Clinical trials: Oxygen Disorders
Covid19
Hyperbaric Oxygen for COVID-19 Patients With Moderate to Severe Hypoxemia
Of the many treatments proposed for COVID-19, few directly address the severe hypoxia among COVID-19 patients. Interim results from our single-center, non-randomized clinical trial (NCT04332081) suggest that hyperbaric oxygen…
- Trial name
- NCT04619719
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Legacy Health System
Respiratory Insufficiency, Lung Cancer
High-flow Nasal Cannula Oxygen Versus Conventional Oxygen Therapy After Pulmonary Lobectomy
The primary objective of this study is to evaluate the effect of early application of nasal high flow oxygen therapy after pulmonary lobectomy on the incidence of postoperative hypoxemia
- Trial name
- NCT02544477
- Testing
- High-flow Nasal Cannula Oxygen (HFNCO), Conventional oxygen treatment
- Where
- Italy
- Volunteers
- 94 people
- Sponsor
- Catholic University of the Sacred Heart
Diabetic Foot Infection, Osteomyelitis
A Clinical Trial Testing the Efficacy of PDT in Preventing Amputation in Diabetic Patients
The feet of diabetic patients continue to be an important problem in medicine. In general, patients with diabetic foot have some sort of amputation, especially in underserved populations.
- Conditions
- Diabetic Foot Infection, Osteomyelitis, Photo Antimicrobial Chemotherapy
- Trial name
- NCT03380403
- Testing
- PDT, Ciprofloxacin
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Faculdade de Medicina do ABC
Overdose
Monitoring of Overdose Patients With and Without Supplemental Oxygen in the Emergency Department
This study will compare the data from pulse oximeters to capnographers as they are used to monitor patients who are being observed in the Emergency Department for a suspected overdose of alcohol or other drugs.
- Trial name
- NCT02101424
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Hennepin Healthcare Research Institute
Chronic Renal Failure
Hyperbaric Oxygen Therapy for Renal Regeneration in Diabetic Nephropathy
Diabetes kidney disease is a leading cause for end stage renal disease in the western world. To date no treatment that can reverse renal damage exists.
- Trial name
- NCT03376282
- Testing
- Hyperbaric Oxygen oxygen therapy (HBOT)
- Where
- Israel
- Volunteers
- 7 people
- Sponsor
- Assaf-Harofeh Medical Center
Bariatric Surgery Candidate, Atelectasis
Effect of High Versus Low Fraction of Inspired Oxygen During Alveolar Recruitment
Intraoperative absorption atelectasis is associated with decreased lung compliance, impaired oxygenation, increased pulmonary vascular resistance, and lung injury.
- Trial name
- NCT06494410
- Testing
- High versus Low Fraction of Inspired Oxygen
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Egymedicalpedia
Coronary Artery Disease
Oxygen-enhanced Magnetic Resonance Imaging (OE-MRI) of the Heart: A Feasibility Study
This exploratory pilot study aims to set up cardiac oxygen enhanced magnetic resonance imaging (OE-MRI). It will involve 10 healthy volunteers and 10 patients with known coronary artery disease (CAD) having a MRI scan.
- Trial name
- OE-MRI (NCT05163327)
- Testing
- Oxygen-enhanced Cardiac MRI
- Where
- United Kingdom
- Sponsor
- Manchester University NHS Foundation Trust
Hypoxia, Altitude
Assessment of Portable Oxygen Concentrators in Infants Undergoing Hypoxic Challenge Testing.
Hypoxic Challenge Testing (HCT) is the recommended method for inflight hypoxia risk assessment. Onboard oxygen administration remains controversial.
- Trial name
- NCT03976986
- Testing
- continuous-flow portable oxygen concentrator (cPOC), pulsed-flow portable oxygen concentrator (pPOC)
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Hospital Son Espases
COVID, Pregnancy Complications, Infectious
International Lung UltraSound Analysis (ILUSA) Study
Currently there is a great need for an accurately and rapid assessment of patients suspected for Covid-19. Like CT, Lung Ultrasound (LUS) examination can potentially help with the initial triage of patients but also help track…
- Conditions
- COVID, Pregnancy Complications, Infectious, Pregnancy Related, Pregnancy, High Risk
- Trial name
- ILUSA (NCT04353141)
- Testing
- standardized Lung Ultrasound (LUS) examination
- Where
- 7 sites in Belgium, Italy and 1 more
- Volunteers
- 1,850 people
- Sponsor
- KU Leuven
Chronic Respiratory Failure, Cardiac Disease, Pulmonary Disease
Advanced Respiratory Monitoring and Oxygen Therapy in Chronically Ill Patients With Acute Respiratory Failure
This study is testing whether a new type of home oxygen therapy, called high-flow nasal cannula (HFNC), can improve breathing comfort and quality of life for people with long-term lung or heart conditions who need oxygen after…
- Conditions
- Chronic Respiratory Failure, Cardiac Disease, Pulmonary Disease, Acute Respiratory Failure (ARF)
- Trial name
- HOME- Oxygen (NCT07157696)
- Testing
- High-Flow Nasal Cannula (HFNC) Oxygen Therapy, Oxygen therapy
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Università degli Studi di Ferrara
Asthma, Helium
Use of Heliox Associated With PEEP in Patients With Asthma
In patients with obstructive lung disease like asthma aerosol therapy is the most used for drug administration. A order to make better use of aerosolized drugs in asthmatic patients, studies focus on ways to optimize this…
- Conditions
- Asthma, Helium, Oxygen, Positive End-Expiratory Pressure
- Trial name
- NCT01268462
- Testing
- Heliox+PEP, Oxygen+PEP, Heliox
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Universidade Federal de Pernambuco
Cerebral Hypoxia, Postoperative Cognitive Dysfunction
The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane
the purpose of this study is to investigate whether propofol and sevoflurane have difference effect on cerebral oxygenation .
- Trial name
- NCT01757561
- Testing
- propofol, sevoflurane
- Where
- China
- Volunteers
- 144 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
PTSD - Post Traumatic Stress Disorder
Hyperbaric Oxygen Therapy for Post Traumatic Stress Disorder - a Pragmatic, Double Blinded Randomized Trial
Post-traumatic stress disorder (PTSD), affecting approximately 6% of the general population and up to one-third of individuals exposed to combat zones and disasters, is a significant contributor to morbidity and mortality among…
- Trial name
- NCT07473362
- Testing
- Hyperbaric Oxygen Therapy
- Where
- Israel
- Volunteers
- 72 people
- Sponsor
- Medical Corps, Israel Defense Force
COPD Exacerbation, Chronic Obstructive Pulmonary Disease Exacerbation
Comparing Mortality for Low vs High Peripheral Oxygen Saturation in COPD-patients With Acute Exacerbation
Chronic obstructive pulmonary disease (COPD) is a common disorder that affects approximately 400,000 Danish citizens. About 3,000-3,500 Danes die yearly because of the disorder, and the costs associated with hospital admissions…
- Trial name
- O2flow-COPD (NCT04223050)
- Testing
- Oxygen gas
- Where
- 4 sites in Denmark
- Volunteers
- 23 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Respiratory Distress Syndrome
Effect of Postural Drainage With or Without Thoracic Squeezing on O2 and Respiratory Rate in Infant With RDS.
This study investigated whether adding thoracic squeezing to postural drainage improves immediate respiratory outcomes in preterm infants with Respiratory Distress Syndrome (RDS).
- Trial name
- NCT07579013
- Testing
- POSTURAL DRAINAGE TECHNIQUE
- Where
- Pakistan
- Volunteers
- 14 people
- Sponsor
- Riphah International University
Stroke
High Intensity Interval Training in Chronic Stroke Patients
Stroke is a global health-care problem that is common, serious and disabling. In most countries, stroke is second or third most common cause of death and one of the main causes of acquired adult disability.
- Trial name
- NCT01777113
- Testing
- High intensity aerobic training, High Intensity Strength Training, Mixed Training
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Universita di Verona
Sepsis, Bacteraemia
Optimising Diagnosis and Antibiotic Prescribing for Acutely Ill Children in Primary Care
Acute illness is the most common presentation of children attending ambulatory care settings. Serious infections (e.g. meningitis, sepsis, pyelonephritis, pneumonia) are rare, but their impact is quite large (increased morbidity…
- Conditions
- Sepsis, Bacteraemia, Meningitis, Abscess
- Trial name
- ERNIE2 (NCT02024282)
- Testing
- Use of C-reactive protein (CRP) point of care test, Brief intervention and parent leaflet, Finger Pulse Oximeter
- Where
- 2 sites in Belgium
- Volunteers
- 8,962 people
- Sponsor
- KU Leuven
Tissue Injury, Surgery
Is Regional Oxygen Saturation Effective in Predicting Perfusion Parameters and Patient Outcomes in Liver Resection
Sudden hypotension, which may develop during liver resection operations performed under general anesthesia, can affect the patient satisfaction at a high rate by causing complications during and after the operation as a result of…
- Conditions
- Tissue Injury, Surgery, Absorption; Disorder
- Trial name
- NCT05077397
- Testing
- StO2, O3
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Marmara University
Single Ventricle Heart Disease
Fontan Udenafil Exercise Longitudinal Assessment Trial - 2
This study will evaluate the clinical efficacy and safety of udenafil, an orally administered, potent and selective inhibitor of PDE5, versus placebo for the treatment of adolescent who have had the Fontan procedure.
- Trial name
- FUEL-2 (NCT05918211)
- Testing
- Udenafil
- Where
- 40 sites in United States, South Korea
- Volunteers
- 436 people
- Sponsor
- Mezzion Pharma Co. Ltd
Obstructive Sleep Apnea, Healthy Subjects
Study to Evaluate the Respiratory Safety of Lemborexant in Adult and Elderly Healthy Subjects and Adult and Elderly Subjects With Mild Obstructive Sleep Apnea
This study will be conducted to determine whether lemborexant as compared to placebo decreases the peripheral oxygen saturation during total sleep time in healthy adult and elderly participants after a single dose of treatment…
- Trial name
- NCT03471871
- Testing
- Lemborexant 10 mg, Lemborexant 25 mg
- Where
- 11 sites in United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.