Clinical trials: Ovulation Induction
Letrozole, Clomiphene Citrate
LE + CC vs. LE for Ovulation Induction
This randomized controlled trial (RCT) aims to evaluate whether, in infertile women with WHO II/IV ovulatory disorders, a combination of letrozole (LE) and clomiphene citrate (CC) compared to LE alone, result in higher live birth…
- Conditions
- Letrozole, Clomiphene Citrate, Ovulation Disorder, Ovulation Induction
- Trial name
- COLA (NCT06934785)
- Testing
- IUI or intercourse
- Where
- Vietnam
- Volunteers
- 600 people
- Sponsor
- Mỹ Đức Hospital
Induction of Ovulation, PCO - Polycystic Ovaries
Sodium-Glucose Co-Transporter-2 Inhibitors as Adjuvant Therapy With Letrozole in Induction of Ovulation in Women With Polycystic Ovarian Syndrome
The aim of the study is to assess the efficacy of adjuvant therapy dapagliflozin, metformin as monotherapy and combination of both in comparison to control group in induction of ovulation with letrozole in women PCOS, focusing…
- Trial name
- SGLT-2/PCOS (NCT07589075)
- Testing
- Metformin 1000 mg Oral Tablet, Dapagliflozin 10 MG Oral Tablet [Farxiga], Combined Dapagliflozin-Metformin 5/1000mg
- Where
- Egypt
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Infertility, Female, Ovulation Induction
Oral GnRH Antagonist (Linzagolix) Versus Injectable GnRH Antagonist in Controlled Ovarian Stimulation for In Vitro Fertilization: A Randomized Controlled Non-Inferiority Trial With a Concurrent Comparator Cohort Undergoing Progestin-Primed Ovarian Stimulation (PPOS)
Women undergoing IVF/ICSI who are candidates for a GnRH-antagonist protocol are randomly assigned 1:1 to oral linzagolix or the standard injectable GnRH antagonist (ganirelix or cetrorelix).
- Trial name
- NCT07732348
- Testing
- Ganirelix ; Cetrorelix, Medroxyprogesterone Acetate ; Micronized Progesterone, Linzagolix
- Volunteers
- 120 people
- Sponsor
- Centro A.M.B.R.A. (Associazione Medici e Biologi per la Riproduzione Assistita)
Infertility, Ovulation Induction
Follitropin Delta Versus Follitropin Alfa in Indonesian Women Undergoing IUI
The goal of this retrospective observational study is to compare two types of follicle-stimulating hormone, follitropin delta and follitropin alfa, used for ovarian stimulation in Indonesian women undergoing intrauterine…
- Conditions
- Infertility, Ovulation Induction, Insemination, Artificial
- Trial name
- NCT07801781
- Testing
- Follitropin Delta, Recombinant, Follitropin Alfa (GONAL-F)
- Where
- Indonesia
- Volunteers
- 228 people
- Sponsor
- Stella Maris Women and Children Hospital
Poor Response to Ovulation Induction, Infertility, Female
Autologous Platelet Rich Plasma Intraovarian Infusion for Poor Responders
Autologous platelet rich plasma (PRP) intraovarian infusion may improve ovarian response to controlled ovarian stimulation as well as the hormonal profile of poor ovarian response infertile women subjected to intracytoplasmic…
- Conditions
- Poor Response to Ovulation Induction, Infertility, Female, Ovarian Insufficiency, Ovarian Failure
- Trial name
- PRPPOR (NCT05181748)
- Testing
- Autologous platelet rich plasma
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genesis Athens Clinic
Low Ovarian Reserve, Poor Response to Ovulation Induction Poseidon Type IV
Follicular Flushing Using Double Lumen Needle Versus Direct Aspiration in Low Prognosis Patients According to the POSEIDON Criteria
This is a prospective, randomized, controlled clinical trial designed to evaluate whether follicular flushing increases the number of cumulus-oocyte complexes (COCs) retrieved compared to single aspiration in patients with poor…
- Conditions
- Low Ovarian Reserve, Poor Response to Ovulation Induction Poseidon Type IV, Poor Response to Ovulation Induction
- Trial name
- FLUSHING (NCT07270081)
- Testing
- follicular flushing, follicular aspiration
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Instituto Bernabeu
Ovulation Induction, Polycystic Ovary Syndrome
Oxytocin Versus Human Chorionic Gonadotropin as Trigger in Ovulation Induction
The goal of this clinical trial is to learn if injection oxytocin can be used as trigger in ovulation induction cycles in infertile women with polycystic ovary syndrome.
- Trial name
- NCT06725004
- Testing
- Oxytocin, Human Chorionic Gonadotropin
- Where
- Bangladesh
- Volunteers
- 60 people
- Sponsor
- Shakeela Ishrat
Clinical Pregnancy Rate, Ovulation Induction
Follicular Long GnRH Agonist Versus Antagonist Protocol in PCOS Women Undergoing in Vitro Fertilization
Pituitary down regulation is widely used during in vitro fertilization (IVF) procedures. It can suppress the spontaneous luteinizing hormone (LH) surge, and can also make follicles growth evenly.
