Central Venous Oxygen SaturationNCT07532772
Transfusion Practices in Intensive Care Units: a Hungarian Nationwide Survey
An observational study of Central Venous Oxygen Saturation and Anaemia, run by Pest County Flór Ferenc Hospital at 1 site in Hungary.
Trial summary
The aim of our data analysis-based questionnaire study is to assess the daily transfusion practices used in the care of critically ill patients in intensive care units in Hungary. Read more about this study
- Who is it for?
- Ages 24 years and olderHealthy volunteers can take part
- Conditions the study is for
- Central Venous Oxygen Saturation, Anaemia, Lactate
- What is being tested?
- Survey using a questionnaire.
- How many people
- 97 participants
- Where
- 1 siteHungary
- Study dates
- 1 Jul 2025to 30 Sep 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 24 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Doctors practicing in Hungarian intensive care units
Who may be able to join
- Hungarian anesthesiologists and intensive care practitioners
Who cannot join
- Anesthesiologists and intensive care practitioners working in non-Hungarian intensive care units
Trial locations and contacts
1 site in 1 country.
About this study
The aim of our data analysis-based questionnaire study is to assess the daily transfusion practices used in the care of critically ill patients in intensive care units in Hungary.
The rate and frequency of the application of physiological parameters (serum lactate level, central venous oxygen saturation and arteriovenous carbon dioxide difference, arteriovenous oxygen content difference) recommended as transfusion triggers in the international literature in daily practice will be assessed.
The aim of our survey is not only to collect statistical data, but also to map practical experiences, knowledge, opinions and possible institutional differences. Our aim is to obtain a more comprehensive picture of the operation of the care system, including transfusion activities, and any possible different practices applied in individual institutions, based on the experiences and observations of colleagues directly involved in patient care.
Read the detailed description
The aim of our study is to assess the transfusion practice applied in the care of anemic, critically ill patients in intensive care units in Hungary.
In this study, we examine the rate and frequency of the application of physiological parameters (serum lactate level, central venous oxygen saturation and arteriovenous carbon dioxide difference, arteriovenous oxygen content difference) recommended as transfusion triggers in the international literature in everyday practice.
This is a non-interventional, cross-sectional observational survey study. We use a descriptive, Hungarian-language online questionnaire (Google Forms, Google Inc., Mountain View, CA) survey regarding the transfusion practice of intensive care units in Hungary is based on 15 mandatory and 1 optional question. Participation in the study is completely voluntary and anonymous. No personal or other sensitive data is recorded or stored during the data collection process, so respondents cannot be identified. The names of the responding institutions are registered solely for the purpose of geographical distribution of responses.
The MedCalc statistical analysis software (MedCalc Software bvba, Ostend, Belgium) was used to evaluate the questionnaires, and the results were expressed as a percentage of the number of respondents, using a 95% confidence interval. The normality of the data was checked using the Kolmogorov-Smirnov test. The data were presented as mean ± standard deviation in the case of normal distribution, and median (interquartile range) in the case of non-normal distribution. The relationship between the different subgroups (specialist trainees vs. specialists; university centers vs. public hospitals) was examined using Pearson's correlation. The analysis between the groups was performed using the chi-square test, and the relationship between the use of the PBM program and transfusion triggers was examined using a two-way repeated measures analysis of variance (2-way RM ANOVA). A p<0.05 was considered statistically significant.
- Being tested
- Survey using a questionnaire.
- Keywords
- blood transfusion, transfusion triggers, Patient Blood Management
- Medical subject headings
- Anemia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Survey using a questionnaire.Other
Also called Transfusion
The questionnaire consists of 15 mandatory and 1 optional question.
| Study group | Role | What they receive |
|---|---|---|
| Hungarian intensivists | Hungarian intensivists Receives: Other: Survey using a questionnaire. |
What is being measured
The primary outcome is the main question the study is designed to answer.
The practice of applying physiological parameters that trigger the need for blood transfusion as assessed by the survey questionnaire
The primary endpoint of the study is the use of physiological parameters (serum lactate level, central venous oxygen saturation, arteriovenous carbon dioxide difference and arteriovenous oxygen content difference) indicating oxygen deficiency / oxygen debt underlying tissue oxygenation disorders in determining the indication for red blood cell transfusions in critically ill patients treated in the intensive care unit.
Measured: through study completion (2 months)
Secondary outcomes (4)
Type of departmental transfusion practice
Assessment of the application of restrictive versus liberal transfusion policy
Measured: through study completion (2 months)
Assessment of the existence and availability of Patient Blood Management (PBM) programs in the respondents' institutions based on the survey questionnaire
Number of institutions where the PBM program is available and its elements are applied in everyday practice will be reported
Measured: through study completion (2 months)
Correlation between applying the PBM program guidelines and the use of transfusion triggers as assessed by the survey questionnaire
To examine how the application of the PBM guideline affects respondents' daily practices regarding the use of physiological triggers for blood transfusion.
Measured: through study completion (2 months)
Transfusion protocol
Availability of a written transfusion protocol adapted to the intensive care unit
Measured: through study completion (2 months)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Apr 2026
- Study start1 Jul 2025
- Primary completion30 Sep 2025
- Study completion30 Sep 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Central Venous Oxygen SaturationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 97 participants (actual)
Sponsor and investigators
- Lead sponsor
- Pest County Flór Ferenc Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Zoltan Ruszkai, MD, PhD, Pest County Flór Ferenc Hospital
- Investigators
- Zoltán Ruszkai, MD, PhD, Study director, Flór Ferenc Hospital KistarcsaCsanád Geréd, MD, Study chair, Flór Ferenc Hospital Kistarcsa
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07532772
- Sponsor's protocol ID
- BM/8863-3/2025
- Status last verified
- Apr 2026
- First submitted
- 30 Mar 2026
- Last updated
- 16 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: IPD will not be collected as participation is anonymus.
Study at a glance
From the registry record, last updated by the sponsor on 16 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Transfusion Practices in Intensive Care Units: a Hungarian Nationwide Survey
- ClinicalTrials.gov ID
- NCT07532772
- Acronym / sponsor ID
- BM/8863-3/2025
- Keywords
- blood transfusion, transfusion triggers, Patient Blood Management
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 97 participants (actual)
- Lead sponsor
- Pest County Flór Ferenc HospitalUniversity, hospital or other
- Study start
- 1 Jul 2025 (actual)
- Primary completion
- 30 Sep 2025 (actual)
- Study completion
- 30 Sep 2025 (actual)
- First posted
- 16 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of our data analysis-based questionnaire study is to assess the daily transfusion practices used in the care of critically ill patients in intensive care units in Hungary.
The rate and frequency of the application of physiological parameters (serum lactate level, central venous oxygen saturation and arteriovenous carbon dioxide difference, arteriovenous oxygen content difference) recommended as transfusion triggers in the international literature in daily practice will be assessed.
The aim of our survey is not only to collect statistical data, but also to map practical experiences, knowledge, opinions and possible institutional differences. Our aim is to obtain a more comprehensive picture of the operation of the care system, including transfusion activities, and any possible different practices applied in individual institutions, based on the experiences and observations of colleagues directly involved in patient care.
Detailed description
The aim of our study is to assess the transfusion practice applied in the care of anemic, critically ill patients in intensive care units in Hungary.
In this study, we examine the rate and frequency of the application of physiological parameters (serum lactate level, central venous oxygen saturation and arteriovenous carbon dioxide difference, arteriovenous oxygen content difference) recommended as transfusion triggers in the international literature in everyday practice.
This is a non-interventional, cross-sectional observational survey study. We use a descriptive, Hungarian-language online questionnaire (Google Forms, Google Inc., Mountain View, CA) survey regarding the transfusion practice of intensive care units in Hungary is based on 15 mandatory and 1 optional question. Participation in the study is completely voluntary and anonymous. No personal or other sensitive data is recorded or stored during the data collection process, so respondents cannot be identified. The names of the responding institutions are registered solely for the purpose of geographical distribution of responses.
The MedCalc statistical analysis software (MedCalc Software bvba, Ostend, Belgium) was used to evaluate the questionnaires, and the results were expressed as a percentage of the number of respondents, using a 95% confidence interval. The normality of the data was checked using the Kolmogorov-Smirnov test. The data were presented as mean ± standard deviation in the case of normal distribution, and median (interquartile range) in the case of non-normal distribution. The relationship between the different subgroups (specialist trainees vs. specialists; university centers vs. public hospitals) was examined using Pearson's correlation. The analysis between the groups was performed using the chi-square test, and the relationship between the use of the PBM program and transfusion triggers was examined using a two-way repeated measures analysis of variance (2-way RM ANOVA). A p<0.05 was considered statistically significant.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Hungarian intensivists | – | Other: Survey using a questionnaire.Hungarian intensivists |
Who may qualify
- Ages
- 24 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Doctors practicing in Hungarian intensive care units
Key inclusion criteria (1 listed)
- Hungarian anesthesiologists and intensive care practitioners
Key exclusion criteria (1 listed)
- Anesthesiologists and intensive care practitioners working in non-Hungarian intensive care units
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Survey using a questionnaire.Also: TransfusionThe questionnaire consists of 15 mandatory and 1 optional question. | Other | Hungarian intensivists |
Primary outcome
The practice of applying physiological parameters that trigger the need for blood transfusion as assessed by the survey questionnaire
Time frame: through study completion (2 months)
The primary endpoint of the study is the use of physiological parameters (serum lactate level, central venous oxygen saturation, arteriovenous carbon dioxide difference and arteriovenous oxygen content difference) indicating oxygen deficiency / oxygen debt underlying tissue oxygenation disorders in determining the indication for red blood cell transfusions in critically ill patients treated in the intensive care unit.
4 secondary outcomes
Type of departmental transfusion practice
Time frame: through study completion (2 months)
Assessment of the existence and availability of Patient Blood Management (PBM) programs in the respondents' institutions based on the survey questionnaire
Time frame: through study completion (2 months)
Correlation between applying the PBM program guidelines and the use of transfusion triggers as assessed by the survey questionnaire
Time frame: through study completion (2 months)
Transfusion protocol
Time frame: through study completion (2 months)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Apr 2026.
- Individual participant dataSharing planned: No. IPD will not be collected as participation is anonymus.
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Post Arrest Patients
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Zoltán Ruszkai, MD, PhD study director
Flór Ferenc Hospital Kistarcsa
Csanád Geréd, MD study chair
Flór Ferenc Hospital Kistarcsa
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Central Venous Oxygen Saturation and Anaemia, run by Pest County Flór Ferenc Hospital at 1 site in Hungary.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Hungary. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The practice of applying physiological parameters that trigger the need for blood transfusion as assessed by the survey questionnaire (time frame: through study completion (2 months)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Apr 2026.