Clinical trials: Ozone
Osteoarthritis of the Knee
Intraarticular Ozone Therapy for Pain Control in Osteoarthritis of the Knee
The purpose of this study is to determine whether an intraarticular injection of Ozone into the knee joint is an effective therapy for pain control in patients with osteoarthritis of the knee.
- Trial name
- NCT00832312
- Testing
- ozone-oxygen mixture
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Ben-Gurion University of the Negev
Sepsis
Methylene Blue and Ozone in Early Sepsis
effects of methylene blue and ozone O3 therapy effects in early sepsis management , and their implications upon outcome
- Trial name
- NCT02910765
- Testing
- methylene blue, ozone, saline infusion
- Volunteers
- 40 people
- Sponsor
- Assiut University
Periodontal Diseases
In-office and Domiciliary Use of a New Ozonized Gel for the Management of Periodontal Disease
The aim of this study is to evaluate the efficacy of non-surgical periodontal therapy with supportive home oral care for the treatment of periodontal disease.
- Trial name
- NCT05254288
- Testing
- Chlorhexidine, Ozoral gels
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Pavia
Fibromyalgia
Impact of Major Ozone Autohemotherapy on Sarcopenia Parameters in Fibromyalgia
Fibromyalgia syndrome (FMS) is a chronic and heterogeneous disorder characterized primarily by widespread pain, accompanied by sleep disturbances, fatigue, depressive symptoms, and cognitive dysfunction.
- Trial name
- NCT07680621
- Testing
- Major Ozone Autohemotherapy, Exercise Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sakarya University
Air Pollution
The Role of Macrophage Activation in Lung Injury Following Ozone Exposure
The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone.
- Trial name
- NCT05794087
- Testing
- Clean Air, Ozone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Pulmonary Disease, Chronic Obstructive
Evaluate the Effects of the Drug (SB-656933-AAA) on the Body After a Single Dose in Subjects Who Have Inhaled Ozone
A study to evaluate the effect of SB-656933-AAA on the body after a single dose in subjects who have been challenged with ozone.
- Trial name
- NCT00551811
- Testing
- SB-656933-AAA
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Primary Apical Periodontite
Ozone Therapy in Endodontic Practice, in Vivo Study
The ozone therapy has been coming up as a new therapeutic modality. Medicine has been practicing since XIX century and counted great results. It is indicated for the treatment of 260 different pathologies.
- Trial name
- NCT00946634
- Testing
- Ozone, Control (no last irrigation), Aqueous Ozone
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Knee Osteoarthritis
Comparison of the Therapeutic Effects of Intra-Articular Injection of Ozone and Corticosteroid in Knee Osteoarthritis
This clinical trial aimed to involve patients aged 40-85 years who had been experiencing knee pain for at least 6 months and had received a clinical diagnosis of knee osteoarthritis through radiologic imaging.
- Trial name
- NCT06328270
- Testing
- Ozone - oxygen Therapy, Corticosteroid
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Caries,Dental
Nano-hydroxyapatite and Ozone - Effect on Approximal Initial Caries
Objectives: to assess the efficiency of three methods of enamel remineralization on initial approximal caries: 1. a nano-hydroxyapatite gel, 2. gaseous ozone therapy 3. combination of a nano-hydroxyapatite gel and ozone.
- Trial name
- NCT04147091
- Testing
- ApaCare & Repair
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Pomeranian Medical University Szczecin
Chronic Obstructive Pulmonary Disease (COPD)
Evaluation of the Effect of PUR118 on Ozone Induced Airway Inflammation in Healthy Normal Volunteers
This trial in healthy subjects will assess PUR118's effect on attenuating ozone induced airway inflammation. This trial will establish the tolerability of PUR118 in healthy normal volunteers.
- Trial name
- NCT01690949
- Testing
- PUR118
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pulmatrix Inc.
Wound Heal
The Effects of Ozone Therapy on Wound Healing
the aim of present study was to evaluate effects of ozone therapy on wound healing after gingivectomy and gingivoplasty operations as a model of secondary wound healing..
- Trial name
- NCT03655158
- Testing
- ozone device ( Ozonytron XL )
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
SARS-CoV Infection
Efficacy and Safety of Ozonised Oil (HOO) in COVID-19 Patients
The anti-viral efficacy of ozone against RNA viruses is already established. Ozone gas have been already proposed as possible therapy for Covid-19 infection with insofar limited success.
