Clinical trials: Oxidative Injury
Oxidative Stress
Impact of Mode of Anesthesia on Ischemia Modified Albumin in Patients With Traumatic Brain Injury
In the current study the investigators intend to evaluate the mode of anesthesia on ischemia modified albumin and outcome in patients with traumatic brain injury undergoing emergency craniotomy
- Trial name
- NCT04490122
- Volunteers
- 54 people
- Sponsor
- Abd-elrahman hassan abd -elaziz
Subarachnoid Hemorrhage, Aneurysmal
Cerebral Nitrosative/Oxidative Stress in Aneurysmal Subarachnoid Haemorrhage
Aneurysmal subarachnoid haemorrhage (SAH) carries a high morbidity and mortality, which is in part due to the development of secondary brain injury.
- Trial name
- NOX2 (NCT05686265)
- Testing
- Oxygen
- Where
- Denmark
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Reperfusion Injury
Myocardial and Renal Dysfunction by Oxidative Stress Caused by Cardiac Surgery
Assessment of the severity of oxidative stress caused by the on-pump and off-pump cardiac surgery using mtDNA, nDNA, carbonilated proteins, nitrotyrosine, oxy-LDL, S100b-protein.
- Trial name
- NCT02394405
- Where
- Russia
- Volunteers
- 21 people
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
Smoking, Cigarette Smoking
e-Cigarette - DNA Adducts
This study will examine the level of toxicity of e-cigarette use compared to smokers and nonsmokers including inflammation markers, toxicant and carcinogen exposure.
- Conditions
- Smoking, Cigarette Smoking, Electronic Cigarettes
- Trial name
- NCT03284632
- Where
- United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Anesthesia, Esophagus Cancer
Different Anesthetic Managements of Esophageal Resection and Reconstruction
Anesthetic management and fluid therapy is crucial in esophageal resection and reconstruction, which is associated with high incidence of postoperative morbidity and mortality.
- Conditions
- Anesthesia, Esophagus Cancer, Postoperative Complications
- Trial name
- NCT02961140
- Testing
- Cardiac Output Maximization, Cardiac Output Normalization
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Amyotrophic Lateral Sclerosis
A Pilot Study of Inosine in Amyotrophic Lateral Sclerosis (ALS)
This is a single center, open label, 12-week study of inosine treatment. Inosine treatment leads to an increase in the levels of urate (uric acid) in the blood.
- Trial name
- NCT02288091
- Testing
- Inosine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Massachusetts General Hospital
Hard-to-heal Wounds
Evaluation of the Efficacy of an Antioxidant Dressing in Chronic Wound Healing
The aim of this study is to compare the effect of antioxidant dressing (active product) on chronic wound healing with the use of non-active wound dressing for healing in a moist environment (standard clinical practice) in…
- Trial name
- REOX (NCT03934671)
- Testing
- Antioxidant dressing (active product), Usual care dressing that create a moist environment (standard clinical practice)
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- University of Jaén
Heart Valve Diseases
Anesthetic Management and Remote Reperfusion Injuries
Ischemia- reperfusion ( IR ) injuries were not only seen in the transplanted organs but also the remote organs such as lungs that brings major postoperative complications.
- Trial name
- NCT00745810
- Testing
- Cardiopulmonary bypass
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Prematurity, Oxidative Injury
Comparison of Different Oxygen Delivery Strategies During Resuscitation of Babies
Preterm infants are born with immature lungs and often require help with breathing shortly after birth. This currently involves administering 100% oxygen.
- Conditions
- Prematurity, Oxidative Injury, Respiratory Distress
- Trial name
- NCT00356902
- Testing
- titration of oxygen during resuscitation
- Where
- Canada
- Volunteers
- 215 people
- Sponsor
- University of Calgary
Cardiac Arrest
Reoxygenation After Cardiac Arrest II (REOX II Study)
The broad objective of this study is to test the association between hyperoxia exposure after resuscitation from cardiac arrest and outcome.
- Trial name
- REOX II (NCT02698826)
- Testing
- Protocol for rapid FiO2 optimization
- Where
- 5 sites in United States
- Volunteers
- 16 people
- Sponsor
- The Cooper Health System
Sickle Cell Disease
Low Dose Iron Chelation as TReatment of Oxidative Damage in Sickle Cell Disease
Objective: To study the safety and efficacy of deferasirox as treatment of oxidative stress in adult subjects with sickle cell disease.
