Clinical trials: Oxygen Disorders
COPD, Pulmonary Hypertension
Effect iNO on Functional Respiratory Imaging in Subjects With WHO Group 3 Pulmonary Hypertension With COPD on Oxygen
The objective of this exploratory study is to examine the utility of high resolution computed tomography (HRCT) to measure changes in functional pulmonary imaging parameters as a function of long term iNO administrationusing the…
- Conditions
- COPD, Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT03135860
- Testing
- Inhaled Nitric Oxide 30mcg/kg IBW/hr
- Where
- Belgium
- Volunteers
- 7 people
- Sponsor
- Bellerophon
Chronic Respiratory Acidosis
Respiratory Stabilization in Chronic Acidosis Before Bronchofiberoscopy & Non-Invasive Ventilation Effectivenes
Bronchofiberoscopy (FOB) is a minimally invasive and safe procedure performed for diagnostic and therapeutic purposes. FOB frequently impairs respiratory function, which may lead to possible exacerbation of respiratory failure.
- Trial name
- NCT06970002
- Testing
- Use of NIV during FOB as a respiratory support method, Use of HFNC during FOB as a respiratory support method
- Volunteers
- 210 people
- Sponsor
- Medical University of Silesia
Infertility
Evaluation of the Impact of Reduced Oxygen Concentration on Live Birth Rate
Clinical in vitro fertilization relies on successful embryo culture. The primary goal of embryo culture is to attempt to recapitulate the in vivo conditions as much as possible.
- Trial name
- NCT03147872
- Testing
- 2% Oxygen
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Peripheral Arterial Disease, Subarachnoid Block
Effect of Subarachnoid Block and Femoropopliteal Block to Limb Perfusion in PAD Patients
This pilot study investigates the effects of femoropopliteal and subarachnoid nerve blocks on tissue oxygen saturation (StO2) in patients with Peripheral Arterial Disease (PAD) during lower limb surgeries.
- Conditions
- Peripheral Arterial Disease, Subarachnoid Block, Femoropopliteal Block, Tissue Oxygen Saturation
- Trial name
- NCT06702202
- Testing
- Mixture of local anesthetics, 0.5% hyperbaric bupivacaine
- Where
- Indonesia
- Volunteers
- 16 people
- Sponsor
- Universitas Indonesia
Bypass Complications, Disorder of Blood Gas
Difference Between Central and Peripheral Arterial Blood Oxygen Saturation With Different CPB Strategy
Femoro-femoral cardiopulmonary bypass with retrograde perfusion is needed for totally thoracoscopic cardiac surgery. one of the major complication of retrograde perfusion is organ hypoperfusion.
- Trial name
- NCT01698853
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Covid19, COVID-19 Pneumonia
Oxygen Requirements and Use in Patients With COVID-19 in LMICs
This observational cohort study will enroll patients in LMICs with suspected or confirmed COVID-19 on oxygen or deemed to require oxygen therapy based on objective criteria.
- Trial name
- O2CoV2 (NCT04918875)
- Where
- Switzerland
- Volunteers
- 2,400 people
- Sponsor
- Pryanka Relan
Overdose
Monitoring of Overdose Patients With and Without Supplemental Oxygen in the Emergency Department
This study will compare the data from pulse oximeters to capnographers as they are used to monitor patients who are being observed in the Emergency Department for a suspected overdose of alcohol or other drugs.
- Trial name
- NCT02101424
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Hennepin Healthcare Research Institute
Ischemic Attack, Transient
Does Positioning Effects on Early Postoperative Cognitive Dysfunction in Laparoscopic Oncological Surgery
Laparoscopic surgery is an alternative to open surgical techniques for reasons such as less blood loss,less need for transfusion, shorter discharge time.
- Trial name
- NCT04714346
- Testing
- no interventions
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Overweight, Physical Inactivity
The Potential of a Low Oxygen Environmental Chamber as an Aid to Exercise Training to Improve Metabolic Health
Obesity is a major global health issue and a primary risk factor for metabolic-related disorders. While physical inactivity is one of the main contributors to obesity, it is a modifiable risk factor with exercise training as an…
- Conditions
- Overweight, Physical Inactivity, Healthy
- Trial name
- NCT05577429
- Testing
- Low-moderate intensity exercise under normoxia, Low-moderate intensity exercise under moderate hypoxia, Low-moderate intensity exercise under high hypoxia
- Where
- Malaysia
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Swinburne University of Technology
Chronic Obstructive Pulmonary Disease
Tiotropium Respimat Versus HandiHaler on SaO2 and Sleep in COPD Patients
The aim of this study was to compare the tiotropium Respimat Soft Mist Inhaler and the HandiHaler in terms of their effects on sleeping oxygen saturation (SaO2) and sleep quality in patients with COPD.
