Clinical trials: Ozone, active
Dental Caries, Early Caries Lesion
Effect of Ozone Therapy on Remineralization of Initial Caries Lesions in Children
Initial caries lesions can be managed using non-invasive treatment approaches that promote remineralization and prevent lesion progression.
- Trial name
- OZONE-CARIES (NCT07671651)
- Testing
- Ozone Therapy, other
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Neslihan Atmaca
Chronic Pelvic Pain Syndrome (CPPS), Radiation-Induced Disorder
Gene and Molecular Pathways of Ozone Treatment Response in Gynecological Tumor Patients With Chronic Pelvic Pain Secondary to Cancer Treatment
Gynecological cancers, including those affecting the ovaries, uterus, and cervix, represent a significant health burden for women.
- Conditions
- Chronic Pelvic Pain Syndrome (CPPS), Radiation-Induced Disorder, Radiotherapy Side Effects, Side Effect of Chemotherapy
- Trial name
- OzoGynEpigen (NCT06816095)
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Bernardino Clavo, MD, PhD
Epicondylitis, Lateral
Comparison of ESWT and Ultrasound-Guided Ozone Injection in Lateral Epicondylitis
Lateral epicondylitis is a common and often debilitating condition characterized by pain over the lateral aspect of the elbow. Although many patients respond to standard conservative treatments, a subset develops a chronic and…
- Trial name
- NCT07427368
- Testing
- ESWT Device, ozone injection
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ankara City Hospital Bilkent
Caries,Dental
Ozone Application Before Fissure Sealants
Decay is a multifactorial infective degenerative disease of hard dental tissues, caused by Streptococcus mutans and Lactobacillus forming the bacterial biofilm of teeth surfaces.
- Trial name
- NCT04040920
- Testing
- Ozone, Pits and fissure sealants
- Where
- Italy
- Volunteers
- 67 people
- Sponsor
- IRCCS Burlo Garofolo
Lumbar Disc Herniation
Intradiscal Ozone/Oxygen Injection for Treatment of Contained Lumbar Disc Herniation
This study is retrospectively designed and aims to evaluate and summarize safety and performance data in eligible participants who have undergone Intradiscal ozone-oxygen injection for treatment of lumbar disc herniation with the…
- Trial name
- NCT07910422
- Testing
- Intradiscal ozone-oxygene injection
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Beam Research, Inc.
Radiation Toxicity, Chemotherapeutic Toxicity
Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2022 and 2025
The main objective of this study is to analyze the impact on the health-related quality of life of patients with refractory symptoms, who have been referred to the HUGCDN Chronic Pain Unit for adjuvant palliative treatment with…
- Conditions
- Radiation Toxicity, Chemotherapeutic Toxicity, Chemotherapy-induced Peripheral Neuropathy, Delayed Wound Healing
- Trial name
- EPOOzo (NCT05417737)
- Testing
- Ozone therapy
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Bernardino Clavo, MD, PhD
Xerostomia Following Radiotherapy
The Effect of Ozone on Salivary Flow in Patients With Xerostomia and Hyposalivation After Radiotherapy (OZONEXEROSTOMI)
Patients who underwent head and neck radiotherapy and developed xerostomia and/or hyposalivation will be selected. The patients will be randomly assigned into two groups, defined as control and treatment.
- Trial name
- ozonexerostomi (NCT07571356)
- Testing
- Ozone therapy
- Volunteers
- 100 people
- Sponsor
- University of Brasilia
Carpal Tunnel Syndrome Treatment
Effectiveness of Corticosteroid and 5% Dextrose Versus USG-guided Ozone Injections in Patients With Carpal Tunnel Syndrome: Three Blind Randomized Studies
Effectiveness of corticosteroid and 5% dextrose versus USG-guided ozone injections in patients with carpal tunnel syndrome: Three blind randomized studies
- Trial name
- NCT07002892
- Testing
- Ozon treatment, Steroid treatment, Dextrose 5%
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Yunus Burak Bayır
Endometriosis, Ozone Therapy
Ozone Therapy for Women With Endometriosis
To evaluate the action of ozone therapy as an adjuvant treatment in patients with endometriosis. Secondary Objective: To evaluate the efficacy of ozone therapy for pelvic analgesia in women with endometriosis; To compare the…
- Conditions
- Endometriosis, Ozone Therapy, Thermography
- Trial name
- NCT07035522
- Testing
- Ozone therapy
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal do Paraná
Rectal Ozone, Neuroprotector
Rectal Ozone as Neuroprotector Post CNS Insult in Children
This study aims to evaluate the efficacy of rectal ozone therapy as a neuroprotective modality in Pediatric acquired brain injury.
