Clinical trials: Ovulation
Polycystic Ovarian Syndrome (PCOS)
Comparative Study Between HOMA1-IR and HOMA2-IR in Prediction of Ovulation Outcome in Women With PCOS
122 women diagnosed with PCOS seeking fertility in the fertility clinic at kasr Alainy hospital will be subjected to Homeostatic model assessment for insulin resistance 1 was calculated for all participants through the equation…
- Trial name
- NCT06793904
- Testing
- Aromatase inhibitor Letrozole
- Where
- Egypt
- Volunteers
- 122 people
- Sponsor
- Cairo University
in Vitro Fertilization
Transfer of Frozen Embryos in Natural Cycle: Evaluation of Impact of Spontaneous Versus HCG-triggered Ovulation on Pregnancy Rate
The purpose of the study is to evaluated whether there is a difference in pregnancy rate when transferring frozen embryos between patietns having spontaneously ovulated versus those triggered to voulate with HCG.
- Trial name
- TECNAT (NCT03428165)
- Testing
- HCG
- Where
- 2 sites in France
- Volunteers
- 103 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Contraception
A proof-of Concept, Randomized 3-month Study to Evaluate the Effects of Three Contraceptive Intrauterine Systems Delivering Copper and a Daily Dose of 5, 20 or 40 μg of Ulipristal Acetate (UPA)
The UPA doses to be tested in this new IUS, 5, 20 or 40 μg per day, are not expected to suppress ovulation, however they should prevent endometrial growth resulting in endometrial atrophy, minimal bleeding, or even amenorrhea.
- Trial name
- NCT03230539
- Testing
- Ulipristal Acetate IUS delivering Cu and 5μg, Ulipristal Acetate IUS delivering Cu and 20μg, Ulipristal Acetate IUS delivering Cu and 40μg
- Where
- Dominican Republic
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Population Council
Oncological Disease, Fertility Preservation
Ovulation Induction With GnRH Analogue or Dual Trigger?
Most medically assisted procreation (ART) techniques, including oocyte cryopreservation for fertility preservation, involve controlled ovarian stimulation.
- Trial name
- NCT07546136
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Poor Response to Ovulation Induction, Infertility, Female
Optimal Embryonic Stage for Transfer in Poor Responders
A Prospective cohort study including couples with poor responder females who undergoing ICSI
- Trial name
- NCT04485819
- Testing
- Cleavage stage transfer, Blast stage transfer
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Ganin Fertility Center
Reproduction
Evaluation of EarlySense for Monitoring Ovulation Cycles and Detection of Early Stages of Pregnancy in Home Environment
The study objective is to collect data to assess the accuracy and reliability of Earlysense fertility cycle monitoring performance vs.
- Trial name
- NCT02634359
- Testing
- EarlySense home device, Vaginal ultrasound, Blood Test
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- EarlySense Ltd.
Infertility Indicated for ICSI
Role of Aromatase Inhibitor to Enhance Ovulation in Poor Responder During Induction With Short Antagonist Protocol in Cases of ICSI
study the effect of aromataze inhibitor induction together with short stimulation protocol by gonadotrphin releasing hormon antagonist in cases that expected to be poor responder before ICSI
- Trial name
- AIPRICSI (NCT02741154)
- Testing
- induction with aromataze inhibitor, HMG, GnRh a
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Minia University
Polycystic Ovarian Syndrome
Comparison of Clomid and Lezra With Lezra for Ovulation Induction in Clomid Resistant PCOS Case
Clomiphene citrate resistant i.e failure to ovulate after 6 cycles of ovulation induction effects 15-40% of patients with PCOS.Two treatment groups will be formed one recieving letrozole alone and another recieving CC and…
- Trial name
- NCT06813118
- Testing
- Clomiphene Citrate and letrozole
- Where
- Pakistan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- HITEC-Institute of Medical Sciences
Ovulation, Female Fertility
FemiClock: Non-invasive Tools Development (Salivary and Hair Progesterone) for Ovulation Detection in Heathy Women With Regular Menstrual Cycles Without Contraception.
Currently, the gold standard to confirm ovulation is measuring LH and/or progesterone in blood. However, because confirmation requires a blood sample, this approach is not suitable for epidemiological studies evaluating the…
- Conditions
- Ovulation, Female Fertility, Menstrual Cycle
- Trial name
- FemiClock (NCT07687823)
- Testing
- Diagnostic Test: Non-invasive ovulation biomarker assessment - Smartwatch, Diagnostic Test: Non-invasive ovulation biomarker assessment - Questionnaires, Hormonal blood assessment
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Pregnancy, Fertility
Creighton Model Effectiveness, Intentions and Behaviors Assessment (CEIBA)
The Creighton Model (CrM) FertilityCare System is a natural family planning method that teaches couples to recognize and chart the signs of fertility and infertility in the woman's cycle and to use that knowledge to either…
- Trial name
- CEIBA (NCT01012596)
- Testing
- Creighton Model System of Natural Family Planning
- Where
- 18 sites in United States, Canada
- Volunteers
- 624 people, healthy volunteers welcome
- Sponsor
- University of Utah
Polycystic Ovary Syndrome, Anovulation
The Effect of Metformin Added to Clomiphene Citrate on Pregnancy Rates in Hyperandrogenic, Chronic Oligoovulatory or Anovulatory Women
The purpose of our study was to conduct a placebo controlled, double-blind randomized trial in chronic oligoovulatory or anovulatory , hyperandrogenic, infertility patients comparing the effects of adjuvant metformin plus…
- Conditions
- Polycystic Ovary Syndrome, Anovulation, Oligoovulation, Infertility
- Trial name
- NCT00413179
- Testing
- Metformin, Clomiphene citrate
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Fertilization, Fertilization in Vitro
BEst Size for Ovulation Triggering in Poseidon 4 Patients (BEST 4 Study)
This observational clinical study aims to determine the optimal timing of ovulation triggering in women aged 35 and above with poor ovarian reserve.
- Trial name
- BEST (NCT06433518)
- Testing
- Ovulation Trigger Timing Based on Leading Follicle Size in POSEIDON Group 4 IVF Patients
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Centrum Clinic IVF Center
Infertility
Luteal Support and Intrauterine Insemination (IUI) With Clomiphene Citrate
The purpose of this study is to assess the effect of luteal phase supplement (LPS) on pregnancy rate in IUI cycles stimulated with clomiphene citrate.
- Trial name
- NCT01046708
- Testing
- micronized progesterone
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Observational Study, Dydrogesterone
Observational Study of Dydrogesterone in Cycle Regularization
Dydrogesterone has been widely used worldwide for various gynecological and obstetric indications: Dydrogesterone is effective in cycle regulation treatment.
- Conditions
- Observational Study, Dydrogesterone, Irregular Menstrual Cycle, Abnormal Uterine Bleeding
- Trial name
- NCT02029144
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Fudan University
in Vitro Fertilization, Ovulation Induction
Trial Comparing Start Stimulation of Recombinant Follicle Stimulating Hormone (rFSH) on Cycle Day 2 Versus Cycle Day 5 in In Vitro Fertilization (IVF)
Background of the study: Milder stimulation protocols have the advantage of being less expensive and more patient-friendly. Moreover, recent evidence suggests that mild stimulation protocols lead to lower embryo aneuploidy rates…
- Trial name
- LITE (NCT00823472)
- Testing
- Mild stimulation
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Infertility
Letrozole vs. Clomiphene Citrate in Patients With Anovulatory Infertility
OBJECTIVE: To compare the effectiveness of letrozole and clomiphene citrate (CC) in patients with anovulatory infertility. DESIGN: Open, prospective, randomized, parallel group, multicentric, comparative trial.
- Trial name
- NCT00610077
- Testing
- Letrozole, Clomiphene citrate
- Where
- India
- Volunteers
- 55 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Polycystic Ovary Syndrome
Letrozole or Laparoscopic Ovarian Diathermy for Women With CC Resistant Polycystic Ovary Syndrome.
The purpose of this study is to compare and determine the efficacy of letrozole administration to that of laparoscopic ovarian diathermy (LOD) in infertile women with Polycystic ovary syndrome(PCOS)not responding to treatment…
- Trial name
- NCT00956267
- Testing
- Letrozole, Laparoscopic ovarian diathermy (LOD)
- Where
- Egypt
- Volunteers
- 260 people
- Sponsor
- Mansoura University
Polycystic Ovary Syndrome, Infertility
Clomiphene Citrate in Infertile PCOS Patients
Anovulatory infertility is a common feature of the polycystic ovary syndrome (PCOS). Clomiphene citrate (CC) represents the first therapeutic option for treating the anovulatory infertility in PCOS patients because it is…
- Trial name
- NCT00501839
- Testing
- clomiphene citrate
- Where
- Italy
- Sponsor
- University Magna Graecia
Low Ovarian Reserve, Poor Response to Ovulation Induction Poseidon Type IV
Follicular Flushing Using Double Lumen Needle Versus Direct Aspiration in Low Prognosis Patients According to the POSEIDON Criteria
This is a prospective, randomized, controlled clinical trial designed to evaluate whether follicular flushing increases the number of cumulus-oocyte complexes (COCs) retrieved compared to single aspiration in patients with poor…
- Conditions
- Low Ovarian Reserve, Poor Response to Ovulation Induction Poseidon Type IV, Poor Response to Ovulation Induction
- Trial name
- FLUSHING (NCT07270081)
- Testing
- follicular flushing, follicular aspiration
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Instituto Bernabeu
Embryonic Development, Pregnancy
Pregnancy Rates in IVF After Ovulation Triggering With Recombinant or Urinary Human Chorionic Gonadotrophin (HCG)
To access whether the ovulation triggering with rec-HCG instead urinary-HCG has any impact on the blastulation rate and pregnancy rate of patients undergoing IVF treatment
- Conditions
- Embryonic Development, Pregnancy, VEGF
- Trial name
- NCT00954265
- Testing
- 10000 IU urinary HCG, 250 mcg recombinant HCG
- Where
- Belgium
- Volunteers
- 130 people
- Sponsor
- Universitair Ziekenhuis Brussel