- Trial name
- HOO-COVID (NCT04651387)
- Testing
- Ozonized oil (HOO
- Sponsor
- Neuromed IRCCS
Hypertonia
Grand Autohemo-Therapy With Oxygen-ozone on Patients With Hypertonia
The objective of this clinical study is to evaluate the influence of the Great autohemotherapy with oxygen-ozone (hyperbaric ozone therapy ) to describe the cardiovascular system in patients with resistant hypertension.
- Trial name
- HAB (NCT01902602)
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- Herrmann Apparatebau GmbH
Adhesive Capsulitis, Shoulder Pain
Ultrasound Guided Shoulder Intra-Articular Ozone Injection Versus Pulsed Radiofrequency Application for Shoulder Adhesive Capsulitis
The aim of this study is to evaluate the efficacy of the ultrasound guided shoulder intra-articular Ozone injection versus pulsed radiofrequency application in patients with shoulder adhesive capsulitis.
- Trial name
- NCT04724317
- Testing
- Steroid Group, Ozone Group, PRF Group
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Ahmed Foula
Post-ischemic Stroke Insomnia
Ozone Autohemotherapy for Ischemic Stroke Sleep Disorder
The purpose of this study is to observe the efficacy and safety of ozonated autohemotherapy in patients of post-ischemic stroke insomnia and to explore its mechanism of action.
- Trial name
- NCT05508113
- Testing
- ozone autohemotherapy
- Where
- 2 sites in China
- Volunteers
- 65 people
- Sponsor
- Mengmeng Chen
Pain, Neck
Clinical Effects of Ozone Therapy in Cervical Disc Hernia
The aim of the study is to evaluate the clinical effects of Ozone-oxygen therapy as therapeutic substance for nucleolysis application in the patients with cervical disc hernia who had chronic pain and weakness on the neck…
- Trial name
- NCT03056911
- Testing
- Ozone
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Sakarya University
Pelvic Toxicity, Radiation Toxicity
Gut Microbiome in Gynecological Cancer Patients With Pelvic Toxicity: Controls Versus Ozone Treatment. (MicrOzoGineTox)
Patients treated for gynecological tumors with radiotherapy (RT) and/or chemotherapy (CT) frequently develop pelvic toxicity (TPIRQT), a condition that can become persistent, progressive, and refractory to standard treatments.
- Conditions
- Pelvic Toxicity, Radiation Toxicity, Chemotherapy Toxicity, Gynecological Tumors
- Trial name
- MicrOGineTox (NCT07259681)
- Where
- 2 sites in Spain
- Volunteers
- 38 people
- Sponsor
- Bernardino Clavo, MD, PhD
Knee Osteoarthristis, Gonarthrosis
Different Ozone Concentrations for Knee Osteoarthritis
Knee osteoarthritis is a common condition that causes pain, stiffness, and difficulty with daily activities. Ozone injection therapy is a minimally invasive treatment that has been increasingly used to relieve symptoms in people…
- Trial name
- NCT07662512
- Testing
- ozone injection
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people
- Sponsor
- Sakarya University
Achilles Tendinopathy (AT)
Ozone Injection vs ESWT for Chronic Achilles Tendinopathy
This randomized controlled clinical trial compares ultrasound-guided local ozone injection, extracorporeal shock wave therapy, and conventional conservative treatment in patients with chronic Achilles tendinopathy.
- Trial name
- NCT07412652
- Testing
- Ultrasound-Guided Local Ozone Injection, Extracorporeal Shock Wave Therapy (ESWT), Conventional Conservative Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Ankara City Hospital Bilkent
Dental, Implant Osseointegration
Validity of Ozonated Olive Oil Gel Versus Injectable Bone Graft
Many of studies have been performed to improve osseointegration and bone density around implants by modifying the implant by adding bone graft or substitute material that increase success of implant.
- Conditions
- Dental, Implant Osseointegration, Ozone Therapy, Bone Graft
- Trial name
- NCT07368114
- Testing
- Immediate implant placement, β-tricalcium phosphate Injectable Bone Graft, Ozonated olive oil gel
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Suez Canal University