Clinical trials: Oxaliplatin Induced Peripheral Neuropathy in Cancer Patients
Colorectal Neoplasms
Role of Xaliproden on Recovery Rate From Severe Neuropathy in Patients Who Have Completed Adjuvant Chemotherapy With Oxaliplatin Based Regimens
Primary objective: To assess the effect of xaliproden hydrochloride (xaliproden) 1 mg per oral daily on the rate of complete resolution of peripheral sensory neuropathy (PSN) at 6 months, following randomization, after the…
- Trial name
- XENON (NCT00603577)
- Testing
- Xaliproden
- Where
- 8 sites in United States, Canada and 6 more
- Volunteers
- 102 people
- Sponsor
- Sanofi
Colorectal Cancer, Chemotherapy-induced Peripheral Neuropathy
Preventive Treatment of Oxaliplatin Induced Peripheral Neuropathy in Metastatic Colorectal Cancer (POLAR-M)
This study evaluates the investigational drug PledOx in the prevention of chronic chemotherapy induced peripheral neuropathy (CIPN) induced by the drug oxaliplatin.
- Trial name
- POLAR-M (NCT03654729)
- Testing
- Calmangafodipir (2 µmol/kg), Calmangafodipir (5 µmol/kg)
- Where
- 98 sites in United States, Belgium and 11 more
- Volunteers
- 291 people
- Sponsor
- Egetis Therapeutics AB (publ)
Cancer, Lung, Colon Neoplasm
Exploration of Circulating microRNAs as Biomarkers of Chemo-induced Peripheral Neuropathy: a Study in Cancer Patients
This study aims to find out whether certain molecules in the blood, called microRNAs, are linked to how often and how severely people develop nerve damage from chemotherapy.
- Conditions
- Cancer, Lung, Colon Neoplasm, Neuropathy;Peripheral
- Trial name
- miR-CIPN#1 (NCT07427537)
- Testing
- Assessment of blood concentrations of microRNAs, Chemotherapy-induced peripheral neuropathy (CIPN) - grade, Pain assessement
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Clermont-Ferrand
Colorectal Cancer
Protective Effect of N-acetylcysteine on Oxaliplatin-Induced Neuropathy in Colorectal Cancer
This study investigates the possible protective role of N-Acetylcysteine against oxaliplatin-induced peripheral neuropathy in patients with colorectal cancer.
- Trial name
- NCT07391163
- Testing
- N-Acetyl Cysteine, Modified FOLFOX-6 regimen
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Tanta University
Peripheral Neuropathy, Cancer
L-carnosine Prophylactic Effect on Oxaliplatin Induced Peripheral Neuropathy in GIT Cancer Patients
This study evaluates the prophylactic effect of exogenous L-CARNOSINE in Oxaliplatin induced peripheral neuropathy, Thus half of the patients will receive L-CARNOSINE with Oxaliplatin and the other half will not receive…
- Trial name
- NCT02808624
- Testing
- L-CARNOSINE
- Where
- Egypt
- Volunteers
- 65 people
- Sponsor
- Cairo University
Colorectal Cancer, Peripheral Neuropathy
Rood's Approach and Oxaliplatin-induced Peripheral Neuropathy in Colorectal Cancer Patients
Oxaliplatin-induced chronic peripheral neuropathy is of major concern to oncologists and patients as it has been shown to affect patients' health-related quality of life.
- Trial name
- NCT05882396
- Testing
- Rood's approach, Traditional physical therapy program
- Volunteers
- 60 people
- Sponsor
- Cairo University
Oxaliplatin Induced Peripheral Neuropathy in Cancer Patients, Metastatic Colorectal Cancer (CRC)
Neuroprotective Potential of Cannabidiol (CBD) in Preventing Oxaliplatin (Ox)-Induced Neuropathy
This is a pilot, prospective, randomized study evaluating the feasibility and acceptability of incorporating hemp-derived cannabidiol (CBD) supplementation to prevent oxaliplatin-induced peripheral neuropathy (OIPN) in patients…
- Conditions
- Oxaliplatin Induced Peripheral Neuropathy in Cancer Patients, Metastatic Colorectal Cancer (CRC), Peripheral Neuropathy Due to Chemotherapy
- Trial name
- NCT07167446
- Testing
- Cannabidiol (CBD), oxaliplatin-based chemotherapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Fox Chase Cancer Center
Colorectal Cancer, Liver Cancer
Acupuncture for Oxaliplatin-induced Peripheral Neuropathy in Gastro-intestinal Cancer Patients
ACUPOX is a multicenter, open label, 2-cohort based phase II clinical study evaluating the interest of a standardized protocol of verum acupuncture in treatment of Oxaliplatin-induced peripheral neuropathy in patients with…
- Conditions
- Colorectal Cancer, Liver Cancer, Gastric Cancer, Pancreas Cancer
- Trial name
- ACUPOX (NCT05850130)
- Testing
- Acupuncture intervention, No acupuncture
- Where
- 15 sites in France
- Volunteers
- 182 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Peripheral Neuropathy, Secondary to Drugs or Chemicals, Oxaliplatin Induced Peripheral Neuropathy in Cancer Patients
Effect of Exercise on Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and often persistent adverse effect of oxaliplatin- and paclitaxel-based chemotherapy.
- Conditions
- Peripheral Neuropathy, Secondary to Drugs or Chemicals, Oxaliplatin Induced Peripheral Neuropathy in Cancer Patients, Paclitaxel Induced Neuropathy
- Trial name
- EX-CIPN (NCT07399561)
- Testing
- Exercise Intervention, Usual Care
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- National Cancer Center, Korea
Neuropathy;Peripheral
The Possible Protective Role of Ketotifen Against Oxaliplatin Induced Peripheral Neuropathy
The aim of current study is to evaluate the possible protective role of Ketotifen against oxaliplatin-induced peripheral sensory neuropathy in patient with stage III colorectal cancer.
