Clinical trials: Overweight, Obesity Grade I
Diabetes Mellitus, Type 2, Insulin Resistance
New Frontiers on Bariatric Surgical Procedures: Classical Bypass for Type-2 Diabetic Patients With Obesity Grade I
Bariatric surgery leads to remission of type 2 diabetes in morbid obese patients in 80% (Roux-en-Y gastric bypass)to 90% (biliopancreatic diversion and duodenal switch) of cases.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Obesity
- Trial name
- NCT00566189
- Testing
- Roux-en-Y Bypass Gastroplasty
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Campinas, Brazil
Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia, FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma
A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial Cancer
This phase II trial studies whether adding tirzepatide injections to a levonorgestrel intrauterine device (LNG-IUD) improves pathologic response (absence of cancer cells in tissue samples after treatment) in women with…
- Trial name
- NCT07349641
- Testing
- Medical Device Usage and Evaluation, Tirzepatide
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- National Cancer Institute (NCI)
Endometrial Hyperplasia, Grade 1 Endometrial Cancer
Uterine Preservation Via Lifestyle Transformation
Up to 60% of endometrial cancer cases are attributed to obesity, in part because obesity promotes development of atypical endometrial hyperplasia (AEH), and up to 40% of women with AEH go on to develop endometrial cancer.
- Trial name
- NCT05903131
- Testing
- Telemedicine behavioral weight intervention, Progestin, Enhanced usual care
- Where
- 3 sites in United States
- Volunteers
- 96 people
- Sponsor
- Washington University School of Medicine
Endometrial Cancer, Endometrial Intraepithelial Neoplasia
Tirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1 Endometrial Cancer
The goal of this study is to determine the anti-proliferative effect of tirzepatide on the endometrium of patients with endometrial intra-epithelial neoplasia (EIN) and Grade 1 endometrial cancer (EC), by comparing archival…
- Conditions
- Endometrial Cancer, Endometrial Intraepithelial Neoplasia, Grade 1 Endometrial Endometrioid Carcinoma
- Trial name
- NCT07078838
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Endometrial Cancer, Endometrial Cancer Stage I
SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer
SHAPE-ENDO is a single-center, open-label, pilot randomized clinical trial conducted at Hospital Universitari de Bellvitge in Barcelona, Spain.
- Conditions
- Endometrial Cancer, Endometrial Cancer Stage I, Atypical Endometrial Hyperplasia and Endometrial Carcinoma Stage I, Atypical Endometrial Hyperplasia
- Trial name
- SHAPE-ENDO (NCT07462663)
- Testing
- GLP-1 Receptor Agonist, Levonorgestrel IUD (Lng-IUD), Oral Progestins
- Volunteers
- 80 people
- Sponsor
- Hospital Universitari de Bellvitge
Endometrial Atypical Hyperplasia, Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia
Semaglutide, Weight Loss, and LNG-IUD for Conservative Treatment of Endometrial Atypical Hyperplasia and Grade 1 Endometrial Cancer
The goal of this clinical trial is to learn if a combination treatment of a hormonal intrauterine device (LNG-IUD), semaglutide, and a structured weight loss program can treat endometrial atypical hyperplasia or grade 1…
- Conditions
- Endometrial Atypical Hyperplasia, Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia, Endometrial Cancer Stage I, Endometrial Cancer
- Trial name
- SWIFT (NCT07820358)
- Testing
- Semaglutide (Wegovy) weekly injection, LNG-IUD (Progestin), Structured Weight Loss Program
- Where
- 4 sites in United States
- Volunteers
- 48 people
- Sponsor
- The Methodist Hospital Research Institute
Obesity, Type 2 Diabetes Mellitus
Surgical Treatment in Diabetic Patients With Grade 1 Obesity
There will be a randomized clinical trial, non-blind, 3-arm treatment (medical, surgical, gastric bypass and ileal transposition surgery with and sleeve), which will be conducted in a single center - S.B.S.
- Trial name
- NCT01857076
- Testing
- Gastric bypass surgery, Surgical ileal transposition with sleeve, Clinical
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- Hospital Sirio-Libanes
Supplementation, Obesity
Clinical Trial to Analyze the Efficacy of a Supplement Extracted From Persimmon on Overweight / Obesity.
Randomized, controlled, double-blind clinical trial, with two parallel branches depending on the product consumed (experimental product and placebo product) and single-center, to measure the efficacy of a supplement extracted…
- Trial name
- PERSOB (NCT05750342)
- Testing
- Experimental Product Caqui
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Obesity
Sodium Tungstate in Obesity
The purpose of this study is to compare the efficacy and safety of sodium tungstate versus placebo in patients with obesity (grade I and II).
- Trial name
- TROTA-1 (NCT00555074)
- Testing
- Sodium Tungstate
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Hospital Clinic of Barcelona
Overweight, Obesity Grade I
Clinical Trial to Evaluate the Effect of a Probiotic Product on Weight
The study of the intestinal microbiota and its relationship with health and disease, as well as the use of probiotics as effective alternative treatments to improve people's well-being is a field of growing research in recent…
- Trial name
- NCT06815926
- Testing
- Probiotic
- Where
- Spain
- Volunteers
- 106 people
- Sponsor
- Bioithas SL
Overweight, Obesity Grade I
Light, Exercise Intensity and Mood in Overweight
The purpose of this study is to determine if an exposure to light in the morning has a positive influence on self-chosen exercise intensity on a bicycle ergometer in overweight and obese patients.
- Trial name
- LEXI-MO (NCT02636335)
- Testing
- Phillips Energy Light HF3319
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Basel
Appetite Regulation, Overweight and Obesity
Effectiveness of a Natural Ingredient on Appetite Regulation
Single-center, double-blind, double-crossed, randomized controlled clinical trial with two crossed branches, designed with the objective of evaluating the effect of the investigational product on satiety.
- Trial name
- SAC (NCT04345029)
- Testing
- Dietary supplement consumption
- Where
- Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Obese
Comparative Effects of Using Black Seed and Cumin Seed on BCP of Obese Grade I
The goal of this Randomized clinical trial is to compare effectiveness of of using black seed (Nigella sativa) and cumin seed (Cuminum cyminum) on Body composition profile of obese grade 1.
- Trial name
- NCT05770791
- Testing
- Black Seed ( Nigella Sativa), Cumin Seed (Cuminum Cyminum)
- Where
- Pakistan
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Sehat Medical Complex
Obesity
Effect of Dapagliflozin/Metformin XR vs Monotherapies on Anthropometric Indicators in Obesity
Obesity has increased to alarming levels in the world. Currently it is estimated that it occurs in a third of the world's population and it is expected that by 2030, 20% of the world's adult population will suffer from obesity…
- Trial name
- NCT03710460
- Testing
- Dapagliflozin, Dapagliflozin plus Metformin XR, Metformin XR
- Where
- Mexico
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Inflammatory Disease, Aging Problems
Umbilical Cord Mesenchymal Stem Cell for Aging-related Low-grade Inflammation
The goal of this single-group, open-label, phase I/II clinical trial is to evaluate the safety and efficacy of the transplantation of umbilical cord mesenchymal stem cells in aging-related low-grade inflammation patients'…
- Conditions
- Inflammatory Disease, Aging Problems, Obese, Lipid Metabolism Disorders
- Trial name
- NCT06448052
- Testing
- umbilical cord mesenchymal stem cell
- Where
- Vietnam
- Volunteers
- 72 people
- Sponsor
- Nguyen Ton Ngoc Huynh
Diabetes Mellitus, Obesity
Surgery Treatment of Type 2 Diabetes Mellitus Patients With Grade 1 Obesity and Overweight
This study evaluate the Duodenal Ileal Interposition with Sleeve Gastrectomy for Type 2 Diabetes Mellitus in grade 1 obesity and overweight patients.
- Conditions
- Diabetes Mellitus, Obesity, Overweight
- Trial name
- NCT03333642
- Testing
- Duodenal Ileal Interposition with Sleeve Gastrectomy
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital Federal de Bonsucesso
Diabetes Mellitus, Obesity
Surgical Treatment in Diabetic Patients With Grade 1 Obesity
Surgical Treatment in Diabetic Patients With Grade 1 Obesity
- Trial name
- NCT02949687
- Testing
- ileal interposition with sleeve and sympathectomy
- Volunteers
- 23 people
- Sponsor
- Universidade Positivo
Obesity and Erectile Dysfuntion
Effect of Tadalafil Administration on Vasodilatation Mediated by Flow in Patients With Obesity Grade I-II
Obesity is a public health problem, not only for its high prevalence, but also because of the comorbidities found in it. Within the physiopathological mechanisms associated with obesity is a low-grade inflammatory state that is…
- Trial name
- NCT03905018
- Testing
- Tadalafil 20 MG
- Where
- Mexico
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centro Universitario de Ciencias de la Salud, Mexico