Clinical trials: Oxygenation,
Prostate Cancer, Physical Activity
Exercise for Improving Prostate Oxygenation in Prostate Tumors (Exipox)
Previous research into metabolic and hypoxic markers has found evidence of preclinical impact of exercise on prostate tumor blood flow and oxygenation in rodents .
- Conditions
- Prostate Cancer, Physical Activity, Hypoxia
- Trial name
- EXIPOX (NCT03365076)
- Testing
- Physical activity
- Where
- Norway
- Volunteers
- 1 people
- Sponsor
- University Hospital of North Norway
Cardiogenic Shock
A Study on the Effects of Left Ventricular Unloading in the Setting of VA ECMO Support
REMAP ECMO is a registry based platform in which multiple response adaptive randomized clinical trials (trial domains) will be embedded.
- Trial name
- REMAP ECMO (NCT05913622)
- Testing
- Intra-aortic balloon pump
- Where
- 14 sites in Belgium, Netherlands
- Volunteers
- 430 people
- Sponsor
- Erasmus Medical Center
Diabetes Mellitus
Assessment of Tissue Oxygenation Using Multispectral Imaging
In Canada, the age-standardized prevalence of diabetes is on the rise (increasing from 3.3% in 1998/99 to 5.6% in 2008/2009 Public Health Agency of Canada (July 2011)) and is almost 1 in 10 globally.
- Trial name
- NCT03516864
- Testing
- MIMOSA Imager, Kent Camera
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Intubation
Utah Study Evaluating Apneic Oxygenation for Emergency Department Intubation
This study will determine rates of first pass success without hypoxemia in emergency department intubations with and without the use of apneic oxygenation by nasal cannula.
- Trial name
- USE AP OX (NCT02961933)
- Testing
- Apneic oxygenation, Pre-oxgenation with NRB, NIPPV, BVM
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Intermountain Health Care, Inc.
Renal Stone, Kidney; Complications
Evaluation of Renal Oxygenation by NIRS in Pediatric Endourologic Stone Surgery
The study aims to compare renal oxygenation levels in retrograde intrarenal surgery (RIRS) and ureteroscopy (URS) procedures with a control group.
- Conditions
- Renal Stone, Kidney; Complications, Ureter Stone, Renal Oxygenation
- Trial name
- NCT06110247
- Testing
- NIRS, Taking a blood sample
- Where
- Turkey (Türkiye)
- Volunteers
- 136 people
- Sponsor
- Ankara City Hospital Bilkent
Coronary Artery Disease
Impact of Breathing Maneuvers on the Oxygenation Supply of the Heart Assessed With MRI in Patients With Coronary Artery Disease
Patients with an impaired blood supply of the heart routinely receive oxygen in order to improve or preserve the oxygen supply of the heart muscle in acute cardiac care.
- Trial name
- CADOS-CMR (NCT02233634)
- Testing
- Oxygen, Hyperventilation Breath-hold (HVBH), HVBH with Oxygen
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hyperglycemia, Glucose Intolerance
Effect of Acute Hyperglycemia on Renal Tissue Oxygenation
Diabetes Mellitus (DM) includes several metabolic diseases all characterized by high sugar levels in the blood. Although diabetic nephropathy is widespread, its underlying pathophysiological mechanisms remain poorly understood…
- Trial name
- Glucox (NCT02346149)
- Testing
- glucose 20%
- Where
- Switzerland
- Volunteers
- 19 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Chronic Pain
Local Cerebral Oxygenation in Chronic Pain Patients Utilizing Spinal Cord Stimulation
The primary objective of the study is to determine changes in cerebral nociceptive hemodynamic response (blood oxygenation/flow) before, during and following spinal cord stimulation (SCS).
- Trial name
- NCT06559735
- Testing
- CereVu Device
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- CereVu Medical, Inc.
Acute Respiratory Failure
Pragmatic Trial Examining Oxygenation Prior to Intubation
Clinicians perform rapid sequence induction, laryngoscopy, and tracheal intubation for more than 5 million critically ill adults as a part of clinical care each year in the United States.
- Trial name
- PREOXI (NCT05267652)
- Testing
- Preoxygenation with Non-Invasive Positive Pressure Ventilation, Facemask Oxygen
- Where
- 16 sites in United States
- Volunteers
- 1,301 people
- Sponsor
- Vanderbilt University Medical Center
Other Complications of Surgical and Medical Procedures
SJOV With WNJ in Microlaryngeal Surgery
The key to a successful microlaryngoscopy is adequate operative field exposure and illumination. A variety of airway control procedures has been developed to improve operative exposure.
- Trial name
- WNJ (NCT03840876)
- Testing
- WEI NASAL JET (WNJ)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Cardiac Arrest
Cerebral Oxygenation in Cardiac Arrest and Hypothermia
Data indicate that neurological prognostication is difficult after cardiac arrest if mild therapeutic hypothermia is part of the post resuscitation care.
- Trial name
- CoCaHYp (NCT01531426)
- Testing
- near infrared spectroscopy (INVOS®, Covidien)
- Where
- Germany
- Volunteers
- 94 people
- Sponsor
- Charite University, Berlin, Germany
Hypertension
Effect of Aliskiren and Hydrochlorothiazide on Kidney Oxygenation in Patients With Hypertension
The goal of this project is to evaluate the chronic effect (8 weeks) of RASILEZ 300mg (aliskiren) on renal tissue oxygenation in patients with stage 1-2 hypertension, and to compare the chronic effect (8 weeks) of RASILEZ 300mg…
- Trial name
- NCT01519635
- Testing
- Aliskiren, Hydrochlorothiazide
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Robot-Assisted Radical Prostatectomy
Effect of Control Ventilation, PEEP, and PEEP With ARM in Robot-assisted Radical Prostatectomy
The goal of this clinical trial is to determine whether different ventilatory strategies improve oxygenation and hemodynamic stability in patients undergoing robot-assisted radical prostatectomy under general anesthesia.
- Trial name
- NCT07462689
- Testing
- PEEP group, PEEP + ARM group
- Where
- South Korea
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ilsan Cha hospital
Prostatic Neoplasms
Normal Prostate: Oxygenation of the Prostate Gland in Men Undergoing Prostate Biopsy
This study is based on previous observation that, in men with localized prostate cancer, non-cancerous prostate tissue is hypoxic, and on the known contribution of hypoxia to the progression of cancer.
- Trial name
- NCT00152789
- Testing
- Oxygen measurement - Eppendorf machine
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Cerebral Oxygenation, Low Flow Anesthesia
The Effect Of Low-Flow And Hıgh-Flow Anesthesıa On Intracranıal Pressure
This prospective randomized study was conducted to evaluate the effects of low-flow and high-flow anesthesia on intracranial dynamics and cerebral oxygenation in patients undergoing laparoscopic hysterectomy in the Trendelenburg…
- Conditions
- Cerebral Oxygenation, Low Flow Anesthesia, Optic Nerve Sheath Diameter Measurement
- Trial name
- NCT07514026
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Bursa City Hospital
Diffuse Apneic Oxygenation
EmergeNcy Department Apneic Oxygenation Versus Usual Care During Rapid Sequence Intubation
To determine the impact, if any the application of oxygen during the apnea period of rapid sequence intubation has on patients being intubated in the emergency department.
- Trial name
- ENDAO (NCT02737917)
- Testing
- Oxygen, Standard of care
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- New York City Health and Hospitals Corporation
Emergencies, Anesthesia
Comparison of Three Pre-oxygenation Strategies
Study objective: Comparing the efficacy of three different preoxygenation strategies, i.e. non-rebreather face mask (NRM), bag-valve-mask (BVM) with and BVM without additional positive end-expiratory pressure (PEEP) in three…
- Trial name
- NCT06370689
- Testing
- Preoxygenation
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Diabetes Mellitus
Effectiveness of Intermittent Vacuum Therapy Combined with Aerobic Exercise in Individuals with Diabetes Mellitus
Consequences of the compromised vascular system in diabetes mellitus (DM) are among the most devastating complications. Reduction in blood flow and oxygen uptake of skeletal muscle leads to muscle fatigue and impaired skeletal…
- Trial name
- NCT06292624
- Testing
- Intermittent vacuum therapy (Weyergans High Care® Medial, Germany), Cycling exercise
- Where
- Hong Kong
- Volunteers
- 12 people
- Sponsor
- The Hong Kong Polytechnic University
Pulmonary Disease, Chronic Obstructive
Effects of Acute Long-acting Bronchodilation on Oxygenation and Peripheral Ventilation in COPD
The goal of this clinical trial was to compare the action of long-acting ß2-agonists (LABA-olodaterol) and muscarinic antagonists (LAMA-tiotropium) on tissue oxygenation in COPD considering their impact on proximal and peripheral…
- Trial name
- NCT05927155
- Testing
- LABA, LAMA
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Erasme University Hospital
Oxygen Deficiency
Cerebral Regional Oxygenation with Manual Versus AutoFlow Ventilation
Anesthesia induction is associated with hemodynamic imbalances that can affect the blood flow to major organs. Moreover it can result in deoxygenation as well.
- Trial name
- NCT05834608
- Testing
- Mechanical ventilator-assisted ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Marmara University