- Trial name
- NCT05624138
- Testing
- Ketotifen Oral Tablet
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Tanta University
Chemotherapy Induced Peripheral Neuropathy
The Possible Protective Role of Omeprazole Against Oxaliplatin Induced Neuropathy in Cancer Patients
Oxaliplatin(OXA) chemotherapy protocols are used in treatment of cancers like colorectal (CRC) and pancreatic cancer. OXA causes peripheral neuropathy which is considered treatment limiting factor.
- Trial name
- NCT05680870
- Testing
- Omeprazole
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Aya Mohamed Sadek Elsaid
Chemotherapy Induced Peripheral Neuropathy (CIPN)
Neoadjuvant FOLFOX Chemotherapy for Colon Cancer: Long-Term Chemotherapy-Induced Peripheral Neuropathy and Impact on Quality of Life
The goal of this observational study was to learn about the long-term effects of neoadjuvant (pre-surgery) chemotherapy on patients with locally advanced colon cancer.
- Trial name
- NEOCIPN-COLON (NCT06844409)
- Where
- Russia
- Volunteers
- 54 people
- Sponsor
- P. Herzen Moscow Oncology Research Institute
Peripheral Neuropathy
The Role of Glutamine for Preventing Oxaliplatin-Induced Peripheral Neuropathy
Oxaliplatin is a chemotherapeutic agent, which is generally used in treatment of colorectal cancer. The dose limiting side effect of oxaliplatin is neurotoxicity.
- Trial name
- GELUPO (NCT02024191)
- Testing
- Glutamine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara Education and Research Hospital
Chemotherapy-induced Peripheral Neuropathy
Assess Safety and Tolerability of ART-123 + FOLFOX + Bevacizumab in Metastatic Colorectal Cancer Patients
To evaluate the safety and tolerability of ART-123 in patients with metastatic colorectal cancer who receive oxaliplatin-containing chemotherapy and bevacizumab
- Trial name
- NCT05251727
- Testing
- thrombomodulin alfa
- Where
- 32 sites in United States, Japan
- Volunteers
- 77 people
- Sponsor
- Veloxis Pharmaceuticals
Stage II Colorectal Cancer AJCC v8, Stage III Colorectal Cancer AJCC v8
Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer
This phase II/III trial studies the best dose of duloxetine and how well it works in preventing pain, tingling, and numbness (peripheral neuropathy) caused by treatment with oxaliplatin in patients with stage II-III colorectal…
- Trial name
- NCT04137107
- Testing
- Oxaliplatin, Duloxetine Hydrochloride, Duloxetine
- Where
- 793 sites in United States, Guam
- Volunteers
- 220 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Neuropathy;Peripheral, Chemotherapy-induced Peripheral Neuropathy
BXQ-350 Pharmacokinetic/Pharmacodynamic Study in Cancer Patients
This study will assess pharmacokinetic (PK)/pharmacodynamic (PD) relationships and whether BXQ-350 may decrease the intensity and/or duration of chemotherapy induced peripheral neuropathy (CIPN) thereby improving quality of life…
- Trial name
- RETRO (NCT05291286)
- Testing
- BXQ-350
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Bexion Pharmaceuticals, Inc.
Peripheral Neuropathy Due to Chemotherapy, Oxaliplatin Induced Peripheral Neuropathy in Cancer Patients
Effects of Oxaliplatin-Induced Peripheral Neuropathy on Hand Function, Grip Strength and Quality of Life in Colorectal Cancer Patients
The aim of this study is to investigate the effects of oxaliplatin-induced peripheral neuropathy on hand function, grip strength, and quality of life in colorectal cancer patients.
- Conditions
- Peripheral Neuropathy Due to Chemotherapy, Oxaliplatin Induced Peripheral Neuropathy in Cancer Patients, Hand Strength
- Trial name
- NCT07203066
- Testing
- observational only
- Where
- Turkey (Türkiye)
- Volunteers
- 103 people
- Sponsor
- Fenerbahce University
Colorectal Cancer, Chemotherapy-induced Peripheral Neuropathy
Preventive Treatment of OxaLiplatin Induced peripherAl neuRopathy in Adjuvant Colorectal Cancer
This study is to evaluate PledOx for prevention of chronic chemotherapy induced peripheral neuropathy induced by oxaliplatin in patients with Stage III or high-risk Stage II colorectal cancer (CRC).
- Trial name
- POLAR-A (NCT04034355)
- Testing
- Calmangafodipir (5 µmol/kg)
- Where
- 65 sites in Belgium, Czechia and 8 more
- Volunteers
- 301 people
- Sponsor
- Egetis Therapeutics AB (publ)
Colorectal Cancer
The Role of Coenzyme Q10 in the Prophylaxis of Oxaliplatin Induced Peripheral Neuropathy in Patients With Colorectal Cancer
This study aims to evaluate the possible beneficial role of coenzyme Q10 against oxaliplatin-induced peripheral neuropathy in patients with colorectal cancer.
- Trial name
- NCT06856447
- Testing
- Coenzyme Q10, Oxaliplatin, 5-Fluorouracil (5-FU)
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- toqa saad mohammed mohammed
Peripheral Neuropathy Due to Chemotherapy
Medical Device for Oxaliplatin-Induced Neuropathy in Gastrointestinal Cancer Patients
This is an observational study related to a medical device designed for the prevention of oxaliplatin-induced peripheral neuropathy (OIPN) in patients with gastrointestinal cancer.
- Trial name
- NCT06873360
- Testing
- Clinical interviews with patients and Usability interviews and glove testing.
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Corporacion Parc Tauli