Clinical trials: Oxygen Disorders
Face Mask, Longterm Oxygen Therapy
Impact of Surgical Mask, FFP2 Mask and FFP3 Mask (With and Without Exhalation Valve) on Exercise Tolerance and Blood Gas Parameters of Patients With Known Lung Disease and Long-term Oxygen Therapy
The aim of the study is to find out how blood gas parameters change under the use of surgical mask, FFP2 masks and FFP3 masks (with and without exhalation valve) in patients with known lung disease and long-term oxygen therapy.
- Trial name
- FFP-O2 (NCT05931016)
- Testing
- 6-MWT, Spiroergometry
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- University Hospital Regensburg
Respiratory Failure
Hyperoxia, Erythropoiesis and Microcirculation in Critically Ill Patient
Prospective observational study in 40 adult critically ill patients. Patients were eligible if they were mechanically ventilated with an FiO2 ≤0.5 and PaO2/FiO2 ≥200 mmHg and hemodynamically stable with a hemoglobin ≥9 g/dL, no…
- Trial name
- NCT02481843
- Testing
- 2 hours of hyperoxia (FiO2 = 1)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Università Politecnica delle Marche
Spinal Cord Injuries
Low Oxygen Therapy to Enhance Walking Recovery After SCI.
The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking function for people with chronic spinal cord injury of different age…
- Trial name
- BO2ST-II (NCT06521723)
- Testing
- Daily acute intermittent hypoxia, Walking + tSTIM
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Spaulding Rehabilitation Hospital
COPD, Chronic Hypoxemic Respiratory Failure
Automated Oxygen Titration with O2matic Home Oxygen Therapy (O2matic HOT) Phase 1
O2matic HOT is a further development of O2matic and is intended for home oxygen use with patients in need of long-term oxygen treatment (LTOT).
- Trial name
- O2matic-HOT1 (NCT04606290)
- Testing
- O2matic HOT, Oxygen concentrator
- Where
- 2 sites in Denmark
- Volunteers
- 10 people
- Sponsor
- Hvidovre University Hospital
Atelectasis, Postoperative Pulmonary Complications
Effect of Inspired Oxygen Concentration on Postoperative Atelectasis After VATS Lobectomy
This study aims to investigate whether using 50% FiO₂ during one-lung ventilation, compared with 100% FiO₂, reduces postoperative atelectasis in the non-dependent (healthy) lung of patients undergoing VATS pulmonary lobectomy…
- Trial name
- NCT07721558
- Testing
- Low inspired oxygen concentration (FiO₂=50%) during one-lung ventilation, High inspired oxygen concentration (FiO₂=100%) during one-lung ventilaion
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Critical Limb Ischemia
Dissolved Oxygen Dressing to Improve Chronic Wound Healing After Revascularization for Critical Limb Ischemia
A Prospective, Randomized, Single-center Pilot Study of The OxyGenesys(TM) Dissolved Oxygen Dressing to Improve Chronic Wound Healing after REvascularization for Critical Limb Ischemia.
- Trial name
- NCT02046226
- Testing
- Oxygenesys(TM) Dissolved Oxygen Dressing
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Halyard Health
COPD, Hypoxia
Automated Oxygen Administration -Rethinking Interventions Alleviating Dyspnea in Patients With COPD
Chronic Obstructive Pulmonary Disease (COPD) is associated with high morbidity and mortality. The Danish Lung Association estimates that 320,000 Danes live with COPD, of which approximately 50,000 with severe COPD.
- Conditions
- COPD, Hypoxia, Closed-Loop Communication, Dyspnea
- Trial name
- NCT04370990
- Testing
- O2matic
- Where
- 5 sites in Denmark
- Volunteers
- 157 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Respiratory Failure, Acute Respiratory Failure Requiring Intubation
Intra-operative Inspiratory Oxygen Fraction and Postoperative Respiratory Complications
Respiratory complications represent the second most frequent type of postoperative complications with an incidence estimated to range from 2.0% to 7.9% It has been shown that intra-operative protective ventilation is associated…
- Conditions
- Respiratory Failure, Acute Respiratory Failure Requiring Intubation, Pulmonary Edema, Pneumonia
- Trial name
- NCT02399878
- Testing
- Inspiratory oxygen
- Volunteers
- 70,000 people
- Sponsor
- Massachusetts General Hospital
Hypoxia-Ischemia, Brain, Ischemia, Vertebral Artery
Oxygen Concentration and Recovery After Carotid Endarterectomy
This study evaluates effects of high inspiratory oxygen on cerebral tissue oxygenation and patient recovery after carotid endarterectomy.
- Conditions
- Hypoxia-Ischemia, Brain, Ischemia, Vertebral Artery, Artery Stenosis, Carotid
- Trial name
- NCT02991976
- Testing
- Oxygen concentration
- Where
- Croatia
- Volunteers
- 80 people
- Sponsor
- Osijek University Hospital
Oxygen Desaturation, Apnea (Central and Obstructive)
Supplemental Oxygen and Oxygen Desaturations in Colonoscopies
This study will compare apnea and oxygen desaturation events among various methods of supplemental oxygen delivery during procedural sedation in colonoscopy patients.
