Clinical trials: PAD - Peripheral Arterial Disease
Peripheral Artery Disease
Post-operative Treatment of Diabetic Peripheral Arterial Disease Guided by Platelet Reactivity Unit
To compare the effect of PRU(platelet (P2Y12) reaction units)-guided treatment on the change in 1. time of initial leg pain and time of termination of exercise test by pain, evaluated on the graded stationary bicycle test, 2.
- Trial name
- NCT02762864
- Testing
- platelet (P2Y12) reaction units, ticagrelor, Comparator
- Volunteers
- 200 people
- Sponsor
- Chang Gung Memorial Hospital
Hypertension
A Trial of Telmisartan Prevention of Cardiovascular Disease
The present research is conducted as a randomized, parallel-group, controlled, open study (using the PROBE method) to primarily verify the effects on various biomarkers in high-risk hypertensive patients treated with ARB…
- Trial name
- ATTEMPT-CVD (NCT01075698)
- Testing
- Non-ARB (standard therapy), ARB (Telmisartan)
- Where
- Japan
- Volunteers
- 1,228 people
- Sponsor
- Kumamoto University
Hypertension, Peripheral Artery Disease
Sarpogrelate Drug Interaction
This is a randomized, open-label, single \& multiple-dose, three-sequence, three-period crossover study to investigate the effect of sarpogrelate hydrochloride on the disposition of metoprolol tartrate in healthy male volunteers
- Trial name
- NCT02097511
- Testing
- Sarpogrelate pretreatment, Sarpogrelate, Metoprolol
- Where
- South Korea
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine
Critical Limb Ischemia
Study to Evaluate the Safety and Efficacy of JVS-100 Administered to Adults With Critical Limb Ischemia
This is a double-blind, placebo controlled study designed to evaluate the safety and efficacy of JVS-100 given to adult subjects with critical limb ischemia (CLI).
- Trial name
- NCT01410331
- Where
- 7 sites in United States, India
- Volunteers
- 48 people
- Sponsor
- Juventas Therapeutics, Inc.
Coronary Artery Disease (CAD), Peripheral Artery Disease (PAD)
A Study to Assess the Engagement and Usefulness of Care4Today Digital Platform for Disease Management in Coronary Artery Disease (CAD) and/or Peripheral Artery Disease (PAD) Population
The purpose of this study is to assess the engagement and usefulness of Care4Today® Connect CAD-PAD digital platform in participants with coronary artery disease or peripheral artery disease (CAD or PAD).
- Trial name
- IPACE-CVD (NCT06052319)
- Testing
- Care4Today® Connect CAD-PAD Mobile Application
- Where
- 6 sites in United States
- Volunteers
- 277 people
- Sponsor
- Janssen Scientific Affairs, LLC
Peripheral Artery Disease, Peripheral Arterial Occlusive Disease
The EasyFlype/EasyHiFlype Post Market Clinical Follow-up Study.
The Easy Flype Carbostent™ is a CE-marked nitinol self-expanding stent for superficial femoral artery (SFA) and Easy HiFlype Carbostent™is a CE-marked nitinol self-expanding stent for iliac vessels.
- Trial name
- NCT05616169
- Testing
- Easy Flype/EasyHiFlype
- Where
- 2 sites in Italy
- Volunteers
- 52 people
- Sponsor
- CID S.p.A.
Healthy, Hypercholesterolemia
In Vitro Demonstration of Direct Platelet-Related Effects of PCSK9 Enzyme
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in lipid metabolism and therapeutic target for hypercholesterolemia and atherosclerotic cardiovascular disease (CVD).
- Conditions
- Healthy, Hypercholesterolemia, Hypertension, Overweight
- Trial name
- NCT06675994
- Testing
- PCSK9 Antibody, PCSK9 Enzyme
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- LifeBridge Health
Chronic (> 2 Weeks) Critical Ischemia With Skin Defect in Lower Limbs
Viennese Registry on Patients With Chronic Critical Limb Ischemia
The rationale of this study is to establish a registry to detect and follow patients with CLI treated in Vienna. The Vienna CLI registry is meant to document the incidence, prevalence, and actual outcome of CLI patients in a real…
- Trial name
- NCT01233141
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Medical University of Vienna
PAD
Endovascular Denervation for the Treatment of Patients With Peripheral Arterial Disease
Sympathetic overactivity partly promotes the development of peripheral artery disease which mainly leads to ischemia of the lower limbs.
- Trial name
- EDPAD (NCT05345431)
- Testing
- endovascular denervation, PTA
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Zhongda Hospital
Intermittent Claudication, Peripheral Vascular Diseases
Objective Evaluation of Proximal Ischemia
The whole study is divided in 4 parallel protocols. The first protocol estimates the reliability of the technique through test-retest recordings.