- Trial name
- NCT02331940
- Testing
- tiotropium, Handihaler, Respimat
- Volunteers
- 200 people
- Sponsor
- University of Crete
Down Syndrome
Oxygen Uptake Kinetics During Submaximal Exercise in Adults With Down Syndrome
This study aims to compare the rate at which oxygen uptake adapts to submaximal, moderate intensity exercise (oxygen uptake kinetics) between adults with and without Down syndrome, to determine the contribution of oxygen uptake…
- Trial name
- NCT05995223
- Testing
- Submaximal exercise protocol
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Chronic Obstructive Pulmonary Disease and Allied Conditions
Predictors of Mortality in Patients With Advanced Lung Disease in Home Oxygen Therapy
Advanced Pulmonary Disease (PAD) is a condition that affects countless individuals around the world. Patients are often functionally very limited, with premature death, which is due to the disease itself or its complications.
- Trial name
- NCT02571582
- Volunteers
- 553 people
- Sponsor
- Federal University of Uberlandia
Sars-CoV2
The Prone Position in Covid-19 Affected Patients
The prone position during mechanical ventilation in patients with Acute Respiratory Distress Syndrome (ARDS) is able to improve oxygenation and thus reduce mortality.
- Trial name
- PRON-COVID (NCT04365959)
- Testing
- Prone position
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- University of Milano Bicocca
Vitreoretinal Surgery, Cognitive Function Abnormal
The Effect of Retrobulbar Block for Eye Surgery on Brain Oxygenation and Cognitive Functions in Elderly Patients
The investigators measured changes in cerebral oxygen saturation (rSO2) and MMSE scores after retrobulbar block performed with levobupivacaine and lidocaine in patients undergoing vitreoretinal surgery.A total of 66 patients over…
- Conditions
- Vitreoretinal Surgery, Cognitive Function Abnormal, Intraoperative Monitoring
- Trial name
- NCT03189329
- Testing
- 2% lidocaine hydrochloride, 0.5% levobupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Cengiz KAYA
T1DM
Efficacy of Hyperbaric Oxygen Therapy (HBOT) in New-onset Type-1 Diabetes Mellitus
Type 1 Diabetes Mellitus (T1DM) is caused by an autoimmune process that progressively destroys the pancreatic β-cells, and leads to dependence on multiple daily insulin subcutaneous injections according to glucose measurements…
- Trial name
- NCT04412200
- Testing
- Hyperbaric oxygen chamber (HBOC)
- Where
- 2 sites in Israel
- Volunteers
- 36 people
- Sponsor
- Assaf-Harofeh Medical Center
Anesthetized Healthy Patients (ASA 1 or 2) in the Supine Position, Excluding Head, Neck and Head Surgeries, Anesthetized Patient With Severe Systemic Disease (ASA 3 or 4)
Gas Kinetics and Metabolism in Anesthesia During Non Steady State
During clinical anesthesia, it is astonishing that CO2 monitoring consists mainly of end-tidal PCO2 to confirm endotracheal intubation and to estimate ventilation, and O2 monitoring consists of a single PO2 measurement to detect…
- Trial name
- NCT00225381
- Testing
- connection of measuring device to anesthesia circuit, drawing of blood sample through an arterial line, placed according to clinical criteria by primary anesthesia team, changing operating room bed position (head down and up position)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Atrial Fibrillation
Cardiac Surgery and the Risk of Atrial Fibrillation: an Intervention Trial Evaluating Melatonin
Atrial fibrillation is a common heart rhythm condition that can occur after cardiac surgery and has been associated with an increase in hospital length of stay, overall hospital costs, worsening clinical condition and higher…
- Trial name
- DREAM (NCT02099331)
- Testing
- Melatonin
- Where
- United States
- Sponsor
- Johns Hopkins University
Brain Injury, Sequelae
Hyperbaric Oxygen Therapy in Chronic Stable Brain Injury
The purpose of this study is to discover the feasibility of conducting clinical research in individuals with chronic sequelae following brain injury who are given hyperbaric oxygen.
- Conditions
- Brain Injury, Sequelae, Stroke, Anoxia
- Trial name
- HYBOBI (NCT00830453)
- Testing
- Hyperbaric oxygen therapy (HBO2)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Intermountain Health Care, Inc.
Pulmonary Atelectasis, Postoperative, Postoperative Pulmonary Complications
Ventilation Mode and Atelectasis After Prone-Position Surgery: A Lung Ultrasound Study
This prospective single-centre observational study compared two intraoperative mechanical ventilation modes, volume-controlled ventilation (VCV) and VCV with AutoFlow/AF, in adults undergoing elective surgery in the prone…
- Trial name
- VENTI-PRONE (NCT07680881)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Encephalopathy, White Matter Hyperintensities
Effect of HBO on Functional Connectivity of Resting State Networks in Patients With Cerebral Small Vessel Disease
The purpose of this study is to extend our previous work, in which we demonstrated an increase in the internal and cross network connectivity of resting state neural networks in patients with cerebral small vessel disease by…
- Conditions
- Encephalopathy, White Matter Hyperintensities, Impaired Oxygen Delivery
- Trial name
- HBO (NCT02232958)
- Testing
- Hyperbaric Oxygen Treatment
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- St. Luke's Hospital, Chesterfield, Missouri