Clinical trials: PCS
Traumatic Brain Injury, Post-traumatic Stress Disorder
Hyperbaric Oxygen Therapy in Chronic Traumatic Brain Injury or Post-Traumatic Stress Disorder
This is an observational research study whose purposes are to see: 1. if 40 Hyperbaric Oxygen Therapy sessions at 1.5 atmospheres (HBOT 1.5) or more (60, or 80 HBOT's) help, worsen, or have no effect on subjects with chronic…
- Trial name
- NBIRR-1 (NCT01105962)
- Where
- 10 sites in United States
- Volunteers
- 133 people
- Sponsor
- International Hyperbaric Medical Foundation
TBI (Traumatic Brain Injury), Post Concussion Syndrome
Hyperbaric Oxygen Therapy (HBOT) in Chronic Traumatic Brain Injury (TBI)/Post Concussion Syndrome (PCS) and TBI/Post-Traumatic Stress Disorder (PTSD)
This is a pilot trial to see if one or two 40 treatment courses of low pressure hyperbaric oxygen therapy can improve cognition and brain imaging in subjects with either chronic mild-moderate traumatic brain injury (TBI), also…
- Conditions
- TBI (Traumatic Brain Injury), Post Concussion Syndrome, Post Traumatic Stress Disorder, Chronic Post Traumatic Stress Disorder
- Trial name
- NCT00760734
- Testing
- Low pressure hyperbaric oxygen therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Paul G. Harch, M.D.
Mild Traumatic Brain Injury
Quetiapine to Reduce Post Concussive Syndrome After Mild Traumatic Brain Injury (mTBI)
A two site, 2-arm, Phase III randomized pragmatic clinical trial evaluating the effectiveness of quetiapine monotherapy in comparison to Treatment As Usual (TAU) medication management for symptoms experienced by veterans…
- Trial name
- NCT06333990
- Testing
- Quetiapine Fumarate, TAU
- Where
- 2 sites in United States
- Volunteers
- 146 people
- Sponsor
- Foundation for Advancing Veterans' Health Research
Post COVID Syndrome Long Covid
Observational Study With CICR-NAM as a Food for Special Medicinal Purposes in Post-COVID Syndrome (PCS)
In patients with post-COVID syndrome, changes in tryptophan metabolism, energy metabolism, and the gut microbiome may occur. In an earlier nutritional study, patients with COVID-19 recovered their physical performance more…
- Trial name
- CICR-NAM-PCS (NCT07798570)
- Testing
- CICR-NAM
- Volunteers
- 100 people
- Sponsor
- University Hospital Schleswig-Holstein
Prostate Cancer
Comparative Study of Radiotherapy Treatments to Treat High Risk Prostate Cancer Patients
In North America, the number of new cases of prostate cancer increases every year. Many efforts have been made to develop more efficient and safer curative treatments for high risk prostate cancer patients.
- Trial name
- NCT02303327
- Testing
- EBRT + HDR brachytherapy boost, Hypofractionated Dose Escalation Radiotherapy, Androgen deprivation therapy
- Where
- 12 sites in Canada
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Early CPAP Ventilation in COVID-19 Patients
Early CPAP in COVID-19 Patients With Respiratory Failure. A Prospective Cohort Study.
This cohort study aims at prospectively collecting detailed clinical information on patients positive to or suspected of COVID-19 visiting Italian emergency departments (EDs). The objectives of the study are: 1.
- Trial name
- EC-COVID-PCS (NCT04323878)
- Where
- Italy
- Volunteers
- 6,000 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
High Risk Prostate Cancer
ADT De-escalation in Selected High-Risk Prostate Cancer Patients (ADaPPt Trial) a GROUQ Led PCS Study (PCS XIV)
High-risk prostate cancer is usually treated with a combination of radiation therapy and hormone therapy (ADT). Radiation destroys cancer cells, while ADT lowers testosterone, a hormone that prostate cancer cells need to grow.
- Trial name
- NCT07777263
- Testing
- ZOLADEX 10.8 mg
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- Dr. Tamim Niazi
Cardiogenic Shock, Pulmonary Edema Cardiac Cause
Hemodynamic Evaluation of Left Atrial Pressure in Relationship to Pulmonary Capillary Wedge Pressure in Cardio Thoracic Patients
Accurate hemodynamic monitoring is critical in cardiothoracic surgery, where left atrial pressure (LAP) serves as the gold standard for assessing left-sided cardiac filling pressures.
- Trial name
- HEART (NCT07163052)
- Volunteers
- 136 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pelvic Pain Syndrome
MRI & MRV in Pelvic Congestion Syndrome in Females
To investigate the feasibility of MRI and MRV in diagnosis of pelvic congestion syndrome.
- Trial name
- PCS (NCT03252041)
- Testing
- MRI
- Volunteers
- 25 people
- Sponsor
- Assiut University
Post-COVID ME/CFS
Study to Investigate Improvement in Physical Function in SF-36 With Vericiguat Compared With Placebo in Participants With Post-COVID-19 Syndrome
The goal of this clinical trial is to evaluate the therapeutic value of an approved drug (Vericiguat) in patients with post-COVID-19 syndrome, who suffer from profound tiredness or fatigue, regardless of bed rest.The main…
- Trial name
- NCT05697640
- Testing
- Vericiguat Oral Tablet
- Where
- Germany
- Volunteers
- 104 people
- Sponsor
- Charite University, Berlin, Germany
Chronic Fatigue Syndrome/ Myalgic Encephalitis (CFS/ME), Post COVID Syndrome
Effectiveness and Safety of a Tele-Rehabilitation Program on Fatigue and Related Variables in Chronic Fatigue Syndrome and Post COVID Syndrome
This is a randomized, single-blind clinical trial that aims to evaluate the effectiveness of a tele-rehabilitation program based on mindful and conscious movement-based exercise (including adapted yoga, breathing exercises, and…
- Trial name
- NCT06978582
- Testing
- Mindful and conscious movement-based exercise, Conventional exercise
- Where
- Spain
- Volunteers
- 147 people
- Sponsor
- University of Seville
Sepsis, Septic Shock
Optimized Caloric-proteic Nutrition in Septic and Septic Shock Patients
In this pilot randomized prospective controlled trial the investigators intend to compare the use of a nutritional therapy based on caloric intake determined by indirect calorimetry and high protein intake with nutritional…
- Trial name
- NCT02731144
- Testing
- Peptamen intense, Novasource senior
- Volunteers
- 10 people
- Sponsor
- Hospital Sao Domingos
Sedation
Assessment of Sedation During Endoscopy
Use of sedation is often required in endoscopic procedures such as ERCP (endoscopic retrograde cholangiopancreatography). However, assessment of the level of sedation during these procedures is not investigated in detail.
- Trial name
- NCT01747733
- Testing
- Bispectral Index
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- Helsinki University Central Hospital
Post-COVID-19 Syndrome
Methylprednisolone in Patients With Cognitive Deficits in Post-COVID-19 Syndrome (PCS)
This clinical trial aims to learn about the therapeutic value of Methylprednisolone, a well-known immunosuppressant, on cognitive deficits in patients with post-COVID-19 syndrome (PCS).
- Trial name
- NCT05986422
- Testing
- Methylprednisolone
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- Charite University, Berlin, Germany
Colonoscopy
Sedation Techniques for Outpatient Colonoscopy
This was a prospective, randomized, single-blind controlled clinical trial comparing three sedative regimens for outpatient colonoscopy.
- Trial name
- NCT04686058
- Testing
- Propofol 10 MG/ML Injection, Midazolam injection, Pethidine Hydrochloride 50 Mg/mL Solution for Injection
- Where
- Malaysia
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Neck Pain, Kinesiophobia
Minimal Clinical Important Change of the Turkish Versions of the FABQ TKS, and PCS in Patients With Chronic Neck Pain
To investigate the reliability and sensitivity of the Fear-Avoidance Beliefs Questionnaire, Tampa Kinesiophobia Scale, and Pain Catastrophizing Scale in patients with chronic nonspecific neck pain undergoing multidisciplinary…
- Conditions
- Neck Pain, Kinesiophobia, Fear of Movement
- Trial name
- NCT06194812
- Testing
- Pain Catastrophizing scale
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Acibadem University
Cardiovascular Diseases, Kidney Diseases
Effect of Barley Supplemented Wheat Bread on Markers of Cardiovascular and Renal Health
The disruption of colonic microbiota has been linked to a number of diseases, mainly cardiovascular and kidney diseases. One possible means to improve the microbiota is to increase dietary fiber intake as the intake of dietary…
- Trial name
- NCT05312788
- Testing
- Effect of Barley Supplemented Wheat Bread on markers of Cardiovascular and Renal Health
- Where
- Pakistan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Urinary Problems, Prostate Cancer
Comparative Study of Use of Alpha-Blockers to Treat Symptoms in Prostate Cancer Patients Undergoing Radiation Therapy
Approximately 50%-95% of prostate cancer patients undergoing radiation therapy (RT) develop symptomatic urinary problems .These symptoms can significantly diminish a patient's quality of life during and shortly after therapy.
- Trial name
- NCT02220829
- Testing
- Preventive administration of Rapaflo, Standard Care
- Where
- Canada
- Volunteers
- 148 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
COPD Exacerbation, Trauma
FreeO2 PreHospital - Automated Oxygen Titration vs Manual Titration According to the BLS-PCS
Evaluation of automated oxygen titration in comparison with manual adjustment oxygen in the out-of-hospital setting by paramedics.
- Trial name
- NCT03696563
- Testing
- Automated oxygen administration - FreeO2, Standard administration of oxygen flow
- Volunteers
- 100 people
- Sponsor
- François Lellouche
Prostate Cancer
The Predictive Value of TMPRSS2-ERG Fusion in High Risk Prostate Cancer Patient
The objective of this study is to evaluate the predictive value of TMPRSS2-ERG gene fusion in patients with prostate cancer treated with radiation and hormonal therapy.
- Trial name
- NCT02588404
- Testing
- LHRH therapy
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital