Clinical trials: Oxygen Disorders
Chronic Obstructive Pulmonary Disease, Idiopathic Pulmonary Fibrosis
Auto-titrating Oxygen in Chronic Respiratory Failure
Long term oxygen therapy (LTOT) increases the life span of patients with chronic obstructive pulmonary disease who have low oxygen levels.
- Trial name
- ASI1 (NCT02248064)
- Testing
- Auto-titrating oxygen system
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Imperial College London
Healthy Volunteer
Calibration of a New Reflectance Oximeter.
This study is about the development of a new medical device for the monitoring of of sleep disordered breathing. This device is developed by the CEA-LETI-LE2S and will be composed of an oximeter, an actimeter in order to measure…
- Trial name
- PATCHSANTESpO2 (NCT02842255)
- Testing
- Calibrate the oximeter ALTITRAINER200®
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Interstitial Cystitis
Prospective Trial Comparing Response to Hyperbaric Oxygen Treatment in Patients With Interstitial Cystitis
To review the results of Hyperbaric Oxygen therapy (HBOT) on the symptoms of interstitial cystitis (IC). To determine if there is greater symptom improvement in the ulcerative vs the non-ulcerative patients with interstitial…
- Trial name
- NCT01479725
- Testing
- HBOT
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Kenneth Peters, MD
Neurocognitive Disorders
Cognitive Functions on Coronary Surgery
The aim of this study is to examine the effects of different but safe levels of arterial oxygen levels used in cardiac surgeries on cerebral oxygenation during the operation.
- Trial name
- NCT04725708
- Testing
- procedure: cerebral oxygenation intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
COPD
Effects of an Auto-Regulating Oxygen System Compared to Constant-Flow Oxygen During Walking in Hypoxemic COPD Patients
Oxygen therapy is a cornerstone in treating patients with severe chronic obstructive pulmonary disease. Usually, oxygen supplementation is delivered using constant-flow rates.
- Trial name
- NCT03803384
- Testing
- Oxygen therapy
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Comparison of Non-invasive Oxygenation Strategies in Patients Admitted for Covid-19 Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome (ARDS) is the main clinical presentation of SARS-CoV-2 (Covid-19) infected patients admitted in Intensive Care Unit (ICU).
- Trial name
- SONIC-19 (NCT04725084)
- Testing
- Use of High Flow Nasal Cannula alone, Use of Non-invasive Ventilation, Use of Continuous Positive Airway Pressure
- Where
- 4 sites in France
- Volunteers
- 355 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Etiology of Hyperlactathemia, Early Period After Cardiopulmonary Bypass Surgery
NEW MONITORING IN DIFFERENTIAL DIAGNOSIS OF HYPERLACTATHEMIA IN CARDIOPULMONARY BYPASS SURGERY
Objective: The objective of the study was to investigate a reverse correlation between blood lactate levels and rSO2, and distinguish between hypoxic and non-hypoxic hyperlactatemia seen in the early postoperative period.
- Conditions
- Etiology of Hyperlactathemia, Early Period After Cardiopulmonary Bypass Surgery, Washout Phenomenon
- Trial name
- NCT04706884
- Testing
- Near infrared spectroscopy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Acibadem University
Lung; Disease, Fibroid (Chronic)
Ambulatory Oxygen in Fibrotic Lung Disease (FLD) (AmbOx)
The main aim of this project is to establish whether ambulatory oxygen in patients with fibrotic ILD whose oxygen saturation falls ≤ 88% on a 6MWT, leads to a significant improvement in health status.
- Trial name
- AmbOx (NCT02286063)
- Testing
- Ambulatory Oxygen
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Pulmonary Vascular Disease, Pulmonary Artery Hypertension
High Altitude (HA) Residents With Pulmonary Vascular Diseases (PVD), 6 Minute Walk Distance (6MWD) Assessed at 2840m (HA) With and Without Supplemental Oxygen Therapy (SOT)
The investigators aim to study the effect of SOT in participants with pulmonary vascular diseases (PVD) defined as pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension (PH) who permanently live >2500m…
- Conditions
- Pulmonary Vascular Disease, Pulmonary Artery Hypertension, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT06003244
- Testing
- 6-minute walk distance (6MWD) test, 6-minute walk distance (6MWD) test with supplemental oxygen (3 l/min, nasal)
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Premature Infant, Work of Breathing
Work of Breathing and Kangaroo Mother Care
To compare work of breathing and oxygen saturation before, during, and after kangaroo mother care in preterm very low birth weight (VLBW) infants stable on non-invasive respiratory support.
- Conditions
- Premature Infant, Work of Breathing, Oxygen Saturation
- Trial name
- NCT03683316
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Christiana Care Health Services
Tracheal Stenosis
A Clinical Trial on Effectiveness and Safety of Hydrogen Generator to Treat Dyspnea for the Patients With Tracheal Stenosis: A Randomized, Double-blind and Single-center Clinical Study
Investigators aim to study the effectiveness and safety of inhaling hydrogen-oxygen which produced by a hydrogen generator with nebulizer to decreases inspiratory effort for the patients with tracheal stenosis.
- Trial name
- NCT02961387
- Testing
- Hydrogen generator treatment, Oxygen-making machine treatment
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Fuchs Endothelial Corneal Dystrophy
Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal Dystrophy
This protocol will investigate whether topical application of N-acetyl cysteine (NAC) eye drops decreases oxidative stress and confers cytoprotection in patients with FECD.
- Trial name
- NCT04440280
- Testing
- N-acetyl cysteine (NAC) 10% solution, N-acetyl cysteine (NAC) 20% solution, Visine Dry Eye Relief eye drops
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Control Patients, Class III Malocclusion
Effect of Face Mask Therapy on Blood Oxygen Levels
Skeletal Class III malocclusions are characterized by maxillary retrusion, mandibular protrusion, or a combination of both. In growing individuals presenting with maxillary deficiency, the face mask appliance is widely recognized…
- Trial name
- NCT06939179
- Testing
- Class III Malocclusion
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Biruni University
Atelectasis
Effects of Different Inhalation Oxygen Concentrations on Postoperative Atelectasis
This study was a single-center, prospective, randomized controlled, two-arm study. This study will be conducted in the First Hospital of China Medical University.
- Trial name
- DIOCA (NCT05627024)
- Testing
- 30% Oxygen, 60% Oxygen
- Where
- China
- Volunteers
- 96 people
- Sponsor
- China Medical University, China
COPD, Chronic Obstructive Pulmonary Disease
Comparison of 3-Minute Step Test (3MStepT) and 6-Minute Walk Test (6MWT) in COPD Patients
The aim of this study is to compare oxygen desaturation during two tests: the 6 minute walk test and the 3 minute step test, for COPD patients.
- Trial name
- NCT02873780
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier des Pays de Morlaix
Autism
Effects of Hyperbaric Oxygen Therapy on Children With Autism
PURPOSE The purpose of this investigation is to evaluate the cognitive and behavioral effects of Hyperbaric Oxygenation Therapy in children who present with a diagnosis of autism spectrum disorder. HYPOTHESIS 1.
- Trial name
- NCT00406159
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Thoughtful House
Hyperbaric Oxygen Therapy, Traumatic Brain Injury
Hyperbaric Oxygen Therapy Effect on Post Concussion Syndrome in Children
Due its high incidence, mTBI and its consequences of PPCS are a major public health issue. There is no consensus regarding the treatment of PPCS in pediatrics.
- Conditions
- Hyperbaric Oxygen Therapy, Traumatic Brain Injury, Post-Concussion Syndrome
- Trial name
- TBIPED (NCT03339037)
- Testing
- Hyperbaric oxygen therapy
- Where
- Israel
- Volunteers
- 52 people
- Sponsor
- Assaf-Harofeh Medical Center
COVID-19
Effects of Inspiratory Muscle Training in Patients With Post COVID-19
Coronavirus-2019 (COVID-19) is a new virus that emerged in December 2019 and spread quickly all over the world. Problems such as hypoxia, dyspnea, increased fatigue, decreased exercise capacity and respiratory muscle strength…
- Trial name
- NCT05231395
- Testing
- Inspiratory Muscle Training Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gazi University
Acute Respiratory Distress Syndrome
Long Term Outcome on Brain and Lung of Different Oxygen Strategies in ARDS Patients
Acute respiratory distress syndrome (ARDS) is a serious disease with high mortality. In patients who survive ARDS, respiratory, neurological and motor sequelae are frequent, negatively impacting on the patient's quality of life…
- Trial name
- LTO-BLOXY (NCT03621293)
- Testing
- Modulation of Inspired Fraction of Oxygen (FiO2)
- Where
- France
- Volunteers
- 259 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Acute Hypoxemic Respiratory Failure
Impact of End-tidal Oxygen Monitoring During Preoxygenation Before Intubation for Acute Hypoxemic Respiratory Failure in ICU Setting
The main objective of this pilot study is to determine if our protocole using EtO2 monitoring during preoxygenation before intubation is feasible in a population of critically ill patients in acute hypoxemic respirator failure…
- Trial name
- PFOX (NCT06198504)
- Testing
- Protocol using end-tidal oxygen monitoring during preoxygenation before intubation
- Where
- 2 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Grenoble
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