Clinical trials: PFAS Exposure
Disease, Cardiovascular Diseases
Biomarkers of Acrylamide, Glycidol, POPs, PFAS and Disease Outcomes and OMICs Signatures
The aim of the project is to assess the associations between biomarkers of acrylamide and glycidol exposure and disease outcomes in a case-cohort study based on two prospective cohorts with biobanks.
- Conditions
- Disease, Cardiovascular Diseases, Cancer, Environmental Exposure
- Trial name
- NCT05930626
- Testing
- Biomarkers of acrylamide, glycidol, POPs, PFAS
- Volunteers
- 9,254 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Innate Inflammatory Response, Vaccination
PFAS Exposure and Immune Response to Vaccination in Adults
This clinical trial aims to investigate how exposure to Perfluorononanoic acid (PFNA), a type of per- and polyfluoroalkyl substance (PFAS), affects the immune response to the standard tetanus and diphtheria (Td) vaccine.
- Conditions
- Innate Inflammatory Response, Vaccination, Diphtheria, Tetanus
- Trial name
- NCT06588530
- Testing
- TENIVAC
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Breast Cancer
Studying The Association Between Environmental Exposure to PFAS and Breast Cancer in Assiut Governorate- Egypt
1. Measuring serum level of PFAS in breast cancer female patients and healthy participants. 2. Studying the correlation between serum level of PFAS and breast cancer risk through statistical modeling and analysis. 3.
- Trial name
- NCT06457282
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Assiut University
PFAS, Environmental Exposures
Use of Bile Acid Binding Resins to Decrease PFAS Levels Via Colesevalem in Veterans Study
The goal of this study is to test the efficacy and feasibility of Colesevelam administration (50% of the recommended dose) to reduce serum PFAS concentration in the Veteran population who have serum PFAS levels that exceed the…
- Conditions
- PFAS, Environmental Exposures, Occupational Exposure to Chemicals, Military Exposure
- Trial name
- PAVERS (NCT07592858)
- Testing
- Colesevelam
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Fetal Alcohol Spectrum Disorder
Parenting Training for Children With FASD
Prenatal alcohol exposure can lead to a myriad of adverse developmental outcomes in children, and is the leading cause of mental disability in Canada.
- Trial name
- SF-FASD (NCT02210455)
- Testing
- Strongest Families FASD intervention, Psychoeducation
- Where
- Canada
- Volunteers
- 119 people
- Sponsor
- IWK Health Centre
Toxicant Exposure, Firefighter
Examining a Novel Gastrointestinal Intervention to Negate Environmental Toxicants (ENGINE)
This randomized, placebo-controlled crossover trial will test the feasibility and acceptability of using colesevelam in male firefighters with high per- and polyfluoroalkyl substances (PFAS) exposure.
- Conditions
- Toxicant Exposure, Firefighter, Occupational Exposure to Chemicals
- Trial name
- ENGINE (NCT07226440)
- Testing
- Colesevelam
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Environmental Exposure, PFAS Exposure
Effect of a Dietary Supplement Versus Placebo on Serum PFAS Levels in Male Firefighters
This study is designed to evaluate the effect of a probiotic dietary supplement containing Streptococcus salivarius on serum PFAS levels in male firefighters with documented occupational PFAS exposure, following twice-daily use…
- Trial name
- AFCRO202 (NCT07846371)
- Testing
- Streptococcus salivarius 46-SL1
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Cambiotics ApS
Environmental Health Effects
Assessing PFAS Exposure for Better Health
The goal of this observational study is to determine whether a personalized PFAS (per- and polyfluoroalkyl substances) blood test and educational report-back can improve environmental health literacy (EHL), empower exposure…
- Trial name
- APEX (NCT07391397)
- Testing
- Blood Test and Report Back
- Where
- United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Million Marker Wellness, Inc.
Environmental Exposure
PFAS Clinical Trial
The purpose of this study is to evaluate whether treatment with cholestyramine for either one, two, three, or four months (up to 120 days), meaningfully influences per- and polyfluoroalkyl substances (PFAS) removal from the body.
- Trial name
- NCT07836023
- Testing
- Cholestyramine, Centrum
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Emory University