Clinical trials: P-cresol
Chronic Kidney Disease
Inulin and Protein Fermentation in Hemodialysis Patients
An important group of protein-bound uremic retention solutes originate from protein fermentation in the colon. P-cresol is a putrefaction metabolite of tyrosine. Indole is generated by fermentation of tryptophan.
- Trial name
- NCT00695513
- Testing
- BENEO synergy1
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Inflammatory Status, P-cresol
HFR Cartridge and Inflammation
A major limitation of standard hemodialysis is that it does not clear the plasma from interleukin-6 (IL-6) and p-cresol, two uremic toxins responsible for the high cardiovascular risk in end stage renal disease (ESRD).
- Trial name
- HFR (NCT01865773)
- Testing
- HFR dialysis
- Where
- Italy
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Federico II University
Hemodialysis
Effect of Short-term Synbiotic Treatment on Plasma P-cresol Levels in Hemodialysis Patients
The interest on gastrointestinal (GI) dysfunction in hemodialysis has been growing in the last years. it is now accepted that GI dysfunction in dialyzed patients may contribute to systemic microinflammation by promoting gut…
- Trial name
- NCT02311868
- Testing
- SYNBIOTIC (Probinul neutro®)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Federico II University
End-stage Renal Disease, Hemodialysis
Protein-bound Toxin Removal Between Limited Blood Flow Super High-flux Online HDF and High-Efficiency Online HDF
High-efficiency post-dilution online hemodiafiltration (OL-HDF) using high-flux dialyzer and requiring high blood flow rate (BF ≥400 mL/min) has been reported to enhance protein-bound toxin and middle molecular toxin removal and…
- Trial name
- NCT03288922
- Testing
- Limited BF OL-HDF with SHF, High-efficiency OL-HDF
- Where
- Thailand
- Volunteers
- 10 people
- Sponsor
- Chulalongkorn University
Chronic Kidney Disease
The Role of P-cresol and Related Protein Fermentation Metabolites in Chronic Kidney Disease Patients
Study on the natural history of uremic retention solutes in patients with mild-to-moderate chronic kidney disease
- Trial name
- NCT00441623
- Testing
- observational
- Where
- Belgium
- Volunteers
- 499 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Kidney Disease Stage 3-5
Effect of Sevelamer on P-cresol Levels in CKD
The accumulation of p-cresol, a product of the metabolism of aromatic aminoacid operated by resident intestinal bacteria increases the cardiovascular risk of chronic kidney disease (CKD) patients.
- Trial name
- NCT02199444
- Testing
- Sevelamer
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Federico II University
Renal Insufficiency, Chronic
Effect of Pre- and Probiotics on P-cresol Plasma Levels in Patients Bearing a Kidney Allograft
The purpose of this study is to establish whether a short treatment with the synbiotic combination Probinul neutro® may decrease the plasma concentration of the uremic toxin p-cresol in patients bearing a kidney allograft.
- Trial name
- NCT02179229
- Testing
- CONTROL, SYNBIOTIC
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Federico II University
Chronic Kidney Disease
The Effect of Antimicrobial Therapy on the Serum Level of P-cresol in Peritoneal Dialysis Patients
An important subgroup of protein-bound toxins are generated as a result of protein fermentation in the colon. P-cresol is a fermentation metabolite of tyrosine.
- Trial name
- NCT00433342
- Testing
- Flucloxacillin
- Where
- Belgium
- Volunteers
- 9 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Autistic Spectrum Disorder, Constipation
Oral Administration of Polyethylene Glycol (PEG) for 6 Months in Chronically Constipated Autistic Children
Many autistic children suffer from chronic constipation. Gut mobilization was obtained administering polyethylene glycol (PEG) at the dose of 6.9 g/d once a day for 6 months in an open trial involving 21 chronically constipated…
- Trial name
- NCT05025553
- Testing
- Gut mobilization
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- University of Messina
Hemodialysis Complication
Effect of Lactobacillus Rhamnosus on Serum Uremic Toxins in Hemodialysis
Uremic toxins such as p-cresol and phenol are suggested to be associated with higher mortality in hemodialysis patients. The aim of this study was to investigate the effects of probiotics on serum p-cresol level in hemodialysis…
- Trial name
- NCT03527680
- Testing
- Lactobacillus rhamnosus
- Volunteers
- 42 people
- Sponsor
- nooshin dalili
Acute Kidney Injury
A Uremic Toxin Absorbent (AST-120) to Treat Hospital Acquired Acute Kidney Injury
Hospital acquired acute kidney injury is an important negative outcome predictor for hospitalized patients. Uremic toxins accumulated after a given renal insult.
- Trial name
- NCT02687841
- Testing
- AST-120and pentoxyphylline (PTX), pentoxyphylline (PTX)
- Where
- Taiwan
- Volunteers
- 206 people
- Sponsor
- National Taiwan University Hospital
Chronic Kidney Disease
Effect of the Synbiotic Probinul-Neutro® on Gastrointestinal Symptoms and Plasma p-Cresol Level in Chronic Renal Failure
The interest on gastrointestinal (GI) dysfunction in CKD has been growing in the last years. it is now accepted that GI dysfunction in dialyzed patients may contribute to systemic microinflammation by promoting gut dysbiosis and…
- Trial name
- NCT02008331
- Testing
- SYNBIOTIC
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Federico II University
Risk Factors, Renal Progression
P-cresol: Correlation With Glomerular Filtration Rate and Outcome in Chronic Kidney Disease
End-stage renal disease is a global epidemia with an estimated incidence of 7% per year and high morbidity-mortality rate. Early detection of chronic kidney disease (CKD) and intervention for CKD complication is important to…
- Conditions
- Risk Factors, Renal Progression, Death
- Trial name
- NCT00888030
- Testing
- there are no interventions currently listed for this study
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Chronic Kidney Disease
Diurnal Variation of Uremic Solutes in Peritoneal Dialysis
Study on the daytime variation of uremic retention solutes and markers of bone-mineral metabolism in patients with end-stage kidney disease treated with peritoneal dialysis
- Trial name
- NCT01093456
- Where
- Belgium
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
End Stage Renal Disease, Haemodialysis
Combination of Medium Cut-off Dialyzer Membrane and Diet Modification to Alleviate Residual Uremic Syndrome of Dialysis Patients
The study will compare achieved levels of protein-bound uremic toxins with dialysis using a medium cut-off membrane compared to the treatment by online haemodiafiltration with a high-flux dialysis membrane.
- Conditions
- End Stage Renal Disease, Haemodialysis, Diet, Healthy
- Trial name
- NCT04247867
- Testing
- medium cut-off (MCO) dialysis membrane, Dietary fiber mixture (Plantago Psyllium and Inulin), Sodium propionate
- Where
- Slovenia
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Ljubljana