Clinical trials: PCA
Hemoglobin SC Disease
Hydroxyurea and Magnesium Pidolate to Treat People With Hemoglobin Sickle Cell Disease
Sickle cell disease (SCD), also known as sickle cell anemia, is an inherited blood disease that can cause intense pain episodes. Hemoglobin SCD (HbSC) is a form of SCD that is characterized by dense red blood cells.
- Trial name
- NCT00532883
- Testing
- Hydroxyurea, Magnesium Pidolate
- Where
- 19 sites in United States
- Volunteers
- 44 people
- Sponsor
- St. Jude Children's Research Hospital
Postoperative Pain
Safety and Efficacy of Patient Controlled Analgesia Using the Sublingual Sufentanil Tablet System (SSTS) in a Fast Track Rehabilitation Program After Total Knee Arthroplasty
The sufentanil sublingual tablet system (SSTS) is an innovative patient-controlled analgesia (PCA) device for the management of acute moderate to severe postoperative pain in hospital settings in adult patients.
- Trial name
- Zalviso (NCT04432428)
- Testing
- Sufentanil Sublingual Tablet
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- University Hospital, Ghent
Post Operative Pain
Comparison of Side Effects of Morphine and Hydromorphone Patient-Controlled Analgesia (PCA)
Both morphine and hydromorphone are pain medications commonly used after surgery. It is thought at the institution that hydromorphone causes less side effects but this has not been studied.
- Trial name
- NCT00385541
- Testing
- Morphine PCA, Hydromorphone PCA
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Healthy
Pharmacokinetic Study for PCA Derivate Formulations
A comparative bioavailability study of PCA slow release versus immediate release formulations, after a single dose to fasting healthy subjects.
- Trial name
- PCA 1 (NCT00729729)
- Testing
- PCA
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Perioperative Analgesia, Hip Replacement, Total
Pericapsular Nerve Group Block Versus Intrathecal Morphine for Analgesia After Total Hip Arthroplasty
The Pericapsular Nerve Group (PENG) block is an effective method for postoperative pain management in patients undergoing primary total hip arthroplasty (THA) via a posterolateral approach.
- Conditions
- Perioperative Analgesia, Hip Replacement, Total, Postoperative Pain, Hip Disease
- Trial name
- NCT07449585
- Testing
- PNEG block, Spinal anesthesia with opioid, Spinal anesthesia without opioid
- Volunteers
- 180 people
- Sponsor
- Medical University of Gdansk
Prostate Cancer
Post-operative or Early Salvage XRT and ADT for High Risk PCa
RATIONALE: Conformal radiation therapy uses a 3-dimensional (3-D) image of the tumor to help focus thin beams of radiation directly on the tumor.
- Trial name
- NCT00949962
- Testing
- antiandrogen therapy, leuprolide acetate, 3-dimensional conformal radiation therapy
- Where
- France
- Volunteers
- 87 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Colorectal Cancer, Pain
Epidural Versus Patient-controlled Analgesia for Reduction in Long-term Mortality Following Colorectal Cancer Surgery
Colorectal cancer is one of the most common cancers in the industrialized world (12% of all cancers). In Sweden, 6000 new cases of colorectal cancer are reported each year, and almost half of these cases result in death.
- Conditions
- Colorectal Cancer, Pain, Other Complications
- Trial name
- EPICOL (NCT01318161)
- Testing
- Ropivacaine + opioid epidurally, Morphine
- Where
- 2 sites in Sweden
- Volunteers
- 221 people
- Sponsor
- Örebro University, Sweden
Post-Operative Pain
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™) for the Treatment of Post-Operative Pain in Patients After Open Abdominal Surgery
The purpose of this study is to compare the efficacy and safety of the Sufentanil NanoTab PCA System/15 mcg to the Placebo Sufentanil NanoTab PCA System for the management of acute moderate to severe post-operative pain after…
- Trial name
- NCT01539642
- Testing
- Sufentanil NanoTab PCA System/15 mcg
- Where
- 12 sites in United States
- Volunteers
- 172 people
- Sponsor
- Talphera, Inc
Idiopathic Scoliosis, Erector Spinae Plane Block
Erector Spinae Plane Block v.s Patient Controlled Analgesia in Correction Surgery for Idiopathic Scoliosis
Scoliosis correction surgery involves extensive surgical wounds, intense intraoperative stimulation, and severe postoperative pain, often necessitating the use of potent opioids.
- Conditions
- Idiopathic Scoliosis, Erector Spinae Plane Block, Patient Controlled Analgesia
- Trial name
- NCT06728046
- Testing
- ESPB, PCA
- Where
- China
- Volunteers
- 40 people
- Sponsor
- West China Hospital
Postoperative Pain, Lumbar Spine Surgery
Effect of Ultrasound-Guided Quadro-Iliac Plane Block on Postoperative Analgesia After Lumbar Spinal Surgery
This prospective observational study aims to evaluate the effect of ultrasound-guided Quadro-Iliac Plane Block (QIPB) on postoperative analgesia in patients undergoing lumbar spinal surgery.