- Conditions
- Oxygen Desaturation, Apnea (Central and Obstructive), Airway Obstruction
- Trial name
- NCT07515755
- Testing
- Breath-synchronized oxygen, CPAP, Control
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University of Utah
Critically Ill, Hypovolemia
Fluid Responsiveness After CArdiac Surgery Study
Study Design: Prospective observational study Study Location: Liverpool Hospital Intensive Care Unit, South Western Sydney Local Health District, Sydney, Australia.
- Trial name
- FRACAS (NCT02841943)
- Where
- Australia
- Volunteers
- 102 people
- Sponsor
- South West Sydney Local Health District
Respiratory Failure With Hypoxia, Respiratory Failure, ICU
Weaning From High Flow Nasal Oxygen in Acute Respiratory Failure : a Target Trial Emulation
Acute respiratory failure is a frequent reason for admission to the intensive care unit (ICU). It is associated with high healthcare consumption and mortality.
- Conditions
- Respiratory Failure With Hypoxia, Respiratory Failure, ICU, High-Flow Nasal Oxygen Therapy
- Trial name
- HFNO-Weaning (NCT07030413)
- Where
- 3 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Poitiers University Hospital
Type 2 Diabetes
Anti-inflammatory Effects of the Fiber
This study will help elucidate the mechanism underlying the cardioprotective and anti-diabetes effect of dietary fiber by exploring a comprehensive set of inflammatory and oxidative stress markers, based on a contemporary…
- Trial name
- NCT02868788
- Testing
- dietary fiber, HFHC meal
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University at Buffalo
Hypoxic-ischemic Encephalopathy
Hyperbaric Oxygen Therapy Improves Outcome of Hypoxic-Ischemic Encephalopathy
The purpose of this study is to to evaluate the safety and efficacy of hyperbaric oxygen in term gestation newborn infants with hypoxic-ischemic encephalopathy..
- Trial name
- NCT02894866
- Testing
- hyperbaric oxygen
- Where
- 10 sites in China
- Volunteers
- 250 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Breast Cancers
A Phase II Single-Arm Clinical Study to Explore the Efficacy and Safety of Hyperbaric Oxygen in the Neoadjuvant Treatment of Breast Cancer Patients
The goal of the study is to explore the efficacy and safety of hyperbaric oxygen in the neoadjuvant treatment of breast cancer patients
- Trial name
- NCT06811870
- Testing
- hyperbaric oxygen treatment
- Where
- 2 sites in China
- Volunteers
- 161 people
- Sponsor
- Guangdong Provincial People's Hospital
COPD, Home Care
FiO2 in Chronic Obstructive Pulmonary Disease (COPD) Patient Normobaric O2 Versus NIV
The purpose of this study is to compare pharyngeal FiO2 in day time with nasal normobaric O2 with inhaled FiO2 in the night time with home care ventilator NIV at the same O2 flow.
- Conditions
- COPD, Home Care, Oxygen Therapy
- Trial name
- NIVLEAKS (NCT02599246)
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Breas Medical S.A.R.L.
Diabetes, Foot Ulcer
Hyperbaric Oxygen Therapy as Adjunctive Treatment of Chronic Diabetic Foot Ulcers
The purpose of this study is to evaluate if hyperbaric oxygen therapy heels more foot ulcers as compared to placebo in patients with diabetes mellitus and chronic foot ulcers.
- Conditions
- Diabetes, Foot Ulcer, Healing
- Trial name
- HODFU (NCT00953186)
- Testing
- hyperbaric air, HBOT
- Where
- Sweden
- Volunteers
- 94 people
- Sponsor
- Mrs. Thelma Zoegas Foundation
Impaired Oxygen Delivery, Congenital Heart Disease
Restrictive Versus Liberal Transfusion Protocol in Infants Undergoing Cardiac Surgery
In neonates and infants </= 10 kg following cardiac surgery for congenital heart disease a more restrictive red blood cell (RBC) transfusion strategy will be as effective as, and possibly superior to, a liberal RBC strategy.
- Trial name
- NCT01484886
- Testing
- Red blood cell transfusion
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- University of Rochester
Chronic Respiratory Disease, Hypoxemia
Observance of Long Term Oxygen Therapy in Chronic Inspiratory Disease Patients
Long-term oxygen therapy (LTOT) is the reference treatment for chronic respiratory failure. This treatment is based on the principle of oxygen supplementation via a source to correct hypoxemia in patients.
- Trial name
- ObsO2 (NCT03188588)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- SOS Oxygene Mediterranee
Chronic Ischemic-Hypoxic Enteropathy
Gut Oxygen Therapy for Ischemic-Hypoxic Bowel Disease
This single-center, double-blind, randomized, intra-individual crossover controlled study aims to investigate the efficacy and safety of intestinal oxygen therapy via a deep intestinal catheter as a targeted route for intestinal…
- Trial name
- NCT07621367
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Second Hospital of Nanjing Medical University
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