Clinical trials: Oxygenation,
Septic Shock, Extracorporeal Membrane Oxygenation Complication
Study on the Efficacy and Timing of ECMO Therapy in Children With Refractory Septic Shock
Severe sepsis and septic shock remain the leading causes of child mortality worldwide. Sepsis is a complex process that ultimately leads to circulation disorders, organ perfusion abnormalities, capillary leakage, tissue hypoxia…
- Trial name
- NCT03948048
- Testing
- ECMO
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Fudan University
Extracorporeal Membrane Oxygenation, Child, Only
ECMO Treatment of Children in China in the Past 10 Years
It is a cross-sectional study to summarize the extracorporeal membrane oxygenation （ECMO）treatment in children in China.
- Trial name
- NCT04709432
- Testing
- ECMO
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Children's Hospital of Fudan University
Rib Fractures, Oxygenation
Deep Breathing Exercises and Incentive Spirometry After Rib Fracture
Chest trauma patients constitute approximately 10-15% of all traffic accidents. Many complications may occur after chest trauma, including rib fracture, pneumothorax, hemothorax, lung contusion, flail chest, atelectasis…
- Trial name
- NCT06853002
- Testing
- Breathing exercise with spirometry, Breathing exercise with deep breathing method
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Samsun University
Extra Corporeal Membrane Oxygenation
Acute Neurological Complications and Neurodevelopmental Outcome in Children Undergoing Extracorporeal Membrane Oxygenation.
The purpose of this retrospective study is to describe the different types of acute neurologic complications in children who underwent extracorporeal membrane oxygenation (ECMO), and their risk factors.
- Trial name
- NeurECMO (NCT04519528)
- Testing
- DENVER scale (under 2 years old) or Pediatric Cerebral Performance Category (PCPC) score (over 2 years old), Pediatric Quality of Life Inventory™ (PedsQL)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Apneic Oxygenation, Endolarengeal Surgery
Oxygen Reserve Index (ORi) in Identifying Desaturation
This randomized clinical trial investigates whether Oxygen Reserve Index (ORi) monitoring enables earlier detection of impending hypoxemia compared with conventional pulse oximetry during apneic intermittent ventilation in adult…
- Conditions
- Apneic Oxygenation, Endolarengeal Surgery, Oxygen Reserve Index
- Trial name
- NCT07415161
- Testing
- oxygen monitoring techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Hyperoxemia, Intraoperative Oxygen Therapy
Oxygen Reserve Index-Guided Oxygen Titration During Surgery in the Beach Chair Position
This study aims to evaluate whether guidance by the Oxygen Reserve Index (ORi) improves inspiratory oxygen fraction (FiO₂) titration compared with conventional pulse oximetry (SpO₂)-guided oxygen administration in adult patients…
- Conditions
- Hyperoxemia, Intraoperative Oxygen Therapy, Beach Chair Position, Cerebral Oxygenation
- Trial name
- ORI-BCP (NCT07404267)
- Testing
- ORi-Guided FiO₂ Titration, SpO₂-Guided FiO₂ Titration
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Muscle Fatigue and Muscle Oxygenation
Grastion and Percussion Therapy
The study aims to investigate the effects of percussion therapy and instrument-assisted soft tissue mobilization (AISM), commonly used in clinical settings, on muscle fatigue, maximum muscle strength, pain threshold, and muscle…
- Trial name
- NCT07389395
- Testing
- Percussion Therapy, Instrument-Assisted Soft Tissue Mobilization (AISM)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Extracorporeal Membrane Oxygenation, Bleeding
Risk Factors of Bleeding Under Veno Arterial Membrane Oxygenation
Veno arterial extracorporeal membrane oxygenation (VA ECMO) is used, for cardiogenic shock, refractory cardiac arrest and post cardiotomy cardiac failure.
- Conditions
- Extracorporeal Membrane Oxygenation, Bleeding, Complication
- Trial name
- ECMO bleeding (NCT03888833)
- Testing
- ECMO
- Where
- France
- Volunteers
- 278 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Oxygenation, Manual Ventilation
AMBU Bag Manual Ventilation vs. Transport Ventilator Mechanical Ventilation for Transport
This is a clinical trial to compare the oxygenation and ventilation performance between manual ventilation and mechanical ventilation when transporting cardiac patients to the ICU.
- Conditions
- Oxygenation, Manual Ventilation, Mechanical Ventilation, Point of Care Ultrasound
- Trial name
- NCT06006208
- Testing
- Hamilton C1 ventilator during transport to the ICU
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Thomas Jefferson University
Extracorporeal Membrane Oxygenation
Impact of the Implementation of a Referral Veno-venous Extracorporeal Membrane Oxygenation Centre on Mortality
Current evidence suggest that regrouping patient supported by veno-venous ECMO in high-volume centre could improve outcome. A dedicated ECMO unit was implemented in Dijon.
- Trial name
- ECMO UNIT (NCT05154071)
- Testing
- Collection of medical data
- Where
- France
- Volunteers
- 172 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Oxygenation Index
Effects of Different Inhaled Oxygen Concentrations on Lung Function in Older Patients After Laparoscopic Gastrointestinal Surgery Under General Anesthesia
This was a multicenter, prospective, parallel-grouping, randomized controlled clinical study comparing low FiO2 (40%) and high FiO2 (80%) levels in older patients undergoing laparoscopic gastrointestinal surgery.
- Trial name
- NCT06359106
- Testing
- 80% Oxygen, 40% Oxygen
- Where
- 16 sites in China
- Volunteers
- 1,176 people
- Sponsor
- China Medical University, China
Cardiac Arrest, Extracorporeal Membrane Oxygenation
Predictors for Survival and Good Neurological Outcome in E-CPR and Non CPR Treated Patients
In ECPR, where CPR times often range from 30 to 120 minutes, only patients with good circulation during CPR survive, while non-survivors commonly suffer from anoxic brain injury.
- Conditions
- Cardiac Arrest, Extracorporeal Membrane Oxygenation, Hypoxia-Ischemia, Brain
- Trial name
- NCT04198792
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 700 people
- Sponsor
- Sahlgrenska University Hospital
Venoarterial Extracorporeal Membrane Oxygenation, Renal Replacement Therapy
Evaluation of Integrated Versus Parallel Connection for Renal Replacement Therapy in ECMO Patients
Extracorporeal membrane oxygenation (ECMO) is an extra-corporeal assistance used in case of respiratory or circulatory failure. In case of circulatory failure, ECMO is in the veno-arterial configuration (VA-ECMO).
- Conditions
- Venoarterial Extracorporeal Membrane Oxygenation, Renal Replacement Therapy, Acute Kidney Injury
- Trial name
- EPIC-ECMO (NCT06038162)
- Testing
- Parallel connection, Integrated connection
- Where
- 12 sites in France
- Volunteers
- 158 people
- Sponsor
- Hospices Civils de Lyon
Constipation, Arterial Stiffness
Acute Effects of Abdominal Massage on Arterial Stiffness, Muscle Oxygenation and Exercise Capacity in Constipation
Constipation is defined as having bowel movements fewer than three times per week or experiencing subjective complaints such as a sensation of incomplete evacuation, abdominal bloating, tightness, restlessness, or discomfort…
- Conditions
- Constipation, Arterial Stiffness, Muscle Oxygenation
- Trial name
- NCT07352449
- Testing
- Abdominal massage, SphygmoCOR XCEL, Moxy Monitor
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gazi University
Extracorporeal Membrane Oxygenation Complication
Anticoagulation-free VV ECMO for Acute Respiratory Failure
Currently international experts recommend therapeutic anticoagulation for veno-venous extracorporeal membrane oxygenation (VV-ECMO).
- Trial name
- A-FREE ECMO (NCT04273607)
- Testing
- Subcutaneous Heparin
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Damian Ratano
Intraoperative Oxygenation and Pulmonary Mechanics
Effects of Magnesium Sulfate on Oxygenation and Lung Mechanics During One-Lung Ventilation
This prospective observational study aims to evaluate the effects of intravenous magnesium sulfate on intraoperative oxygenation and lung mechanics in patients undergoing thoracic surgery with one-lung ventilation.
- Trial name
- NCT07325773
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Marmara University
Arterial Stiffness, Football Players
Arterial Stiffness Intercostal Muscle Oxygenation and Aerobic-Anaerobic Capacity in Elite American Football Players
American football has become an increasingly popular sport in Türkiye, and one of the key determinants of success in this discipline is the development of strong aerobic and anaerobic exercise capacities.
- Conditions
- Arterial Stiffness, Football Players, Muscle Oxygenation
- Trial name
- NCT07319962
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gazi University
Extracorporeal Membrane Oxygenation Complication
Transplantation of Autologously Derived Mitochondria Following Ischemia
The investigators propose a robust therapeutic intervention to ameliorate myocardial ischemia/ reperfusion injury and significantly decrease morbidity and mortality in patients requiring extracorporeal membrane oxygenation…
- Trial name
- NCT02851758
- Testing
- autologous mitochondria transplantation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Boston Children's Hospital
Extracorporeal Membrane Oxygenation, Cardiac Arrest
ON-SCENE Initiation of Extracorporeal CardioPulmonary Resuscitation During Refractory Out-of-Hospital Cardiac Arrest
Hypothesis: Implantation of on-scene ECPR by the HEMS teams in patients with sustained out-of-hospital cardiac arrest, results in the rapid return of circulation and, thus, improved survival and less neurological impairment…
- Trial name
- ON-SCENE (NCT04620070)
- Testing
- ECPR
- Where
- 4 sites in Netherlands
- Volunteers
- 221 people
- Sponsor
- Erasmus Medical Center
Compartment Syndrome of Leg, Extracorporeal Membrane Oxygenation Complication
Continuous Compartment Pressure Monitoring for Compartment Syndrome in VA-ECMO Patients
Acute compartment syndrome (ACS) is a surgical emergency that can develop in patients on extracorporeal membrane oxygenation (ECMO).
- Conditions
- Compartment Syndrome of Leg, Extracorporeal Membrane Oxygenation Complication, Limb Ischemia, Limb Ischemia, Critical
- Trial name
- VA-ECMO (NCT05830721)
- Testing
- MY01 + Standard of Care, 14-Gauge Slit Catheter + Standard of Care, Standard of Care
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Johns Hopkins University