- Conditions
- Postoperative Pain, Lumbar Spine Surgery, Postoperative Analgesia
- Trial name
- NCT07326774
- Testing
- QIPB, LAI
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Respiratory Depression, Sedation
Incidence of Opioid-Induced Respiratory Depression in Medical and Trauma Patients
The primary objective of this prospective, blinded observational study is to correlate assessment of sedation and respiratory status with capnography and pulse oximetry monitoring in hospitalized adult medical and trauma patients…
- Trial name
- NCT03647696
- Sponsor
- Poudre Valley Health System
Acne Vulgaris
Effectivity and Safety of Combination Cream of Salicylic Acid, Aqua Posae Filiformis, Niacinamide, Lipohydroxy Acid, Procerad and Zinc PCA
This clinical study will compare the effectivity and safety of combination cream of Salicylic Acid, Aqua Posae Filiformis, Niacinamide, Lipohydroxy Acid, Procerad, and Zinc PCA as adjuvant therapy for acne vulgaris patients.
- Trial name
- NCT05497323
- Testing
- Combination Cream, Adapalene 0,1% cream
- Where
- 5 sites in Indonesia
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- Dr.dr.Irma Bernadette, SpKK (K)
Pain, Postoperative Pain
Comparison of the Effectiveness of Midpoint Transverse Process to Pleura (MTP) Block and Erector Spinae Plane (ESP) Block in Video-Assisted Thoracoscopic Surgery (VATS) at RS Ngoerah
This randomized, double-blind controlled trial compares two ultrasound-guided fascial plane blocks, the midpoint transverse process to pleura (MTP) block and the erector spinae plane (ESP) block, for postoperative analgesia in…
- Trial name
- MESA-VATS (NCT07868484)
- Testing
- Midpoint Transverse Process to Pleura (MTP) block, Erector spinae plane (ESP) block
- Where
- Indonesia
- Volunteers
- 51 people
- Sponsor
- Udayana University
Acute Pain, Postoperative
Multicenter Study to Compare Intravenous and Oral Acetaminophen for the Treatment of Acute Moderate to Severe Pain
The purpose of this study is to compare intravenous (IV) and oral acetaminophen for the treatment of acute moderate to severe pain in combination with standard patient-controlled analgesia (PCA) in adult subjects following total…
- Trial name
- NCT02746263
- Testing
- IV acetaminophen, Oral acetaminophen, Morphine
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Mallinckrodt
Inguinal Hernia Unilateral, Postoperative Pain
Quadro-Iliac Plane Block for Postoperative Analgesia in Laparoscopic Inguinal Hernia Repair
The goal of this randomized controlled trial is to learn whether an ultrasound-guided quadro-iliac plane block (QIPB) reduces opioid use and pain after laparoscopic inguinal hernia repair in adults aged 18-65 years.
- Conditions
- Inguinal Hernia Unilateral, Postoperative Pain, Opioid Use
- Trial name
- QIPB-LIHR (NCT07878936)
- Testing
- Quadro-iliac plane block
- Volunteers
- 64 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Provide Post Hepatectomy Pain Control
Bilateral External Oblique Intercostal Plane Block in Post Operative Pain Management in Hepatectomy
The majority of cases undergoing hepatectomy suffer from inadequate postoperative analgesia. Therefore, multimodal analgesic techniques are required to relieve pain and discomfort such as intravenous, and epidural analgesia, and…
- Trial name
- EOI (NCT06822309)
- Testing
- External Oblique Intercostal Plane Block, Patient controlled analgesia
- Volunteers
- 40 people
- Sponsor
- Sherif Alaa Embaby
Postoperative Pain, Caesarean Section
Postoperative Pain Management of Caesarean Section
Caesarean section is one of the most frequent surgeries causing severe postoperative pain. Poor management of acute pain can contribute to postoperative complications, late recovery and the development of chronic pain.
- Conditions
- Postoperative Pain, Caesarean Section, Analgesia
- Trial name
- NCT05009771
- Testing
- Intravenous patient-control analgesia, Dinalbuphine sebacate
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- Mackay Memorial Hospital
Analgesia, Patient-Controlled, Epidural Analgesia
Intrathecal Morphine Analgesia vs. Continuous Epidural Analgesia vs. Systemic Analgesia in Colorectal Surgery.
The purpose of this study is to determine which postoperative analgesia is optimal after colorectal surgery. The investigators will compare intrathecal morphine, continuous epidural analgesia and standard systemic analgesia.
- Conditions
- Analgesia, Patient-Controlled, Epidural Analgesia, Anesthesia; Spinal, Morphine
- Trial name
- KOLORIT (NCT03007121)
- Testing
- Morphine intrathecal, Bupivacaine + Sufentanil epidural, Morphine intravenous
- Where
- Czechia
- Volunteers
- 75 people
- Sponsor
- Charles University, Czech Republic
Breast Cancer, Pain, Acute
ESP in Breast Surgery Due to Cancer
Patients scheduled for breast surgery due to cancer. Each patient will be treated with intravenous (i.v.) oxycodone - patient-controlled analgesia (PCA).
- Conditions
- Breast Cancer, Pain, Acute, Anesthesia, Local
- Trial name
- NCT04726878
- Testing
- Erector spinae plane block, General anesthesia, Patient-controlled analgesia
- Where
- Poland
- Volunteers
- 75 people
- Sponsor
- Medical University of Lublin
Lumbar Spinal Stenisis or Lumbar Herniated Intervertebral Disc
The Analgesic Effect of Nefopam on the Fentanyl Based PCA (Patient-controlled Analgesia) After Lumbar Spinal Surgery
Posterior lumbar spinal surgical pain leads to a severe degree of pain, and, hence, various means of pain management are required.
- Trial name
- NCT01808014
- Testing
- nefopam
- Where
- South Korea
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Yonsei University