- Trial name
- TROS (NCT05392101)
- Testing
- Deferasirox 360 MG
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Brain Injuries, Traumatic
Early Redox Biomarker Changes After Stellate Ganglion Block in Traumatic Brain Injury
Oxidative stress is a key mediator of secondary brain injury after traumatic brain injury (TBI). The stellate ganglion block (SGB) has been shown to modulate cerebral hemodynamics and neuroinflammation in brain-injured patients…
- Trial name
- NCT07844811
- Testing
- Ultrasound-guided stellate ganglion block (parent study)
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University Medical Centre Ljubljana
COVID-19, Kidney Injury
Morphofunctional, Gene, Inflammation Molecules and Oxidative Stress Analysis in Kidney Tissue of COVID-19 Patients
The involvement of the kidneys in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the outset of the pandemic was associated with high mortality rates worldwide.
- Conditions
- COVID-19, Kidney Injury, Gene Amplification, Oxidative Stress
- Trial name
- NCT06444893
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
Autosomal Dominant Polycystic Kidney Disease
NOX4 and Related Biomarkers in ADPKD
To determine the value of NOX4, markers of mitochondria injury and function, and oxidative stress as real-time biomarkers to assess disease severity in patients with early autosomal dominant polycystic kidney disease (ADPKD).
- Trial name
- NCT04630613
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
STEMI - ST Elevation Myocardial Infarction (MI), Primary PCI - STEMI
Early Intracoronary N-Acetylcysteine During Primary PCI in STEMI: A Pilot Randomized Trial of Reperfusion Injury Biomarkers and Functional Recovery
Myocardial ischemia-reperfusion injury still poses a major therapeutic challenge in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI).
- Trial name
- NCT06850831
- Testing
- Antipac
- Where
- Indonesia
- Volunteers
- 110 people
- Sponsor
- dr. Ahmad Yasa, Sp.JP, Subsp.K.I.(K), M.Kes, FIHA, FasCC, FA
Renal Failure, Nutrition Disorders
Etiology, Epidemiology and Prognostics of Acute Kidney Injury (AKI)
To investigate the etiology, epidemiology and prognostic factors of acute kidney injury. To find out risk factors that relate with the prognosis of acute kidney injury,focusing on inflammation, oxidative stress and nutritional…
- Trial name
- NCT00953992
- Where
- China
- Volunteers
- 651 people
- Sponsor
- Huashan Hospital
Bronchopulmonary Dysplasia, Prematurity
Gastrin-Releasing Peptide and Bronchopulmonary Dysplasia
The purpose of this study is to identify biological markers that might predict premature infants who are at a higher risk for developing BPD, and to correlate the presence of these markers with infant symptoms and lung function…
- Trial name
- GRP (NCT01748565)
- Where
- 2 sites in United States
- Volunteers
- 260 people
- Sponsor
- Duke University
Cold Exposure
The Influence of Race and MitoQ Supplementation on Skin Blood Flow in the Cold
Individuals who operate in cold weather are at risk of developing cold injuries, for example, frostbite. They also often experience a loss of hand function and joint mobility due to a decrease in skin temperature and blood flow.
- Trial name
- NCT06784531
- Testing
- Mitoquinone mesylate (MitoQ), Cold Water Hand Immersion, Cold Air Exposure
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Birth Asphyxia, Premature Birth
Oxygen Toxicity in the Resuscitation in Extremely Premature Infants
The investigators hypothesize that using low oxygen concentrations during resuscitation of extremely premature infants will avoid oxidative stress derived damage and improve outcome.
- Trial name
- OXTOX (NCT00494702)
- Testing
- Resuscitation
- Where
- Spain
- Volunteers
- 88 people
- Sponsor
- Fundacion Para La Investigacion Hospital La Fe
Nephrotoxicity, Acute Kidney Injuries
Rutin and Ascorbic Acid for Prevention of Vancomycin-Induced Nephrotoxicity in Adult Patients" - a Clinical Trial Protocol Evaluating Whether Combined Rutin/Vitamin C Supplementation Reduces Kidney Toxicity From Vancomycin, Compared to Vitamin C Alone and Control.
Background: Vancomycin, a key antibiotic for MRSA infections, frequently causes nephrotoxicity (kidney damage) via oxidative stress, especially at the higher doses and longer durations now recommended.
- Trial name
- NCT07873372
- Testing
- Rutin + Ascorbic Acid (RUTA C60®), Ascorbic Acid (C-Retard®)
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams University