Clinical trials: PCO, open to volunteers
Polycystic Ovary Syndrome, Obesity
Effects of GLP-1RAs on Reproductive Outcomes in PCOS and Obesity
The goal of this clinical trial is to examine whether benalutide combined with metformin and healthy lifestyle education in women with PCOS and obesity prior to fertility treatment improves live birth rate and other reproductive…
- Conditions
- Polycystic Ovary Syndrome, Obesity, Infertility, Female
- Trial name
- NCT06775093
- Testing
- GLP-1 receptor agonist, Metformin, healthy lifestyle education
- Where
- China
- Volunteers
- 392 people
- Sponsor
- Peking University Third Hospital
Polycystic Ovary Syndrome (PCOS), Insulin Resistance Syndrome
Evaluation of MG53 (TRIM72) Levels in Women With Polycystic Ovary Syndrome: An Observational Study
Purpose of the Study: This study is being conducted to examine a protein called MG53 (also known as TRIM72) in women with polycystic ovary syndrome (PCOS).
- Trial name
- PCOSMG53 (NCT07094776)
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Havva Betül Bacak
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
IVF\ICSI Outcome in Women With Polycystic Ovary Syndrome
Polycystic ovarian syndrome (PCOS) occurs in 5% to 10% of all women of reproductive age and 50% of women who present with sub-fertility due to anovulatory infertility .
- Trial name
- NCT05756023
- Testing
- the pregnancy rate at IVF / ICSI cycles
- Where
- Egypt
- Volunteers
- 156 people
- Sponsor
- Egymedicalpedia
Polycystic Ovary Syndrome (PCOS)
Brown Adipose Tissue Modulation in Polycystic Ovary Syndrome Using Infrared Thermography
This study will investigate brown adipose tissue-related physiological responses in women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT07896642
- Testing
- inositol
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Health and Technology University
Polycystic Ovary Syndrome (PCOS), Metabolic Dysfunction-Associated Steatotic Liver Disease
Biomarker Panel for PCOS-Associated Liver Steatosis in Adolescent Girls (COMPASS-pedPCOS)
This single-center, prospective, observational, cross-sectional mechanistic pilot study will evaluate whether polycystic ovary syndrome (PCOS) contributes to hepatic steatosis in adolescent girls independently of adiposity.
- Conditions
- Polycystic Ovary Syndrome (PCOS), Metabolic Dysfunction-Associated Steatotic Liver Disease, Pediatric Obesity, Hyperandrogenism
- Trial name
- COMPASSpedPCOS (NCT07731373)
- Testing
- Extended Serum Biomarker and Hormonal Panel, Liver Elastography with Controlled Attenuation Parameter, Targeted Genotyping of PNPLA3 rs738409 and HSD17B13 rs72613567
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Polycystic Ovarian Syndrome in Adolescent Females, Vitamin D Deficiency
Evaluation of the Clinical and Psychological Impact of Vitamin D Replacement in Adolescent Females at Risk for Polycystic Ovarian Syndrome (PCOS)
This study is a double blind, placebo controlled, randomized trial of study subjects with PCOS and low vitamin D to 2 groups- placebo and vitamin D replacement.
- Trial name
- NCT04355572
- Testing
- Vitamin D 4000IU daily
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Puberty, Hyperandrogenism
Acute Progesterone Suppression of Wake vs. Sleep Luteinizing Hormone Pulse Frequency in Pubertal Girls With and Without Hyperandrogenism
The purpose of this study is two-fold. (1) We will determine if in mid- to late pubertal girls without hyperandrogenism (HA), progesterone (P4) acutely reduces waking luteinizing hormone (LH) frequency to a greater extent than…
- Trial name
- CRM003 (NCT00929006)
- Testing
- Micronized progesterone suspension
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Virginia
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Subclinical Hypothyroidism
Best Treatment for Women With Both (Polycystic Ovary Syndrome) PCOS and Subclinical Hypothyroidism
The goal of this randomized controlled trial is to compare letrozole alone versus letrozole plus levothyroxine for ovulation induction in infertile women with both PCOS and subclinical hypothyroidism.
- Conditions
- PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Subclinical Hypothyroidism, Female Infertility
- Trial name
- NCT06041204
- Testing
- Letrozole 2.5mg, Levothyroxine 25 Mcg (0.025 Mg) Oral Tablet
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Muhamed Ahmed Abdelmoaty Muhamed Alhagrasy
Polycystic Ovary Syndrome (PCOS), Thrombophilia
Construction of a Multi-dimensional Risk Assessment System: a Clinical Study of Polycystic Ovary Syndrome Complicated With Thrombophilia
This observational case-control study aims to develop a multidimensional risk assessment model for thrombophilia-related abnormalities in females with polycystic ovary syndrome (PCOS).
- Trial name
- NCT07571096
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Guangdong Women and Children Hospital
PCOS, NAFLD
Androgens and NAFLD Longitudinal Cohort Study
The researchers want to learn how androgens, a type of sex hormone, might affect nonalcoholic fatty liver (NAFLD) in young women over time.
- Conditions
- PCOS, NAFLD, NASH
- Trial name
- NCT06124261
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of California, San Francisco
Polycystic Ovary Syndrome, Glucose Profile
Glucose Profiles in Women With Polycystic Ovary Syndrome
Polycystic ovary syndrome is a very common condition that is associated with metabolic complications. Patients with polycystic ovary syndrome exhibit insulin resistance and are at greater risk to develop type 2 diabetes.
- Conditions
- Polycystic Ovary Syndrome, Glucose Profile, Insulin Resistance, Continuous Glucose Monitoring
- Trial name
- PROGLYSOPK (NCT07483723)
- Testing
- sensor, Age reader
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
PCOS (Polycystic Ovary Syndrome), Obese Adolescents
Lean Beef as Part of a Healthy Meal Plan in Adolescents With Polycystic Ovary Syndrome (PCOS)/Polyendocrine Metabolic Ovarian Syndrome (PMOS)
This pilot randomized controlled study will plan to enroll 36 adolescent females with Polycystic Ovary Syndrome (PCOS)/Polyendocrine Metabolic Ovarian Syndrome (PMOS) to evaluate the effectiveness and feasibility of a tailored…
- Conditions
- PCOS (Polycystic Ovary Syndrome), Obese Adolescents, Overweight (Without Type 2 Diabetes) With Weight-related Comorbidities, Overweight Adolescents
- Trial name
- Beef+ (NCT07780188)
- Testing
- Beef+
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Texas A&M University
Polycystic Ovary Syndrome
Acupuncture for Insulin Resistance in Women With Polycystic Ovary Syndrome
This two-stage clinical research programme aims to evaluate the preliminary effectiveness and safety of acupuncture for improving insulin resistance in women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT07806656
- Testing
- Active Acupuncture, Lifestyle Management
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Peking University Third Hospital
PCOS
Cabergoline & Letrozole Versus Letrozole in Ovulation Induction in PCOS
Does combined Cabergoline and letrozole increase ovulation rate What medical problems do participants have when taking drug Cabergoline and Letrozole ? Researchers will compare drug combination of Cabergoline and letrozole to…
- Trial name
- PCOS OID (NCT07255911)
- Testing
- Letrozole 0.5mg, Cabergoline 0.5 mg
- Where
- Bangladesh
- Volunteers
- 72 people
- Sponsor
- Mst.Sumyara Khatun
Polycystic Ovarian Syndrome
Sitagliptin or BeiDouGen Capsule Improve the Pregnancy Outcome in Patients with PCOS
This study will be carried out under the guidance of professional doctor, patients with PCOS will be treated with Sitagliptin or BeiDouGen capsule or both two to assess their ovarian function and reproductive outcomes, and…
- Trial name
- NCT06587698
- Testing
- Sitagliptin, BeiDouGen, Sitagliptin+BeiDouGen
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking University Third Hospital
Polycystic Ovary Syndrome Health-related Quality of Life
Translation and Validation of the French mPCOSQ (mPCOSQ-F).
This study is a prospective, observational, bicentric study, evaluating the validity and reliability of a French version of the mPCOSQ questionnaire (mPCOSQ-F), used to assess health-related quality of life (HRQOL) in women with…
- Trial name
- NCT07016035
- Testing
- mPCOSQ-F and SF-36
- Where
- France
- Volunteers
- 350 people
- Sponsor
- CHU de Reims
Polycystic Ovarian Syndrome (PCOS), Pregnancy Outcomes
Comparison of Pregnancy Outcomes in Women with Polycystic Ovarian Syndrome with and Without Glucophage
The goal of this clinical trial is to learn if Glucophage (metformin) improves pregnancy outcomes in women with polycystic ovarian syndrome (PCOS). It will also evaluate the safety of Glucophage during pregnancy.
- Trial name
- NCT06713967
- Testing
- Metformin (Glucophage), Standard Care (Diet and Exercise Only)
- Volunteers
- 70 people
- Sponsor
- University of Health Sciences Lahore
Polycystic Ovarian Syndrome (PCOS)
Effects of Wet-Cupping on Polycystic Ovary Syndrome Patients
The goal of this clinical trial is to evaluate whether wet cupping therapy (Hijama) can improve reproductive and metabolic outcomes in women diagnosed with Polycystic Ovary Syndrome (PCOS).
- Trial name
- NCT07169292
- Testing
- Wet-cupping
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Princess Nourah Bint Abdulrahman University
PCOS (Polycystic Ovary Syndrome)
Fecal Microbiota Transplantation for Obese Women With Polyendocrine Metabolic Ovarian Syndrome
This prospective, two-stage clinical trial aims to evaluate the safety, preliminary efficacy, and reproductive outcomes of oral Fecal Microbiota Transplantation (FMT) freeze-dried capsules in overweight and obese patients with…
- Trial name
- FMT-PMOS (NCT07746635)
- Testing
- oral Fecal Microbiota Transplantation
- Where
- China
- Volunteers
- 201 people
- Sponsor
- Shanghai Changzheng Hospital
Polycystic Ovary Syndrome (PCOS)
Protein and Polycystic Ovary Syndrome (PCOS)
Polycystic ovary syndrome (PCOS) is a significant public health problem and is one of the most common hormonal disturbances affecting women of reproductive age.
- Trial name
- NCT07158723
- Testing
- Higher protein dietary pattern, Calorie restriction
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Arkansas, Fayetteville