Clinical trials: Oxygen Disorders
Physiological Responses, Pilates Exercise
Effect of Muscle Strengthening Training with Pilates Reformer on Overweight/obese and Normal Body Weight Women (PRET)
This study investigates the physiological responses and the metabolic burden of a Pilates Reformer strength training session in physically inactive premenopausal women with a body mass index of 18-24.9 and 25.01-39.9.
- Conditions
- Physiological Responses, Pilates Exercise, Overweight and Obese Women, Energy Expenditure
- Trial name
- PRET (NCT06675162)
- Testing
- Pilates Reformer Training
- Where
- 2 sites in Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Vitiligo Vulgaris
Mitochondrial Network Modulation Approach Using Hyperbaric Oxygen (HBO) Therapy and Nb-UVB for Treating Vitiligo
Vitiligo affects approximately 1 to 2% of the global population and significantly impacts people's quality of life. Achieving the best treatment outcomes for vitiligo involves addressing the autoimmune inflammatory response for…
- Trial name
- MitOxyVit (NCT07557693)
- Testing
- OXYGENE MEDICINAL LIQUIDE AIR PRODUCTS MEDICAL
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Lower Limb Ischaemia
Development and Validation of a Clinical Prediction Rule for Lower Limb Critical Limb Ischaemia (PREDICCMI)
Critical limb ischaemia (CLI) is the most serious stage of peripheral occlusive arterial disease (POAD). Despite progress in the revascularization procedures, half these patients experience amputation or death after one year.
- Trial name
- PREDICCMI (NCT02637492)
- Testing
- Collection of clinical signs and symptoms
- Where
- 3 sites in France
- Volunteers
- 603 people
- Sponsor
- University Hospital, Bordeaux
Persistent Pulmonary Hypertension of the Newborn, Hypoxemic Respiratory Failure
Preductal Oxygen Saturation Target in Term and Late Preterm Neonates With Hypoxemic Respiratory Failure or Pulmonary Hypertension
The purpose of this research is to evaluate two oxygen saturation goals for newborns with pulmonary hypertension. Participation in this research will involve random assignment to one of two oxygen saturation goals, review of the…
- Trial name
- POST-IT (NCT04938167)
- Testing
- 95% - 99% SpO2 target
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of California, Davis
Anemia of Prematurity, Necrotizing Enterocolitis
Transfusion-related Inflammatory Cytokine and Neutrophil Extracellular Trap Quantification in Neonates
Despite many advances in neonatal care, necrotizing enterocolitis (NEC) remains a leading cause of morbidity and mortality among premature infants.
- Trial name
- NCT01735552
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
Coronary Artery Disease
A Prospective Study to Evaluate the Effect of Chronic Nitrate Therapy on Vasodilation Function in Coronary Heart Disease
Basic studies has showed that sustained use of nitrates might associated with adverse effects on vascular function mediated by an increase in nitrate-induced oxidative stress.
- Trial name
- NCT01430780
- Testing
- nitrate group, control group
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Zhejiang University
Type 1 Diabetes Mellitus
The MICRON Study - A Steno 1 Substudy
The goal of this observational study is to compare cardiac and renal oxygen consumption among subjects with type 1 diabetes treated with either multifactorial intervention or according to the current standard care.
- Trial name
- MICRON (NCT07270172)
- Where
- 5 sites in Denmark
- Volunteers
- 40 people
- Sponsor
- University of Aarhus
Infant, Newborn, Diseases, Mechanical Ventilation Complication
Optimising Neonatal Ventilation with Closed-loop Oxygen Control
Ventilated newborns frequently need supplemental oxygen but its use must be monitored carefully as both giving too much or too little oxygen can have harmful effects.
- Trial name
- NCT05657795
- Testing
- Closed-loop automated oxygen control (Oxygenie, SLE6000)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- King's College Hospital NHS Trust
Respiratory Failure
Preoxygenation in the Intensive Care Unit Using a Nose-mouth Mask Versus High-flow Nasal Cannula Oxygen.
Preoxygenation is routinely performed before endotracheal intubation. In the intensive care unit, preoxygenation is often accomplished using a nose-mouth mask.
- Trial name
- NCT01994928
- Testing
- Nose-mouth mask, High flow nasal cannula oxygen, Intubation
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Spinal Cord Injuries
Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury
Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with…
- Trial name
- NCT02323945
- Testing
- AIH, Walk, Strength
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Electroconvulsive Therapy Treated Patients, Obesity
LMA vs High-flow Nasal Oxygen During ECT in Obese Patients
This study aims to compare two oxygenation strategies-laryngeal mask airway (LMA) ventilation and high-flow nasal cannula (HFNC)-during electroconvulsive therapy (ECT) in obese patients.
- Trial name
- NCT07093372
- Testing
- Laryngeal Mask Airway, High-Flow Nasal Cannula
- Volunteers
- 25 people
- Sponsor
- Eulji University Hospital
Coronavirus Infections
Covid-19 Triage Using Camera-based AI
The vital signs are critical in assessing the severity and prognosis of infections, such as Covid-19. The devices used today for measuring the vital signs have to be in physical contact with the patients.
- Trial name
- NCT04383457
- Testing
- RIA-device (Remote Investigation and Assessment)
- Where
- Sweden
- Volunteers
- 214 people
- Sponsor
- Vastra Gotaland Region
Apnea of Prematurity, Desaturation of Blood
Arterial Oxygen Saturation on Ventilatory Stability in Extremely Premature Infants
This is a prospective crossover study to compare the within-subject effect of the two target ranges of arterial oxygen saturation (SpO2), both within the clinically recommended range of 90- 95%.
- Conditions
- Apnea of Prematurity, Desaturation of Blood, Central Apnea, Periodic Breathing
- Trial name
- NCT03695900
- Testing
- Targeting SpO2 at 93-95%, Targeting SpO2 at 90-92%
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Miami
Chronic Renal Failure
Hyperbaric Oxygen Therapy for Renal Regeneration in Diabetic Nephropathy
Diabetes kidney disease is a leading cause for end stage renal disease in the western world. To date no treatment that can reverse renal damage exists.
- Trial name
- NCT03376282
- Testing
- Hyperbaric Oxygen oxygen therapy (HBOT)
- Where
- Israel
- Volunteers
- 7 people
- Sponsor
- Assaf-Harofeh Medical Center
Wound Healing Disorder, Post-Surgical Complication
NovoX®Cup as Primary Dressing After Breast Reduction
Breast reduction is one of the most frequently performed plastic surgeries. Studies have shown that breast reduction surgery significantly improves the patients' suffering and leads to a better health-related quality of…
- Conditions
- Wound Healing Disorder, Post-Surgical Complication, Mammaplasty
- Trial name
- NCT06420323
- Testing
- Treatment with NovoX® Cup, Treatment with Omnistrip®
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- MOSS S.p.A.
Post-Operative Confusion
Braindex Cerebral Tissue Oxygen Saturation (SctO2) Measurement Algorithm Assessment and Improvement
The objective of this clinical trial is to optimize Braindex brain tissue oxygen saturation (SctO2) measurement algorithm compared to a mixed reference value of jugular venous and systemic arterial saturation, during proven…
- Trial name
- POC-SctO2 (NCT05897060)
- Testing
- Venus Jugular O2 Saturation optical fiber
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Braindex
Post COVID-19 Condition, Post-COVID-19 Syndrome
Improving Post COVID-19 Syndrome With Hyperbaric Oxygen Treatments
Over 500 million people have been infected with COVID-19, and to date, more than 6 million people have died. Many individuals who have recovered from COVID-19 continue to experience symptoms even after they have been "cured" of…
- Conditions
- Post COVID-19 Condition, Post-COVID-19 Syndrome, Post-COVID Syndrome, COVID-19
- Trial name
- PCS-HBOT (NCT06082518)
- Testing
- Monoplace Hyperbaric Chamber (Class III medical device).
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Sunnybrook Health Sciences Centre
Overweight and Obesity
Daily Low Oxygen Exposure and Weight Status
The objective of this single-blind, parallel-arm, randomized clinical trial is to evaluate changes in body weight and composition, assess determinants of energy balance, and measure modulators of energy intake and expenditure…
- Trial name
- LOWS (NCT04801810)
- Testing
- Normobaric hypoxia, Normobaric normoxia
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Florida State University
COPD
Oxygen Therapy During Exercise Training in Inpatient Rehabilitation in Chronic Lung Disease- Does it Matter?
The aim of the current study is the effect of SSOT during a 3-weeks inpatient pulmonary rehabilitation program. Further aim is to analyze exercise endurance, distinguishing between those exercising whilst breathing air at 760m…
- Trial name
- NCT07044843
- Testing
- Oxygen, Standard ambiant air will be breathed during endurance training.
- Where
- 2 sites in Kyrgyzstan, Switzerland
- Volunteers
- 54 people
- Sponsor
- Eastern Switzerland University of Applied Sciences
Respiratory Distress Syndrome, Lower Respiratory Tract Infection
A Low-Resource Oxygen Blender Prototype for Use in Modified Bubble CPAP Circuits
Purpose: Using a novel oxygen blender prototype with modified bCPAP to manage children 1 month to 5 years of age hospitalized with respiratory distress due to lower respiratory tract infection (LRTI) in low-resource settings is…
- Trial name
- NCT04311320
- Testing
- Low-Resource Oxygen Blender
- Where
- Cambodia
- Volunteers
- 33 people
- Sponsor
- University of Minnesota
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