- Conditions
- Clinical Pregnancy Rate, Ovulation Induction, IVF
- Trial name
- NCT02496754
- Testing
- GnRH-a, GnRH-anta
- Where
- China
- Volunteers
- 1,266 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Ovulation Induction
A Phase 2 Trial to Evaluate if Corifollitropin Alfa (Org 36286), Followed by a Low Daily Dose of hCG or Recombinant FSH Can Induce Monofollicular Growth in Women With WHO Group II Anovulatory Infertility (P05693)
The primary objective of this trial is to evaluate whether a corifollitropin alfa (Org 36286) regimen applying a single or repeated dose of corifollitropin alfa followed by a low daily dose of Human Chorion Gonadotropin (hCG) or…
- Trial name
- NCT00697255
- Testing
- corifollitropin alfa, recombinant Follicle Stimulating Hormone (recFSH), human Chorion Gonadotropin (hCG)
- Volunteers
- 8 people
- Sponsor
- Organon and Co
Poor Response to Ovulation Induction
Effect of LH Supplementation on the Endometrial Gene Expression Profile in Poor Ovarian Responders
This is a prospective randomized open-label cross-over study. Poor responder patients will undergo two ovarian stimulation cycles.
- Trial name
- NCT05405686
- Testing
- Lutropin alfa, Follitropin alfa, Endometrial biopsy
- Sponsor
- CRG UZ Brussel
Poor Response to Ovulation Induction
A Prospective Observational Study of Biomarkers for a Personalised IVF Treatment
Study investigates the effect of four-dimensional patient data (medical, lifestyle, environmental, and genetic) on the outcomes of ovarian stimulation for IVF.
- Trial name
- NAITIVE (NCT05780632)
- Where
- Czechia
- Volunteers
- 500 people
- Sponsor
- Cognitive IVF a.s.
Poor Response to Ovulation Induction
Ovarian Response in Oocyte Donors Triggered With GnRH Agonists
The use of agonist of GnRH (aGnRH) trigger to avoid ovarian hyperstimulation syndrome is nowadays widely used. The action of the aGnRH in the hypophysis triggers an LH and FSH surge, which mimicks the natural surge that occurs in…
- Trial name
- NCT05109403
- Where
- Spain
- Volunteers
- 224 people
- Sponsor
- Clínica EUGIN
Ovulation Induction, Polycystic Ovary Syndrome
Myo-inositol Versus Clomiphene Citrate in PCOS
Specific aim: To compare inositol and the golden standard first line treatment of ovulation induction, namely clomiphene citrate.
- Conditions
- Ovulation Induction, Polycystic Ovary Syndrome, Clomiphene, Inositol
- Trial name
- NCT04306692
- Testing
- Myo-inositol, Clomiphene Citrate
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- University Hospital, Ghent
Poor Response to Ovulation Induction, PCOS
The Angiotensin-Melatonin Axis in Poor and Hyper Responders for IVF Treatment
According the World Health Organization (WHO), infertility is a disease of the male or female reproductive system defined by the failure to achieve a pregnancy after 12 months or more of regular unprotected sexual intercourse.
- Conditions
- Poor Response to Ovulation Induction, PCOS, Endometriosis, Infertility, Female
- Trial name
- NCT05298657
- Where
- United Arab Emirates
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fatima College of Health Sciences
Infertility, Female, Poor Response to Ovulation Induction
Does DHEA IVF Outcomes in Poor Responders?
This study is a RCT to examine whether DHEA is capable of improving results for poor responders to ovarian stimulation during IVF treatment
- Trial name
- DHEA (NCT04066478)
- Testing
- Dehydroepiandrosterone
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- Homerton University Hospital NHS Foundation Trust
PCO, Induction of Ovulation
Parameters Declaring PCO Infertile Patients Either Sensitive or Resistant to Different Doses of Clomiphene Citrate.
Polycystic ovary syndrome (PCOS) is a common endocrinological disorder seen in 6%-10% of women (Human Reproduction, 2004). It is characterized by polycystic ovaries, anovulatory cycles, and hyperandrogenism.
- Conditions
- PCO, Induction of Ovulation, Clomiphene Citrate
- Trial name
- NCT04887402
- Testing
- Clomiphene Citrate
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Poor Response to Ovulation Induction Poseidon Type IV
Growth Hormone Pretreatment in Poseidon Type IV Undergoing ICSI Using Minimal Induction Protocol: A Randomized Controlled Trial
This study is done aiming to Assess Efficiency of Growth hormone as an adjuvant in pretreatment of Poseidon type IV group " poor responders "undergoing ICSI using minimal induction protocol
- Trial name
- Growth hormone (NCT05089344)
- Testing
- Growth Hormone, Clomiphene citrate daily and recombinant FSH (Gonal-F®)
- Where
- Egypt
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Clomiphene Citrate Resistance, Ovulation Induction
Letrozole Versus Gonadotropins in Clomiphene Citrate Resistance
Clomiphene citrate resistance (CCR) occur in 15-40% in women with PCOS. Several studies have shown that letrozole is superior to CC regarding side effects, ovulation, and pregnancy rates.
- Conditions
- Clomiphene Citrate Resistance, Ovulation Induction, Letrozole, Gonadotropins
- Trial name
- NCT04834791
- Testing
- Letrozole 2.5mg, Gonadotropin
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Ovulation Induction, Polycystic Ovary Syndrome
Effect of Adding Isoflavonoids to Clomiphene Citrate for Ovulation Induction in Women With Polycystic Ovary Syndrome
This prospective, randomized clinical trial double blinded study, has been carried on 160 infertile patients seeking pregnancy in Gynecology and Obstetrics Department, Zagazig University Hospitals during the period from January…
- Trial name
- NCT04610957
- Testing
- Rosafem (FEMININE FORMULA)
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- FAlbasri
Poor Response to Ovulation Induction, Infertility, Female
Optimal Embryonic Stage for Transfer in Poor Responders
A Prospective cohort study including couples with poor responder females who undergoing ICSI
- Trial name
- NCT04485819
- Testing
- Cleavage stage transfer, Blast stage transfer
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Ganin Fertility Center