Clinical trials: Oxygen Disorders
Chronic Obstructive Pulmonary Disease
Long-term Oxygen Treatment (LTOT) in Chronic Obstructive Pulmonary Disease: Factors Influencing Survival
The purpose of this prospective cohort study is to determine factors involved in survival in new COPD patients treated by long-term oxygen therapy. Background: long-term oxygen therapy is indicated in patients with severe COPD.
- Trial name
- NCT00871962
- Testing
- OXYGEN SUPPLEMENTATION
- Where
- France
- Volunteers
- 750 people
- Sponsor
- Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche
Physiological Responses, Pilates Exercise
Effect of Muscle Strengthening Training with Pilates Reformer on Overweight/obese and Normal Body Weight Women (PRET)
This study investigates the physiological responses and the metabolic burden of a Pilates Reformer strength training session in physically inactive premenopausal women with a body mass index of 18-24.9 and 25.01-39.9.
- Conditions
- Physiological Responses, Pilates Exercise, Overweight and Obese Women, Energy Expenditure
- Trial name
- PRET (NCT06675162)
- Testing
- Pilates Reformer Training
- Where
- 2 sites in Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Pulmonary Arterial Hypertension Related to Eisenmenger Physiology
Effects of Tracleer (Bosentan) on Pulmonary Arterial Hypertension Related to Eisenmenger Physiology
This study evaluates the effects of bosentan on oxygen saturation, hemodynamics and exercise capacity in patients with pulmonary arterial hypertension related to Eisenmenger physiology.
- Trial name
- NCT00317486
- Testing
- bosentan
- Volunteers
- 54 people
- Sponsor
- Actelion
Pregnancy, Infertility
The Effects of Physiologic Oxygen Tension on Clinical In Vitro Fertilization Outcomes
Primary Aim Evaluate whether human embryo exposure to physiologic levels of oxygen during culture improves the percentage of women who deliver a baby following in vitro fertilization and embryo transfer.
- Trial name
- PhOx (NCT01010386)
- Testing
- Atmospheric oxygen tension, Physiologic oxygen tension
- Where
- 4 sites in United States
- Volunteers
- 851 people
- Sponsor
- Yale University
Diabetes, Foot Ulcer
Hyperbaric Oxygen Therapy as Adjunctive Treatment of Chronic Diabetic Foot Ulcers
The purpose of this study is to evaluate if hyperbaric oxygen therapy heels more foot ulcers as compared to placebo in patients with diabetes mellitus and chronic foot ulcers.
- Conditions
- Diabetes, Foot Ulcer, Healing
- Trial name
- HODFU (NCT00953186)
- Testing
- hyperbaric air, HBOT
- Where
- Sweden
- Volunteers
- 94 people
- Sponsor
- Mrs. Thelma Zoegas Foundation
Coma, Carbon Monoxide Poisoning
Carbon Monoxide-induced Coma: Prognostic Factors
The primary objective of the study is to determine prognostic factors for hospital-mortality following carbon monoxide (CO)-induced coma.
- Trial name
- Coma-CO (NCT03926494)
- Where
- France
- Volunteers
- 212 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension
24 Hour Ambulatory Cardiac Oxygen Consumption
A randomized,double-blind, active controlled,15 week study to evaluate the effects of nebivolol and valsartan alone and in combination on 24-hour ambulatory cardiac work and variability of heart rate-mean central systolic…
- Trial name
- ACRPP (NCT05170061)
- Testing
- Nebivolol, Valsartan, Nebivolol/valsartan combination
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- State University of New York at Buffalo
Chronic Obstructive Pulmonary Disease
Effects of HFOT on Exercise Performance in Patients With COPD. A Randomized, Controlled Trial.
This will be a randomized, cross-over trial evaluating the efficacy of nasal high-flow oxygen therapy (HFOT) vs. low-flow oxygen therapy (LFOT) on cycling endurance in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT03955770
- Testing
- High-flow oxygen therapy (HFOT), Low-flow oxygen therapy (LFOT)
- Where
- Kyrgyzstan
- Volunteers
- 79 people
- Sponsor
- University of Zurich
Central Venous Oxygen Saturation, Anaemia
Transfusion Practices in Intensive Care Units: a Hungarian Nationwide Survey
The aim of our data analysis-based questionnaire study is to assess the daily transfusion practices used in the care of critically ill patients in intensive care units in Hungary.
- Conditions
- Central Venous Oxygen Saturation, Anaemia, Lactate, Transfusion
- Trial name
- NCT07532772
- Testing
- Survey using a questionnaire.
- Where
- Hungary
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Pest County Flór Ferenc Hospital
Respiratory Distress Syndrome, Adult
Pilot Study of Positive-End Expiratory Pressure in Acute Respiratory Distress Syndrome
Randomized controlled pilot trial in 70 patients with Acute Respiratory Distress Syndrome (ARDS) ventilated with low tidal volumes and limitation on airway pressure at 35 centimeters of water (cmH2O), to compare two different…
- Trial name
- PEEP-HUPA (NCT01119872)
- Testing
- Positive End-expiratory Pressure (PEEP)
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Universitario Principe de Asturias
Acute Ischemic Stroke
Stimulation-Temperature-Oxygen-Positioning Multimodal Neuroprotection for Acute Ischemic Stroke (STOP)
Acute ischemic stroke may result in substantial disability despite timely reperfusion therapy because ischemic and reperfusion-related brain injury can continue before, during, and after restoration of blood flow.
- Trial name
- STOP (NCT07840794)
- Testing
- Stimulation-Temperature-Oxygen-Positioning (STOP) Multimodal Neuroprotective Strategy, Guideline-Based Reperfusion Therapy and Standard Stroke-Unit Care
- Volunteers
- 380 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hypoxemia During Surgery, Atelectasis
Usage of High Flow Nasal Cannula in Preventing Desaturations in Elderly Patients Going for Lower Limb Surgeries
To study the effect of high flow nasal cannula in comparisons with nasoprong used intraoperatively in patients oxygenation status
- Trial name
- NCT06054022
- Testing
- high flow nasal cannula, nasoprong oxyen 2Litres per minute
- Where
- Malaysia
- Volunteers
- 50 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Congenital Heart Disease
Hybrid Versus Norwood Management Strategies in Infants Undergoing Single Ventricle Palliation
The purpose of this trial is to determine, at 3 years of life, how the neurologic and functional outcomes in infants with single ventricles are different when comparing children treated with the Hybrid strategy to the Norwood…
- Trial name
- NCT01134302
- Testing
- Norwood management strategy, Hybrid Strategy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- The Hospital for Sick Children
Primary Peritoneal Cavity Cancer, Stage I Endometrial Carcinoma
EF5 in Finding Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Cervical, Endometrial, or Ovarian Epithelial Cancer
This phase II trial is studying how well EF5 works in finding oxygen in tumor cells of patients who are undergoing surgery or biopsy for cervical, endometrial, or ovarian epithelial cancer.
- Conditions
- Primary Peritoneal Cavity Cancer, Stage I Endometrial Carcinoma, Stage I Ovarian Epithelial Cancer, Stage IA Cervical Cancer
- Trial name
- NCT00107445
- Testing
- EF5
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute (NCI)
Delirium, Dementia, Amnestic, Cognitive Disorders, Arthroplasty, Hip Replacement
Cerebral Regional Oxygen Saturation and Markers of Brain Damage During Primary Hip Arthroplasty
Postoperative Cognitive Disorders (POCD) are common in hospitalized people > 60 year old, especially in orthopedic patients. Etiology of POCD is complex, and in some aspects still remains unclear.
- Trial name
- NCT02342236
- Testing
- cemented or cementless type of hip prothesis
- Where
- Poland
- Volunteers
- 18 people
- Sponsor
- Military Institute od Medicine National Research Institute
Vitiligo Vulgaris
Mitochondrial Network Modulation Approach Using Hyperbaric Oxygen (HBO) Therapy and Nb-UVB for Treating Vitiligo
Vitiligo affects approximately 1 to 2% of the global population and significantly impacts people's quality of life. Achieving the best treatment outcomes for vitiligo involves addressing the autoimmune inflammatory response for…
- Trial name
- MitOxyVit (NCT07557693)
- Testing
- OXYGENE MEDICINAL LIQUIDE AIR PRODUCTS MEDICAL
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
COPD Exacerbation, Trauma
FreeO2 PreHospital - Automated Oxygen Titration vs Manual Titration According to the BLS-PCS
Evaluation of automated oxygen titration in comparison with manual adjustment oxygen in the out-of-hospital setting by paramedics.
- Trial name
- NCT03696563
- Testing
- Automated oxygen administration - FreeO2, Standard administration of oxygen flow
- Volunteers
- 100 people
- Sponsor
- François Lellouche
Critical Illness
Peripheral Oxygen Saturation (SpO2) Directed Oxygen Therapy
Investigators hypothesized that a relative low SpO2 directed oxygen therapy would reduced the mortality in patients staying longer than 72 hours in ICUs.
- Trial name
- POSDOT (NCT02999932)
- Testing
- SpO2 directed oxygen therapy
- Where
- 13 sites in China
- Volunteers
- 1,706 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
High Grade Gliomas, Hypoxia Brain
Brain Radiotherapy Imaging for High-grade Glioma Using Hypoxia Targeting Through Oxygen-Enhanced Response
High-grade gliomas (HGGs) are the most common type of brain cancer in adults. Life expectancy for patients with HGGs is low. Radiotherapy aims to cure the tumour, but this is hard because HGGs are resistant to treatment.
- Conditions
- High Grade Gliomas, Hypoxia Brain, Glioblastoma (GBM), Brain Neoplasms, Adult
- Trial name
- BRIGHTER (NCT07670455)
- Testing
- Oxygen-Enhanced MRI (OE-MRI)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Lung Cancer
Investigation of the Effects of Functional Inspiratory Muscle Training in Patients With Lung Cancer
Patients' pulmonary functions and diffusion capacity worsen following lung cancer surgery. Diaphragmatic activity and lung compliance decrease due to surgery.
- Trial name
- NCT06245343
- Testing
- Functional inspiratory muscle training group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gazi University