Clinical trials: Oxygen Disorders
Diabetes Mellitus
Hyperbaric Oxygenation in Diabetic Ulcer
Hyperbaric oxygenation (HBO) involves breathing of 100% oxygen under elevated ambient pressure. In correlation to the pressure level oxygen dissolves in the plasma resulting in an increase of total oxygen in the body.
- Trial name
- NCT02042339
- Testing
- Hyperbaric oxygen
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Medical University of Graz
Neonatal Respiratory Failure, Congenital Heart Defect
Validation of a Novel Oxygen Consumption Measurement Technique in Neonates
The measurement of how much oxygen a baby consumes provides important information about the health of the baby, and of how much energy they are consuming.
- Trial name
- NCT03154112
- Testing
- Measurement of oxygen consumption and caloric expenditure
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Boston Children's Hospital
ST Elevation Myocardial Infarction
Supplemental Oxygen in Catheterized Coronary Emergency Reperfusion
The aim of SOCCER is to evaluate the effects of treatment with supplemental O2 before and during acute balloon angioplasty (PCI) for patients with ST-elevation myocardial infarction (STEMI).
- Trial name
- SOCCER (NCT01423929)
- Testing
- Oxygen, Room air
- Where
- 3 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Region Skane
Covid19, Acute Hypoxemic Respiratory Failure
High-Flow Nasal Cannula in Severe COVID-19 With Acute Hypoxemic Respiratory Failure.
This open label randomized controlled multicenter phase II trial will evaluate the clinical impact of the use of HFNC vs. conventional oxygen therapy in patients with moderate and severe hypoxemic acute respiratory failure…
- Trial name
- HiFlo-COVID (NCT04609462)
- Testing
- Conventional oxygen therapy, High flow nasal cannula
- Where
- Colombia
- Volunteers
- 199 people
- Sponsor
- Fundacion Clinica Valle del Lili
Premature Infant, Respiratory Distress Syndrome
The Hilo Pilot -Trial to Assess Feasibility
Preterm birth, or birth before 37 weeks' gestation, is increasingly common, occurring in 8% of pregnancies in Canada. Preterm birth is associated with many health complications, particularly when the birth happens before 29…
- Trial name
- HiLo-Pilot (NCT03706586)
- Testing
- 30% group, 60% group
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University of Alberta
Diabetes, Periodontitis
Hyperbaric Oxygen Therapy as Adjunctive Therapy to Scaling and Root-planing in the Management of Periodontitis in Patients With Type 2 Diabetes
Diabetes and Periodontitis are both prevalent diseases affecting millions of Americans. Periodontitis is prevalent among Diabetics.
- Trial name
- NCT02671136
- Testing
- Hyperbaric Oxygen therapy, Conventional Wound Therapies
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Loma Linda University
Diabetic Foot, Postoperative Wound Healing
OEOd-Based Wound Dressing in Post-Surgical Diabetic Foot Ulcers
This study is a prospective randomized controlled pilot study evaluating the efficacy and safety of an OEOd-based wound dressing compared with standard wound care in patients with post-surgical diabetic foot ulcers.
- Trial name
- OEOd-DFU-pilot (NCT07368816)
- Testing
- OEOd-based wound dressing, Standard of Care (Investigator Choice)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Ospedale San Donato
Apnea, Postanesthetic, Desaturation of Blood
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Could Decrease the Incidence of Oxygen Desaturation During Suspension Laryngoscopy: a Randomized Controlled Trial (Optilaryngo)
Suspension laryngoscopy is realised during apnea. In effect, surgeons are in the mouth of the patient and we can't have access at the aiways.
- Conditions
- Apnea, Postanesthetic, Desaturation of Blood, Apnea, Anesthesia
- Trial name
- optilaryngo (NCT03843580)
- Testing
- optiflow
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Caen
Dyspnea, Respiratory Rate
Evaluating the Effectiveness of Incentive Spirometry
Post-operative pulmonary complications (PPCs) have a major impact on patients and healthcare expenses. The goal of perioperative respiratory therapy is to improve airway clearance, increase lung volume, and mitigate atelectasis.
- Conditions
- Dyspnea, Respiratory Rate, Oxygen Saturation, Oxygen Requirements
- Trial name
- NCT02952027
- Testing
- Use-recording, patient-reminder alarm for incentive spirometry
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Lifespan
Type 2 Diabetes Mellitus, Diabetic Kidney Disease
Renal Oxygenation, Oxygen Consumption and Hemodynamic Kinetics in Type 2 DIabetes: an Ertugliflozin Study.
Current study will render insight in to the role of renal hypoxia in the diabetic kidney and is able to associate its finding with measurements of renal perfusion and glomerular filtration rate.
- Conditions
- Type 2 Diabetes Mellitus, Diabetic Kidney Disease, Diabetic Nephropathy, Renal Hypoxia
- Trial name
- ROCKIES (NCT04027530)
- Testing
- Ertugliflozin 15 mg
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Impotence, Prostatic Neoplasms
Can Hyperbaric Oxygen Improve Erectile Function Following Surgery for Prostate Cancer
The purpose of this study is to determine if adding hyperbaric oxygen therapy, a therapy that delivers oxygen under slight pressure, to a drug treatment of PDE5I (such as Viagra, Levitra, Cialis)for men following surgery for…
- Trial name
- HBOT (NCT00906269)
- Testing
- Sildenafil therapy plus post-NSRRP HBO2T
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Hartford Hospital
Chronic Obstructive Pulmonary Disease
Innovation in NOn Invasive Ventilation in COPD Patients Treated by Long Term Oxygen Therapy
The aim of this study is to investigate the efficacy of non-invasive ventilation (NIV) on nocturnal hypoventilation in patients with chronic obstructive pulmonary disease (COPD) who are on long term oxygen therapy (LTOT) at home.
- Trial name
- INOV-LTOT (NCT03584269)
- Testing
- NIV Device + LTOT, LTOT
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Grenoble
Hearing Loss, Sudden, Prednisone Acetate
Treatment of Sudden Deafness With Prednisone+Hyperbaric Oxygen and Prednisone+Somatosensory Stimulation
To study the effective treatment of sudden deafness by giving prednisone, hyperbaric oxygen and somatosensory stimulation to sudden deafness patients.
- Conditions
- Hearing Loss, Sudden, Prednisone Acetate, Hyperbaric Oxygen, Somatic Stimulus
- Trial name
- NCT04129983
- Testing
- Drugs and Stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Dan Su
Ulcer Foot, Diabetic Foot Ulcer
Adjunctive Hyperbaric Oxygen Therapy (HBOT) for Lower Extermity Diabetic Ulcer:
Diabetic foot ulcers are associated with high risk of amputation. About 50% of patients undergoing non-traumatic lower limb amputations are diabetics5.
- Trial name
- NCT03675269
- Testing
- HBOT, Standard wound care
- Sponsor
- King Hamad University Hospital, Bahrain
Hypoxemia, Pneumonia
Effect of High-Flow Nasal Cannula Oxygen Therapy on Hypoxemia in Pediatric Sedated Bronchoscopy
Due to children's lower oxygen reserves and higher oxygen consumption, sedation can easily lead to respiratory adverse events such as hypoxemia.
- Conditions
- Hypoxemia, Pneumonia, Pulmonary Neoplasm
- Trial name
- NCT07563075
- Testing
- High-flow nasal cannula, Regular Nasal Cannula
- Where
- 4 sites in China
- Volunteers
- 430 people
- Sponsor
- Zhejiang University
Hypertension,Essential
Brain BOLD fMRI in Hypertensive and Normotensive Participants
This study will explore the brainstem activity in response to stress in hypertensive patients and normotensive subjects. In addition, it will evaluate if the response in hypertensive patients can be modulated by blocking the…
- Trial name
- BRAIrdN (NCT03473275)
- Testing
- Cold Pressor test, PinPrick test
- Where
- Switzerland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Arteriosclerosis, Coronary
Aquatic and Land Aerobic Training, Cardiorespiratory and Metabolic Variables in Cardiorespiratory Diseases
In the pathophysiological process of coronary artery disease (CAD), are present, autonomic dysfunction and reduced functional capacity.
- Trial name
- NCT02198872
- Testing
- Exercise, Aerobic (Water based), Land Group
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Metodista de Piracicaba
Pneumonia, Hypoxemia
Solar Oxygen Study
Globally, approximately 7.7 million children per year die before the age of 5 years. Infectious diseases account for a large proportion of these deaths, with pneumonia being the leading cause of mortality (2.1 million…
- Trial name
- SOS (NCT03851783)
- Testing
- Solar-powered oxygen
- Where
- 20 sites in Uganda
- Volunteers
- 2,405 people
- Sponsor
- University of Alberta
Coronary Artery Disease
Effect of Intraoperative Arterial Oxygen Targets on Thiol-Disulfide Homeostasis and Ischemia-Modified Albumin
This single-center randomized trial compared two intraoperative arterial oxygen tension (PaO2) target strategies in adults undergoing elective isolated coronary artery bypass graft surgery.
- Trial name
- NCT04627220
- Testing
- Intraoperative Oxygenation Strategy: PaO2 200 mmHg or Greater, Intraoperative Oxygenation Strategy: PaO2 80 to Less Than 200 mmHg
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Post-Operative Confusion
Braindex Cerebral Tissue Oxygen Saturation (SctO2) Measurement Algorithm Assessment and Improvement
The objective of this clinical trial is to optimize Braindex brain tissue oxygen saturation (SctO2) measurement algorithm compared to a mixed reference value of jugular venous and systemic arterial saturation, during proven…
- Trial name
- POC-SctO2 (NCT05897060)
- Testing
- Venus Jugular O2 Saturation optical fiber
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Braindex
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