical trial are to pilot test weekly SMS sent to parents/caregivers of infants to improve feeding practices and decrease excessive weight gain in infants who are participants of the Women, Infants…
- Trial name
- SMS (NCT02903186)
- Testing
- SMS
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University of Puerto Rico
Overfeeding
Polyphenols and Overfeeding
Obesity is a complex and multifactorial disease representing a major public health challenge. Indeed, overweight and obese people carry a major risk of developing insulin resistance and type 2 diabetes mellitus.
- Trial name
- Poly-Nut (NCT02145780)
- Testing
- 2g of grape polyphenol extract
- Where
- France
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon