Clinical trials: Overload
Lymphedema, Lower Limb, Lymphedema
Detecting the Undetected: Heart Failure Screening at the Lymphoedema Point of Care
Heart failure affects more people than the four most common cancers combined. When identified early, management is more straightforward, preventing complications, hospitalisations, and fatalities.
- Conditions
- Lymphedema, Lower Limb, Lymphedema, Heart Failure, Heart Failure (for Example, Fluid Overload)
- Trial name
- NCT07498868
- Where
- United Kingdom
- Volunteers
- 618 people
- Sponsor
- Swansea Bay University Health Board
Beta Thalassemia Major
Iron Accumulation in Erythrocytes in Patients
Thalassemia refers to a group of blood disorders characterized by a decrease or absence of the synthesis of one or more normal globin chains.
- Trial name
- NCT07486531
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Acute Heart Failure (AHF), Heart Failure (for Example, Fluid Overload)
ReDS-guided Decongestion Strategy in Patients Hospitalized for Heart Failure
This clinical trial aims to determine whether a ReDS-guided treatment strategy is superior to the current standard of care for adults hospitalized with heart failure.
- Conditions
- Acute Heart Failure (AHF), Heart Failure (for Example, Fluid Overload), Heart Failure Hospitalization
- Trial name
- ReDS-SAFE HF 2 (NCT07484009)
- Testing
- Remote Dielectric Sensing System, Blinded ReDS data
- Where
- 25 sites in Spain
- Volunteers
- 1,014 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
MRI Scans
Quantitative Susceptibility Mapping (QSM) to Guide Iron Chelating Therapy
The overall goal of this research is to help develop a new magnetic resonance (MR) method, Quantitative Susceptibility Mapping (QSM), to improve the measurement of liver iron concentrations without the need for a liver biopsy.
- Trial name
- NCT04171635
- Testing
- Quantitative Susceptibility Mapping (QSM) Magnetic Resonance Imaging (MRI), R2* Magnetic Resonance Imaging (MRI)
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
ALS (Amyotrophic Lateral Sclerosis), Iron Overload
Focal Accumulation of Iron in Cerebral Regions in Early ALS (Amyotrophic Lateral Sclerosis) Patients
The FAIR-ALS study is to investigate the safety and efficacy of a scavenger treatment of iron deferiprone, which would reduce the brain iron to limit the development of amyotrophic lateral sclerosis.
- Trial name
- SAFEFAIRALS (NCT02164253)
- Testing
- Deferiprone
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Lille
Physical Inactivity, Phosphate Overload
Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity
Studies in mice demonstrated that dietary phosphate (Pi) loading that mimic the level of US adult consumption leads to reduced spontaneous locomotor activity, exercise capacity, and reduced resting metabolic rate when in normal…
- Conditions
- Physical Inactivity, Phosphate Overload, Visceral Obesity
- Trial name
- NCT05147909
- Testing
- Sodium Phosphate, Sodium Chloride
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Acute Renal Failure (ARF), Acute Kidney Injury (AKI)
Retrospective Analysis of Prismaflex HF20 Set Versus ppCRRT Registry
A retrospective multicenter, observational design intended to capture data on pediatrics (weighing between 8 - 20 kg) who underwent continuous renal replacement therapy (CRRT) using the HF20 set.
- Conditions
- Acute Renal Failure (ARF), Acute Kidney Injury (AKI), Fluid Overload in Dialysis Patients
- Trial name
- NCT06633029
- Testing
- Prismaflex HF20
- Where
- 5 sites in United States
- Volunteers
- 59 people
- Sponsor
- Vantive Health LLC
Fluid Overload, Critical Care, Intensive Care
Timing and Dose of Fluid Deresuscitation in Critically Ill Patients
Fluid deresuscitation is an important intervention in the Intensive Care Unit (ICU). This study aims to find (1) determinants of successful deresuscitation, (2) the optimal rate (dose) of deresuscitation based on these…
- Conditions
- Fluid Overload, Critical Care, Intensive Care, Deresuscitation
- Trial name
- TIDE (NCT07275658)
- Where
- 2 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Thalassemia, Iron Overload
Evaluation of the Quality of Life in Patients With Chronic Iron Overload Due to Hemoglobinopathies in Greece.
This observational clinical study aims to evaluate the HRQoL of thalassemia patients with iron overload in Greece, who are under treatment with deferasirox based on standard clinical practice.
- Trial name
- FEROUSA (NCT07352878)
- Volunteers
- 150 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Acute Kidney Injury, Fluid Overload
Early Deresuscitation Strategy Driven by Tissue Perfusion in Renal Replacement Therapy in Patients With Acute Renal Failure
In Intensive Care Unit (ICU) patients with acute kidney injury (AKI) and treated with renal replacement therapy (RRT) often present a fluid overload which is associated with morbidity (mechanical ventilation duration increase…
- Trial name
- EarlyDry (NCT05817539)
- Testing
- Fluid balance negativation, Body weight Stabilization
- Where
- 14 sites in France
- Volunteers
- 250 people
- Sponsor
- Hospices Civils de Lyon
Inferior Vena Cava Abnormality, Fluid Responsiveness
Transhepatic Echography for Fluid Responsiveness After Cardiovascular Surgery
Fluid expansion in critically ill patients following high risk surgery may induce fluid overload and worse outcome. Several tools have been developped to predict fluid responsiveness in such situation in order to avoid…
- Conditions
- Inferior Vena Cava Abnormality, Fluid Responsiveness, Fluid Overload, Venous Congestion
- Trial name
- THEFRACS (NCT04914455)
- Testing
- Echocardiography and transhepatic inferior vena cava assessment using ultrasound.
