Clinical trials: Overlap Syndromes
OSA COPD Overlap Syndrome
Comparing Two Types of Breathing Support in People With COPD, High Carbon Dioxide Levels, and Sleep Apnea
This pilot study compares two positive airway pressure strategies for patients with both COPD and obstructive sleep apnea (overlap syndrome) who retain excess carbon dioxide.
- Trial name
- PAVE-OVS (NCT07891962)
- Testing
- Bilevel
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Asthma-COPD Overlap Syndrome, Pulmonary Rehabilitation
Effect of Video Game-Based Breathing Exercises on Respiratory Dysfunction in ACOS
Asthma and COPD are significant respiratory diseases that can coexist, referred to as Asthma-COPD Overlap Syndrome (ACOS). Patients with ACOS experience more severe clinical outcomes, including rapid decline in lung function…
- Conditions
- Asthma-COPD Overlap Syndrome, Pulmonary Rehabilitation, Video Games
- Trial name
- NCT07185178
- Testing
- Video game-based breathing exercises, Group 2:Telerehabilitation-based breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istinye University
MDS (Myelodysplastic Syndrome), MDS/Myeloproliferative Neoplasm (MPN) Overlap Syndrome
Dresden MDS Registry With an Accompanying Biomaterial Collection
A registry for the study of the epidemiology, clinical course, and progression of myelodysplastic neoplasms (MDS), myelodysplastic/myeloproliferative neoplasms (MDS/MPN overlap syndromes), and their precursor syndromes (CHIP…
- Conditions
- MDS (Myelodysplastic Syndrome), MDS/Myeloproliferative Neoplasm (MPN) Overlap Syndrome, CHIP, CCUS Clonal Cytopenia of Undetermined Significance
- Trial name
- NCT07561385
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Technische Universität Dresden
Sleep Apnea Syndrome, Obstructive Sleep Apnea
Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)
Obstructive sleep apnea (OSA) and Chronic Obstructive Pulmonary Disease (COPD) are highly prevalent chronic respiratory diseases in the Veteran population.
- Conditions
- Sleep Apnea Syndrome, Obstructive Sleep Apnea, COPD, Overlap Syndrome
- Trial name
- NCT04179981
- Testing
- Positive airway pressure, Conservative care (control arm)
- Where
- United States
- Volunteers
- 668 people
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease
The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)
Major progress has been made in the area of cardiovascular disease, but we believe that further progress will involve mechanistically addressing underlying respiratory causes including chronic obstructive pulmonary disease (COPD)…
- Conditions
- Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, Overlap Syndrome
- Trial name
- CRESCENDO-SLP (NCT05237505)
- Testing
- bi-level positive pressure non invasive ventilation, Oxygen gas
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of California, San Diego
Obstructive Sleep Apnea, OSA COPD Overlap Syndrome
Neurocognitive and Health Impact of Sleep Apnea in Elderly Veterans With Comorbid COPD
Cognitive dysfunction in the aging Veteran population is a growing health concern in the Veterans Health System. It is not known whether OSA coexisting with COPD will enhance the risk for cognitive dysfunction.
- Trial name
- NCT02703207
- Testing
- Positive airway pressure, NIPPV and /or oxygen
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- VA Office of Research and Development
Myelofibrosis, Myelodysplastic Syndrome
Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neoplasms
The purpose of this study is to evaluate the safety, tolerability, and preliminary efficacy of INCB057643 as monotherapy or combination with ruxolitinib for participants with myelofibrosis (MF) and other myeloid neoplasms.
- Conditions
- Myelofibrosis, Myelodysplastic Syndrome, Myelodysplastic/Myeloproliferative Neoplasm Overlap Syndrome, Myeloproliferative Neoplasm
- Trial name
- LIMBER (NCT04279847)
- Testing
- INCB057643, Ruxolitinib
- Where
- 48 sites in United States, Canada and 6 more
- Volunteers
- 140 people
- Sponsor
- Incyte Corporation
Chronic Myelomonocytic Leukemia, Myelodysplastic Syndromes
Momelotinib in Combination With Hypomethylating Agent for Chronic Phase Myelodysplastic Syndromes/Myeloproliferative Overlap Neoplasms and Chronic Neutrophilic Leukemia
This research is being done to evaluate effectiveness, safety, and tolerability of a study drug called momelotinib in participants with myelodysplastic/myeloproliferative neoplasms (MDS/MPNs), MDS/MPN-not otherwise specified…
- Conditions
- Chronic Myelomonocytic Leukemia, Myelodysplastic Syndromes, Myeloproliferative Overlap Neoplasms, Chronic Neutrophilic Leukemia
- Trial name
- M-HArbOr (NCT07071155)
- Testing
- Momelotinib, Azacitidine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Aggressive B-Cell Non-Hodgkin's Lymphoma (NHL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)
A Study of PRT2527 as Monotherapy and in Combination With Zanubrutinib or Venetoclax in Participants With R/R Hematologic Malignancies
This is a Phase 1 dose-escalation study of PRT2527, a potent and highly selective cyclin-dependent kinase (CDK) 9 inhibitor, in participants with select relapsed or refractory (R/R) hematologic malignancies.
- Conditions
- Aggressive B-Cell Non-Hodgkin's Lymphoma (NHL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Mantle Cell Lymphoma (MCL), Richter's Syndrome
- Trial name
- NCT05665530
- Testing
- PRT2527, Zanubrutinib, Venetoclax
- Where
- 24 sites in United States, Australia and 8 more
- Volunteers
- 86 people
- Sponsor
- Prelude Therapeutics Incorporated
Epidermal Necrolysis, Lyell Syndrome
LYell SYndrome MEsenchymal Stromal Cells Treatment
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe cutaneous adverse reactions (SCARs) to drugs.
- Conditions
- Epidermal Necrolysis, Lyell Syndrome, Toxic Epidermal Necrolysis, Overlap Syndrome
- Trial name
- LYSYME (NCT04711200)
- Testing
- Adipose derived stromal cells intravenously injected
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sleep Apnea, COPD Exacerbation
Impact of Continuous Positive Airway Pressure on the Occurrence of Acute Exacerbations of COPD in Patients With COPD-OSA Overlap Syndrome (CO-OS)
Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA) are both frequent respiratory diseases with estimated prevalences between 8 and 15% of the adult population.
- Conditions
- Sleep Apnea, COPD Exacerbation, Overlap Syndrome
- Trial name
- SLEEPOVEA (NCT05958563)
- Testing
- continuous positive airway pressure treatment
- Where
- 15 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Angers
Chronic Obstructive Pulmonary Disease Overlap Syndrome, Asthma
Combined Neuromuscular Electrical Stimulation for Quadriceps and Triceps During Pulmonary Rehabilitation in COPD
Patients with COPD frequently have muscle disorders. Pathogenic mechanisms generate significant pathophysiological changes in the locomotor muscles structure, leading to decreased strength, decreased endurance and limited…
- Trial name
- COMBIELEC (NCT04684966)
- Testing
- Neuromuscular Electrical Stimulation
- Where
- France
- Volunteers
- 266 people
- Sponsor
- University Hospital, Brest
Asthma, COPD
Small Airway Obstruction in Asthma, COPD, ACOS
This study was designed as retrospective chart review to test our hypothesis whether there are the differences in inflammatory and anti-inflammatory mediators between asthmatic and ACOS patients with small airway obstruction, and…
- Conditions
- Asthma, COPD, Asthma-COPD Overlap Syndrome
- Trial name
- NCT03423693
- Testing
- No any intervention
- Where
- Thailand
- Volunteers
- 230 people
- Sponsor
- Mahidol University
COPD, Overlap Syndrome
Biomarkers of Dementia in Chronic Sleep and Breathing Disorders
Chronic obstructive pulmonary disease (COPD), obstructive sleep apnoea (OSA) and overlap syndrome are associated with obstructions in breathing and disturbed sleep.
- Conditions
- COPD, Overlap Syndrome, OSA
- Trial name
- ORACLE (NCT06377332)
- Testing
- High density electroencephalogram (HdEEG), Functional near infrared spectroscopy (fNIRS), Magnetic resonance imaging (MRI)
- Where
- Australia
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Woolcock Institute of Medical Research
Pulmonary Disease, Chronic Obstructive
Etiology of Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) in Japan
The purpose of this prospective, epidemiological, cohort study is to evaluate the lung microbiome in stable-state chronic obstructive pulmonary disease (COPD) in Japanese participants
- Trial name
- NCT03957577
- Testing
- Prospective observational cohort study
- Where
- 13 sites in Japan
- Volunteers
- 70 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease, Chronic Bronchitis
Pulmonary and Cardiac Effects of E-Cigarette Use in Pulmonary Patients Who Smoke Cigarettes
The purpose of this study is to compare the effects of e-cigarettes and continued smoking on pulmonary and cardiac outcomes in a population with established pulmonary disease.
- Conditions
- Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema, Asthma-COPD Overlap Syndrome
- Trial name
- NCT05610514
- Testing
- E-Cigarette, Financial Incentives
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Vermont
Asthma-COPD Overlap Syndrome, Asthma
The Application of Impulse Oscillometry on the Diagnosis of ACOS,Asthma and COPD.
To Assess the Utility of Impulse Oscillometry on a Differential Diagnosis among the Patients with ACOS,asthma and COPD over Age 40.
- Conditions
- Asthma-COPD Overlap Syndrome, Asthma, COPD, Diagnoses Disease
- Trial name
- NCT03181152
- Testing
- Impulse Oscillometry
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shengjing Hospital
COPD, Asthma-COPD Overlap Syndrome
Biomarkers of Chronic Obstructive Pulmonary Disease
There are few studies about immunological explorations in COPD. Because of the complications of lung biopsies, analyses are generally made on blood samples instead of lung tissue.
- Conditions
- COPD, Asthma-COPD Overlap Syndrome, Asthma
- Trial name
- BIOBPCO (NCT04963023)
- Testing
- Physical examinations, blood test
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Celiac Disease, Irritable Bowel Syndrome
Irritable Bowel Syndrome Overlaping Celiac Disease
The goal of this prospective observational cohort stuty is to assess the prevalence of overlap irritable bowel syndrome on coeliac disease in patients on gluten-free diet.
- Conditions
- Celiac Disease, Irritable Bowel Syndrome, Overlap Syndrome
- Trial name
- IBSonCD (NCT05740306)
- Where
- Poland
- Volunteers
- 500 people
- Sponsor
- Centre of Postgraduate Medical Education
Rheumatoid Arthritis, Autoimmune Rheumatologic Disease
COvid-19 Vaccine Booster in Immunocompromised Rheumatic Diseases
People living with Systemic autoimmune rheumatic diseases (SARDs) face a new and urgent dilemma: immunosuppression increases risk for worse COVID-19 infection, yet an immune stimulation, such as vaccination, could re-activate…
- Conditions
- Rheumatoid Arthritis, Autoimmune Rheumatologic Disease, Systemic Lupus Erythematosus, Systemic Vasculitis
- Trial name
- COVBIRD (NCT05236491)
- Testing
- COVID-19 vaccine
- Where
- 2 sites in Canada
- Volunteers
- 287 people
- Sponsor
- Paul R Fortin