- Conditions
- Rectal Ozone, Neuroprotector, CNS, Insult
- Trial name
- NCT07153627
- Testing
- Rectal ozone sessions, Conventional rehabilitation program
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Al-Azhar University
Air Pollution Exposure, Oxidative Stress
Savannah Environmental Nutrition Study (SENS): Nutrition Intervention to Reduce Air Pollution-Related Airway Inflammation and Oxidative Stress
This pilot clinical trial will evaluate the feasibility and potential health effects of a nutrition-based intervention among adults living in communities affected by air pollution near the Port of Savannah, Georgia.
- Conditions
- Air Pollution Exposure, Oxidative Stress, Airway Inflammation
- Trial name
- NCT07797413
- Testing
- Antioxidant- and Nutrient-Rich Food-Based Nutrition Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Georgia Southern University
Gingival Enlargement
The Effect of Ozone Therapy on Gingivoplasty
Ozone therapy after gingivectomy and gingivoplasty has been found to reduce patients' pain levels and positively impact their quality of life.
- Trial name
- NCT06753305
- Testing
- Gingivectomy and gingivoplasty surgery and periodontal paste +ozone therapy application, Gingivectomy and gingivoplasty surgery and periodontal paste application
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Kutahya Health Sciences University
Pain, Dry Socket
Ozone Oil-based Gel and CHX Gel After Lower Third Molar Removal
Overall, 100 patients of both genders were included in the study, with indication of surgical extraction of lower third molar, positioned similarly after being clinically and radiographically checked by X-ray and…
- Trial name
- NCT07549672
- Testing
- Ozone Oil-based Gel
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Air Pollution
The Role of Macrophage Activation in Lung Injury Following Ozone Exposure
The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone.
- Trial name
- NCT05794087
- Testing
- Clean Air, Ozone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Pelvic Toxicity, Radiation Toxicity
Gut Microbiome in Gynecological Cancer Patients With Pelvic Toxicity: Controls Versus Ozone Treatment. (MicrOzoGineTox)
Patients treated for gynecological tumors with radiotherapy (RT) and/or chemotherapy (CT) frequently develop pelvic toxicity (TPIRQT), a condition that can become persistent, progressive, and refractory to standard treatments.
- Conditions
- Pelvic Toxicity, Radiation Toxicity, Chemotherapy Toxicity, Gynecological Tumors
- Trial name
- MicrOGineTox (NCT07259681)
- Where
- 2 sites in Spain
- Volunteers
- 38 people
- Sponsor
- Bernardino Clavo, MD, PhD
Pulpitis - Irreversible, Ozone
Zinc Oxide Ozonated Olive Oil in LSTR
This study will be carried out to evaluate and compare the clinical and radiographic effect of zinc oxide-ozonated olive oil (ZnO-OO) versus Modified Triple Antibiotic Paste (MTAP) as a Lesion Sterilization and Tissue Repair…
- Conditions
- Pulpitis - Irreversible, Ozone, Pulp Disease, Dental, Primary Teeth
- Trial name
- Zn-OO/MTAP (NCT06854744)
- Testing
- lesion sterlization and tissue repair, Zinc Oxide Ozonated Oil, Modified Triple Antibiotic Paste
- Where
- 2 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tanta University
Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia
Ozone Treatment in Paresthesia (Numbness, Tingling) Secondary to Chemotherapy-induced Peripheral Neuropathy
The goal of this phase II/III randomized clinical trial is to evaluate the effect of adding rectal ozone therapy to the usual management of patients with paresthesia (numbness and/or tingling) due to chemotherapy-induced…
- Conditions
- Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia, Numbness, Tingling
- Trial name
- OzoParQT (NCT06706544)
- Testing
- Ozone therapy
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Bernardino Clavo, MD, PhD
Inguinal Hernia Unilateral, Postoperative Wound Inflammation
Postoperative Ozonated Oil Dressing After Open Inguinal Hernia Repair: A Randomized Pilot Trial
This study looks at whether a special wound dressing containing ozonated oil can reduce early wound inflammation after open inguinal hernia surgery.
- Trial name
- OZONE-HERNIA (NCT07328698)
- Testing
- ozonated oil, Standard Sterile Dressing
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Nigde Omer Halisdemir University
Apical Periodontitis, Oxidative Stress
Effect of Ozone Use in Intracanal Irrigation on Oxidative Stress Level in Teeth With Asymptomatic Apical Periodontitis
This clinical study aims to investigate the oxidative stress-related effects of ozone irrigation in patients with asymptomatic apical periodontitis undergoing root canal treatment.
- Trial name
- NCT07171762
- Testing
- Ozonytron XP, Physiological saline solution (0.9% NaCl)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- KEZBAN MELTEM ÇOLAK
Respiratory Viral Infection
Macrophage Regulation of Ozone-Induced Lung Inflammation
The purpose of this research study to understand how prior respiratory infections affect the susceptibility to lung inflammation following environmental exposures.
- Trial name
- MOLI (NCT05773001)
- Testing
- Ozone
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Robert Tighe, MD