Clinical trials: Overweight and Obese Volunteers
Obesity
To Assess the Safety, Tolerability, Pharmacokinetics and Pharmakodynamics of AZD2820 After Multiple Ascending Doses
This is a randomised and single-blind, placebo-controlled study to investigate the safety, tolerabilty, pharmacokinetics and pharmacodynamics of repeated and ascending doses of AZD2820 to obese but otherwise healthy male subjects.
- Trial name
- NCT01469923
- Testing
- AZD2820
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Weight Loss
Evaluation of Efficacy of a Cashew Apple Extract on Weight Management and Associated Metabolic Risk Factors in Overweight/Obese Volunteers
The purpose of this study is to assess the efficacy and safety of a cashew apple extract on weight management and associated metabolic risk factors in overweight/obese volunteers, versus placebo, after 12 weeks of treatment.
- Trial name
- NCT02493140
- Testing
- Cashew apple extract (Cashewin)
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Dialpha
Obesity
Evaluation of the Absorption Rate From Different Oral Fe-supplements in Obese Volunteers Pre- and Post-RYGB
Obese volunteers who have scheduled a gastric bypass (RYGB) in UZ Leuven will be asked to participate in a cross-over study using commercial available iron supplements.
- Trial name
- NCT02569593
- Testing
- Iron supplements, more specific Ferrodyn and Vista Ferrum
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- KU Leuven
Healthy Volunteers, Overweight
A Research Study Looking at the Comparability (Bioequivalence) of Two Versions of Semaglutide
The study will look at how two different versions of semaglutide reach and stay in the blood after injection. The study aims to show similar levels of semaglutide in the blood when using the different versions.
- Conditions
- Healthy Volunteers, Overweight, Obesity
- Trial name
- NCT04228354
- Testing
- Semaglutide
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Obesity, Lipid Disorders
A Clinical Study to Evaluate the Safety,Tolerability and PK of ZYT1, Following Oral Administration in Healthy Volunteers
This is a clinical study to evaluate the safety, tolerability and pharmacokinetics of ZYT1, following oral administrations in healthy volunteers. The study shall be divided into four plans as given below: 1.
- Trial name
- NCT01543269
- Testing
- ZYT1
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Zydus Lifesciences Limited
Healthy, Obesity
Fat Tissue Microperfusion to Measure Leptin Secretion and Its Relations With Fat Breakdown in Humans
Leptin is a hormone that acts in the body as a chemical messenger. It is produced in fat cells and is believed to regulate body weight in humans. Leptin decreases appetite and influences the energy balance of the body.
- Trial name
- NCT00001722
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Healthy Volunteers Only
A Study of Body Fat Distribution and Airway Mechanics in Healthy Adults
This study investigates how body fat distribution affects airway closure and lung mechanics in healthy adults. Using Electrical Impedance Tomography (EIT), esophageal manometry, and computed tomography (CT), we aim to…
- Trial name
- NCT07019831
- Testing
- Body positioning
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maurizio F. Cereda, MD
Obesity
Oral Sodium Blood Pressure in Normal Weight, Overweight and Obese Volunteers
The primary objective of this study is to analyze the sensitivity of blood pressure to oral salt intake. Matched male and female participants will be selected as normal weight, overweight, and obese.
- Trial name
- PLADSEL (NCT01532401)
- Testing
- sodium chloride, Methylcellulose crystalline
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Poitiers University Hospital
Obesity, Type 2 Diabetes Mellitus
Green Tea, High in Epigallocatechin Gallate (EGCG) and Postprandial Fat Oxidation
The body of evidence regarding the health benefits of green tea has grown considerably during the last decade and includes antioxidant properties, anti- cancer, anti-obesity and anti-diabetes effects.