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Lille
Fluid Overload, Glomerulosclerosis, Focal Segmental
Interview Study of Adult and Child Patients and Parents of Children With Swelling Due to Nephrotic Syndrome.
Researchers from the University of Michigan and Northwestern University are studying people's experiences with swelling caused by Nephrotic Syndrome.
- Conditions
- Fluid Overload, Glomerulosclerosis, Focal Segmental, Edema, Membranous Nephropathy
- Trial name
- Prepare-NS (NCT05505500)
- Testing
- Interview
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Michigan
Mechanical Ventilation, Fluid Overload
Lung Ultrasound-Guided Fluid Deresuscitation in ICU Patients
Timely recognition and treatment of fluid overload can expedite liberation from invasive mechanical ventilation in intensive care unit (ICU) patients.
- Conditions
- Mechanical Ventilation, Fluid Overload, Deresuscitation, Ventilator-free Days
- Trial name
- CONFIDENCE (NCT05188092)
- Testing
- Lung ultrasound guided deresuscitation
- Where
- 3 sites in Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Fluid Overload, Cardiac Surgery
Fluid Responsiveness in Post-cardiac Surgery
the study aims to examine the validity of combined end-expiratory and end-inspiratory occlusion test and tidal volume challenge test for prediction of fluid responsiveness in immediate post-cardiac surgery patients
- Conditions
- Fluid Overload, Cardiac Surgery, Postoperative Complications
- Trial name
- NCT05957003
- Testing
- Combined end-expiratory occlusion and end-inspiratory occlusion test, Tidal volume challenge test
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Fluid Overload
Fluid Balance Neutralization During CRRT (Continuous Renal Replacement Therapy)
Fluid overload is associated with increased mortality in critically ill patients with acute kidney injury. Fluid balance controlled is associated with improved outcome in observational studies, and is deemed safe in…
- Trial name
- GO-NEUTRAL (NCT04801784)
- Testing
- Increased net ultrafiltration with advanced hemodynamic monitoring, Zero or near-zero net ultrafiltration
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Hospices Civils de Lyon
Fluid Overload, Hemodynamic Instability
Hemodynamic Effects of Variations in Net Ultrafiltration Rate During Continuous Renal Replacement Therapy.
Net ultra filtration (NUF) is one of the most important parameters during renal replacement therapy (RRT) whose role is to control fluid balance by water removal.
- Trial name
- NEPTUNE (NCT06071026)
- Testing
- Net Ultra Filtration Rate
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Heart Failure With Volume Overload
A Study of HRS-9057 in Patients With Heart Failure and Volume Overload
The study is an open-label, Tolvaptan-controlled Phase I study to evaluate the safety, tolerability, PK/PD profile and efficacy of HRS-9057 in the treatment of heart failure with volume overload.
- Trial name
- NCT06506994
- Testing
- HRS-9057, Tolvaptan
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Cirrhosis, Liver, Volume Overload
Compare the Diuretic Effect With Furosemide vs Furosemide and Albumin Combined in Cirrhotic Patients
A common complication of the progression of cirrhosis is fluid retention (ascites, edema, or pleural effusion). Loop diuretics are the treatment of choice for fluid retention in cirrhotic patients; however, many of these patients…
- Conditions
- Cirrhosis, Liver, Volume Overload, Fluid Overload
- Trial name
- NCT04216784
- Testing
- Furosemide Injection, Albumin Human
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Rush University Medical Center
Liver Fibrosis, Beta Thalassemia Major
Elastography vs Iron Regulators in the Diagnosis of Hepatic Fibrosis- Iron Overload in Children With Beta- Thalassemia
The goal of this cross-sectional observational study is to evaluate the accuracy of serum ferritin and serum hepcidin versus non-invasive scores in the diagnosis of liver fibrosis and iron overload in beta- thalassemia children.
- Trial name
- NCT07153926
- Testing
- Serum ferritin, Serum hepcidin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Acute Kidney Injury, Uremia
Timing of Renal Replacement Therapy in the Critically Ill Patients
Background: Severe acute kidney injury (AKI) among critically ill patients is sometimes treated with renal replacement therapy (RRT), and in Sweden continuous RRT (CRRT) is the dominant modality used in this population.
- Conditions
- Acute Kidney Injury, Uremia, Fluid Overload, Dialysis; Complications
- Trial name
- TORRT (NCT03629977)
- Testing
- CRRT
- Where
- Sweden
- Volunteers
- 50,000 people
- Sponsor
- Karolinska University Hospital