Clinical trials: Oxycontin
Chronic Pain
Efficacy and Safety of Fentanyl Buccal Tablets Compared With Oxycodone for the Management of Break Through Pain
Evaluate the efficacy of treatment with Fentanyl Buccal Tablets (FBT) compared with immediate release oxycodone in alleviating breakthrough pain in opioid tolerant patients with chronic pain.
- Trial name
- NCT00463047
- Testing
- Fentanyl Buccal Tablets Compared With Immediate-Release Oxycodone
- Where
- 45 sites in United States
- Volunteers
- 323 people
- Sponsor
- Cephalon
Trauma, Opioid Use
Relieving Acute Pain (RAP) Study: A Pilot Study
The United States (US) faces a crisis of pain management. According to the 2012 National Health Interview Survey, almost 50 million adults in the US reported having significant chronic or severe pain (Nahin 2015).
- Conditions
- Trauma, Opioid Use, Spine Fusion
- Trial name
- NCT03426137
- Testing
- Oxycodone, Ketorolac
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Maryland, Baltimore
Pain
Long-term Safety of PF-00345439 (Oxycodone)
Long-Term Safety Of PF-00345439 (Oxycodone) In Patients With Moderate To Severe Chronic Low Back Pain Or Osteoarthritis
- Trial name
- NCT01559701
- Testing
- PF-00345439
- Volunteers
- 823 people
- Sponsor
- Pain Therapeutics
Cancer
Immediate-Release Oxycodone Capsules Study in Cancer Pain
The efficacy of dose titration of OxyNorm™(Oxycodone) immediate-release capsules versus morphine immediate-release tablets in the treatment of cancer pain.
- Trial name
- NCT01675622
- Testing
- Oxycodone, Morphine
- Volunteers
- 242 people
- Sponsor
- Mundipharma (China) Pharmaceutical Co. Ltd
Opioid Use Disorder
Examining Analgesic Synergy and Efficacy in Trauma Care
Traumatic injury is responsible for over 25 million (16%) Emergency Department visits and over 225,000 deaths each year per 2021 Center for Disease Control data. This is the 3rd leading cause of death in the US.
- Trial name
- EASE (NCT07435077)
- Testing
- Buprenorphine, Oxycodone
- Where
- United States
- Volunteers
- 282 people
- Sponsor
- Wake Forest University Health Sciences
Cancer, Pain
Oxycodone and Pregabalin for the Treatment of Oncological Neuropathic Pain
The aim of the study is to assess tolerability and activity of oxycodone and pregabalin in combination for the treatment of oncological neuropathic pain with two different strategies.
- Trial name
- NCT00637975
- Testing
- oxycodone, pregabalin
- Where
- 8 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Associazione Progetto Oncologia UMAN.A
Coughing Responses at Tracheal Extubation
Comparison of the Effects of Oxycodone Versus Fentanyl on Airway Reflex to Tracheal Extubation and Postoperative Pain
This study was performed to compare the effects of oxycodone and fentanyl on airway and hemodynamic responses and postoperative pain during recovery period in patients undergoing laparoscopic cholecystectomy.
- Trial name
- NCT03204045
- Testing
- fentanyl, Oxycodone, control
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Yeungnam University College of Medicine
Recreational Drug Use
A Study to Evaluate the Oral Abuse Potential of PF614 in Non-Dependent Recreational Opioid Users (PF614-104)
This will be a randomized, double-blind, placebo- and active-controlled, 5-way crossover study to evaluate the abuse potential, safety and pharmacokinetics of orally administered PF614 relative to oxycodone IR (immediate-release)…
- Trial name
- NCT05571345
- Testing
- PF614, Oxycodone Hydrochloride 40 mg
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Ensysce Biosciences
Postoperative Pain After Ambulatory Surgery
Controlled-Release Oxycodone Versus Naproxen at Home After Ambulatory Surgery: A Randomized Controlled Trial
the primary objective of this study is to assess and compare the efficacy, safety and benefits of Controlled Release (CR) oxycodone/paracetamol with our current pain protocol (paracetamol/naproxen) in the treatment of acute…
- Trial name
- NCT02152592
- Testing
- PCM/Oxy1, PCM/Oxy2
- Where
- Netherlands
- Volunteers
- 105 people
- Sponsor
- Maastricht University Medical Center
Moderate-to-severe Chronic Low Back Pain
Efficacy and Safety of Egalet-002 in Patients With Moderate-to-Severe Chronic Low Back Pain
The purpose of this study is to determine the analgesic efficacy of Egalet-002 twice daily (BID) in patients with moderate-to-severe chronic low back pain
- Trial name
- NCT02716857
- Testing
- Oxycodone extended-release
- Where
- 74 sites in United States
- Volunteers
- 549 people
- Sponsor
- Egalet Ltd
Liver Cancer, Radiofrequency Ablation
Dexmedetomidine-esketamine for Percutaneous Radiofrequency Liver Ablation
Percutaneous radiofrequency ablation is a commonly treatment for patients with liver cancer that cannot be surgically resected. During the procedure, patients need to keep awake and cooperate with the procedure, including deep…
- Conditions
- Liver Cancer, Radiofrequency Ablation, Esketamine, Dexmedetomidine
- Trial name
- NCT06003218
- Testing
- Dexmedetomidine-esketamine combination, Remifentanil, Oxycodone
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Peking University First Hospital
Oxycodone, Chronic Pain, Postoperative
Effect of Preventive Analgesia with Oxycodone and Parecoxib Sodium on the Chronification of Acute Post-operative Pain
The goal of this clinical trial is to learn if the administration of oxycodone for preventive analgesia works to reduce the chronification of acute postoperative pain in adult participants undergoing major abdominal surgery.
- Trial name
- AOPC (NCT06721988)
- Testing
- oxycodone and parecoxib sodium combinations
- Volunteers
- 1,316 people
- Sponsor
- Ailin Luo
Healthy Volunteers
Evaluation of Oral PF614 Relative to OxyContin (PF614-102)
This is a single-center study incorporating 2 parts: A Multiple Ascending Dose Study (Part A) and a comparative Bioavailability/Bioequivalence and Food Effect study (Part B).
- Trial name
- NCT05043766
- Testing
- PF614, Naltrexone Hydrochloride, OxyContin
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ensysce Biosciences
Pain
Long-Term Safety of Twice Daily Oxycodone Hydrochloride Controlled-release Tablets in Children Who Completed OTR3001
The purpose of this study is to characterize the long-term safety of oxycodone hydrochloride (HCl) controlled-release (CR) tablets in opioid experienced pediatric patients aged 6 to 17 years, inclusive, with moderate to severe…
- Trial name
- NCT01369615
- Testing
- Oxycodone hydrochloride controlled-release tablets
- Where
- 14 sites in United States, Israel
- Volunteers
- 23 people
- Sponsor
- Purdue Pharma LP
Moderate to Severe Postoperative Pain
Comparison of the Efficacy and Safety of Q8003 Versus Its Individual Components in Bunionectomy Patients
This is a randomized, double-blind, multicenter, fixed dose factorial study of Q8003 12 mg/8 mg versus its individual morphine sulfate and oxycodone hydrochloride components for the management of acute moderate to severe…
- Trial name
- NCT01016808
- Testing
- Q8003, Morphine sulfate, Oxycodone HCl
- Where
- 5 sites in United States
- Volunteers
- 522 people
- Sponsor
- QRxPharma Inc.
Postoperative Pain
A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-182)
The purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of pain following dental surgery.
- Trial name
- NCT00092313
- Testing
- MK0966, rofecoxib, Comparator: oxycodone and acetaminophen
- Volunteers
- 271 people
- Sponsor
- Merck Sharp & Dohme LLC
Back Pain
The Safety and Efficacy of the Buprenorphine Transdermal Delivery System in Subjects With Chronic Low Back Pain.
The objective of this study is to demonstrate the effectiveness and tolerability of the buprenorphine transdermal system (5, 10, and 20 mg) in comparison to placebo transdermal system and immediate release oxycodone/acetaminophen…
- Trial name
- NCT00315874
- Testing
- Buprenorphine transdermal delivery system
- Where
- 12 sites in United States
- Volunteers
- 225 people
- Sponsor
- Purdue Pharma LP
Healthy
Single-Dose, Crossover Study To Compare Bioavailability Of Two Formulations Under Fed And Fasted Conditions
To Compare The Bioavailability Of 40 Mg Doses Of Pf-00345439 Modified Formulation K Vs. Original Formulation X Under Fed And Fasting Conditions In Healthy Volunteers
- Trial name
- NCT02059915
- Testing
- Oxycodone
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Pain Therapeutics
Narcotic Abuse
Aprepitant Effects on Oxycodone Response
Addressing the issue of opioid dependence and tolerance has public health implications for the treatment of opioid abuse (both heroin as well as pharmaceutical opioids) and for the treatment of pain.
- Trial name
- NCT00999544
- Testing
- Aprepitant 0mg, Aprepitant 40mg, Aprepitant 200mg
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Sharon Walsh
Healthy
Abuse Potential of Gabapentin Taken Orally Concomitantly With Oxycodone Hydrochloride in Healthy, Non-Drug-Dependent, Recreational Opioid Users
The purpose of the present study is to assess prospectively the abuse potential of gabapentin when taken with and without oxycodone compared to placebo in healthy non-drug-dependent recreational opioid drug users under fasted…
- Trial name
- NCT07813026
- Testing
- Oxycodone 20mg, gabapentin 600 mg, Gabapentin 1200mg
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Viatris Inc.