Clinical trials: PERIPHERAL VASCULAR DISEASE
Peripheral Arterial Disease
A Single-dose Escalation Safety and PK Study for PLC in Healthy Chinese
The main objective is to evaluate the effect of single dose Propionyl-L-Carnitine Hydrochloride on clinical pharmacokinetic characteristics and its effect of clinical pharmacokinetic characteristics and safety on healthy Chinese…
- Trial name
- NCT02786069
- Testing
- Propionyl L-carnitine Hydrochloride
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Lee's Pharmaceutical Limited
Meningitis, Encephalitis
The Effectiveness and Safety of Human Lumbar Puncture Assist Device (LPat)
The purpose of this study is to proof and investigate the effectiveness and safety of the invented device named "Human Lumbar Puncture Assist Device (LPat)" as an assist tool to be utilized to improve the success rate of…
- Conditions
- Meningitis, Encephalitis, Guillain-Barré, Subarachnoid Hemorrhage
- Trial name
- LPat (NCT03710278)
- Testing
- LPat Device
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Spartanburg Regional Healthcare System
Carotid Artery Disease, Atherosclerosis
Telerobotic Ultrasound for Carotid Imaging - Feasibility Study
In this proposal, the investigators will demonstrate the feasibility and noninferiority of telerobotic ultrasonography as compared to traditional manual acquisition in performing a limited carotid Duplex examination and in…
- Conditions
- Carotid Artery Disease, Atherosclerosis, Atheromatous Plaques, Arteriosclerosis
- Trial name
- NCT05654935
- Testing
- Ultrasound for Carotid Arteries, Telerobotic Ultrasound for Carotid Arteries
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Bone Diseases
How Does Early Age Life Style Affect Bone Strength and General Health Parameters at Middle Age?
The purpose of this study is to evaluate the effect of vigorous physical activity versus extremely sedentary life style during young age on the bone mineral density and general health in later life.
- Trial name
- NCT00270608
- Testing
- Quantitative Computed Tomography of the tibia and spine, MRI of the spine and the right knee, Blood test
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Peripheral Vascular Diseases
Understanding the Genetic Basis of Atherosclerosis and Peripheral Arterial Disease
Atherosclerosis, a condition in which fatty deposits build up along the inner walls of arteries, can occur throughout the body. The purpose of this study is to examine the possible genetic differences that may influence where…
- Trial name
- GenePAD (NCT00380185)
- Where
- 2 sites in United States
- Volunteers
- 1,789 people, healthy volunteers welcome
- Sponsor
- Stanford University
Vasodilation, Diabetes Mellitus, Type 2
Impact of Regional Vibration Application and Flow Mediated Dilation on Brachial Artery Hemodynamics
Application of vibration has been previously shown to affect tissue perfusion and utilized in different branches of medicine. Little is known about the acute impact of vibration application on peripheral artery hemodynamics.
- Trial name
- VMD (NCT05492071)
- Testing
- Local Vibration Application Following Flow Mediated Dilation, Flow mediated dilation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Diabetic Foot, Peripheral Neuropathy With Type 2 Diabetes
The Effects of Different Exercises on Tissue Mechanics, Strength and Neuropathy Symptoms in Type 2 Diabetes Patients
To examine the effects of aerobic exercise and foot exercises in addition to aerobic exercise on lower extremity distal tissue mechanics, muscle strength and neuropathy symptoms in type 2 diabetics with peripheral neuropathy.
- Trial name
- NCT05422235
- Testing
- Routine Medical Treatment, Aerobic Exercise, Aerobic Exercise+ Foot-Related Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Peripheral Arterial Disease, Cardiovascular Diseases
Mitochondrial Function in Peripheral Arterial Disease
The aim of this study is to investigate the effect of different treatment strategies on mitochondrial function and to correlate in-vitro results to findings from in-vivo measurements of mitochondrial function.
- Trial name
- MIVA (NCT05644158)
- Testing
- Revascularization, Exercise therapy
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Peripheral Vascular Disease
RCT to Evaluate the Renal Protective Effects of Remote Ischaemic Preconditioning in Peripheral Angioplasty
This study aims to demonstrate if remote ischaemic preconditioning (RIPC) may confer renal protection in patients undergoing peripheral angioplasty.
- Trial name
- NCT02054871
- Testing
- RIPC
- Where
- Ireland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mid Western Regional Hospital, Ireland
Hypertension,Essential
Peripheral Vascular Effects of Sulfhydryl-containing Antihypertensive Pharmacotherapy on Microvessels in Humans
High blood pressure can cause physical changes to the blood vessels of the body (remodeling). If a person who has high blood pressure also has a lot of blood vessel remodeling with their condition, they are more likely to have…
- Trial name
- H2SPharm (NCT03179163)
- Testing
- Captopril Pill, Enalapril Pill, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Penn State University
Arteriosclerosis
Association Between Peripheral Artery Stiffness and Cardiovascular Disease
Arterial pulse wave velocity (PWV) is strongly correlated with atherosclerosis, and the PWV of carotid or femoral artery could predict the severity of arterial atherosclerosis.
- Trial name
- NCT00201565
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Raynaud Disease, Raynaud Phenomenon
Investigation of the Rewarming og the Fingers After Cooling and the Autonomic Nervous System in Raynaud's Phenomenon
Patients with Raynaud's disease have an increased tendency of chest pain and migraine, and studies indicate that the disease might be associated with increased cardiovascular morbidity and mortality.
- Conditions
- Raynaud Disease, Raynaud Phenomenon, Hand and Arm Vibration Syndrome, Diabetes Mellitus
- Trial name
- RaynAUT (NCT03094910)
- Testing
- Examination of vibration perception threshold in fingertips, Ewing's tests, Tilt table test
- Where
- Denmark
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Peripheral Arterial Disease
To Investigate the Effect of Far-infrared Radiation on Lower Extremity Acupoints on the Blood Circulation of Lower Extremities in Patients With Hemodialysis
This study intends to irradiate the acupoints of both lower extremities of hemodialysis patients with far-infrared therapeutic apparatus to explore its effect on foot blood circulation, peripheral artery occlusion disease (PAOD)…
- Trial name
- NCT05822960
- Testing
- far-infrared radiation
- Where
- 2 sites in Taiwan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Raynaud's Phenomenon
MQX-503 Applied to the Hand Versus Nitroglycerin Ointment Applied to the Chest: A Pharmacokinetic Comparison
The purpose of this clinical study is to compare the pharmacokinetic profiles of a topical cream formulation of 0.9% nitroglycerin, MQX 503, and Nitroglycerin Ointment 2%, USP.
- Trial name
- NCT00841594
- Testing
- nitroglycerin 0.9 % (MXQ-503), Nitroglycerin ointment 2%, USP
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- MediQuest Therapeutics
Diabetes, Peripheral Vascular Disease
Open-label Pilot Study to Assess the Use of Magic Foot™ in the Improvment of Parameters in Subject With Foot Symptoms
This is a single-arm, single-center, open-label, pilot study . 30 subjects with foot symptoms attributable to diabetes or peripheral vascular disease will be screened .
- Trial name
- MF (NCT01784471)
- Testing
- Magic Foot™
- Where
- Israel
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Yaffa Golan, Ltd.
Peripheral Artery Disease
Comparative Pharmacokinetic Study Between Two Extended-Release Cilostazol Formulations in Korea
This is a randomized, open-label, multiple-dose, two-sequence, two-period crossover study to to compare the safety/tolerability and pharmacokinetics between Pletaal SR Cap. and Cilostan CR Tab. in healthy volunteers
- Trial name
- NCT03524963
- Testing
- Cilostan CR Tab., Pletaal SR Cap.
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bundang CHA Hospital
Dementia, Movement Disorders
Comparison of NeuroEXPLORER PET/CT Versus Standard-of-care PET/CT of the Head and Neck Region.
The goal of this clinical study is to compare the current standard-of-care PET/CT scanner with the new NeuroEXPLORER PET/CT, with the aim of demonstrating the added diagnostic value of the new scanner.
- Conditions
- Dementia, Movement Disorders, ALS - Amyotrophic Lateral Sclerosis, Epilepsy
- Trial name
- NCT07595666
- Testing
- Standard-of-care PET/CT, NeuroEXPLORER
- Where
- Belgium
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- prof. dr. Koen Van Laere
Patient With IV Cannula Induce Phlebitis
Comparison of Magnesium Sulphate Versus Cold Compress in IV Cannula Induces Phlebitis
The use of intravenous (IV) devices is an integral part of patient care in hospitals, clinics, maternity home etc. approximately 80% of hospitalized patients receive I.V therapies.
- Trial name
- NCT06072729
- Testing
- comparison of magnesium sulphate versus cold compression
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Lahore
Stroke, Hemiparesis;Poststroke/CVA
Muscle Oxygenation and Spasticity in Hemiparetic Stroke Patients
Conditions such as hemiparesis, sensory and motor impairment, perceptual impairment, cognitive impairment, aphasia, and dysphagia may be observed after stroke.
- Conditions
- Stroke, Hemiparesis;Poststroke/CVA, Spasticity as Sequela of Stroke
- Trial name
- NCT06362954
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ankara Medipol University
Peripheral Arterial Disease
Maximal Exercise Capacity, Physical Activity and Respiratory Muscle Strength in Peripheral Artery Disease
The primary aim of the study is to evaluate the maximal and submaximal exercise capacity in patients with peripheral artery disease (PAD).
- Trial name
- NCT03458754
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Gazi University