Clinical trials: Oxygen Disorders
Diabetes, Periodontitis
Hyperbaric Oxygen Therapy as Adjunctive Therapy to Scaling and Root-planing in the Management of Periodontitis in Patients With Type 2 Diabetes
Diabetes and Periodontitis are both prevalent diseases affecting millions of Americans. Periodontitis is prevalent among Diabetics.
- Trial name
- NCT02671136
- Testing
- Hyperbaric Oxygen therapy, Conventional Wound Therapies
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Loma Linda University
Type 2 Diabetes
Type 2 Diabetes and Exercise Function in Single Leg Exercises
This study plans to learn more about the effects of type 2 diabetes (T2DM) on exercise blood flow and muscle oxygen uptake. This study will evaluate \& compare exercise function during single leg plantar flexion exercise in a…
- Trial name
- NCT01793909
- Testing
- Single Leg Exercise Training
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Oxygen Consumption
Change in Oxygen Consumption Following Inhalation Beta Agonists in Healthy Adults
Albuterol is the most commonly used β agonist to treat reversible lower airway obstruction. Albuterol contains a racemic mixture of two enantiomers. Levalbuterol contains the single R form enantiomer.
- Trial name
- NCT02802111
- Testing
- Albuterol, Levalbuterol
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Obstructive Sleep Apnea
Comparison of High Flow Nasal Cannula Therapy to Nasal Oxygen as a Treatment for Obstructive Sleep Apnea in Infants
This is a small pilot study that will compare High Flow Nasal Cannula (HFNC) therapy to oxygen nasal cannula therapy on infants who have obstructive sleep apnea (OSA) and are scheduled for a clinically ordered sleep study called…
- Trial name
- NCT02858154
- Testing
- HFNC, Low flow oxygen by nasal cannula
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Sleep Apnea
Estimating Apnea Phenotypes From Polysomnography: Oxygen
This study seeks to employ advanced methods to estimate the individual factors contributing to sleep apnea from standard recordings made during routine clinical sleep studies.
- Trial name
- PSGtraits-O2 (NCT01751971)
- Testing
- Inspired oxygen (40%)
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Brigham and Women's Hospital
Post-concussive Symptoms, Traumatic Brain Injury
Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI)
This is a Phase II randomized trial designed to describe the magnitude of change between baseline and follow-up outcomes for symptom surveys and a battery of neuropsychological tests administered at time points corresponding…
- Trial name
- HOPPS (NCT01306968)
- Testing
- hyperbaric oxygen
- Where
- 5 sites in United States
- Volunteers
- 79 people
- Sponsor
- U.S. Army Medical Research and Development Command
Premature Birth
Neonatal Pulse Oximetry Sensor Study
To validate the SpO2 accuracy, bias, and precision of Medline's reprocessed pulse oximetry sensors as compared to SaO2 in arterial blood samples as assessed by CO-oximetry in neonates.
- Trial name
- NCT05250102
- Testing
- Pulse oximeter sensors
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Medline Industries
Heart Failure, Central Sleep Apnea
The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients With Heart Failure and Central Sleep Apnea
The purpose of this trial is to evaluate the long-term effects of Nocturnal Oxygen Therapy (NOXT) on the mortality and morbidity of patients with stable heart failure and a reduced ejection fraction (HFrEF), already receiving…
- Trial name
- NCT03745898
- Testing
- Oxygen, Room Air
- Where
- 26 sites in United States
- Volunteers
- 98 people
- Sponsor
- Brigham and Women's Hospital
Gastro-esophageal Reflux
Safety Study of Airway Clearance Techniques in Infants.
The purpose of this study is to determine whether three airway clearance techniques ( Bouncing, Assisted Autogenic Drainage ( AAD) and bouncing and AAD) provoke or aggravate gastro-esophageal reflux in infants under the age of 1…
- Trial name
- NCT02128867
- Testing
- Assisted Autogenic Drainage (AAD), bouncing and AAD, bouncing
- Where
- Belgium
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
IVH- Intraventricular Hemorrhage, Extreme Prematurity
Delayed Cord Clamping With Oxygen In Extremely Low Gestation Infants
This study is being conducted to compare the incidence of preterm infants (up to 28+6 weeks GA) who achieve a peripheral oxygen saturation of 80 percent by 5 minutes of life (MOL) given mask CPAP/PPV with an FiO2 of 1.0 during…
- Conditions
- IVH- Intraventricular Hemorrhage, Extreme Prematurity, Hypoxia Neonatal, Hyperoxia
- Trial name
- DOXIE (NCT04413097)
- Testing
- Delayed Cord Clamping with Low Oxygen concentration, Delayed Cord Clamping with High Oxygen concentration
- Where
- 3 sites in United States
- Volunteers
- 140 people
- Sponsor
- Sharp HealthCare
Airway Obstruction, Apnea
Effectiveness of Continuous Negative External Pressure in Preventing Upper Airway Impairment During Routine Colonoscopy
The primary goal of this study is to determine the effectiveness and safety of delivering continuous negative external pressure (cNEP) to the upper airway as a means of preventing episodes of respiratory impairment (RI) such as…
- Conditions
- Airway Obstruction, Apnea, Hypopnea
- Trial name
- NCT01895062
- Testing
- Airway Management System (AMS)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- 5i Sciences, Inc.
Pulmonary Arterial Hypertension
Clinical Study of Pulsed, Inhaled Nitric Oxide Versus Placebo in Symptomatic Subjects With PAH
Phase 3, placebo controlled, double-blind, randomized clinical study to determine safety, tolerability, and efficacy of pulsed, inhaled nitric oxide (iNO) versus placebo in symptomatic subjects with pulmonary arterial…
- Trial name
- INOvation-1 (NCT02725372)
- Testing
- Inhaled Nitric Oxide 75 mcg/kg IBW/hr
- Where
- 109 sites in United States, Australia and 16 more
- Volunteers
- 207 people
- Sponsor
- Bellerophon Pulse Technologies
Stroke
Ventilation Strategies, Anesthetic Techniques and Cerebral Oxygenation in the Beach Chair Position
The seated or "beach chair" position during surgery and general anesthesia decreases brain oxygen levels and can result in stroke. As such, poor neurological outcome following beach chair positioning is a growing concern.
- Trial name
- NCT01535274
- Testing
- Inspired oxygen fraction / end tidal carbon dioxide
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- University of Michigan
Idiopathic Pulmonary Fibrosis, Hypoxemia
Study to Evaluate the Effect of GBT440 Administered to Subjects With IPF on Supplemental Oxygen at Rest
This is an open label study in which eligible IPF subjects who are using supplemental oxygen at rest will receive GBT440 orally daily.
- Trial name
- Zephyr (NCT02989168)
- Testing
- GBT440
- Where
- 9 sites in United States, United Kingdom
- Volunteers
- 14 people
- Sponsor
- Global Blood Therapeutics
Pneumonia, Respiratory Insufficiency
Helmet Continuous Positive Airway Pressure (CPAP) Versus Oxygen Venturi in Severe Acute Respiratory Failure in Pneumonia
The purpose of this study is to compare the efficacy of CPAP application by a helmet and O2 administration by a Venturi mask in terms of achievement of criteria for endotracheal intubation during severe acute respiratory failure…
- Trial name
- NCT01383213
- Testing
- Oxygen therapy, Helmet CPAP
- Where
- Italy
- Volunteers
- 81 people
- Sponsor
- University of Milan
Lung Diseases, Interstitial
Oxygen Therapy Use in Patients With Fibrotic Interstitial Lung Disease
The purpose of this study is to describe initiation and use of oxygen therapy among patients with fibrotic Interstitial Lung Disease (ILD) and to assess the impact of oxygen therapy on clinical outcomes among patients with…
- Trial name
- NCT05957198
- Where
- United States
- Volunteers
- 114,921 people
- Sponsor
- Boehringer Ingelheim
Soft Contact Lenses, Myopia
DAILIES TOTAL1 Versus ACUVUE TruEye - Effects on the Biology of the Ocular Surface and Lid Margin
This is a prospective, single center, randomized, bilateral crossover, dispensing clinical trial to evaluate the effects of the water gradient lens, DAILIES TOTAL1, on the biology of corneal epithelium over two months of daily…
- Trial name
- TruEyeTotal1 (NCT02347631)
- Testing
- Soft Contact Lens - Daily Disposable Alcon Dailies Total 1 and ACUVUE TruEye, Soft Contact Lens - Acuvue TruEye and Alcon DAILIES TOTAL 1.
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Prematurity; Extreme
Use of NIRS in Preterm Population Born at Altitude
Near-infrared spectroscopy (NIRS), is a technology that can provide continuous, non-invasive monitoring of oxygenation in tissue.
- Trial name
- NCT04639583
- Testing
- Near-infrared spectroscopy (NIRS) utilization
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of New Mexico
Bronchiolitis, Heliox
Helium-oxygen Gas Mixtures Delivered by a High Flow Nasal Cannula in Bronchiolitis
The aim of this prospective pilot study is to determine the effect of heliox delivered via a proprietary calibrated heated and humidified high flow nasal cannula (HFNC) system (Vapotherm Precision Flow Heliox) in children ages…
- Conditions
- Bronchiolitis, Heliox, Pediatrics
- Trial name
- NCT02373683
- Testing
- Vapotherm-Heliox
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Case Western Reserve University
Non-Alcoholic Fatty Liver Disease, Insulin Resistance
Effects of High-Intensity Interval Training Exercise in Adolescents With Hepatosteatosis
This is a research study about how short-term exercise intervention affects adolescents with a disease called non-alcoholic fatty liver disease (NAFLD).
- Conditions
- Non-Alcoholic Fatty Liver Disease, Insulin Resistance, High Intensity Interval Training, Childhood Obesity
- Trial name
- NCT04342390
- Testing
- High-Intensity Interval Training (HIIT)
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute