Clinical trials: PCI
Acute ST Segment Elevation Myocardial Infarction
Effects of N-acetyl Cysteine During Primary Percutaneous Coronary Intervention
The aim of this study is to evaluate the effects of N-acetyl cysteine on major cardiac and cerebral events in patients undergoing primary percutaneous coronary intervention who have moderate to high risk for contrast induced…
- Trial name
- EASE-PRM-PCI (NCT01878344)
- Testing
- NAC, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Suleyman Demirel University
Non-ST-elevation Myocardial Infarction, Multivessel Coronary Artery Disease
Complete Revascularization Versus Culprit Lesion Only PCI in NSTEMI
Prospective, randomized, controlled, multicenter, open-label trial to study whether multivessel percutaneous coronary intervention (PCI) is superior over culprit-lesion only PCI in patients with non-ST-segment elevation…
- Trial name
- CompleteNSTEMI (NCT05786131)
- Testing
- Culprit-lesion revascularization, Non-culprit-lesion revascularization
- Where
- 58 sites in Austria, Germany
- Volunteers
- 3,390 people
- Sponsor
- Leipzig Heart Science gGmbH
Myocardial Infarction (MI), Cardiogenic Shock
Optimal Timing of Microaxial Flow Pump(Impella CP) in AMI-related Cardiogenic Shock
PRIME-SHOCK is a prospective, single-center, open-label, randomized, superiority trial. Eligible participants with AMICS and a clinical decision to use Impella CP will be randomized in a 1:1 ratio before culprit-lesion PCI.
- Conditions
- Myocardial Infarction (MI), Cardiogenic Shock, ST-Segment Elevation Myocardial Infarction(STEMI), Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
- Trial name
- PRIME-SHOCK (NCT07817472)
- Testing
- Routine pre-PCI Impella CP, Selective post-PCI Impella CP
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Chonnam National University Hospital
Coronary Artery Disease With Myocardial Infarction
Pragmatic Trial Comparing Symptom-Oriented Versus Routine Stress Testing in High-Risk Patients Undergoing Percutaneous Coronary Intervention
The primary objective of the POST-PCI trial is to compare the clinical outcomes of a post-percutaneous coronary intervention(PCI) aggressive management strategy of routine noninvasive functional testing to a usual-care strategy…
- Trial name
- POST PCI (NCT03217877)
- Testing
- routine stress testing, No Routine stress testing
- Where
- 11 sites in South Korea
- Volunteers
- 1,700 people
- Sponsor
- Seung-Jung Park
Coronary Artery Disease
Angiomax® or Unfractionated Heparin for Patients Undergoing Percutaneous Coronary Intervention
The objective of the study is to assess the safety and efficacy of Angiomax® (bivalirudin) versus unfractionated heparin (UFH) in patients presenting with stable angina or silent ischemia (positive stress test without chest pain)…
- Trial name
- STATUS PCI (NCT01464671)
- Testing
- Bivalirudin, Heparin
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Stony Brook University
Ischemic Heart Disease, Acute Coronary Syndrome
Parenteral Antiplatelet Agents in Real-world Spanish PCI Patients
This registry will provide exploratory and descriptive information regarding contemporary practice patterns of parenteral antiplatelet therapy in the PCI (Percutaneous Coronary Intervention) setting and will investigate as well…
- Trial name
- PATREAL (NCT05193019)
- Testing
- Parenteral antiplatelet agents
- Where
- 12 sites in Spain
- Volunteers
- 717 people
- Sponsor
- Fundación EPIC
Alpha 1-antitrypsin Deficiency (AATD)
Screening for Alpha-1 Antitrypsin Deficiency in Patients With Airway Obstruction
Brief Summary: This study aims to find out if a genetic condition called Alpha-1 Antitrypsin Deficiency (AATD) is more common in people who have shortness of breath and signs of airway obstruction on their breathing tests.
- Trial name
- AATD-SAO (NCT07152834)
- Testing
- Blood Sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 734 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Coronary Angiography, Percutaneous Coronary Intervention
Radial accEss Crossover for PErcutaneous Coronary Procedures And ouTcome: the REPEAT Study
All patients who undergo to percutaneous coronary diagnostic or interventional procedures through transradial access (TRA) will be screened for inclusion in this prospective observational study and patients with TRA failure…
- Trial name
- REPEAT (NCT05340998)
- Testing
- Transradial access for percutaneous coronary procedures
- Where
- 10 sites in Italy
- Volunteers
- 1,357 people
- Sponsor
- Ospedale Sandro Pertini, Roma
Coronary Artery Diseases
BIOFLOW III Satellite-Italy Orsiro Stent System
Clinical evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES). 500 subjects will be enrolled in this registry.
- Trial name
- NCT02028728
- Where
- 18 sites in Italy
- Volunteers
- 609 people
- Sponsor
- Biotronik Italia S.p.A.
Adult Giant Cell Glioblastoma, Adult Glioblastoma
Radiation Therapy and Gadolinium Texaphyrin in Treating Patients With Supratentorial Glioblastoma Multiforme
Phase I trial to study the effectiveness of radiation therapy and gadolinium texaphyrin in treating patients who have supratentorial glioblastoma multiforme. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Conditions
- Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma
- Trial name
- NCT00004262
- Testing
- conventional surgery, 3-dimensional conformal radiation therapy, stereotactic radiosurgery
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Coronary Artery Disease
A Precision Medicine Approach to Identify Patients Undergoing Elective PCI at Risk of Peri-PCI Myocardial Infarction
Despite the relative safety of PCI with new generation stents, peri-PCI thrombotic complications, including myocardial infarction and myocardial injury, are common in elective PCI, occurring in up to 30% of patients.
- Trial name
- NCT05332262
- Testing
- Assessment of platelet reactivity, Troponin measurement
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Florida
Clopidogrel Non-Responsiveness
The Comparison of Effects Between Increased Dose of Clopidogrel and Addition of Cilostazol
To compare the effect of increased dosing of clopidogrel and adding cilostazol to standard dose of clopidogrel after the insertion of drug-eluting stent in patients with clopidogrel resistance
- Trial name
- 4C-DES (NCT00620646)
- Testing
- aspirin, clopidogrel, aspirin, clopidogrel, cilostazol
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Samsung Medical Center
ACS - Acute Coronary Syndrome, CYP2C19 Polymorphism
CYP2C19 Genotype-Guided P2Y12 Receptor Inhibitor Selection After Complex Percutaneous Coronary Intervention
In Ease Asia clinical trials, P2Y12 inhibitor (ticagrelor or clopidogrel) monotherapy after 3-month dual antiplatelet therapy (DAPT) resulted in a lower incidence of clinically significant bleeding, without increasing risk of…
- Trial name
- NCT06283888
- Testing
- CYP2C19 Genotype Guided DAPT, Conventional DAPT
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Zunyi Medical College
Acute Myocardial Infarction, Percutaneous Coronary Intervention
CardiOvascular Risk and idEntificAtion of Potential High-risk Population in Acute Myocardial Infarction II (COREA-AMI II)
This study is intended to provide contemporary data on the residual cardiovascular risk in all consecutive patients with acute myocardial infarction, especially in patients who survived stably within one-year after percutaneous…
- Conditions
- Acute Myocardial Infarction, Percutaneous Coronary Intervention, Major Adverse Cardiovascular Events, Bleeding
- Trial name
- NCT02806102
- Testing
- Percutaneous coronary intervention, Dual-antiplatelet therapy
- Where
- 2 sites in South Korea
- Volunteers
- 13,000 people
- Sponsor
- Seoul St. Mary's Hospital
ST Segment Elevation Myocardial Infarction
Ischemic Postconditioning in STEMI Patients Treated With Primary PCI
In a prospective, randomized clinical trial the iPOST2 trial will determine whether ischemic postconditioning reduces reperfusion injury and this will translate into improved clinical outcome of heart failure and death for STEMI…
- Trial name
- iPOST2 (NCT03787745)
- Testing
- Ischemic postconditioning, Conventional
- Where
- Denmark
- Volunteers
- 1,800 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Complex Higher Risk Indicated Patients Undergoing PCI
IVUS CHIP China Registry
The goal of this observational study is to learn about in patients with complex coronary lesions undergoing PCI. The main question[s] it aims to answer are: the clinical efficacy and safety of an IVUS-guided approach in patients…
- Trial name
- NCT06274645
- Testing
- The OptiCross High Definition (60 MHz) and OptiCross (40MHz) Intravascular Ultrasound (IVUS) catheter from Boston Scientific
- Where
- China
- Volunteers
- 2,020 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Artery Disease, Percutaneous Coronary Intervention
Naples PCI Registry
The aim of the Naples PCI registry is to collect prospective data on baseline clinical, laboratory, and angiographic characteristics of patients undergoing PCI for acute or chronic coronary artery disease.
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Myocardial Ischemia, Myocardial Infarction
- Trial name
- NCT05248165
- Testing
- PCI
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- Federico II University
ST Elevation Myocardial Infarction
Bivalirudin With Prolonged Full Dose Infusion Versus Heparin Alone During Emergency PCI
This study is aimed to investigate if the bivaliruding with prolonged full dose infusion after PCI is superior to heparin alone in reducing 30-day mortality or major bleeding for patients with STEMI treated with emergency PCI.
- Trial name
- BRIGHT-4 (NCT03822975)
- Testing
- Bivalirudin, unfractionated Heparin
- Where
- 85 sites in China
- Volunteers
- 6,016 people
- Sponsor
- Shenyang Northern Hospital
ST-elevation Myocardial Infarction, Multivessel Coronary Disease
MULTivessel Immediate Versus STAged RevaScularization in Acute Myocardial Infarction -The MULTISTARS AMI Trial
The primary objective of the trial is to compare, in patients presenting with ST segment elevation myocardial infarction (STEMI) and multi-vessel disease (MVD), the safety and efficacy of immediate complete revascularization of…
- Trial name
- MULTISTARS AMI (NCT03135275)
- Testing
- Staged complete PCI, Immediate complete PCI, Synergy™ stent
- Where
- Switzerland
- Volunteers
- 840 people
- Sponsor
- University of Zurich
Patients With Acute Coronary Syndrome
Prasugrel Versus Clopidogrel in Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI)
Background: Both prasugrel and clopidogrel are prescribed drugs which compete as platelet inhibitors in patients with acute coronary syndrome (ACS).
- Trial name
- NCT01090336
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Heidelberg University