Clinical trials: Oxygen Consumption
Long COVID, Post-COVID-19 Condition
Mitochondrial Function in Peripheral Blood Mononuclear Cells, Muscle, and Skin of Long COVID Patients
Mitochondria are structures inside cells that are responsible for producing energy from nutrients through a series of steps, using oxygen.
- Trial name
- MitoLoCo (NCT07134673)
- Where
- Belgium
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Spinal Cord Injuries
VO2peak and Exercise Efficiency in Upper-body Poling
This study compares peak oxygen uptake (VO2peak) and exercise efficiency in upper-body poling versus arm crank ergometry in trained able-bodied and paraplegic participants.
- Trial name
- NCT03284086
- Testing
- upper-body double-poling, arm crank ergometry
- Where
- Norway
- Volunteers
- 18 people
- Sponsor
- Norwegian University of Science and Technology
Atrial Fibrillation, Diastolic Dysfunction
Atrial Fibrillation: Chronic Beta-blocker Use Versus As-needed Rate Control Guided by Implantable Cardiac Monitor
The goal of this study is to test the feasibility of guiding as-needed pharmacological rate control of atrial fibrillation (AF) by implantable cardiac monitors and to assess the impact of continuous beta-blocker therapy versus…
- Conditions
- Atrial Fibrillation, Diastolic Dysfunction, HFpEF - Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT05745337
- Testing
- As needed pharmacological rate control with beta-blocker (metoprolol tartrate, metoprolol succinate) or calcium channel blocker (diltiazem, verapamil)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Vermont
Lung Cancer
Investigation of the Effects of Functional Inspiratory Muscle Training in Patients With Lung Cancer
Patients' pulmonary functions and diffusion capacity worsen following lung cancer surgery. Diaphragmatic activity and lung compliance decrease due to surgery.
- Trial name
- NCT06245343
- Testing
- Functional inspiratory muscle training group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gazi University
Stroke
High Intensity Interval Training in Chronic Stroke Patients
Stroke is a global health-care problem that is common, serious and disabling. In most countries, stroke is second or third most common cause of death and one of the main causes of acquired adult disability.
- Trial name
- NCT01777113
- Testing
- High intensity aerobic training, High Intensity Strength Training, Mixed Training
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Universita di Verona
Effect of Different Types of Aerobic Training on Diastolic Heart Failure Patients
Effect of Different Types of Aerobic Training on Peak VO2 and Ejection Fraction for Diastolic Heart Failure Patients; a Comparative Randomized Control Trial
Background: Heart failure is described by a lack of confirmed efficient therapies and exercise intolerance. Physical activity is related to a lower risk of adverse cardiovascular consequences, involving heart failure.
- Trial name
- NCT05637125
- Testing
- aerobic exercise for upper limb, aerobic exercise for lower limb
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Beni-Suef University
Eccentric Exercise, Isokinetic Test
Metabolic, Respiratory, and Muscle Oxygenation Responses to Sub-maximal Eccentric and Concentric Isokinetic Exercise to Exhaustion
This study aims to measure and compare the metabolic response during sub maximal eccentric and concentric isokinetic exercise performed to exhaustion.
- Trial name
- MUSOX-EX (NCT07548333)
- Testing
- Sub maximal concentric exercise, Sub maximal eccentric exercise
- Where
- Greece
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Cystic Fibrosis in Children
Cardiopulmonary Fitness in Children With Cystic Fibrosis Compared to Healthy Children
Cystic fibrosis is the most common severe genetic disease with autosomal recessive transmission in the Caucasian population. Its prognosis has improved considerably since the creation of Cystic Fibrosis centers (CF centers) and…
- Trial name
- VOmuco (NCT06242951)
- Testing
- VO2 max assessment
- Where
- France
- Volunteers
- 345 people
- Sponsor
- University Hospital, Montpellier
Cancer, Surgery
The ICALIC 2 International Multicentric Study
Clinicians need to measure energy expenditure (EE) by indirect calorimetry (IC) to optimize nutritional support for a better clinical outcome, especially in patients with chronic conditions or with high risk of under- and over…
- Conditions
- Cancer, Surgery, Hemodialysis
- Trial name
- ICALIC2 (NCT03947294)
- Testing
- Q-NRG®
- Where
- Switzerland
- Volunteers
- 137 people
- Sponsor
- Prof. Claude Pichard
Cardio-Respiratory Failure
Evaluation of Modification in VO2 Max After Performing the "Physical Activity and Health Course (PAPS) 53" Program
Physical inactivity is the leading cause of preventable death in developed countries, ahead of smoking. It is responsible for 5.3 million (9%) of the 57 million deaths worldwide in 2008 and 10% of deaths in Europe.
- Trial name
- EVOP-53 (NCT05082324)
- Testing
- Adapted physical activity
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Angers
Rhabdomyolysis Linked to a Hereditary Disease of Metabolism
Evaluate the Effort Test as a Therapeutic Monitoring Tool in Acute Rhabdomyolyses
The prognosis of rhabdomyolyses related to hereditary diseases of metabolism is poor and treatments are only symptomatic. Rhabdomyolysis outbreaks are frequently precipitated by fever and fasting. They are unpredictable.
- Trial name
- EFFORHAB (NCT03802279)
- Testing
- Effort test, Functional tests on fibroblasts
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 1 Diabetes
Impact of Eccentric Training in Hypoxia With Creatine on Metabolic Control and VO2max in Patients With Type 1 Diabetes
Exercise plays an important role in treatment of diabetes. In recent years exercise training in normobaric hypoxia is used in training programs for athletes and in rehabilitation and also commercially.
- Trial name
- NCT06345612
- Testing
- hypoxia, normoxia, creatine supplementation
- Where
- Poland
- Volunteers
- 28 people
- Sponsor
- Silesian Centre for Heart Diseases
Aged, Oxygen Consumption
Oxygen Consumption After Acute Whole Body Vibration Session
Noninvasive assessment of VO2 during a single session of whole body vibration and changes in blood flow caused by the acute activity.
- Trial name
- NCT02774577
- Testing
- whole body vibration training in vibrating platform in young, whole body vibration training in vibrating platform in elderly
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maíra F Pessoa
Polycystic Kidney Disease, Adult, Polycystic Kidney, Autosomal Dominant
PErfusioN, OxyGen ConsUmptIon and ENergetics in ADPKD (PENGUIN)
Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of end-stage kidney disease (ESKD). The disorder is characterized by development and continued growth of multiple cysts requiring renal…
- Trial name
- PENGUIN (NCT04407481)
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 milligrams per milliliter (MG/ML), PET/CT Scan
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Colorado, Denver
Heart Failure.
The Increase Study. Effect of Incremental Versus Fixed Pump on Peak Oxygen Consumption in Heart Failure Patients Supported With a Continuous Flow Left Venticular Assist Device
The purpose of the study is to examine the relationship between working capacity (peak oxygen consumption) and pump speed of continuous flow left ventricular assist devices (CF-LVADs)in heart failure patients.
- Trial name
- NCT01698398
- Testing
- Incremental pump speed of CF-LVAD.
- Where
- Denmark
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Red Blood Cell Transfusion, Oxygen Consumption
Assessment of Oxygen Extraction Rate Changes Following Red Blood Cell Transfusion in the Intensive Care Unit
Restrictive and liberal approaches to hemoglobin targets are used when deciding on red blood cell transfusions in patients who do not have acute bleeding and have a hemodynamically stable course in the intensive care unit.
- Trial name
- NCT05798130
- Testing
- No intervention group.
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Izmir Katip Celebi University
Body Composition, Physical Fitness
Metabolic Cost of Bodyweight Training
In this study, the investigators will be able to estimate the metabolic cost of several foundational bodyweight training exercises.
- Conditions
- Body Composition, Physical Fitness, Energy Expenditure, Resting Metabolic Rate
- Trial name
- BWT-UTH (NCT05221203)
- Testing
- TR-30, TR-45
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Single Ventricle Heart Disease
Fontan Udenafil Exercise Longitudinal Assessment Trial - 2
This study will evaluate the clinical efficacy and safety of udenafil, an orally administered, potent and selective inhibitor of PDE5, versus placebo for the treatment of adolescent who have had the Fontan procedure.
- Trial name
- FUEL-2 (NCT05918211)
- Testing
- Udenafil
- Where
- 40 sites in United States, South Korea
- Volunteers
- 436 people
- Sponsor
- Mezzion Pharma Co. Ltd
Lymphoblastic Leukemia, Cancer Survivors
Exercise Training and NR Supplementation Trial to Improve Fitness in AYA HCT Survivors
This will be a randomized, placebo-controlled trial with a 2x2 factorial design testing the effects of an NAD+ precursor (NR) and exercise on skeletal muscle quality and VO2max in AYA HCT survivors.
- Conditions
- Lymphoblastic Leukemia, Cancer Survivors, Aplastic Anemia, Myelodysplastic Syndromes
- Trial name
- IAMFIT (NCT05194397)
- Testing
- Nicotinamide Riboside, Exercise Intervention
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Children's Hospital of Philadelphia
Amputation of Lower Extremity, All Causes
Gait and Energy Expenditure in Children With Lower Limb Amputation (MAPEDE)
In lower limb amputation, prosthetic gait has been shown to be particularly energy-intensive. While energy expenditure has been the focus of many studies in adult amputees, this area of research is less developed for paediatric…
- Trial name
- MAPEDE (NCT07076602)
- Testing
- Gait and energy expenditure
- Where
- 8 sites in France
- Volunteers
- 48 people
- Sponsor
- Rennes University Hospital