Clinical trials: Oxygen Disorders
Hyperbaric Oxygen Therapy, Neuroprotective
Hyperbaric Oxygen Therapy as a Neuroprotective Modality in Pediatric Acquired Brain Injury With Motor Disability
This study aimed to assess the efficacy of hyperbaric oxygen therapy as a neuroprotective intervention in children with acquired brain injury.
- Conditions
- Hyperbaric Oxygen Therapy, Neuroprotective, Pediatric, Acquired Brain Injury
- Trial name
- NCT06954389
- Testing
- Hyperbaric oxygen therapy, Conventional rehabilitation
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Kafrelsheikh University
Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease
Two-Part Dose-Confirming Study of Pulsed Inhaled Nitric Oxide in Subjects With WHO Group 3 Pulmonary Hypertension Associated With COPD
This is a placebo-controlled, double-blind, parallel, randomized, two-part, dose-confirming clinical study characterizing the pharmacodynamic effects of pulsed iNO using the combination product, inhaled nitric oxide/INOpulse DS-C…
- Trial name
- NCT01728220
- Testing
- Inhaled NO delivered via INOpulse DS-C Device
- Where
- 43 sites in United States
- Volunteers
- 159 people
- Sponsor
- Bellerophon Pulse Technologies
Chronic Obstructive Pulmonary Disease (COPD)
Comparative Effectiveness of a Peer-led O2 Infoline for Patients and Caregivers
About 1 million individuals in the US have a prescription for supplemental oxygen (O2). Using O2 can prolong life and increase quality of life.
- Trial name
- PELICAN (NCT02098369)
- Testing
- Written education material (basic), Additional education material, PELICAN-Proactive
- Where
- 6 sites in United States
- Volunteers
- 444 people
- Sponsor
- University of Illinois Chicago
Pre-Term, Respiratory Disease
Closed-loop Oxygen Control in Ventilated Infants Born at or Near Term
Ventilated neonates frequently require supplementary oxygen to allow for adequate oxygen delivery to the tissues and normal cell metabolism.
- Trial name
- NCT05017727
- Testing
- Closed-loop automated oxygen control with Oxygenie Auto-O2 software (SLE6000)
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- King's College Hospital NHS Trust
Non Invasive Test of Pulse and Oxygen Saturation
Ambulatory Measurements of Physiological Parameters
Ambulatory monitoring of physiological variables is important in following the health status of individuals in non-hospital controlled situations.
- Trial name
- LIFEBEAM (NCT01267513)
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Acute Kidney Injury
Effect of Xuebijing in Alleviating Acute Kidney Injury After High-voltage Electrical Burns
High-voltage electrical burns frequently lead to acute kidney injury (AKI), a severe complication with high mortality. This study investigated the clinical efficacy and safety of Xuebijing injection, a traditional Chinese…
- Trial name
- Xuebijing (NCT07026227)
- Testing
- Xuebijing Injection, Conventional Treatment for High-Voltage Electrical Burns and AKI
- Where
- China
- Volunteers
- 96 people
- Sponsor
- The First Hospital of Hebei Medical University
Normative Oxygen Saturation Data Will Help us in, Discharge Planning
Trends In Oxygen Saturation In Healthy Term Infants In The First Few Days Of Life: The "TOST" Study
Oxygen is carried in the blood attached to hemoglobin molecules. Oxygen saturation is a measure of how much oxygen hemoglobin is carrying as a percentage of the maximum it could carry.
- Conditions
- Normative Oxygen Saturation Data Will Help us in, Discharge Planning, Describing Guidelines for Pulse Oximetry Screening, Identification of High Risk Infants
- Trial name
- NCT02095041
- Where
- 4 sites in Canada
- Volunteers
- 293 people
- Sponsor
- University of Calgary
Acute Respiratory Failure, Oxygen Inhalation Therapy
External Validation of the BREF Models
Introduction High-flow oxygen therapy is increasingly used to treat acute respiratory failure (ARF). It can reduce intubation rates without increasing mortality.
- Conditions
- Acute Respiratory Failure, Oxygen Inhalation Therapy, Respiratory Distress
- Trial name
- BREF2 (NCT06669312)
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Istituto Clinico Humanitas
Chronic Heart Failure, Central Sleep Apnea
Nocturnal Oxygen Needs and Central Sleep Apnea in Patients With Chronic Heart Failure.
The aims of this study are to 1) determine the optimal levels of O2 flow which prevent nocturnal O2 desaturation while minimizing periods of hyperoxia during the course of nocturnal oxygen therapy (NOXT) in heart failure patients…
- Trial name
- HO2F (NCT03254212)
- Testing
- Titration of nocturnal oxygen needs to prevent desaturations
- Where
- 2 sites in Canada
- Volunteers
- 14 people
- Sponsor
- Laval University
Chronic Obstructive Pulmonary Disease
High Flow Nasal Cannula During Pulmonary Rehabilitation
The primary purpose of this study is to compare and assess the immediate and long-term effects on pulmonary rehabilitation training with the usage of HFNC or conventional oxygen therapy device.
- Trial name
- NCT03237962
- Testing
- High Flow Nasal Cannula, Nasal Cannula
- Where
- 2 sites in Taiwan
- Volunteers
- 32 people
- Sponsor
- Chang Gung University
Acute Kidney Injury, Children
Renal Oxygen Saturation and Its Association With Acute Renal Injury
Peri-operative renal dysfunction is a major mortality and morbidity cause following cardiac and major vascular surgery. Although several intra-operative strategies are proposed for better outcomes, no effective and fast resulting…
- Conditions
- Acute Kidney Injury, Children, Cardiac Surgery
- Trial name
- NCT03608956
- Where
- Turkey (Türkiye)
- Sponsor
- Marmara University
Exposure to Man-made Visible Light
Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 2 of 7)
NOTE: This is the second of in total 7 sub-studies related to the Ethics Committee of the Canton of Bern Ref. No. KEK-BE 2016-00674.
- Trial name
- NCT02882529
- Testing
- Visible light exposure
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bern
COVID-19
Bidirectional Oxygenation Valve in the Management of Pulmonary Complications of COVID-19
The objective of this study is to determine the safety, feasibility and efficacy of a bidirectional oxygenation Positive End Expiratory Pressure (PEEP) mouthpiece in coronavirus disease 2019 (COVID-19) patients requiring…
- Trial name
- GO2 PEEP (NCT04331366)
- Testing
- GO2 PEEP MOUTHPIECE
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Emory University
Anesthetized Healthy Patients (ASA 1 or 2) in the Supine Position, Excluding Head, Neck and Head Surgeries, Anesthetized Patient With Severe Systemic Disease (ASA 3 or 4)
Gas Kinetics and Metabolism in Anesthesia During Non Steady State
During clinical anesthesia, it is astonishing that CO2 monitoring consists mainly of end-tidal PCO2 to confirm endotracheal intubation and to estimate ventilation, and O2 monitoring consists of a single PO2 measurement to detect…
- Trial name
- NCT00225381
- Testing
- connection of measuring device to anesthesia circuit, drawing of blood sample through an arterial line, placed according to clinical criteria by primary anesthesia team, changing operating room bed position (head down and up position)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Congenital Heart Disease
Value of 6-minute Walk Test in Grown Ups With Congenital Heart Defects (GUCH)
The six-minute walk test is an established submaximal exercise test. Its role in examination of grown-up patients with congenital heart disease (GUCH) is not studied so far.
- Trial name
- NCT02193243
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Postoperative Cognitive Dysfunction
Cerebral Oximetry and Neurological Outcomes in Aortic Arch Surgery Patients
The investigators hypothesize that early intervention to optimize regional cerebral oxygenation detected by cerebral oximetry monitoring during deep hypothermic circulatory arrest (DHCA) for patients undergoing aortic surgery…
- Trial name
- NCT01149148
- Testing
- INVOS Somanetics Cerebral Oximeter
- Volunteers
- 25 people
- Sponsor
- University of Michigan
Surgical Anastomosis
Intraoperative Hyperspectral Imaging in Gastrointestinal Anastomoses
In this study, gastrointestinal anastomoses are examined with a hyperspectral camera.
- Trial name
- HSIGI (NCT03667950)
- Testing
- Hyperspectral Imaging
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Acute Respiratory Failure
Pragmatic Trial Examining Oxygenation Prior to Intubation
Clinicians perform rapid sequence induction, laryngoscopy, and tracheal intubation for more than 5 million critically ill adults as a part of clinical care each year in the United States.
- Trial name
- PREOXI (NCT05267652)
- Testing
- Preoxygenation with Non-Invasive Positive Pressure Ventilation, Facemask Oxygen
- Where
- 16 sites in United States
- Volunteers
- 1,301 people
- Sponsor
- Vanderbilt University Medical Center
Head Trauma, Traumatic Coma
The Effect of Auditory and Tactile Stimuli in Traumatic Coma
This study focused on examining the effects of auditory and tactile stimuli to reduce sensory deprivation on consciousness, oxygen saturation and mean arterial pressure in traumatic coma patients.
- Conditions
- Head Trauma, Traumatic Coma, Nursing Caries
- Trial name
- NCT05195606
- Testing
- Auditory stimulus, Tactile stimulus
- Volunteers
- 90 people
- Sponsor
- Akdeniz University
Hearing Loss, Sensorineural
Hydrogen-oxygen Gas Mixture Inhalation in Patients With Sudden Sensorineural Hearing Loss
Idiopathic sudden sensorineural hearing loss (ISSHL) is defined according to American Academy of Otolaryngology as a hearing loss of at least 30 decibel over 3 contiguous test frequencies occurring within a 72h period.
- Trial name
- NCT04881435
- Testing
- Hydrogen gas therapy
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
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