- Trial name
- NCT00152737
- Testing
- Exercise test with Transcutaneous oxygene pressure, Ankle and arm pressure values
- Where
- France
- Volunteers
- 165 people
- Sponsor
- University Hospital, Angers
Intermittent Claudication
Resistance to Aspirin and/or Clopidogrel Among Patients With PAD.
263 patients with peripheral atherosclerosis were examined to evaluate the activity of the platelets during the standard treatment, including aspirin.
- Trial name
- NCT00262561
- Testing
- Aspirin
- Where
- Denmark
- Volunteers
- 263 people
- Sponsor
- Aalborg University Hospital
Peripheral Artery Disease (PAD)
Vascular Physician Offer and Report (VAPOR) Trial
The purpose of the study is to see if vascular physicians (your provider) using a combination of proven smoking cessation tools in an organized way can help vascular patients quit smoking better than usual.
- Trial name
- VAPOR (NCT02220686)
- Testing
- Offer and Report Protocol
- Where
- 8 sites in United States
- Volunteers
- 156 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Peripheral Artery Disease
Clinical Trial for Evaluation of Vermillion's Blood Test to Predict the Probability of Peripheral Artery Disease
Purpose This study is to verify and validate PAD1 as a qualitative serum test which will combine the results of multiple assays into a single numeric result, to be determined by evaluation of the study data.
- Trial name
- PAD-001 (NCT01336426)
- Where
- 10 sites in United States
- Volunteers
- 1,033 people
- Sponsor
- Vermillion, Inc.
Atherosclerosis of Artery, Peripheral Artery Disease
NAC Treatment and Outcomes in Patients With Advanced Atherosclerosis and DM
Atherosclerosis and diabetes are related to coronary artery disease and peripheral artery disease. The mechanisms are related to increased reactive oxygen species (ROS) formation and inflammatory cytokine secretion.
- Conditions
- Atherosclerosis of Artery, Peripheral Artery Disease, Diabetes Mellitus, Inflammation
- Trial name
- RENEWAL (NCT05908513)
- Testing
- N-acetylcysteine
- Where
- 2 sites in China
- Sponsor
- University of Missouri-Columbia
Intermittent Claudication, Peripheral Arterial Disease
York Study of Unloading Shoes for Vascular Intermittent Claudication
Some people experience a cramp-like leg pain during walking that is relieved only by rest. This is called intermittent claudication (IC) and it is a common symptom of peripheral arterial disease.
- Trial name
- YORVIC (NCT02505503)
- Testing
- Unloading shoes, Unadapted control shoe
- Where
- 2 sites in United Kingdom
- Volunteers
- 38 people
- Sponsor
- York Teaching Hospitals NHS Foundation Trust
Peripheral Arterial Disease
Hydrogen Sulfide and Peripheral Arterial Disease
This will be an observational study comparing the plasma levels of free hydrogen sulfide in patients with and without peripheral arterial disease using a novel recently published method of measuring hydrogen sulfide.
- Trial name
- NCT01407172
- Where
- United States
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Atherosclerosis, Angioplasty
Local Paclitaxel Delivery for SFA Disease
To see if restenosis rates of superficial femoral artery atherosclerosis with percutaneous techniques can be improved using paclitaxel.
- Conditions
- Atherosclerosis, Angioplasty, Peripheral Arterial Disease
- Trial name
- IRRITAX (NCT00821028)
- Testing
- Paclitaxel
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Oklahoma
Peripheral Arterial Disease, Cardiovascular Disease
The OPC for Optimal Delivery of Paclitaxel for the Prevention of Endovascular Restenosis - Above and Below the Knee
The purpose of this study is to assess the safety and efficacy of paclitaxel administration using the occlusion perfusion catheter (OPC) for the prevention of restenosis in infrainguinal de novo, restenotic femoropopliteal and…
- Conditions
- Peripheral Arterial Disease, Cardiovascular Disease, Peripheral Vascular Disease
- Trial name
- COPPER-A (NCT02464501)
- Testing
- Paclitaxel administration using the OPC
- Where
- 17 sites in United States
- Volunteers
- 112 people
- Sponsor
- Horizons International Peripheral Group
Peripheral Arterial Disease
Post-Market Evaluation of Active Thrombectomy and Proximal Aspiration During Lower Extremity Tibial Interventions
Post-Market Evaluation of Active Thrombectomy and Proximal Aspiration during Lower Extremity Tibial Interventions
- Trial name
- Protexus 1 (NCT06929832)
- Volunteers
- 20 people
- Sponsor
- Protexa Endovascular, Inc.
Critical Limb Ischemia, Tibialis Vessels Occlusion
Single Versus Multiple Vessels Endovascular Tibial Arteries Revascularization for Critical Limb Ischemia
This study aims to Compare the outcomes of angioplasty for single tibial vessel occlusion versus multiple tibial vessel occlusions in patients with critical limb ischemia.
- Trial name
- NCT07383064
- Testing
- Endovascular Revascularization
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Aswan University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.