- Trial name
- NCT00867555
- Testing
- Effect of the green tea extract TEAVIGO, high in EGCG, on postprandial fat oxidation
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Overweight and Obesity
Evaluation of Fiit-ns® in Health-related Quality of Life Improvement in Overweight and Obese Subjects
The purpose of this study is to evaluate the effects of a 16-week supplementation with a polyphenol-rich extract, Fiit-ns®, on improvement of health-related quality of life (HR-QOL) of overweight and obese volunteers, as compared…
- Trial name
- NCT03423719
- Testing
- Fiit-ns®
- Where
- Spain
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Fytexia
Healthy, Overweight
Effects of Pioglitazone on Insulin Sensitivity in Healthy Overweight and Obese Males (MK-0000-170)
The purpose of this study is to evaluate whether 30 mg of pioglitazone administered once daily for up to 28 days to healthy overweight and obese subjects will lead to a significant change in insulin sensitivity, measured in the…
- Conditions
- Healthy, Overweight, Obesity
- Trial name
- NCT01115712
- Testing
- Comparator: Pioglitazone, Comparator: Hyperinsulinemic Euglycemic Clamp
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Healthy
Effect of Late Dinner on Nocturnal Metabolism
This study examines the impact of routine dinner time versus late dinner time on nocturnal metabolism. Specifically, investigators will examine plasma profiles of free fatty acids, glucose, insulin, triglycerides, and oxidation…
- Trial name
- NCT03525717
- Testing
- Routine Dinner, Late dinner
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Heart Failure, Obesity
Fatty Acid Radiotracer Comparison Study in Heart Failure Patients
A single center, open-label baseline controlled imaging study to designed to assess whether Positron Emission Tomography (PET) measurements of myocardial Fatty Acid (FA) metabolism performed with [18F]FluorbetaOx correlates with…
- Conditions
- Heart Failure, Obesity, Type 2 Diabetes Mellitus, Health Normal Volunteer Subjects
- Trial name
- NCT01648296
- Testing
- [18F]FluorbetaOx
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Obesity, Gastroesophageal Reflux
Ultrasound Assessment for Comparison of Gastric Residual Volume After Ingestion of Carbohydrate Drink and Water in Obesity Class II and III Volunteers at Risk of Aspiration
The goal of this clinical trial is to compare gastric residual volume between drinking a carbohydrate drink and water in obesity class II and III volunteers at risk of aspiration.
- Trial name
- CarbDrinkUltra (NCT06941623)
- Testing
- Ultrasonography of gastric residual volume, Point-of-care testing of glucose, Hunger numeric rating scale
- Where
- Thailand
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Obesity
Metabolic Impact of Fat Digestion
In this study, the investigators are interested in investigating how the emulsification state and amount of fat in a meal can modify the kinetics of postprandial lipemia and inflammatory outcomes (including endotoxemia) in obese…
- Trial name
- LIPINFLOX (NCT01249378)
- Testing
- All subjects receive three sequences of a standard breakfast
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Healthy, Overweight
Postprandial Effects of High-fat Meals With Different Dairy Products on Lipid Metabolism and Inflammation
The aim of this project is to elucidate how high-fat meals with different kinds of dairy products affect postprandial responses of lipid metabolism and inflammatory markers in healthy and obese subjects.
- Conditions
- Healthy, Overweight, Obesity
- Trial name
- NCT02836106
- Testing
- Butter, Cheese, Whipped cream
- Where
- Norway
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Obesity, Cardiovascular Diseases
The First Twenty for Volunteer Firefighters
The purpose of this study is to assess the efficacy of an internet-based firefighter health and wellness program for volunteer fire departments.
- Conditions
- Obesity, Cardiovascular Diseases, Occupational Injuries
- Trial name
- NCT03181321
- Testing
- The First Twenty
- Where
- United States
- Volunteers
- 419 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Overweight and Obesity
Effect of ANACA3 Slimming Gel on Loss of Abdominal and Thigh Circumferences in Healthy Volunteers
Overweight and obesity is defined, according to the World Health Organization (WHO), by abnormal or excessive accumulation of adipose or fatty tissue that may be harmful to health.
- Trial name
- NCT03685656
- Testing
- Slimming gel
- Where
- France
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Nutravalia
Healthy Volunteer, Obestity
Assessing the Impact of Perceptions of Unpredictability on Objective Measures of Food Consumption and Metabolism
Background: Many people in the United States are overweight or obese. This natural history study will look into how life events during childhood can impact eating behaviors and weight gain as adults.
- Trial name
- NCT06690294
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Healthy, Obesity
A Study to Test How Well Different Doses of BI 3034701 Are Tolerated by Japanese Healthy People and Japanese People With Obesity or Overweight
Part 1: To investigate safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of BI 3034701 in Japanese male and female participants with body mass index (BMI) ≥27.0 kg/m² or more following subcutaneous…
- Trial name
- NCT07693231
- Testing
- BI 3034701
- Where
- 3 sites in Japan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim