Clinical trials: Oxygen Disorders
Acute Respiratory Failure, Hypoxemic Respiratory Failure
Standard Oxygen Versus High Flow Nasal Cannula Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Failure
First-line therapy of patients with acute respiratory failure consists in oxygen delivery through standard oxygen, high-flow nasal oxygen therapy through cannula or non-invasive ventilation.
- Trial name
- SOHO (NCT04468126)
- Testing
- Standard oxygen, High-flow nasal oxygen therapy
- Where
- France
- Volunteers
- 1,504 people
- Sponsor
- Poitiers University Hospital
Pneumonia, Respiratory Failure
CPAP Versus HFNO for the Treatment of Acute Hypoxemic Respiratory Failure Due to Community Acquired Pneumonia
the study compares two non-invasive respiratory support modalities ie CPAP and High Flow nasal cannula oxygen for the treatment of severe hypoxemic respiratory failure attributed to Community acquired Pneumonia.
- Trial name
- NCT05755425
- Testing
- CPAP, HFNO
- Where
- 2 sites in Greece
- Volunteers
- 100 people
- Sponsor
- Evangelismos Hospital
COPD, Chronic Obstructive Pulmonary Disease
Comparison of 3-Minute Step Test (3MStepT) and 6-Minute Walk Test (6MWT) in COPD Patients
The aim of this study is to compare oxygen desaturation during two tests: the 6 minute walk test and the 3 minute step test, for COPD patients.
- Trial name
- NCT02873780
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier des Pays de Morlaix
Infant Respiratory Distress Syndrome, Ventilator Lung; Newborn
Closed-loop Automatic Oxygen Control (CLAC-4) in Preterm Infants
Two-center, randomised controlled, cross-over clinical trial in preterm infants born at gestational age below 34+1/7 weeks receiving supplemental oxygen and respiratory support (Continous positive airway pressure (CPAP) or…
- Trial name
- CLAC-4 (NCT03163108)
- Testing
- Closed-loop automatic oxygen control (CLAC) fast in addition to RMC, Closed-loop automatic oxygen control (CLAC) slow in addition to RMC
- Where
- 2 sites in Germany
- Volunteers
- 19 people
- Sponsor
- University Hospital Tuebingen
Prematurity, Apnea
Caffeine to Reduce Mechanical Ventilation in Preterm Infants
Most premature infants require mechanical ventilation for prolonged periods of time and a significant proportion of them develop Bronchopulmonary Dysplasia (BPD).
- Conditions
- Prematurity, Apnea, Respiratory Failure
- Trial name
- NCT01751724
- Testing
- Caffeine citrate, Normal saline
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Miami
Obesity &Amp;Amp; Overweight, Elderly (People Aged 65 or More)
Evaluation of Oxygen Reserve Index (ORi) in Obese and Non-Obese Patients Over 65 Years Old
After obtaining ethical committee approval, this single-center, prospective, observational study included volunteer patients of both sexes, aged 65 years and older, with ASA II-III risk scores, who were scheduled for elective…
- Conditions
- Obesity &Amp;Amp; Overweight, Elderly (People Aged 65 or More), Oxygen Reserve Index
- Trial name
- NCT07679724
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
COPD, COPD (Chronic Obstructive Pulmonary Disease)
Impact of Home Non Invasive Ventilation in Patients With Chronic Obstructive Pulmonary Disease Discharged From Assiut University Hospital
This study aims to evaluate the impact of long-term home non-invasive ventilation (NIV) on patients with COPD
- Conditions
- COPD, COPD (Chronic Obstructive Pulmonary Disease), Ventilation Therapy, Non Invasive Ventilation (NIV)
- Trial name
- NCT07198880
- Testing
- BiPAP device (non invasive ventilation), Optimal Medical Management ( long acting beta agonist , long acting muscarinic antagonist and inhaled corticosteroids)
- Volunteers
- 40 people
- Sponsor
- Assiut University
COPD
Closed Loop Oxygen Control in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Nasal High Flow in the Hospital
The trial aims to evaluate whether the Airvo 3 device in OptiO2 mode can maintain patients' SpO2 levels within the target range better than manual oxygen titration in hospitalized COPD patients with hypoxemia/respiratory distress.
- Trial name
- NCT07222410
- Testing
- Closed loop oxygen control, Manual titration
- Where
- 4 sites in United States
- Volunteers
- 70 people
- Sponsor
- Fisher and Paykel Healthcare
Carbon Monoxide Poisoning, Chronic Encephalopathy
Hyperbaric Oxygen for Carbon Monoxide Induced Chronic Encephalopathy
In some patients, a few days or weeks after recovery from carbon monoxide poisoning, new symptoms develop. These can affect mood, ability to think or remember clearly, and movements.
- Trial name
- HACMICE (NCT04118491)
- Sponsor
- University of Nebraska
COVID -19, Respiratory Failure
Use of Oxygen Hoods in Patients Failing on Conventional High-flow Oxygen Delivery Systems, Effects on Oxygenation in Hypoxic COVID-19 Patients. Prospective Cohort Study.
To determine whether the use of oxygen hoods as compared to conventional high-flow oxygen delivery systems, and the effects on oxygenation, mechanical ventilation and mortality rates in hypoxic patients with COVID-19.
- Conditions
- COVID -19, Respiratory Failure, Hypoxia
- Trial name
- NCT04407260
- Testing
- Oxygen Hood
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Northwell Health
Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ), Oxygen
Topical Oxygen Therapy for BRONJ
A randomized clinical trial comparing Blue®m oral gel and autologous PRF membrane as adjuncts to surgical debridement in BRONJ/MRONJ patients.
- Conditions
- Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ), Oxygen, Topical Administration, Wound Healing
- Trial name
- OXY-BRONJ Tria (NCT07725107)
- Testing
- Topical Blue®m application, PRF membrane placement
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Mansoura University
Autism, Oxidative Stress
Effect of Hyperbaric Therapy on Markers of Oxidative Stress in Children With Autism
This study will look at the changes taking place in the blood levels of key markers of oxidative stress. Oxidative stress is the biological equivalent of rust on a car. It changes vital cell chemistry.
- Trial name
- NCT00263367
- Testing
- Hyperbaric Oxygen
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The International Child Development Resource Center
Coronary Artery Disease (CAD)
Endothelial Progenitor Cells and Nitric Oxide in Cardiac Rehabilitation Program Participants
This study will measure blood levels of endothelial progenitor cells (EPCs) and nitric oxide (NO) in patients with coronary artery disease (CAD) who are participating in a 3-month cardiac rehabilitation program at Suburban…
- Trial name
- NCT00308633
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
COPD, Physical Activity
Intervention Study to Investigate Supplemental Oxygen in COPD
The purpose of this trial is to study the effects on exercise capacity, physical activity, inflammatory markers and quality of life of supplemental ambulatory oxygen, to be used during physical activity, in patients with COPD who…
- Conditions
- COPD, Physical Activity, Sedentary
- Trial name
- NCT01783808
- Testing
- Supplemental oxygen
- Where
- Sweden
- Volunteers
- 144 people
- Sponsor
- Uppsala University
Diabetes
Assessment of Blood Glucose Monitoring Systems - Evaluation of Oxygen Dependency
Systems for blood glucose monitoring with glucose oxidase enzyme reaction on test strips can be affected by the partial pressure of oxygen of the blood sample.
- Trial name
- IDT-1326-IU (NCT01871831)
- Testing
- 6 blood glucose monitoring systems for self-testing
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institut für Diabetes-Technologie Forschungs- und Entwicklungsgesellschaft mbH an der Universität Ulm
Central Venous Oxygen Saturation, Anaemia
Transfusion Practices in Intensive Care Units: a Hungarian Nationwide Survey
The aim of our data analysis-based questionnaire study is to assess the daily transfusion practices used in the care of critically ill patients in intensive care units in Hungary.
- Conditions
- Central Venous Oxygen Saturation, Anaemia, Lactate, Transfusion
- Trial name
- NCT07532772
- Testing
- Survey using a questionnaire.
- Where
- Hungary
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Pest County Flór Ferenc Hospital
Acute Hypercapnic Respiratory Failure, Acute Exacerbation of COPD
High VS Low Flow Nasal O2 for Acute Hypercapnic Respiratory Failure
Chronic lung conditions such as smoking related lung damage lead to breathing fail. This results in accumulation of gases such as carbon-di-oxide in the body especially during periods of illness known as exacerbation.
- Trial name
- NCT04640948
- Testing
- High flow nasal therapy, Low flow oxygen
- Where
- 2 sites in United Kingdom
- Volunteers
- 82 people
- Sponsor
- Belfast Health and Social Care Trust
Postoperative Respiratory Complications
Effect of Speaking Aloud After Abdominal Surgery.
Hypoxia and reduced vital capacity is commonly occurring after abdominal surgery. Positive expiratory pressure is one treatment suggested to improve lung function after surgery.
- Trial name
- NCT04276584
- Testing
- Positive expiratory pressure, Speaking loudly during about 3 minutes
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Umeå University
Respiratory Failure
Hyperoxia, Erythropoiesis and Microcirculation in Critically Ill Patient
Prospective observational study in 40 adult critically ill patients. Patients were eligible if they were mechanically ventilated with an FiO2 ≤0.5 and PaO2/FiO2 ≥200 mmHg and hemodynamically stable with a hemoglobin ≥9 g/dL, no…
- Trial name
- NCT02481843
- Testing
- 2 hours of hyperoxia (FiO2 = 1)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Università Politecnica delle Marche
COVID-19
Nitrate-based Nutritional Formula for Oxygen Saturation and Patient-reported Outcomes in Covid-19
A preliminary open-label case report demonstrated the beneficial effects of an innovative nitrate-based nutritional formula on oxygen saturation in patients with COVID-19.
- Trial name
- COVID-NITRA (NCT05290298)
- Testing
- NITRATE
- Where
- Serbia
- Volunteers
- 52 people
- Sponsor
- University of Novi Sad, Faculty of Sport and Physical Education
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