Clinical trials: Oxidative Injury
Arsenic Poisoning, Toxic Effect of Arsenic and Its Compounds
Effects of Folic Acid Supplementation on Arsenic Lowering
The purpose of this study is to determine whether folic acid supplementation are effective on arsenic lowering in a chronic, low-level arsenic exposed population.
- Trial name
- NCT02235948
- Testing
- folic acid supplementation
- Volunteers
- 450 people
- Sponsor
- Wenzhou Medical University
Cardiac Surgery
Risk of Oxygen During Cardiac Surgery Trial
The investigators will recruit and randomize 200 elective cardiac surgery patients to receive physiologic oxygenation (normoxia) or hyper-oxygenation (hyperoxia) during surgery to test the hypothesis that intraoperative…
- Trial name
- ROCS (NCT02361944)
- Testing
- Oxygen - normoxia, Oxygen - hyperoxia
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Vanderbilt University
Peripheral Arterial Disease
Mechanisms That Produce the Leg Dysfunction of Claudication & Treatment Strategies
Intermittent claudication afflicts 5% of the US population older than 55 years of age and develops along with hardening of the arteries of the legs.
- Trial name
- NCT01970332
- Testing
- Revascularization Surgery, Supervised exercise therapy
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- University of Nebraska
Diabetes, Obesity
Effects of Antioxidants and B Vitamins Supplements on Inflammation in Obese Diabetic Patients
Substantial evidence shows that diets incorporating antioxidants and B-group vitamins can offer significant protection against infections and cardiovascular disease (CVD) especially in diabetic patients.
- Trial name
- NCT01691365
- Testing
- vitamins
- Volunteers
- 100 people
- Sponsor
- United Arab Emirates University
Heart Arrest, Sport Injury
Tour de Borobudur Troponin Study on Predictors and Synergistic Role of MDA and Hs-CRP Levels
Prospective observational study to determine predictors that related to cardiac troponin I (cTnI) release, malondialdehyde (MDA) and high sensitivity C Reactive Protein (hs-CRP) after Tour de Borobudur (TdB) 2017
- Conditions
- Heart Arrest, Sport Injury, Inflammatory Response, Oxidative Stress
- Trial name
- TdBTS (NCT03310450)
- Testing
- 140kms cycling
- Where
- Indonesia
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Universitas Negeri Semarang
Vascular System Injuries
Natural Antioxidant Ice-cream, Oxidative Stress and Vascular Function
Formation of reactive oxygen species (ROS) contributes to pathogenesis and progression of several diseases. Polyphenols, have been shown to be beneficial against ROS.
- Trial name
- NCT02685163
- Testing
- Antioxidant ice-cream, Control Ice-cream
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Chronic Beryllium Disease
Targeting Oxidative Stress in Chronic Beryllium Disease
The purpose of this study is to understand if a drug called mesalamine helps to control inflammation associated with chronic beryllium disease (CBD).
- Trial name
- NCT01088243
- Testing
- Mesalamine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Jewish Health
Breast Neoplasms, Ischemia-Reperfusion Injury
DIEP Flap Breast Reconstruction: Perioperative Biomarkers and Outcomes
Brief Summary This observational study will follow patients who undergo DIEP flap breast reconstruction to better understand a common surgical challenge called ischemia-reperfusion (I/R) injury.
- Conditions
- Breast Neoplasms, Ischemia-Reperfusion Injury, Postoperative Complications, Wound Healing
- Trial name
- NCT07263347
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hubei Cancer Hospital
Fetal Growth Retardation
Melatonin to Prevent Brain Injury in Unborn Growth Restricted Babies
Intrauterine growth restriction is the term used to describe a condition where an unborn baby does not reach its optimum size. In the short and long term, intrauterine growth restricted babies have a higher risk of serious…
- Trial name
- NCT01695070
- Testing
- Melatonin
- Where
- Australia
- Volunteers
- 16 people
- Sponsor
- Monash University
Anesthesia; Adverse Effect, Spinal and Epidural, Anaesthetic Complication Neurological
Neurotoxicity of Spinal Anesthesia With Ropivacaine and Bupivacaine
Consenting patients, scheduled for orthopaedic surgery under spinal anesthesia will be randomly assigned (1:1) to receive ropivacaine or bupivacaine as a single shot before the start of surgery, followed by bolus doses of the…
- Trial name
- BuRoNe (NCT03293472)
- Testing
- Ropivacaine, Bupivacaine
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- University of Rzeszow
Parkinson Disease
Effects of High-dose Coenzyme Q10 on Biomarkers of Oxidative Damage and Clinical Outcome in Parkinson Disease
The investigators hypothesise that measuring biomarkers of oxidative damage could better inform investigators on the potential merits (and pitfalls) of CoQ10 supplementation in PD subjects.
- Trial name
- NCT01892176
- Testing
- coenzyme q10
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- National University Hospital, Singapore
Vitamin C Deficiency, Smoking
The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients
The goal of this study is to perform a randomized clinical trial to assess the effects of vitamin C versus placebo on wound healing in mandibular fracture patients.
- Conditions
- Vitamin C Deficiency, Smoking, Surgery, Surgery--Complications
- Trial name
- NCT03938584
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Hennepin Healthcare Research Institute
Muscular Injury
Turmeric and Exercise-Induced Muscle Damage and Oxinflammation
The purpose of this study is to measure the effect of using a turmeric-based supplement for 2-weeks on muscle damage and soreness that occur in the body after 90-minutes of exercise.
- Trial name
- NCT04765527
- Testing
- Turmeric Strength for Joint
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Systemic Inflammation, Cardiopulmonary-bypass
Preventing Systemic Inflammation After Cardiac Surgery With Alkaline Phosphatase
Study should demonstrate that alkaline phosphatase reduces the incidence and extent of acute kidney injury after cardiopulmonary bypass (CPB) as defined by the AKIN criteria.
- Trial name
- APPIRED-III (NCT03050476)
- Testing
- RESCAP®
- Where
- 21 sites in Australia, Austria and 9 more
- Volunteers
- 1,250 people
- Sponsor
- Alloksys Life Sciences B.V.
Acute Lung Injury
Limb RIPC in Patients Undergoing Lung Lobectomy. Study of Oxidative Lung Damage
Background: In patients undergoing lung lobectomy, lung collapse and re-expansion after resection is associated to severe oxidative lung injury.
- Trial name
- NCT02734654
- Testing
- remote ischemic preconditioning (RIPC)
- Volunteers
- 53 people
- Sponsor
- Instituto de Salud Carlos III
Renal Failure, Renal Insufficiency, Acute
The Effect of Vitamin E-coated Polysulfone Membrane on Oxidative Stress, Inflammation and Monocytes in Critically Ill Patients in CRRT
The study evaluate the effect of a membrane in polysulfone covered with vitamin E (ViE15-A, ASAHI Kasey, Tokyo, Japan) versus non-vitamin E polysulfone membrane (REXEED-15A, ASAHI Kasey, Tokyo, Japan) in critically ill patients…
- Trial name
- Vitabrane E (NCT03489759)
- Testing
- ViE15-A, REXEED-15A
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- St. Bortolo Hospital
Leptospirosis
N-Acetylcysteine in Patients With Leptospirosis
The goal of this clinical trial is to learn whether oral N-acetylcysteine (NAC) can reduce markers of kidney tubular injury, oxidative stress, and inflammation in adults with non-severe leptospirosis.
- Trial name
- NCT07821853
- Testing
- N-acetylcysteine
- Where
- Indonesia
- Volunteers
- 64 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Liver Transplantation, Ischemia/Reperfusion Injury
Effect of Nitric Oxide (NO) on Ischemic/Reperfusion Injury During Extended Donor Criteria (EDC) Liver Transplantation
In this study, the researchers propose to investigate the efficacy of inhaled nitric oxide to prevent ischemia-reperfusion (I/R) hepatocyte injury in patients who receive extended donor criteria(EDC)liver grafts based on changes…
- Conditions
- Liver Transplantation, Ischemia/Reperfusion Injury, Oxidative Injury
- Trial name
- NCT00948194
- Testing
- Nitric Oxide
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Colorado, Denver
Oxidative Stress
The Effect of Protandim Supplementation on Oxidative Damage and Athletic Performance
Nutrition supplementation with antioxidants have been discussed as a way to further enhance overall well-being of athletes, promote faster recovery, and improve overall performance.
- Trial name
- NCT02172625
- Testing
- Protandim Dietary Supplement
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Psychoses
Brain Cell Injury in Patients With A First Episode of Psychosis
Patients experiencing a first episode of psychosis may have brain cell damage due to a chemical process called oxidation. This study will compare patients with psychosis to healthy volunteers to determine if there are differences…
- Trial name
- NCT00070889
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)