Clinical trials: Oxygen Disorders
Stroke, Cognitive Impairment
Effects of Hyperbaric Oxygen Combined With Aerobic Exercise on Working Memory Among Stroke Patients
This single-center randomized controlled trial enrolled stroke patients with working memory impairment. Participants were randomly divided into the hyperbaric oxygen combined low-intensity focused ultrasound intervention group…
- Trial name
- NCT07772947
- Testing
- Conventional rehabilitation therapy, Moderate-intensity aerobic exercise, Hyperbaric Oxygen Therapy (HBOT)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University
Pneumoperitoneum
CO2 Absorption During Laparoscopy
CO2 absorption from the pneumoperitoneum increases over time during laparoscopic procedures. Adding 4% of oxygen to the carbon dioxide was shown in rabbits to decrease CO2 resorbtion through prevention of mesothelial hypoxia.
- Trial name
- NCT01340989
- Testing
- alteration of the insufflation gas, full conditioning, standard pneumoperitoneum
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Exercise Therapy, Physical Activity
HOPE (Home-based Oxygen [Portable] and Exercise) for Patients on Long Term Oxygen Therapy (LTOT)
Long term oxygen therapy (LTOT) is proven to increase the survival of patients with respiratory failure, most commonly from diseases such as Chronic Obstructive Pulmonary Disease (COPD).
- Conditions
- Exercise Therapy, Physical Activity, Respiratory Failure, Oxygen Inhalation Therapy
- Trial name
- HOPE (NCT03662438)
- Testing
- Home-based physiotherapy program, Prescription of a Portable Oxygen Concentrator (POC) device
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Singapore General Hospital
Coronary Heart Disease
Estimating Peak Oxygen Uptake in People Living With Coronary Heart Disease
In people living with coronary heart disease (CHD), V̇O2 peak predicts all-cause mortality. V̇O2 peak increases with regular exercise training.
- Trial name
- NCT05505344
- Testing
- VentriJect Seismofit validation
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Sheffield Hallam University
Neurocognitive Disorders
Cognitive Functions on Coronary Surgery
The aim of this study is to examine the effects of different but safe levels of arterial oxygen levels used in cardiac surgeries on cerebral oxygenation during the operation.
- Trial name
- NCT04725708
- Testing
- procedure: cerebral oxygenation intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Surgical Wound, Diabetes
EO2 Oxygen Delivery To Study Success Rate of Surgically Closed Wounds
The investigators will test the efficacy of the novel oxygen diffusion dressing allows delivery tissue oxygenation via TransCu O2® Oxygen Delivery System for use in caring for patients with surgically closed wounds.
- Conditions
- Surgical Wound, Diabetes, Amputation Wound, Incision Wound
- Trial name
- NCT03960463
- Testing
- Transcu O2®
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Baylor College of Medicine
Organophosphate Poisoning
Adding Nebulized Salbutamol to Intravenous Atropine and Oxygen in OP Poisoning
We hypothesize that salbutamol will speed removal of alveolar fluid compared to atropine alone in OP poisoned patients. We propose to compare the effect of two stat doses of nebulized salbutamol (2.5 mg; 5.0 mg), with nebulized…
- Trial name
- SalbutamolOP (NCT02160548)
- Testing
- Standard care, Standard care+ 2.5 mg Salbutamol, Standard care+ 5 mg Salbutamol
- Where
- Bangladesh
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sylhet M.A.G.Osmani Medical College
Sickle Cell Disease
Oxygen Therapy and Pregnancy in Sickle Cell Disease
The purpose of this study is to assess the efficiency of the preventive oxygen therapy on the occurrence of vaso-occlusive complications, which last more than 24 hours and require hospitalisation, in women with sickle cell…
- Trial name
- DRO2G (NCT02813850)
- Testing
- oxygen therapy
- Where
- France
- Volunteers
- 178 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Cancers
A Clinical Study to Explore the Efficacy and Safety of Hyperbaric Oxygen in the Neoadjuvant Treatment of Hormone Receptor Positive Breast Cancer Patients
The goal of this study is to explore the efficacy and safety of hyperbaric oxygen in the neoadjuvant treatment of hormone receptor positive breast cancer patients
- Trial name
- NCT06825949
- Testing
- Hyperbaric oxygen treatment
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Guangdong Provincial People's Hospital
Obstructive Sleep Apnea (OSA), Bariatric Surgery
Desaturations and Nursing Interventions in Patients Receiving Supplemental Oxygen Therapy After Metabolic and Bariatric Surgery
The goal of this observational study is to learn about the effect of supplemental oxygen therapy during the first night after bariatric and metabolic surgery in a population that is not (routinely) tested for obstructive sleep…
- Trial name
- SATBAR (NCT07174674)
- Where
- Netherlands
- Volunteers
- 563 people
- Sponsor
- Rijnstate Hospital
Coronary Artery Disease
Conservation of Red Cell Mass , Oxygen Supply and Demand in Cardiac Surgery
Fifty patients will be enrolled into the study. The purpose of the study is to investigate the relevance of Hct levels in determining need for transfusion during operations employing bypass as well as to test the hypothesis that…
- Trial name
- NCT00660608
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Infant, Newborn, Hypertension, Pulmonary
Inhaled Nitric Oxide Study for Respiratory Failure in Newborns
Respiratory failure in term newborns is associated with increased rates of death and long-term neurodevelopmental problems. This large international multicenter trial randomized newborns who had failed to respond to intensive…
- Conditions
- Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome, Pneumonia, Aspiration
- Trial name
- NINOS (NCT00005776)
- Testing
- Inhaled nitric oxide
- Where
- 20 sites in United States, Canada
- Volunteers
- 235 people
- Sponsor
- NICHD Neonatal Research Network
Heart Failure, Heart Diseases
Effects of Passive Heat Therapy on Oxygen Consumption and Cardiovascular Fitness in Adults
The purpose of this study is to determine if enhanced endothelial arterial distensibility observed with heat therapy translates into improved cardiorespiratory fitness.
- Conditions
- Heart Failure, Heart Diseases, Cardiovascular Diseases, Endothelial Dysfunction
- Trial name
- NCT04026126
- Testing
- Heat Therapy Treatment
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Pulmonary Fibrosis
Oxygen Nanobubble Drink Impact on Exercise in Pulmonary Fibrosis
Approximately 1 in 5 (or 12.7 million adults) in the UK have longstanding respiratory illnesses, and 6.5 million patients report taking prescription medication to ease the burden.
- Trial name
- NCT05711290
- Testing
- Oxygen Nanobubble
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- University of Oxford
COPD, Severe or Very Severe Airflow Obstruction and/or Receiving or Eligible to Receive Long-term Oxygen Therapy
Study of Default Options in Advance Directives
Default options represent the events or conditions that are set into place if no alternatives are actively chosen. The setting of default options has well-established effects on a broad range of human decisions, but its influence…
- Conditions
- COPD, Severe or Very Severe Airflow Obstruction and/or Receiving or Eligible to Receive Long-term Oxygen Therapy, Idiopathic Pulmonary Fibrosis, Other Interstitial Lung Disease Without Curative Therapy
- Trial name
- NCT01817686
- Testing
- Comfort Default AD forms, Life Extension Default AD forms, Standard Default AD forms
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Corporal Michael J. Crescenz VA Medical Center
Preterm Infant, RDS
Effects of Automated Adjustment of FiO2 on Cerebral and Arterial Oxygenation in Preterm Infants
In this study the investigators test the hypothesis that automated FiO2 adjustment increases the time of brain tissue oxygenation within the intended reference range.
- Trial name
- FiO2-Contr (NCT01942473)
- Testing
- Automated FiO2 Control
- Where
- Germany
- Volunteers
- 17 people
- Sponsor
- University of Ulm
Respiratory Distress Syndrome, Hyperoxia
Clinical Evaluation of a Closed Loop Oxygen Controller for Neonatal Respiratory Care
Nearly forty years ago Berran and coworkers tested an analog oxygen controller to maintain incubator oxygen levels for infants suffering neonatal respiratory disease in order to prevent hyperoxia.
- Conditions
- Respiratory Distress Syndrome, Hyperoxia, Prematurity
- Trial name
- NCT00887731
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Hypovolemia, Impaired Oxygen Delivery
Observational Study of Oxygen Delivery During a Fractional Fluid Expansion
Fluid expansion during cardiocirculatory insufficiency was helped by cardiac output monitoring. However, the goal of fluid expansion was to increase the oxygen delivery, which consider cardiac output, but also Haemoglobin which…
- Conditions
- Hypovolemia, Impaired Oxygen Delivery, Cardiac Output, Low
- Trial name
- OR (NCT01826253)
- Testing
- hydroxyethylstarch 130/0.4
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
One Lung Ventilation OLV, Esophageal Atresia
The Effect of Dexmedetomidine on Oxygen During One Lung Ventilation in Pediatric Surgery.
The children who will undergo OLV (one lung ventilation) through general anesthesia will be divided into two groups: The first will be intravenous infusion of dexmedetomidine at 0.4 mcg / kg / hour, and the second will be…
- Conditions
- One Lung Ventilation OLV, Esophageal Atresia, Hydrocystoma, Pneumonectomy
- Trial name
- RCT (NCT04932746)
- Testing
- Dexmedetomidine
- Where
- Syria
- Volunteers
- 110 people
- Sponsor
- Damascus University
Chronic Obstructive Pulmonary Disease
Long-term Oxygen Treatment (LTOT) in Chronic Obstructive Pulmonary Disease: Factors Influencing Survival
The purpose of this prospective cohort study is to determine factors involved in survival in new COPD patients treated by long-term oxygen therapy. Background: long-term oxygen therapy is indicated in patients with severe COPD.
- Trial name
- NCT00871962
- Testing
- OXYGEN SUPPLEMENTATION
- Where
- France
- Volunteers
- 750 people
- Sponsor
- Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche
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