Clinical trials: Overload
Acute Kidney Injury, Fluid Overload
Forced Fluid Removal in High Risk Acute Kidney Injury
The objective of this pilot trial is to assess the feasibility of forced fluid removal in patients admitted to the intensive care unit (ICU) with high-risk AKI and severe fluid overload.
- Conditions
- Acute Kidney Injury, Fluid Overload, Critical Illness
- Trial name
- FFAKI (NCT02458157)
- Testing
- Furosemide (Furix), Continuous renal replacement therapy (CRRT), Resuscitation
- Where
- 3 sites in Denmark
- Volunteers
- 21 people
- Sponsor
- Nordsjaellands Hospital
Aluminium Overload, Biological Availability
Effect of Three Silicon Based Food Supplements on the Urinary Excretion of Aluminum and Other Metals (SILIAL)
Aluminum is a very abundant element in nature. Humans are exposed to this metal through the environment, diet, and drinking water, as well as through the consumption of certain medications.
- Trial name
- SILIAL (NCT05116982)
- Testing
- ORGONO Living Silica Acacia Gum-MMST Powder, ORGONO Living Silica Malto-OSA Powder, ORGONO Living Silica Collagen Booster
- Where
- 2 sites in Spain
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Iron Metabolism Disorders, Iron Overload
Inhibiting Dietary Iron Absorption in Subjects With Hereditary Hemochromatosis by a Natural Polyphenol Supplement
Polyphenolic compounds are very strong Inhibitors of non-heme iron absorption, as they form insoluble complexes with ferrous iron.
- Conditions
- Iron Metabolism Disorders, Iron Overload, Polyphenols
- Trial name
- NCT03990181
- Testing
- meal matrix & NPPS, meal matrix & CS, no-matrix & NPPS
- Where
- 2 sites in Portugal, Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Sickle Cell Disease, Thalassemia
Genes Influencing Iron Overload State
Iron overload, which can be defined operationally as too much iron in the body, develops as a consequence of too many blood transfusions given, or due to genetic defects hereditary hemochromatosis).
- Conditions
- Sickle Cell Disease, Thalassemia, Marrow Aplasia
- Trial name
- NCT01158794
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- St. Jude Children's Research Hospital
Insulin Resistance, Iron Overload
Effects of Phlebotomy on Insulin Sensitivity in Insulin Resistance-associated Hepatic Iron Overload Patients
The purpose of this study is to evaluate efficacy of phlebotomy on insulin sensitivity as evaluated by euglycemic-hyperinsulinic clamp in insulin resistance-associated hepatic iron overload patients.
- Trial name
- SAINPOS (NCT01572818)
- Testing
- phlebotomy, dietary and lifestyle counseling
- Where
- 2 sites in France
- Volunteers
- 13 people
- Sponsor
- Rennes University Hospital
Beta-Thalassemia, Iron Overload
Amlodipine as Adjuvant Treatment to Iron Chelation for Prevention of Cardiac Iron Overload in Thalassemia Patients
This is a randomized, open label, two arms superiority trial of a representative population of patients with a primary diagnosis of transfusion dependent thalassemia with evidence of moderate cardiac iron overload, defined as an…
- Trial name
- CANALI (NCT02474420)
- Testing
- Amlodipine, Deferasirox
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Kevin H.M. Kuo, MD, MSc, FRCPC
Acute Kidney Injury, Fluid Overload
Volume Removal Intolerance During Net Ultrafiltration in Acute Kidney Injury Patients
Acute kidney injury (AKI) is common in critically ill patients and is frequently associated with fluid overload, which can worsen clinical outcomes.
- Conditions
- Acute Kidney Injury, Fluid Overload, Fluid Overload in Dialysis Patients, Critical Illness
- Trial name
- VINKO (NCT07643597)
- Where
- 10 sites in Brazil, Chile and 5 more
- Volunteers
- 128 people
- Sponsor
- Hospital Las Higueras
Heart Failure, Congestive
Influence of Angiotensin Converting Enzyme (ACE) Genotype on Lung Diffusion in Heart Failure
In patients with chronic heart failure ACE-inhibitor treatment improves lung diffusion and prevents pulmonary edema after fluid overload. In the western country, 3 population types of ACE genotypes exist (DD, ID, II).
- Trial name
- NCT00361127
- Testing
- isotonic saline infusion
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Piergiuseppe Agostoni
Iron Overload, Hemosiderosis
Non-invasive Quantification of Liver Iron With MRI
The purpose of this study is to validate magnetic resonance imaging as a biomarker of hepatic iron concentration (HIC). Excessive accumulation of iron in the body is highly toxic, specifically in the liver.
- Trial name
- NCT01516853
- Testing
- Non-contrast MRI
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Iron Overload Due to Repeated Red Blood Cell Transfusions
Pharmacokinetics of SSP-004184 in the Treatment of Chronic Iron Overload Requiring Chelation Therapy
The purpose of this study is to evaluate SSP-004184AQ in patients with transfusional iron overload whose primary diagnosis is hereditary or congenital anemia.
- Trial name
- NCT01604941
- Testing
- SPD602
- Where
- 12 sites in United States, Canada and 3 more
- Volunteers
- 32 people
- Sponsor
- Shire
Heart Failure, Heart Failure (for Example, Fluid Overload)
Molecular Underpinnings of Heart Failure, Integrative Multi-Omics, and Non-Coding RNA Profiling
The main objective of the study is to achieve a comprehensive phenotyping of patients with heart failure, combining detailed clinical characterization with in-depth molecular profiling.
- Trial name
- BIOCARDIUM-HF (NCT07158086)
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- University of Zurich
Heart Failure
Lymphatic System Stimulation in Heart Failure
The goal of this pilot clinical trial is to obtain preliminary data on the effects of lymphatic exercise training in patients with heart failure. The main question[s] it aims to answer are: 1.
- Trial name
- NCT05834400
- Testing
- The Optimal Lymph FLow (TOLF), Daily Monitoring
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Rutgers, The State University of New Jersey
End Stage Renal Disease, Hypertension
Blood Pressure Slopes and Ultrafiltration in Hemodialysis Patients
Kidney failure has been recognized as one of the most costly chronic conditions among United States Veterans. Approximately 13,000 Veterans develop kidney failure each year, and most require hemodialysis initiation.
- Conditions
- End Stage Renal Disease, Hypertension, Extracellular Volume Overload, Intradialytic Hypotension
- Trial name
- NCT04163614
- Testing
- IBPS-Guided Ultrafiltration
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- VA Office of Research and Development
Dysmetabolic Iron Overload Syndrome
A Prospective, Mono-center, Interventional Study Evaluating the Effect of One Year Initial Care by Hygieno-dietary Advices With or Without Phlebotomy on Glycemia After at Least 5 Years in Patients With Dysmetabolic Iron Overload Syndrome
A prospective, mono-center, interventional study evaluating the effect of one year initial care by hygieno-dietary advices with or without Phlebotomy on glycemia after at least 5 years in Patients with dysmetabolic iron overload…
- Trial name
- EvoHSD (NCT03942432)
- Testing
- Oral Glucose Tolerance Test (OGTT), Clinical exam, Blood sample
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Rennes University Hospital
Endothelial Dysfunction, Hemolysis
Optimization of Prime Fluid Strategy to Preserve Microcirculatory Perfusion During Cardiac Surgery With Cardiopulmonary Bypass, Part II
Acute microcirculatory perfusion disturbances is common in critical illness and associated with increased morbidity and mortality.
- Conditions
- Endothelial Dysfunction, Hemolysis, Fluid Overload
- Trial name
- PRIME part II (NCT05647200)
- Testing
- Treatment: additional albumin during cardiopulmonary bypass, control: additional ringers during cardiopulmonary bypass
- Where
- Netherlands
- Volunteers
- 64 people
- Sponsor
- Amsterdam UMC, location VUmc
Sports Injuries
Adaptation in Lower Extremity After 3 Running Days, With a Group Trained by Eccentric Overload
This study evaluates the changes in muscles and tendons in the lower limb after an intervention of fatigue during 3 consecutive days between trained or not healthy subjects.
- Trial name
- NCT02481063
- Testing
- Control, Eccentric Overload
- Where
- Spain
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Universidad San Jorge
Fluid Overload
Comparison of PVI-guided Fluid Management With Traditional Fluid Management in Colorectal Surgery
The first objective of this study was to compare the traditional fluid management (TFM) with PVI guided goal-directed fluid management (GDFM) in terms of controlled intraoperative fluid volume, surgical end-point fluid balance…
- Trial name
- NCT03339895
- Testing
- pvı-guided, traditional-guided
- Volunteers
- 70 people
- Sponsor
- Kocaeli University
Chronic Kidney Disease, Peritoneal Dialysis
Treatment of Asymptomatic Fluid Overload in Peritoneal Dialysis Patients
INTRODUCTION Peritoneal dialysis (PD) is a life-saving treatment for end-stage renal disease patients. However, cardiovascular disease remains the major cause of morbidity and mortality in PD patients.
- Trial name
- NCT02168283
- Testing
- treatment arm, Control arm
- Where
- Hong Kong
- Sponsor
- Chinese University of Hong Kong
Fluid Overload
Restrictive or Doppler-guided Fluid Treatment in Colorectal Surgery
This is a clinical randomised double blinded multicentre trial of two different fluid treatments during colorectal surgery in an enhanced recovery programme A restricted fluid regimen aiming at zero fluid balance and less than…
- Trial name
- NCT03677622
- Testing
- Voluven to near maximal stroke volume of the heart
- Volunteers
- 150 people
- Sponsor
- Holbaek Sygehus
Endothelial Dysfunction, Hemolysis
CPB Prime Fluid Strategies to Preserve Mcirocirculatory Perfusion
Acute microcirculatory perfusion disturbances is common in critical illness and associated with higher morbidity and mortality. Recent findings by the investigators' group showed that microcirculatory perfusion is disturbed…
- Conditions
- Endothelial Dysfunction, Hemolysis, Fluid Overload
- Trial name
- PRIME (NCT05647057)
- Testing
- A: gelofusine + ringers, B: albumine + ringers, C: ringers + retrograde autologous priming
- Where
- Netherlands
- Volunteers
- 48 people
- Sponsor
- Amsterdam UMC, location VUmc