Clinical trials: PAD - Peripheral Arterial Disease
Peripheral Arterial Disease, Venous Insufficiency
Evaluation of the Safety of Compressive Socks to Treat Venous Insufficiency in Patients With Peripheral Arterial Disease
Elastic compression stockings are recommended in the treatment venous insufficiency. Degressive compressive stockings have been used for many decades and are characterized by a high pressure applied at the ankle and a decreasing…
- Trial name
- NCT02431819
- Testing
- contention socks
- Where
- 2 sites in France
- Volunteers
- 18 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Critical Lower Limb Ischemia, Critical Limb Ischemia
Evaluation of Carbothera in the Treatment of Foot Ulcers
Foot ulceration usually precedes more serious foot complications such as infection, gangrene or amputation. The risk of developing foot ulcers has been estimated to be higher in individuals with kidney disease.
- Conditions
- Critical Lower Limb Ischemia, Critical Limb Ischemia, Foot Ulcer, Skin Ulceration
- Trial name
- NCT02239419
- Testing
- CO2-Enriched Tap Water (Carbothera), Non-CO2-Enriched Tap Water
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Peripheral Arterial Disease, Superficial Femoral Artery Stenosis
Study of Drug Eluting Peripheral Vascular Stent System in Superficial Femoral Artery Stenosis and /or Occlusion
Evaluation of drug eluting peripheral vascular stent system for the treatment of superficial femoral artery stenosis and / or occlusion, there is better in effectiveness and clinical performance compared with similar products…
- Conditions
- Peripheral Arterial Disease, Superficial Femoral Artery Stenosis, Superficial Femoral Artery Occlusion
- Trial name
- NCT03121430
- Testing
- Drug eluting peripheral vascular stent system, Nitinol Stent System
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Zhejiang Zylox Medical Device Co., Ltd.
Critical Limb Ischemia
Drug-Eluting Balloon Angioplasty Versus Bypass Surgery as First-Line Strategies in Infrageniculate Arterial Disease for Critical Limb Ischemia in Type 2 Diabetic Pacients: a Randomised Controlled Clinical Trial
The aim of this study is to evaluate the outcomes of drug-eluting balloon angioplasty and vein bypass surgery in diabetic patients with critical limb ischemia due to infrapopliteal arterial disease.
- Trial name
- NCT04760119
- Testing
- Vein bypass surgery first strategy, Endovascular treatment first (drug coated balloon angioplasty) strategy
- Where
- Lithuania
- Volunteers
- 40 people
- Sponsor
- Lithuanian University of Health Sciences
Peripheral Vascular Disease, Intermittent Claudication
Effect of Nike FuelBand on Exercise and Function in Claudicants; a Randomised Controlled Trial
This is a randomised controlled study of patients suffering from intermittent claudication (IC), to assess the impact of wearing a Nike FuelBand (NFB) on walking distances, exercise levels and quality of life.
- Trial name
- NCT01822457
- Testing
- Nike FuelBand (NFB)
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Imperial College London
Peripheral Artery Disease
Unacylated Ghrelin to Improve Functioning in PAD
GIFT is a pilot, randomized, double-blinded clinical trial that will examine the effects of unacylated ghrelin on walking ability in people with peripheral artery disease (PAD) compared to placebo.
- Trial name
- GIFTII (NCT04377126)
- Testing
- Ghrelin
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Peripheral Artery Disease
Walking Impairment Questionnaire in PAD
Purpose is to test and validate a new questionnaire (the WELCH questionnaire) to estimate walking capacity in patients with claudication
- Trial name
- WELCH (NCT01114178)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 340 people
- Sponsor
- University Hospital, Angers
Critical Limb Ischemia, Peripheral Arterial Disease
ALD-301 for Critical Limb Ischemia, Randomized Trial
This study will treat patients with such severe lower leg ischemia or vascular compromise that they have pain at rest. The goal is to compare treatment of the patient's painful disorder by injecting cells into the calf of the leg…
- Conditions
- Critical Limb Ischemia, Peripheral Arterial Disease, Peripheral Vascular Disease
- Trial name
- CLI-001 (NCT00392509)
- Testing
- ALDH-br bone marrow cells vs. mononuclear bone marrow cells
- Where
- 5 sites in United States
- Volunteers
- 20 people
- Sponsor
- Aldagen
Peripheral Arterial Disease
Near-Infrared Spectroscopy-Guided Exercise Training in Peripheral Arterial Disease
Background: Patients suffering with atherosclerotic peripheral arterial disease (PAD) have limited therapeutic options to improve claudication.
- Trial name
- NCT03478085
- Testing
- Oxygen guided exercise therapy
- Volunteers
- 18 people
- Sponsor
- Augusta University
Peripheral Vascular Diseases
Autologous Bone Marrow Cell Treatment in Peripheral Atherosclerosis
Implantation of bone marrow cells, including endothelial progenitor cells, into ischemic limbs has been shown to improve collateral vessel formation.
- Trial name
- NCT00306085
- Testing
- Autologous bone marrow cells
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Naples
Peripheral Arterial Disease
Safety and Preliminary Efficacy of Adipose Derived Stem Cells and Low Frequency Ultrasound in PAD
This is a single center, open label, prospective, randomized, controlled study in patients with non- revascularizable moderate or severe lower extremity Peripheral Arterial Disease (PAD) receiving autologous stem cells therapy…
- Trial name
- NCT02756884
- Testing
- LoFU and aADSC, adipose derived stem cells
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Arkansas Heart Hospital
Peripheral Arterial Disease, Lower Extremity Arterial Disease
EverFlex Post Approval Study
This post-approval study is designed to confirm the long-term safety and effectiveness of the EverFlex™ Self-Expanding Stent System for the treatment of atherosclerotic superficial femoral artery (SFA) and proximal popliteal…
- Trial name
- DURABILITY PAS (NCT01680835)
- Testing
- EverFlex™ Self-Expanding Peripheral Stent System
- Where
- 23 sites in United States
- Volunteers
- 108 people
- Sponsor
- Medtronic Endovascular
Peripheral Artery Disease
Online Support for Outpatient Peripheral Arterial Disease Self-management
This study looks to examine whether an online patient tool to monitor factors affecting patients peripheral artery disease can lead to improvements in patients' disease and slow its progression.
- Trial name
- NCT03464006
- Testing
- Online Support Module, Standard of Care
- Volunteers
- 200 people
- Sponsor
- McMaster University
Peripheral Arterial Disease, Critical Limb Ischemia
Use of Thermal Imaging Camera to Assess Perfusion Before and After Vascular Intervention
This is a preliminary prospective observational study measuring change in lower extremity temperature in response to revascularization procedure.
- Conditions
- Peripheral Arterial Disease, Critical Limb Ischemia, Critical Lower Limb Ischemia
- Trial name
- TIC (NCT06544135)
- Testing
- FLIR One Pro LT
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- University Hospitals Cleveland Medical Center
Peripheral Arterial Disease
A Study Evaluating the Endovascular Treatment of Subjects With Stenotic or Restenotic Lesions of the Common Femoral Artery With the Supera Vascular Mimetic Implant Compared to Surgical Common Femoral Artery Endarterectomy
The SUPERSURG RCT trial investigates the efficacy and safety of the endovascular treatment of stenosis or restenosis in the common femoral artery (CFA) of patients presenting with Rutherford classification 2,3 or 4 with a Supera…
- Trial name
- SUPERSURG-RCT (NCT04349657)
- Testing
- Supera Peripheral Stent System treatment group, Endarterectomy treatment group
- Where
- 13 sites in Belgium, Netherlands and 1 more
- Volunteers
- 286 people
- Sponsor
- KANDO Research
Peripheral Arterial Disease
Effects of Different Protocols of Physical Training on Levels of Muscle Strength and Functional Capacity
Introduction: the peripheral obstructive arterial disease is an condition that affects around 15% of the world population interfering in muscle strength, life quality and functional capacity of patients.
- Trial name
- NCT03092336
- Testing
- Electrical Stimulation, Strength training
- Where
- Brazil
- Volunteers
- 73 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Critical Limb Ischemia
Switch to Ticagrelor in Critical Limb Ischemia Anti-platelet Study
Critical Limb Ischemia (CLI) is defined as limb pain that occurs at rest, or impending limb loss that is caused by severe compromise of blood flow to the affected extremity.
- Trial name
- STT-CLIPS (NCT02091921)
- Testing
- Ticagrelor
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Catherization
Cotavance™ Paclitaxel-Coated Balloon Versus Uncoated Balloon Angioplasty for Treatment of In-stent Restenosis in SFA and Popliteal Arteries
In stent restenosis in peripheral artery disease (superficial and popliteal artery) either treated with uncoated or paclitaxel coated balloons.
- Trial name
- NCT01594684
- Testing
- balloon angiolplasty - drug coated balloon (Cotavance, Medrad Inc.), drug coated balloon inflation (Cotavance, Medrad Inc.), uncoated balloon (e.g. Admiral, Medtronic)
- Where
- 6 sites in Germany
- Volunteers
- 112 people
- Sponsor
- Prof. Dr. med. Gunnar Tepe
Cardiovascular Diseases, Heart Failure, Systolic
HeartMate App-Based Remote Monitoring for Cardiovascular Risk Factor Management
This exploratory pilot randomized controlled trial evaluates whether a HeartMate application-based remote patient monitoring (RPM) and digital cardiac rehabilitation program improves cardiovascular, functional, and psychological…
- Conditions
- Cardiovascular Diseases, Heart Failure, Systolic, Coronary Artery Disease, Heart Valve Diseases
- Trial name
- NCT07721584
- Testing
- HeartMate App-Based Remote Cardiac Rehabilitation Program, Usual Care with HeartMate App-Based rPPG Measurement Only
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Intermittent Claudication
Pharmacokinetic Study of Once Daily PMR Compared to Twice Daily Cilostazol IR Tablets in Healthy Volunteers
The study is designed to evaluate the bioequivalency between the test formulations of extended-release tablet of cilostazol (PMR) administered once-daily and the reference formulation of immediate-release tablet of cilostazol…
- Trial name
- NCT03480321
- Testing
- Cilostazol 100 mg, PMR 150 mg, PMR 200 mg
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Genovate Biotechnology Co., Ltd.,
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